HECTD2-AS1

Summary

HECTD2-AS1 (HECTD2 antisense RNA 1, HGNC:48679) is a long non-coding RNA gene on chromosome 10q23.32.

At a glance

• Clinical variants (ClinVar): 3 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48679
Approved symbol	HECTD2-AS1
Name	HECTD2 antisense RNA 1
Location	10q23.32
Locus type	RNA, long non-coding
Status	Approved
Entrez	100188947
RNAcentral	URS000075B789 — lncRNA, 1038 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr10q23

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	2
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3523 predictions. Top by Δscore:

Variant	Effect	Δscore
10:91410574:GCG:G	donor_gain	1.0000
10:91410576:GGTA:G	donor_loss	1.0000
10:91410577:G:GG	donor_gain	1.0000
10:91410578:T:G	donor_loss	1.0000
10:91425279:AG:A	acceptor_gain	1.0000
10:91425280:GG:G	acceptor_gain	1.0000
10:91425406:GAATG:G	donor_gain	1.0000
10:91425407:AATGG:A	donor_loss	1.0000
10:91425408:ATGG:A	donor_loss	1.0000
10:91425409:TGG:T	donor_loss	1.0000
10:91425410:GGTAA:G	donor_loss	1.0000
10:91425411:G:T	donor_loss	1.0000
10:91425412:T:A	donor_loss	1.0000
10:91460416:A:AG	acceptor_gain	1.0000
10:91460417:T:G	acceptor_gain	1.0000
10:91460418:A:AG	acceptor_gain	1.0000
10:91460419:C:G	acceptor_gain	1.0000
10:91460423:A:AG	acceptor_gain	1.0000
10:91460423:ACAGT:A	acceptor_gain	1.0000
10:91460424:CAGTG:C	acceptor_gain	1.0000
10:91460425:A:AG	acceptor_gain	1.0000
10:91460425:AGT:A	acceptor_gain	1.0000
10:91460425:AGTGA:A	acceptor_gain	1.0000
10:91460426:G:GA	acceptor_gain	1.0000
10:91460426:GT:G	acceptor_gain	1.0000
10:91460426:GTG:G	acceptor_gain	1.0000
10:91460426:GTGA:G	acceptor_gain	1.0000
10:91460426:GTGAG:G	acceptor_gain	1.0000
10:91460561:TTTCA:T	donor_gain	1.0000
10:91460562:TTCA:T	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000000543 (10:91556098 C>T), RS1000005287 (10:91330825 TA>T,TAA), RS1000010439 (10:91349979 A>T), RS1000015057 (10:91562855 T>C), RS1000018277 (10:91420328 G>A), RS1000019188 (10:91480561 A>G), RS1000025891 (10:91379758 G>A,C), RS1000031444 (10:91490771 G>A,C), RS1000043372 (10:91446237 G>A,T), RS1000053866 (10:91565566 T>C,G), RS1000096098 (10:91591065 C>T), RS1000132761 (10:91574890 G>A), RS1000146243 (10:91467531 G>A,T), RS1000152813 (10:91387961 G>A), RS1000214003 (10:91543940 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
benzo(e)pyrene	increases methylation	1
fipronil	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation	1
Cisplatin	increases expression	1
DEET	affects cotreatment, decreases expression	1
Methapyrilene	increases methylation	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.