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HDGFL3

gene
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Also known as HRP-3Hdgfrp3

Summary

HDGFL3 (HDGF like 3, HGNC:24937) is a protein-coding gene on chromosome 15q25.2, encoding Hepatoma-derived growth factor-related protein 3 (Q9Y3E1). Enhances DNA synthesis and may play a role in cell proliferation.

Predicted to enable microtubule binding activity. Predicted to be involved in microtubule polymerization; negative regulation of microtubule depolymerization; and neuron projection development. Located in nucleoplasm.

Source: NCBI Gene 50810 — RefSeq curated summary.

At a glance

  • GWAS associations: 1
  • Clinical variants (ClinVar): 51 total
  • Druggable target: yes — 1 molecules with ChEMBL bioactivity
  • MANE Select transcript: NM_016073

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:24937
Approved symbolHDGFL3
NameHDGF like 3
Location15q25.2
Locus typegene with protein product
StatusApproved
AliasesHRP-3, Hdgfrp3
Ensembl geneENSG00000166503
Ensembl biotypeprotein_coding
OMIM616643
Entrez50810

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000299633, ENST00000562702, ENST00000563404, ENST00000563790, ENST00000568129, ENST00000568294, ENST00000715404, ENST00000939084, ENST00000939085

RefSeq mRNA: 1 — MANE Select: NM_016073 NM_016073

CCDS: CCDS32314

Canonical transcript exons

ENST00000299633 — 6 exons

ExonStartEnd
ENSE000011590568312775383139275
ENSE000026229548320733183207823
ENSE000034660598315121583151361
ENSE000035458228315790383158041
ENSE000036065498315741583157573
ENSE000036077158316399983164075

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 99.17.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 29.4763 / max 645.9126, expressed in 1680 samples.

FANTOM5 promoters (14 alternative TSS)

Promoter IDTPM avgSamples expressed
15131113.64661607
1513076.75181438
1513134.42851318
1513021.5208538
1513150.8645388
1513100.5857393
1513140.5147284
1513120.2887126
2076280.254291
1513090.251089

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
cortical plateUBERON:000534399.17gold quality
ganglionic eminenceUBERON:000402398.67gold quality
calcaneal tendonUBERON:000370198.29gold quality
embryoUBERON:000092297.73gold quality
ventricular zoneUBERON:000305397.66gold quality
Brodmann (1909) area 23UBERON:001355496.84gold quality
entorhinal cortexUBERON:000272896.82gold quality
postcentral gyrusUBERON:000258196.68gold quality
parietal lobeUBERON:000187296.63gold quality
orbitofrontal cortexUBERON:000416796.45gold quality
corpus epididymisUBERON:000435996.39gold quality
CA1 field of hippocampusUBERON:000388196.32gold quality
endothelial cellCL:000011596.31gold quality
superior frontal gyrusUBERON:000266196.24gold quality
cauda epididymisUBERON:000436096.23gold quality
prefrontal cortexUBERON:000045196.18gold quality
choroid plexus epitheliumUBERON:000391196.02gold quality
Brodmann (1909) area 46UBERON:000648395.73gold quality
substantia nigra pars compactaUBERON:000196595.50gold quality
dorsal motor nucleus of vagus nerveUBERON:000287095.40gold quality
adult organismUBERON:000702395.30gold quality
tendonUBERON:000004395.29gold quality
temporal lobeUBERON:000187195.23gold quality
amygdalaUBERON:000187695.01gold quality
superior vestibular nucleusUBERON:000722794.98gold quality
medulla oblongataUBERON:000189694.88gold quality
occipital lobeUBERON:000202194.84gold quality
adrenal tissueUBERON:001830394.75gold quality
Ammon’s hornUBERON:000195494.71gold quality
hypothalamusUBERON:000189894.68gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

ExperimentMarker?Max mean expression
E-ANND-3yes15.34
E-MTAB-9543yes12.07

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

127 targeting HDGFL3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-6758-5P100.0066.211470
HSA-MIR-6856-5P100.0065.471298
HSA-MIR-3924100.0072.092394
HSA-MIR-1277-5P100.0073.955056
HSA-MIR-4789-3P99.9970.752484
HSA-MIR-366299.9973.825684
HSA-MIR-548C-3P99.9974.017587
HSA-MIR-371B-5P99.9975.344759
HSA-MIR-103A-3P99.9869.141595
HSA-MIR-10799.9869.141595
HSA-MIR-548N99.9871.944170
HSA-MIR-373-5P99.9875.364753
HSA-MIR-616-5P99.9875.584775
HSA-MIR-477599.9875.006394
HSA-MIR-314899.9775.066478
HSA-MIR-493-5P99.9672.472382
HSA-MIR-548AJ-3P99.9673.385345
HSA-MIR-548X-3P99.9673.385345
HSA-MIR-570-3P99.9672.414910
HSA-MIR-426799.9666.532368
HSA-MIR-9983-3P99.9471.483631
HSA-MIR-101-3P99.9475.032230
HSA-MIR-144-3P99.9473.982698
HSA-MIR-548J-3P99.9472.614881
HSA-MIR-548AE-3P99.9372.664867
HSA-MIR-548AH-3P99.9372.544872
HSA-MIR-548AM-3P99.9372.544872
HSA-MIR-548AQ-3P99.9372.664867
HSA-MIR-338-5P99.9272.342951
HSA-MIR-6809-3P99.9171.453814

Literature-anchored findings (GeneRIF, showing 9)

  • LEDGF/p75 and HRP2 IBDs avidly bind HIV-1 Integrase, share a similar domain organization and have an evident evolutionary and likely functional relationship (PMID:15371438)
  • Hepatoma-derived growth factor-related protein-3 interacts with microtubules and promotes neurite outgrowth in mouse cortical neurons (PMID:19237540)
  • Depletion of HRP-3 induces apoptosis of radio- and chemoresistant A549 cells. HRP-3 is essential for regulating reactive oxygen species-dependent, p53-induced cell death. (PMID:24012673)
  • Glucose deprivation-induced HRP-3 up-regulation potentially plays a major role in protecting hepatocellular carcinoma cells against apoptosis caused by energy pressure. (PMID:26823754)
  • The study observed higher expression levels of HDGFRP3 and ID2 in bipolar disorder (BD) patients who favourably respond to lithium. Both of these genes are involved in neurogenesis, and HDGFRP3 has been suggested to be a neurotrophic factor. (PMID:28854847)
  • HRP3 PWWP is a new family of minor groove-specific DNA-binding proteins (PMID:31162607)
  • A novel function of HRP-3 in regulating cell cycle progression via the HDAC-E2F1-Cyclin E pathway in lung cancer. (PMID:34714604)
  • HDGFRP3 interaction with 53BP1 promotes DNA double-strand break repair. (PMID:36794849)
  • Bulk RNA-Seq Combined with Single-Cell Transcriptome Sequencing Reveals the Possible Mechanisms by Which HDGFL3 Involves in Prostate Cancer Growth and Metastasis. (PMID:37681334)

Cross-species orthologs

3 orthologs

OrganismSymbolGene ID
ENSDARG00000101464
mus_musculusHdgfl3ENSMUSG00000025104
rattus_norvegicusHdgfl3ENSRNOG00000019740

Paralogs (4): HDGFL1 (ENSG00000112273), HDGF (ENSG00000143321), PSIP1 (ENSG00000164985), HDGFL2 (ENSG00000167674)

Protein

Protein identifiers

Hepatoma-derived growth factor-related protein 3 — Q9Y3E1 (reviewed: Q9Y3E1)

Alternative names: Hepatoma-derived growth factor 2

All UniProt accessions (3): Q9Y3E1, H3BPM9, H3BPQ6

UniProt curated annotations — full annotation on UniProt →

Function. Enhances DNA synthesis and may play a role in cell proliferation.

Subcellular location. Nucleus.

Tissue specificity. Detected in testis, heart, spinal cord and brain.

Similarity. Belongs to the HDGF family.

RefSeq proteins (1): NP_057157* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000313PWWP_domDomain

Pfam: PF00855

UniProt features (24 total): strand 6, compositionally biased region 5, modified residue 4, helix 3, turn 2, chain 1, domain 1, region of interest 1, short sequence motif 1

Structure

Experimental structures (PDB)

5 structures.

PDBMethodResolution (Å)
6IIPX-RAY DIFFRACTION0.95
6IIQX-RAY DIFFRACTION1.85
6IITX-RAY DIFFRACTION2.1
6IIRX-RAY DIFFRACTION2.2
6IISX-RAY DIFFRACTION2.36

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9Y3E1-F171.880.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 121, 122, 162, 110

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 127 (showing top): YAGI_AML_WITH_INV_16_TRANSLOCATION, GOBP_REGULATION_OF_MICROTUBULE_BASED_PROCESS, GOZGIT_ESR1_TARGETS_DN, GOBP_NEUROGENESIS, GOMF_GROWTH_FACTOR_ACTIVITY, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, GOBP_MICROTUBULE_DEPOLYMERIZATION, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_DISASSEMBLY, DODD_NASOPHARYNGEAL_CARCINOMA_UP, GOBP_PROTEIN_DEPOLYMERIZATION, SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP, JAATINEN_HEMATOPOIETIC_STEM_CELL_UP, GOBP_CELL_PROJECTION_ORGANIZATION, GOBP_REGULATION_OF_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION

GO Biological Process (4): negative regulation of microtubule depolymerization (GO:0007026), neuron projection development (GO:0031175), microtubule polymerization (GO:0046785), signal transduction (GO:0007165)

GO Molecular Function (3): microtubule binding (GO:0008017), growth factor activity (GO:0008083), tubulin binding (GO:0015631)

GO Cellular Component (5): extracellular region (GO:0005576), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure4
microtubule depolymerization1
negative regulation of microtubule polymerization or depolymerization1
regulation of microtubule depolymerization1
negative regulation of protein depolymerization1
negative regulation of supramolecular fiber organization1
neuron development1
plasma membrane bounded cell projection organization1
microtubule nucleation1
microtubule polymerization or depolymerization1
protein polymerization1
supramolecular fiber organization1
cell communication1
cellular process1
signaling1
regulation of cellular process1
cellular response to stimulus1
tubulin binding1
receptor ligand activity1
cytoskeletal protein binding1
intracellular membrane-bounded organelle1
nuclear lumen1
cytoplasm1
intracellular anatomical structure1

Protein interactions and networks

STRING

536 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
HDGFL3HMCN2Q8NDA2447
HDGFL3BRPF1P55201416
HDGFL3PON3Q15166411
HDGFL3MORF4L1Q9UBU8374
HDGFL3C15orf40Q8WUR7369
HDGFL3ANTXR2P58335358
HDGFL3SDR42E1Q8WUS8349
HDGFL3BTBD1Q9H0C5348
HDGFL3RAMACQ9BTL3310
HDGFL3URADA6NGE7306
HDGFL3ANAPC15P60006299
HDGFL3FSD2A1L4K1297
HDGFL3RSPH10BP0C881294
HDGFL3BNC1Q01954293
HDGFL3SGIP1Q9BQI5291

IntAct

31 interactions, top by confidence:

ABTypeScore
GPANK1ALOX12Bpsi-mi:“MI:0914”(association)0.530
GRB2SH3PXD2Bpsi-mi:“MI:0914”(association)0.530
SENP8HDGFL3psi-mi:“MI:0915”(physical association)0.400
BAZ2BHDGFL3psi-mi:“MI:0915”(physical association)0.400
TERF2IPHDGFL3psi-mi:“MI:0915”(physical association)0.370
APPESYT2psi-mi:“MI:0914”(association)0.350
RNF13AP3D1psi-mi:“MI:0914”(association)0.350
PLSCR1psi-mi:“MI:0914”(association)0.350
BSCL2B4GAT1psi-mi:“MI:0914”(association)0.350
MTERF2DCXpsi-mi:“MI:0914”(association)0.350
CDKL5DHX16psi-mi:“MI:0914”(association)0.350
CDK17DHPSpsi-mi:“MI:0914”(association)0.350
ZNF280ANUCB2psi-mi:“MI:0914”(association)0.350
BAZ2BINApsi-mi:“MI:0914”(association)0.350
ZNF23POLR1Fpsi-mi:“MI:0914”(association)0.350
SLC30A6ACTBL2psi-mi:“MI:0914”(association)0.350
MAPTSHTN1psi-mi:“MI:0914”(association)0.350
SF3B2HTATSF1psi-mi:“MI:0914”(association)0.350
HDGFL2CIBAR1psi-mi:“MI:0914”(association)0.350
VPS37APHF2psi-mi:“MI:0914”(association)0.350
FAM161AGH1psi-mi:“MI:0914”(association)0.350
NOD2HSPA8psi-mi:“MI:0914”(association)0.350
RBM42TNFSF10psi-mi:“MI:0914”(association)0.350
ZIC2EEF1A2psi-mi:“MI:0914”(association)0.350
ZRANB3COPS9psi-mi:“MI:0914”(association)0.350
CPXCR1VTA1psi-mi:“MI:0914”(association)0.350
EBAG9psi-mi:“MI:0914”(association)0.350

BioGRID (48): HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS), HDGFRP3 (Affinity Capture-MS)

ESM2 similar proteins: A0A1B0GTU1, A2CG63, A8MW92, D3Z8Y2, F8VPQ2, G3V8T1, O75475, O96028, P29374, P46100, P51858, P51859, Q0VEE6, Q2TB10, Q32N87, Q3TYA6, Q3UMU9, Q4LE39, Q4V9H5, Q5F363, Q5F489, Q5XXA7, Q5XXA9, Q62315, Q66T72, Q6P2L6, Q6P4K1, Q7YQM3, Q7YQM4, Q7Z4V5, Q812D1, Q8BVE8, Q8C9B9, Q8CCG4, Q8CCJ9, Q8MJG1, Q8NFC6, Q8R515, Q8VHK7, Q923W4

Diamond homologs: A4FUF0, F4I907, F4K4D6, O75475, P51858, P51859, Q175F8, Q29NG1, Q32N87, Q3UMU9, Q49A26, Q562D5, Q5R7T2, Q5RKH0, Q5RKN4, Q5XXA9, Q5ZLS7, Q66T72, Q6K431, Q6P2L6, Q6P4K1, Q7Q161, Q7Z4V5, Q812D1, Q8MJG1, Q8MT36, Q8T079, Q8VHK7, Q922P9, Q923W4, Q925G1, Q99JF8, Q9BZ95, Q9FNE4, Q9JMG7, Q9LEY4, Q9LSV0, Q9LYZ0, Q9SF36, Q9SZE1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance35
Likely benign1
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2931 predictions. Top by Δscore:

VariantEffectΔscore
15:83115843:A:AGacceptor_gain1.0000
15:83115843:AGT:Aacceptor_gain1.0000
15:83115844:G:GTacceptor_gain1.0000
15:83115844:GT:Gacceptor_gain1.0000
15:83115844:GTG:Gacceptor_gain1.0000
15:83115844:GTGT:Gacceptor_gain1.0000
15:83119678:GGGA:Gdonor_gain1.0000
15:83119679:G:GTdonor_gain1.0000
15:83119679:GGA:Gdonor_gain1.0000
15:83119680:GA:Gdonor_gain1.0000
15:83119680:GAG:Gdonor_gain1.0000
15:83119682:G:GGdonor_gain1.0000
15:83139144:CAAA:Cdonor_gain1.0000
15:83151208:T:TAdonor_gain1.0000
15:83151209:CCTTA:Cdonor_loss1.0000
15:83151210:CTTA:Cdonor_loss1.0000
15:83151211:TTA:Tdonor_loss1.0000
15:83151212:TA:Tdonor_loss1.0000
15:83151213:A:ACdonor_gain1.0000
15:83151213:A:ATdonor_loss1.0000
15:83151213:AC:Adonor_gain1.0000
15:83151213:ACC:Adonor_gain1.0000
15:83151214:C:CCdonor_gain1.0000
15:83151214:CC:Cdonor_gain1.0000
15:83151214:CCC:Cdonor_gain1.0000
15:83157411:TAAC:Tdonor_loss1.0000
15:83157413:A:AGdonor_loss1.0000
15:83157426:A:ACdonor_gain1.0000
15:83157435:T:TAdonor_gain1.0000
15:83157569:ATTGC:Aacceptor_gain1.0000

AlphaMissense

1333 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
15:83157940:A:CI88R1.000
15:83157940:A:TI88K1.000
15:83157943:T:AE87V1.000
15:83157944:C:TE87K1.000
15:83157949:A:GL85S1.000
15:83157952:C:AG84V1.000
15:83157952:C:TG84E1.000
15:83157953:C:GG84R1.000
15:83157953:C:TG84R1.000
15:83157960:A:CF81L1.000
15:83157960:A:TF81L1.000
15:83157961:A:CF81C1.000
15:83157961:A:GF81S1.000
15:83157962:A:CF81V1.000
15:83157962:A:GF81L1.000
15:83157962:A:TF81I1.000
15:83157964:C:TG80E1.000
15:83157965:C:GG80R1.000
15:83157965:C:TG80R1.000
15:83157970:C:GR78P1.000
15:83157974:T:CK77E1.000
15:83157988:A:GF72S1.000
15:83158010:A:CY65D1.000
15:83158018:A:GL62P1.000
15:83158018:A:TL62H1.000
15:83158033:A:GL57P1.000
15:83158033:A:TL57Q1.000
15:83158035:A:CF56L1.000
15:83158035:A:TF56L1.000
15:83158036:A:GF56S1.000

dbSNP variants (sampled 300 via entrez): RS1000053900 (15:83178093 G>A), RS1000095506 (15:83132257 T>C), RS1000125578 (15:83135458 T>C), RS1000150718 (15:83195942 T>A,C), RS1000166847 (15:83146154 C>T), RS1000224301 (15:83159534 G>A), RS1000244268 (15:83175124 G>C), RS1000265689 (15:83195587 G>C), RS1000328733 (15:83203797 TTG>T), RS1000347467 (15:83162779 C>T), RS1000357412 (15:83190116 C>T), RS1000403146 (15:83183559 G>A,C), RS1000406326 (15:83208810 A>G), RS1000431642 (15:83191559 T>A,C), RS1000467142 (15:83168341 C>A)

Disease associations

OMIM: gene MIM:616643 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

StudyTraitp-value
GCST90020028_1761Hip circumference adjusted for BMI3.000000e-08

EFO canonical traits (1, from GWAS)

EFO IDTrait name
EFO:0008039BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5724672 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 1,538 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

MoleculeNamePhasePatents
CHEMBL1232461MOLIBRESIB21,538

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChemblTypeValueUnitMolecule
8.00IC5010nMMOLIBRESIB
7.82Kd15nMMOLIBRESIB

PubChem BioAssay actives

2 with measured affinity, of 7 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

CompoundAssayTypeValueUnit
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide2178394: Inhibition of HDGF2 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisic500.0100uM

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects cotreatment, decreases expression, affects expression, increases methylation6
bisphenol Adecreases expression2
sodium arseniteaffects methylation, increases expression2
Asbestos, Serpentineincreases expression2
aristolochic acid Idecreases expression1
FR900359increases phosphorylation1
trichostatin Adecreases expression1
1-UFT protocoldecreases response to substance1
S 1 (combination)decreases response to substance1
CGP 52608affects binding, increases reaction1
entinostatdecreases expression1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, decreases expression1
dorsomorphinaffects cotreatment, decreases expression1
picoxystrobindecreases expression1
bisphenol AFincreases expression1
Capecitabinedecreases response to substance1
Air Pollutantsincreases abundance, decreases expression1
Benzo(a)pyreneincreases expression1
Fluorouracilaffects reaction, decreases expression1
Methotrexateaffects response to substance1
Phenobarbitalincreases expression1
Rotenonedecreases expression1
Tretinoinincreases expression1
Cyclosporineincreases expression1
Aflatoxin B1increases expression1
Lithium Chloridedecreases expression1
Okadaic Acidincreases expression1
Particulate Matterdecreases expression, increases abundance1

ChEMBL screening assays

7 unique, capped per target: 7 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL5697124BindingInhibition of HDGF2 (unknown origin) assessed as fold change at 10 uM incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisInhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. — Nature

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 78

This page pulls from 78 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_assaychembl_documentchembl_moleculechembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpatent_compoundpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomerefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot