HECTD3

Summary

HECTD3 (HECT domain E3 ubiquitin protein ligase 3, HGNC:26117) is a protein-coding gene on chromosome 1p34.1, encoding E3 ubiquitin-protein ligase HECTD3 (Q5T447). E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8.

Source: NCBI Gene 79654 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 130 total
• MANE Select transcript: NM_024602

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26117
Approved symbol	HECTD3
Name	HECT domain E3 ubiquitin protein ligase 3
Location	1p34.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ21156
Ensembl gene	ENSG00000126107
Ensembl biotype	protein_coding
OMIM	618638
Entrez	79654

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 17 protein_coding, 5 protein_coding_CDS_not_defined

ENST00000372168, ENST00000372172, ENST00000466423, ENST00000484564, ENST00000486132, ENST00000486296, ENST00000487488, ENST00000875134, ENST00000875135, ENST00000875136, ENST00000875137, ENST00000875138, ENST00000875139, ENST00000875140, ENST00000875141, ENST00000875142, ENST00000875143, ENST00000875144, ENST00000875145, ENST00000927793, ENST00000949667, ENST00000949668

RefSeq mRNA: 1 — MANE Select: NM_024602 NM_024602

CCDS: CCDS41318

Canonical transcript exons

ENST00000372172 — 21 exons

Exon	Start	End
ENSE00000957527	45005997	45006116
ENSE00001046371	45009144	45009226
ENSE00001046377	45009986	45010121
ENSE00001046378	45008240	45008321
ENSE00001046384	45008536	45008701
ENSE00001046388	45007219	45007271
ENSE00001046392	45010201	45010293
ENSE00001046395	45007413	45007595
ENSE00001218189	45009369	45009482
ENSE00001218194	45009568	45009683
ENSE00001407801	45010546	45010706
ENSE00001918003	45010889	45011324
ENSE00003492866	45004600	45004806
ENSE00003497096	45006692	45006795
ENSE00003508250	45006951	45007015
ENSE00003536147	45004248	45004377
ENSE00003549280	45004060	45004134
ENSE00003591802	45003669	45003740
ENSE00003659004	45003855	45003936
ENSE00003673264	45005794	45005883
ENSE00003848090	45002548	45003576

Expression profiles

Bgee: expression breadth ubiquitous, 267 present calls, max score 96.54.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 17.9826 / max 205.4568, expressed in 1808 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12106	17.8962	1808
12105	0.0864	30

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ileal mucosa	UBERON:0000331	96.54	gold quality
mucosa of transverse colon	UBERON:0004991	96.49	gold quality
transverse colon	UBERON:0001157	95.25	gold quality
small intestine Peyer’s patch	UBERON:0003454	95.21	gold quality
body of pancreas	UBERON:0001150	95.07	gold quality
small intestine	UBERON:0002108	94.72	gold quality
rectum	UBERON:0001052	94.29	gold quality
skin of leg	UBERON:0001511	94.05	gold quality
duodenum	UBERON:0002114	93.84	gold quality
right lobe of liver	UBERON:0001114	93.54	gold quality
skin of abdomen	UBERON:0001416	93.50	gold quality
mucosa of stomach	UBERON:0001199	93.39	gold quality
minor salivary gland	UBERON:0001830	93.28	gold quality
metanephros cortex	UBERON:0010533	92.99	gold quality
saliva-secreting gland	UBERON:0001044	92.96	gold quality
body of stomach	UBERON:0001161	92.94	gold quality
right adrenal gland cortex	UBERON:0035827	92.92	gold quality
right adrenal gland	UBERON:0001233	92.70	gold quality
intestine	UBERON:0000160	92.65	gold quality
right lobe of thyroid gland	UBERON:0001119	92.63	gold quality
right coronary artery	UBERON:0001625	92.55	gold quality
granulocyte	CL:0000094	92.51	gold quality
colon	UBERON:0001155	92.49	gold quality
tibial nerve	UBERON:0001323	92.41	gold quality
right ovary	UBERON:0002118	92.41	gold quality
large intestine	UBERON:0000059	92.33	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.33	gold quality
jejunal mucosa	UBERON:0000399	92.29	gold quality
descending thoracic aorta	UBERON:0002345	92.29	gold quality
left adrenal gland	UBERON:0001234	92.24	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.92
E-MTAB-6386	no	193.81

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

95 targeting HECTD3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-6857-5P	99.87	65.32	985
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-26B-5P	99.78	73.51	2305
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-378G	99.71	64.90	1106

Literature-anchored findings (GeneRIF, showing 6)

• All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara. (PMID:18194665)
• Overexpression of MALT1 partially rescues HECTD3 depletion-induced apoptosis. (PMID:23358872)
• HECTD3 as a tumor suppressor modulating the activity of this important oncogenic signaling pathway. (PMID:28636940)
• This review describes the progress in the recent studies of HECTD3 in cancer and other diseases. [review] (PMID:31637449)
• HECTD3 regulates the tumourigenesis of glioblastoma by polyubiquitinating PARP1 and activating EGFR signalling pathway. (PMID:36088509)
• E3 ubiquitin ligase HECTD3 is a tumor suppressor and mediates the polyubiquitination of SLC7A11 to promote ferroptosis in colon cancer. (PMID:37422058)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	hectd3	ENSDARG00000038905
mus_musculus	Hectd3	ENSMUSG00000046861
rattus_norvegicus	Hectd3	ENSRNOG00000018363

Protein

Protein identifiers

E3 ubiquitin-protein ligase HECTD3 — Q5T447 (reviewed: Q5T447)

Alternative names: HECT domain-containing protein 3, HECT-type E3 ubiquitin transferase HECTD3

All UniProt accessions (1): Q5T447

UniProt curated annotations — full annotation on UniProt →

Function. E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8.

Subunit / interactions. Interacts with TRIOBP. Interacts with STX8.

Subcellular location. Cytoplasm. Perinuclear region.

Pathway. Protein modification; protein ubiquitination.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5T447-1	1	yes
Q5T447-2	2

RefSeq proteins (1): NP_078878* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000569	HECT_dom	Domain
IPR004939	APC_su10/DOC_dom	Domain
IPR008979	Galactose-bd-like_sf	Homologous_superfamily
IPR035983	Hect_E3_ubiquitin_ligase	Homologous_superfamily
IPR042469	HECTD3	Family

Pfam: PF00632, PF03256

Enzyme classification (BRENDA):

• EC 2.3.2.26 — HECT-type E3 ubiquitin transferase (BRENDA: 14 organisms, 64 substrates, 19 inhibitors, 5 Km, 5 kcat entries)

Substrate kinetics (BRENDA)

1 substrates with measured Km, best-characterized 1. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
[UBC5B]-L-LYSINE	0.0046–0.037	5

UniProt features (10 total): domain 2, modified residue 2, splice variant 2, initiator methionine 1, chain 1, active site 1, mutagenesis site 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
9R6V	X-RAY DIFFRACTION	1.61
9R85	ELECTRON MICROSCOPY	3.04
9R8T	ELECTRON MICROSCOPY	6.06
9R94	ELECTRON MICROSCOPY	6.38

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T447-F1	84.48	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 823 (glycyl thioester intermediate)

Post-translational modifications (2): 2, 12

Mutagenesis-validated functional residues (1):

Position	Phenotype
823	loss of ubiquitin-ligase activity.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation

MSigDB gene sets: 132 (showing top): GCM_GSPT1, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION, REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION, GCM_ZNF198, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, chr1p34, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, GOBP_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS, GOBP_PROTEIN_CATABOLIC_PROCESS, PARENT_MTOR_SIGNALING_UP, GOBP_PROTEOLYSIS, GOMF_SYNTAXIN_BINDING

GO Biological Process (2): protein ubiquitination (GO:0016567), proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)

GO Molecular Function (5): ubiquitin-protein transferase activity (GO:0004842), syntaxin binding (GO:0019905), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), transferase activity (GO:0016740)

GO Cellular Component (2): perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Class I MHC mediated antigen processing & presentation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
protein modification by small protein conjugation	1
ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
ubiquitin-like protein transferase activity	1
SNARE binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
catalytic activity	1
cytoplasm	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1185 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HECTD3	KIAA2013	Q8IYS2	552
HECTD3	DHRS7	Q9Y394	461
HECTD3	GGT7	Q9UJ14	414
HECTD3	NOTO	A8MTQ0	369
HECTD3	VIT	Q6UXI7	367
HECTD3	ADAM19	Q9H013	353
HECTD3	PLS1	Q14651	346
HECTD3	MTDH	Q86UE4	332
HECTD3	DTX3	Q8N9I9	307
HECTD3	GPR75	O95800	305
HECTD3	PKDCC	Q504Y2	303
HECTD3	WWC2	Q6AWC2	300
HECTD3	TRIP12	Q14669	296
HECTD3	RNF114	Q9Y508	280
HECTD3	PSME4	Q14997	266

IntAct

152 interactions, top by confidence:

A	B	Type	Score
EIF4E2	GIGYF1	psi-mi:“MI:0914”(association)	0.730
MAVS	RIPK2	psi-mi:“MI:0914”(association)	0.580
PPL	HECTD3	psi-mi:“MI:0915”(physical association)	0.560
YJU2B	RCCD1	psi-mi:“MI:0914”(association)	0.530
RBFA	METTL15	psi-mi:“MI:0914”(association)	0.530
ODAD4	GNPAT	psi-mi:“MI:0914”(association)	0.530
SERPINA5	ZZEF1	psi-mi:“MI:0914”(association)	0.530
CPA6	PPM1G	psi-mi:“MI:0914”(association)	0.530
ANGPT2	ZZEF1	psi-mi:“MI:0914”(association)	0.530
GAST	ZZEF1	psi-mi:“MI:0914”(association)	0.530
FOSL2	ZZEF1	psi-mi:“MI:0914”(association)	0.530
CAVIN1	ZZEF1	psi-mi:“MI:0914”(association)	0.530
TRMT10C	ZZEF1	psi-mi:“MI:0914”(association)	0.530
POGLUT1	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPS24	ZZEF1	psi-mi:“MI:0914”(association)	0.530
CHRDL1	ZZEF1	psi-mi:“MI:0914”(association)	0.530
PARD6B	ZZEF1	psi-mi:“MI:0914”(association)	0.530
COPS7B	ZZEF1	psi-mi:“MI:0914”(association)	0.530
WFDC10A	ZZEF1	psi-mi:“MI:0914”(association)	0.530
CLEC3A	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPS34	ZZEF1	psi-mi:“MI:0914”(association)	0.530
GREM2	ZZEF1	psi-mi:“MI:0914”(association)	0.530

BioGRID (203): HECTD3 (Two-hybrid), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS), HECTD3 (Affinity Capture-MS)

ESM2 similar proteins: A0A0K9RDW0, A1L4V7, A2Y8B9, A3BN26, A6NHR9, B4FTR7, B8B0E2, B9EYZ1, F4I933, F4J117, O35099, O49931, O81360, P03271, P03272, P03273, P93236, P93740, Q0DST9, Q0DVX2, Q0JCU7, Q0WL81, Q3U487, Q56X76, Q5E9N5, Q5M721, Q5QLS7, Q5T447, Q5VRY0, Q5VS72, Q60649, Q69TY5, Q6ATB4, Q6K9C1, Q6YSY5, Q7X745, Q8H4D4, Q8IZ73, Q8S2E5, Q8W519

Diamond homologs: B4F6W9, C6KTB7, E1B7Q7, F1LP64, F1RCR6, G5E870, Q14669, Q15751, Q3U487, Q5T447, D3ZEF4, O43149, O95714, Q14999, Q4U2R1, Q5RCJ3, Q5SSH7, Q80TT8, Q8IWT3, Q8VE73, Q9VR91, A2A5Z6, A6NED2, A9JRZ0, D3ZBM7, D3ZGQ5, E1C656, F1N6G5, F2Z461, F8W2M1, O74881, O75592, O95199, P0C5Y8, P14199, P18754, P23800, P34664, Q15034, Q1LZE1

SIGNOR signaling

8 interactions.

A	Effect	B	Mechanism
Ub:E2	“up-regulates activity”	HECTD3	ubiquitination
HECTD3	“down-regulates quantity by destabilization”	TRIOBP	polyubiquitination
HECTD3	“down-regulates quantity by destabilization”	STX8	polyubiquitination
HECTD3	“down-regulates activity”	CASP8	polyubiquitination
HECTD3	“up-regulates quantity by stabilization”	MALT1	polyubiquitination
HECTD3	“down-regulates quantity by destabilization”	RAF1	polyubiquitination
HECTD3	“down-regulates activity”	CASP9	polyubiquitination
ERK1/2	“up-regulates activity”	HECTD3	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 149 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial translation initiation	8	12.1×	4e-05
Mitochondrial translation elongation	8	12.1×	4e-05
Mitochondrial ribosome-associated quality control	8	11.7×	4e-05
Mitochondrial translation	7	11.5×	2e-04
Mitochondrial translation termination	8	10.5×	7e-05
Translation	9	6.7×	5e-04

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	8	11.1×	6e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

130 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	105
Likely benign	5
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

2812 predictions. Top by Δscore:

Variant	Effect	Δscore
1:45003575:CA:C	acceptor_gain	1.0000
1:45003577:C:CC	acceptor_gain	1.0000
1:45003664:CCCA:C	donor_loss	1.0000
1:45003666:CAC:C	donor_loss	1.0000
1:45003668:C:G	donor_loss	1.0000
1:45003851:TCA:T	donor_loss	1.0000
1:45003852:CAC:C	donor_loss	1.0000
1:45003853:A:AC	donor_gain	1.0000
1:45003853:A:AT	donor_loss	1.0000
1:45003853:AC:A	donor_gain	1.0000
1:45003853:ACC:A	donor_gain	1.0000
1:45003853:ACCC:A	donor_gain	1.0000
1:45003854:C:CC	donor_gain	1.0000
1:45003854:CC:C	donor_gain	1.0000
1:45003854:CCC:C	donor_gain	1.0000
1:45003854:CCCC:C	donor_gain	1.0000
1:45003854:CCCCA:C	donor_gain	1.0000
1:45003932:GTCCT:G	acceptor_gain	1.0000
1:45003935:CT:C	acceptor_gain	1.0000
1:45003937:C:CC	acceptor_gain	1.0000
1:45003938:T:A	acceptor_loss	1.0000
1:45004055:CTGA:C	donor_loss	1.0000
1:45004056:TGAC:T	donor_loss	1.0000
1:45004057:GACCG:G	donor_loss	1.0000
1:45004058:A:AC	donor_gain	1.0000
1:45004058:A:C	donor_loss	1.0000
1:45004059:C:CC	donor_gain	1.0000
1:45004130:CCGGG:C	acceptor_gain	1.0000
1:45004131:CGGG:C	acceptor_gain	1.0000
1:45004131:CGGGC:C	acceptor_gain	1.0000

AlphaMissense

5576 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:45003514:T:A	D855V	1.000
1:45003515:C:G	D855H	1.000
1:45003520:T:A	D853V	1.000
1:45003523:A:T	I852N	1.000
1:45003531:G:C	C849W	1.000
1:45003532:C:T	C849Y	1.000
1:45003533:A:G	C849R	1.000
1:45003541:G:T	A846D	1.000
1:45003553:A:G	L842P	1.000
1:45003701:G:C	C823W	1.000
1:45003702:C:T	C823Y	1.000
1:45003703:A:G	C823R	1.000
1:45003717:G:T	P818H	1.000
1:45003718:G:A	P818S	1.000
1:45003903:C:A	G794V	1.000
1:45003903:C:T	G794D	1.000
1:45003904:C:G	G794R	1.000
1:45003909:A:T	V792D	1.000
1:45003911:A:C	F791L	1.000
1:45003911:A:T	F791L	1.000
1:45003912:A:G	F791S	1.000
1:45003913:A:G	F791L	1.000
1:45003918:A:G	L789P	1.000
1:45003930:C:G	R785P	1.000
1:45004077:A:G	L777P	1.000
1:45004259:A:G	L754P	1.000
1:45005859:A:G	W624R	1.000
1:45005859:A:T	W624R	1.000
1:45006026:C:A	G606W	1.000
1:45006026:C:G	G606R	1.000

dbSNP variants (sampled 300 via entrez): RS1000689718 (1:45010979 G>A), RS1000869341 (1:45007634 A>G), RS1001053303 (1:45012627 T>C), RS1001647308 (1:45012776 G>A), RS1001840437 (1:45013217 T>C), RS1001908940 (1:45011268 C>T), RS1001953903 (1:45011740 C>A,G,T), RS1002303555 (1:45008350 A>G), RS1002331523 (1:45008089 T>C), RS1002685942 (1:45009765 G>A,C), RS1002774560 (1:45002309 C>T), RS1002785985 (1:45003173 G>A,C), RS1003856792 (1:45005561 G>A,C), RS1003918163 (1:45011652 A>T), RS1004430579 (1:45011462 C>G)

Disease associations

OMIM: gene MIM:618638 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases expression	5
sodium arsenite	increases abundance, increases expression	2
aristolochic acid I	increases expression	1
2,4,6-tribromophenol	increases expression	1
trichostatin A	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
pentabrominated diphenyl ether 100	decreases expression	1
Sunitinib	increases expression	1
Air Pollutants	increases expression, increases abundance	1
Arsenic	increases abundance, increases expression	1
Atrazine	increases expression	1
Cadmium	decreases expression, increases abundance	1
Carcinogens	decreases expression	1
Coumestrol	decreases expression	1
Doxorubicin	decreases expression	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	increases expression	1
Cadmium Chloride	decreases expression, increases abundance	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.