HEG1

Summary

HEG1 (heart development protein with EGF like domains 1, HGNC:29227) is a protein-coding gene on chromosome 3q21.2, encoding Protein HEG homolog 1 (Q9ULI3). Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity.

Predicted to enable calcium ion binding activity. Involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of Rho-dependent protein serine/threonine kinase activity; and negative regulation of membrane permeability. Located in cell-cell junction.

Source: NCBI Gene 57493 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 247 total
• MANE Select transcript: NM_020733

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29227
Approved symbol	HEG1
Name	heart development protein with EGF like domains 1
Location	3q21.2
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1237, HEG
Ensembl gene	ENSG00000173706
Ensembl biotype	protein_coding
OMIM	614182
Entrez	57493

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 2 protein_coding, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000311127, ENST00000480667, ENST00000482699, ENST00000488654, ENST00000650592

RefSeq mRNA: 1 — MANE Select: NM_020733 NM_020733

CCDS: CCDS46898

Canonical transcript exons

ENST00000311127 — 17 exons

Exon	Start	End
ENSE00001184970	124990787	124990824
ENSE00001184975	124990944	124990986
ENSE00001184978	124997689	124997823
ENSE00001184980	125001852	125002012
ENSE00001184983	125002257	125002315
ENSE00001184987	125005265	125005368
ENSE00001184995	125009705	125009824
ENSE00001184997	125010439	125010555
ENSE00001274034	124977859	124977946
ENSE00001308188	125012623	125013990
ENSE00001317153	124965710	124970801
ENSE00001329347	124973731	124973905
ENSE00001371349	125020792	125021130
ENSE00001378214	125027205	125027507
ENSE00001382448	125019262	125019597
ENSE00001409218	125029195	125029488
ENSE00001563765	125055575	125055997

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 99.42.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.6514 / max 748.0491, expressed in 1655 samples.

FANTOM5 promoters (17 alternative TSS)

Promoter ID	TPM avg	Samples expressed
44270	15.6411	1512
44268	2.2628	845
44266	1.9261	804
44271	1.1704	723
44264	1.1030	525
44273	0.9028	663
44265	0.6594	343
44269	0.5491	298
44261	0.5132	276
44272	0.4686	276

Top tissues by expression

299 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parietal pleura	UBERON:0002400	99.42	gold quality
pleura	UBERON:0000977	99.20	gold quality
visceral pleura	UBERON:0002401	99.11	gold quality
germinal epithelium of ovary	UBERON:0001304	98.35	gold quality
cardiac muscle of right atrium	UBERON:0003379	97.92	gold quality
lower lobe of lung	UBERON:0008949	97.73	gold quality
synovial joint	UBERON:0002217	97.70	gold quality
vena cava	UBERON:0004087	97.37	gold quality
myocardium	UBERON:0002349	96.78	gold quality
superficial temporal artery	UBERON:0001614	96.46	gold quality
tendon of biceps brachii	UBERON:0008188	96.36	gold quality
ventricular zone	UBERON:0003053	96.27	gold quality
layer of synovial tissue	UBERON:0007616	96.21	gold quality
cardia of stomach	UBERON:0001162	95.79	gold quality
heart right ventricle	UBERON:0002080	95.75	gold quality
urethra	UBERON:0000057	95.65	gold quality
pericardium	UBERON:0002407	95.62	gold quality
colonic epithelium	UBERON:0000397	95.26	gold quality
left ventricle myocardium	UBERON:0006566	95.00	gold quality
adult organism	UBERON:0007023	94.97	gold quality
mucosa of urinary bladder	UBERON:0001259	94.63	gold quality
gall bladder	UBERON:0002110	94.48	gold quality
pylorus	UBERON:0001166	94.40	gold quality
hair follicle	UBERON:0002073	94.36	gold quality
mucosa of paranasal sinus	UBERON:0005030	94.31	gold quality
lung	UBERON:0002048	94.24	gold quality
saphenous vein	UBERON:0007318	94.15	gold quality
blood vessel layer	UBERON:0004797	93.70	gold quality
subthalamic nucleus	UBERON:0001906	93.64	gold quality
inferior vagus X ganglion	UBERON:0005363	93.54	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-8205	yes	385.03
E-GEOD-135922	yes	38.06
E-CURD-119	yes	23.47
E-ANND-3	yes	20.37
E-GEOD-124858	no	662.15
E-MTAB-10137	no	3.90

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

210 targeting HEG1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3689D	100.00	66.14	1181
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-6851-5P	100.00	65.63	1294
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753

Literature-anchored findings (GeneRIF, showing 12)

• Identification of the zebrafish heart of glass (heg) gene. Description of HEG’s role in the regulation of concentric heart growth in zebrafish. (PMID:14680629)
• These data show that HEG1 can recruit the Rap1-KRIT complex to the plasma membrane. (PMID:23814056)
• Human patients with cerebral cavernous malformations who lack exonic mutations in krev interaction trapped protein (KRIT)1, cerebral cavernous malformation (CCM) protein 2, or programmed cell death (PDCD)10 protein do not have mutations in HEG. (PMID:24643410)
• These studies establish that the binding of HEG1 to Rasip1 mediates Rap1-dependent recruitment of Rasip1 to and stabilization of endothelial cell cell-cell junctions. (PMID:26780829)
• Study shows that HEG homolog 1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma. (PMID:28361969)
• he specific detection of mesothelioma with SKM9-2 can thus be performed by the recognition of sialylated glycan modification in the specific region of HEG1 (PMID:30250045)
• HEG1 overexpression significantly promotes HCC cell migration, invasion and epithelial-mesenchymal transition. (PMID:31278131)
• HEG1 Is a Highly Specific and Sensitive Marker of Epithelioid Malignant Mesothelioma. (PMID:32205484)
• HEG1-responsive microRNA-23b regulates cell proliferation in malignant mesothelioma cells. (PMID:32284171)
• LncRNA SNHG12 promotes proliferation and epithelial mesenchymal transition in hepatocellular carcinoma through targeting HEG1 via miR-516a-5p. (PMID:33774129)
• Membranous HEG1 expression is a useful marker in the differential diagnosis of epithelioid and biphasic malignant mesothelioma versus carcinomas. (PMID:34240508)
• HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells. (PMID:38099436)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	heg1	ENSDARG00000018441
mus_musculus	Heg1	ENSMUSG00000075254
rattus_norvegicus	Heg1	ENSRNOG00000001793

Protein

Protein identifiers

Protein HEG homolog 1 — Q9ULI3 (reviewed: Q9ULI3)

All UniProt accessions (3): Q9ULI3, A0A994J6K3, H7C4K2

UniProt curated annotations — full annotation on UniProt →

Function. Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions.

Subunit / interactions. Interacts with CCM2 and KRIT1; KRIT1 markedly facilitates interaction with CCM2.

Subcellular location. Cell membrane. Cell junction Secreted.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9ULI3-1	1	yes
Q9ULI3-2	2

RefSeq proteins (1): NP_065784* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000152	EGF-type_Asp/Asn_hydroxyl_site	PTM
IPR000742	EGF	Domain
IPR001881	EGF-like_Ca-bd_dom	Domain
IPR018097	EGF_Ca-bd_CS	Conserved_site
IPR049883	NOTCH1_EGF-like	Domain

Pfam: PF00008, PF07645

UniProt features (50 total): compositionally biased region 13, glycosylation site 9, region of interest 7, disulfide bond 6, sequence variant 5, topological domain 2, splice variant 2, domain 2, signal peptide 1, chain 1, modified residue 1, transmembrane region 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
4HDQ	X-RAY DIFFRACTION	1.95
3U7D	X-RAY DIFFRACTION	2.49

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULI3-F1	42.34	0.02

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 1359

Disulfide bonds (6): 989–1000, 994–1011, 1013–1022, 1029–1040, 1034–1049, 1051–1062

Glycosylation sites (9): 67, 123, 159, 180, 314, 462, 520, 610, 1137

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 356 (showing top): GOBP_CARDIAC_CHAMBER_DEVELOPMENT, GOBP_ENDOTHELIAL_CELL_DEVELOPMENT, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, GOBP_EPITHELIUM_DEVELOPMENT, KOBAYASHI_EGFR_SIGNALING_24HR_UP, GOBP_MUSCLE_TISSUE_DEVELOPMENT, GOBP_CARDIAC_SEPTUM_DEVELOPMENT, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_REGULATION_OF_PHOSPHORYLATION, DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN, GOBP_HEART_TRABECULA_MORPHOGENESIS, GOBP_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY, GOBP_CARDIAC_CHAMBER_MORPHOGENESIS, GOBP_EPITHELIAL_CELL_DEVELOPMENT, MODULE_45

GO Biological Process (26): vasculogenesis (GO:0001570), in utero embryonic development (GO:0001701), endothelial cell morphogenesis (GO:0001886), lymph vessel development (GO:0001945), lymph circulation (GO:0003017), cardiac atrium morphogenesis (GO:0003209), ventricular trabecula myocardium morphogenesis (GO:0003222), ventricular septum development (GO:0003281), heart development (GO:0007507), post-embryonic development (GO:0009791), lung development (GO:0030324), negative regulation of Rho protein signal transduction (GO:0035024), multicellular organism growth (GO:0035264), cell-cell junction organization (GO:0045216), venous blood vessel morphogenesis (GO:0048845), regulation of body fluid levels (GO:0050878), cardiac muscle tissue growth (GO:0055017), pericardium development (GO:0060039), positive regulation of fibroblast growth factor production (GO:0090271), protein localization to cell junction (GO:1902414), negative regulation of membrane permeability (GO:1905709), obsolete negative regulation of Rho-dependent protein serine/threonine kinase activity (GO:2000299), endothelial cell development (GO:0001885), vasculature development (GO:0001944), regulation of macromolecule metabolic process (GO:0060255), regulation of biological quality (GO:0065008)

GO Molecular Function (2): calcium ion binding (GO:0005509), protein binding (GO:0005515)

GO Cellular Component (7): extracellular region (GO:0005576), cell-cell junction (GO:0005911), external side of plasma membrane (GO:0009897), plasma membrane (GO:0005886), cell surface (GO:0009986), membrane (GO:0016020), anchoring junction (GO:0070161)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
blood vessel morphogenesis	2
animal organ development	2
multicellular organismal process	2
developmental growth	2
cell differentiation	1
chordate embryonic development	1
endothelial cell development	1
epithelial cell morphogenesis	1
vasculature development	1
anatomical structure development	1
circulatory system process	1
cardiac chamber morphogenesis	1
cardiac atrium development	1
ventricular cardiac muscle tissue morphogenesis	1
heart trabecula morphogenesis	1
cardiac ventricle development	1
cardiac septum development	1
circulatory system development	1
multicellular organism development	1
respiratory tube development	1
respiratory system development	1
Rho protein signal transduction	1
regulation of Rho protein signal transduction	1
negative regulation of small GTPase mediated signal transduction	1
cell junction organization	1
venous blood vessel development	1
regulation of biological quality	1
cardiac muscle tissue development	1
heart growth	1
heart development	1
epithelium development	1
positive regulation of cytokine production	1
fibroblast growth factor production	1
regulation of fibroblast growth factor production	1
intracellular protein localization	1
metal ion binding	1
binding	1
anchoring junction	1
plasma membrane	1

Protein interactions and networks

STRING

1211 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HEG1	KRIT1	O00522	966
HEG1	CCM2	Q9BSQ5	837
HEG1	PDCD10	Q9BUL8	773
HEG1	RASIP1	Q5U651	662
HEG1	CCM2L	Q9NUG4	584
HEG1	CTNNB1	P35222	532
HEG1	ITGB1BP1	O14713	507
HEG1	CCDC102A	Q96A19	460
HEG1	STK25	O00506	386
HEG1	C1orf198	Q9H425	371
HEG1	ARHGAP29	Q52LW3	366
HEG1	RAP1A	P10113	359
HEG1	KTN1	Q86UP2	352
HEG1	RPA1	P27694	349
HEG1	COX7A2	P14406	349
HEG1	INO80D	Q53TQ3	349

IntAct

20 interactions, top by confidence:

A	B	Type	Score
HEG1	KRIT1	psi-mi:“MI:0915”(physical association)	0.730
HEG1	KRIT1	psi-mi:“MI:0407”(direct interaction)	0.730
LGALS1	PODXL	psi-mi:“MI:0914”(association)	0.530
LGALS3	PODXL	psi-mi:“MI:0914”(association)	0.530
LGALS1	LAMA5	psi-mi:“MI:0914”(association)	0.530
FBXO2	TMEM131L	psi-mi:“MI:0914”(association)	0.530
LGALS8	SLC22A23	psi-mi:“MI:0914”(association)	0.350
LGALS3	PODXL	psi-mi:“MI:0914”(association)	0.350
KRIT1	UBFD1	psi-mi:“MI:0914”(association)	0.350
LGALS8	NPC1	psi-mi:“MI:0914”(association)	0.350
LGALS3	SDCBP	psi-mi:“MI:0914”(association)	0.350

BioGRID (18): HEG1 (Affinity Capture-MS), HEG1 (Affinity Capture-MS), HEG1 (Affinity Capture-MS), HEG1 (Affinity Capture-MS), HEG1 (Affinity Capture-MS), HEG1 (Affinity Capture-RNA), HEG1 (Proximity Label-MS), HEG1 (Affinity Capture-MS), HEG1 (Affinity Capture-MS), HEG1 (Affinity Capture-MS), HEG1 (Affinity Capture-MS), HEG1 (Affinity Capture-MS), HEG1 (Affinity Capture-RNA), HEG1 (Proximity Label-MS), HEG1 (Proximity Label-MS)

ESM2 similar proteins: A0A1B0GUW6, A1EGX6, A6NM11, A6NMS7, A6QLF8, D3YU32, I3L273, J3KML8, O35930, O60309, Q08DY0, Q14242, Q2TBI7, Q32KG4, Q32L62, Q3MIW9, Q3TNW5, Q3V0E1, Q4R729, Q5VWK0, Q5VYM1, Q62170, Q659K0, Q68DN1, Q6AZ54, Q6MG22, Q6UXB8, Q6ZRG5, Q8BUE7, Q8K4E0, Q8N307, Q8N3K9, Q8TCU4, Q8WNU4, Q8WXI7, Q95JY5, Q96F05, Q96JA4, Q96M34, Q96M43

Diamond homologs: A0A096LNW5, A2RUV0, B4DH59, G3I6Z6, O35474, O35516, O75095, O89019, P07207, P0DPK3, P0DPK4, P13508, P20749, P21783, P31695, P46530, P46531, P82279, Q01705, Q04721, Q07008, Q20911, Q499M5, Q502K3, Q5RBP1, Q61982, Q6UXI9, Q6UY11, Q7Z3S9, Q810B6, Q8AVH7, Q8IUX8, Q91V88, Q99466, Q9FY48, Q9JJZ5, Q9P2R3, Q9QW30, Q9QXT5, Q9R172

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

247 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	191
Likely benign	22
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

2496 predictions. Top by Δscore:

Variant	Effect	Δscore
3:124970806:T:TC	acceptor_gain	1.0000
3:124970810:C:CT	acceptor_gain	1.0000
3:124970810:C:T	acceptor_gain	1.0000
3:124970811:A:T	acceptor_gain	1.0000
3:124973681:T:TA	donor_gain	1.0000
3:124973726:CACA:C	donor_loss	1.0000
3:124973727:ACAC:A	donor_loss	1.0000
3:124973728:CA:C	donor_loss	1.0000
3:124973729:A:AC	donor_gain	1.0000
3:124973729:AC:A	donor_loss	1.0000
3:124973730:C:CC	donor_gain	1.0000
3:124973730:CCGAG:C	donor_loss	1.0000
3:124973744:T:TA	donor_gain	1.0000
3:124973773:T:TA	donor_gain	1.0000
3:124973774:C:A	donor_gain	1.0000
3:124973902:CTTT:C	acceptor_gain	1.0000
3:124973906:C:CC	acceptor_gain	1.0000
3:124977853:ACTT:A	donor_loss	1.0000
3:124977854:CTTA:C	donor_loss	1.0000
3:124977855:TTAC:T	donor_loss	1.0000
3:124977856:TACCT:T	donor_loss	1.0000
3:124977857:ACC:A	donor_loss	1.0000
3:124977858:C:CT	donor_loss	1.0000
3:124990785:A:AC	donor_gain	1.0000
3:124990786:C:CC	donor_gain	1.0000
3:124990825:C:CC	acceptor_gain	1.0000
3:124990833:C:CT	acceptor_gain	1.0000
3:124990833:C:T	acceptor_gain	1.0000
3:124990834:A:T	acceptor_gain	1.0000
3:124990939:CCTAC:C	donor_loss	1.0000

AlphaMissense

8829 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:124973806:C:A	W1307C	1.000
3:124973806:C:G	W1307C	1.000
3:124990983:C:G	C1219S	1.000
3:124990983:C:T	C1219Y	1.000
3:124990984:A:T	C1219S	1.000
3:124970718:G:C	C1360W	0.999
3:124970720:A:G	C1360R	0.999
3:124973808:A:G	W1307R	0.999
3:124973808:A:T	W1307R	0.999
3:124990795:C:G	C1242S	0.999
3:124990796:A:T	C1242S	0.999
3:124990816:A:C	F1235C	0.999
3:124990822:C:G	C1233S	0.999
3:124990822:C:T	C1233Y	0.999
3:124990823:A:G	C1233R	0.999
3:124990823:A:T	C1233S	0.999
3:124990949:G:C	C1230W	0.999
3:124990950:C:G	C1230S	0.999
3:124990950:C:T	C1230Y	0.999
3:124990951:A:G	C1230R	0.999
3:124990951:A:T	C1230S	0.999
3:124990982:A:C	C1219W	0.999
3:124990983:C:A	C1219F	0.999
3:124990984:A:G	C1219R	0.999
3:124997694:C:G	C1216S	0.999
3:124997695:A:G	C1216R	0.999
3:124997695:A:T	C1216S	0.999
3:124997721:A:C	F1207C	0.999
3:124997736:C:G	C1202S	0.999
3:124997737:A:G	C1202R	0.999

dbSNP variants (sampled 300 via entrez): RS1000026269 (3:125031395 T>C), RS1000067244 (3:124988184 A>C), RS1000096236 (3:125032726 A>T), RS1000120483 (3:125055300 T>A,C), RS1000173451 (3:125055158 T>A), RS1000203711 (3:125007370 T>A), RS1000265116 (3:125055820 GGCA>G,GGCAGCA), RS1000272629 (3:125015174 T>C), RS1000277785 (3:125037746 G>A), RS1000288939 (3:124971303 G>A,T), RS1000290739 (3:125038250 CCTCG>C), RS1000290971 (3:124994595 T>A), RS1000300286 (3:125056090 C>T), RS1000330652 (3:125001481 A>C), RS1000370570 (3:125044469 T>C)

Disease associations

OMIM: gene MIM:614182 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010083_122	Hemoglobin levels	3.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004509	hemoglobin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

60 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Estradiol	increases reaction, affects cotreatment, decreases expression, increases expression	4
sodium arsenite	affects cotreatment, increases abundance, decreases expression	3
Aflatoxin B1	affects expression, increases expression, increases methylation	3
Particulate Matter	decreases expression, increases abundance	3
perfluorooctane sulfonic acid	decreases expression	2
entinostat	decreases expression, affects cotreatment	2
belinostat	decreases expression, affects cotreatment	2
Panobinostat	affects cotreatment, decreases expression	2
Air Pollutants	decreases expression, increases abundance	2
Arsenic	affects methylation, affects cotreatment, decreases expression, increases abundance	2
Benzo(a)pyrene	affects methylation, increases expression	2
Nickel	increases expression	2
Tamoxifen	affects expression, affects cotreatment, increases expression, decreases expression	2
Tobacco Smoke Pollution	decreases expression	2
Valproic Acid	increases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2
Raloxifene Hydrochloride	affects expression, affects cotreatment, increases expression, decreases expression	2
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
hydroxyhydroquinone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	affects cotreatment, increases expression	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	increases abundance, affects cotreatment, decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
lead chloride	increases expression, affects cotreatment	1
cadmium sulfate	affects cotreatment, increases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
avobenzone	increases expression	1
CGP 52608	affects binding, increases reaction	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.