HEIH

Summary

HEIH (hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA, HGNC:45049) is a long non-coding RNA gene on chromosome 5q35.3.

Biomarker of esophagus squamous cell carcinoma.

Source: NCBI Gene 100859930 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45049
Approved symbol	HEIH
Name	hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA
Location	5q35.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC-HEIH, lncRNA-HEIH, LINC00848, HCCAT2
Ensembl gene	ENSG00000278970
Ensembl biotype	lncRNA
OMIM	618615
Entrez	100859930
RNAcentral	URS000075C8CD — lncRNA, 1681 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000623091, ENST00000651563, ENST00000751341, ENST00000751342, ENST00000751343, ENST00000751344, ENST00000751345, ENST00000751346, ENST00000751347, ENST00000751348, ENST00000751349, ENST00000751350

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000623091 — 1 exons

Exon	Start	End
ENSE00004096500	180829954	180831639

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 96.41.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.3349 / max 144.2165, expressed in 1729 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
65343	7.4741	1677
65342	1.3006	587
65338	0.8617	299
65341	0.2955	114
65337	0.2228	96
65340	0.1694	67
65339	0.0107	2

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
parotid gland	UBERON:0001831	96.41	gold quality
ileal mucosa	UBERON:0000331	95.75	gold quality
cardiac muscle of right atrium	UBERON:0003379	95.31	gold quality
pericardium	UBERON:0002407	94.56	gold quality
pancreatic ductal cell	CL:0002079	94.38	silver quality
left ventricle myocardium	UBERON:0006566	94.29	gold quality
kidney epithelium	UBERON:0004819	93.94	gold quality
upper arm skin	UBERON:0004263	93.50	gold quality
lower esophagus mucosa	UBERON:0035834	93.46	gold quality
right lobe of thyroid gland	UBERON:0001119	93.38	gold quality
left lobe of thyroid gland	UBERON:0001120	93.28	gold quality
granulocyte	CL:0000094	93.24	gold quality
thyroid gland	UBERON:0002046	92.90	gold quality
nasal cavity epithelium	UBERON:0005384	92.72	gold quality
renal medulla	UBERON:0000362	92.40	gold quality
nipple	UBERON:0002030	92.40	gold quality
body of pancreas	UBERON:0001150	92.32	gold quality
tibialis anterior	UBERON:0001385	92.29	silver quality
myocardium	UBERON:0002349	92.24	gold quality
trachea	UBERON:0003126	92.11	gold quality
saphenous vein	UBERON:0007318	92.05	gold quality
subcutaneous adipose tissue	UBERON:0002190	91.88	gold quality
blood	UBERON:0000178	91.85	gold quality
pigmented layer of retina	UBERON:0001782	91.81	gold quality
spleen	UBERON:0002106	91.76	gold quality
layer of synovial tissue	UBERON:0007616	91.71	gold quality
cardia of stomach	UBERON:0001162	91.63	gold quality
pituitary gland	UBERON:0000007	91.61	gold quality
vena cava	UBERON:0004087	91.58	gold quality
right uterine tube	UBERON:0001302	91.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• The data suggested that lncRNA-HEIH may serve as a promising prognostic biomarker and therapeutic target for melanoma. (PMID:28487474)
• Study showed that lncRNA-HEIH is up-regulated in colorectal cancer (CRC) tissues and cell lines, associated with tumor size, invasion depth, and poor outcome of CRC patients. HEIH promotes CRC cell proliferation and inhibits CRC cell apoptosis in vitro, and promotes CRC tumor growth in vivo via counteracting miR-939-mediated transcriptional repression of Bcl-xL. (PMID:29081216)
• HEIH could accelerate the proliferation and metastasis of NSCLC, providing a novel therapeutic target for clinical treatment. (PMID:30230600)
• patients with tumor size >/= 5 cm or advanced clinical stage had higher levels of HEIH expression than patients with tumor size < 5 cm or early clinical stage triple-negative breast cancer (PMID:31456112)
• Results reveal that HEIH may contribute to breast cancer development via modulation of microRNA-200b/axis and inducing the activation of Wnt/beta-catenin pathway. (PMID:31526439)
• LncRNA HEIH Enhances Paclitaxel-Tolerance of Endometrial Cancer Cells via Activation of MAPK Signaling Pathway. (PMID:31650338)
• Downregulation of lncRNA-HEIH curbs esophageal squamous cell carcinoma progression by modulating miR-4458/PBX3. (PMID:32449803)
• Long non-coding RNA HEIH suppresses the expression of TP53 through enhancer of zeste homolog 2 in oesophageal squamous cell carcinoma. (PMID:32729661)
• lncRNA HEIH, an indicator of high malignancy and poor prognosis, functions as an oncogene in breast cancer. (PMID:32945377)
• Effects of lncRNA-HEIH on proliferation, apoptosis and invasion of gastric cancer cells. (PMID:33015781)
• Exosomal lncRNA HEIH promotes cisplatin resistance in tongue squamous cell carcinoma via targeting miR-3619-5p/HDGF axis. (PMID:33130420)
• LncRNA HEIH promotes cell proliferation, migration and invasion by suppressing miR-214-3p in gastric carcinoma. (PMID:33226411)
• LncRNA HEIH/miR-939-5p interplay modulates triple-negative breast cancer progression through NOS2-induced nitric oxide production. (PMID:33368266)
• Long non-coding RNA HEIH modulates CDK8 expression by inhibiting miR-193a-5p to accelerate nasopharyngeal carcinoma progression. (PMID:33577031)
• LncRNA-HEIH is a Novel Diagnostic and Predictive Biomarker in Gastric Cancer. (PMID:33877891)
• Identification and verification of YBX3 and its regulatory gene HEIH as an oncogenic system: A multidimensional analysis in colon cancer. (PMID:36059530)
• HEIH Promotes Malignant Progression of Gastric Cancer by Regulating STAT3-Mediated Autophagy and Glycolysis. (PMID:36246567)
• Exosomal lncRNA HEIH, an essential communicator for hepatocellular carcinoma cells and macrophage M2 polarization through the miR-98-5p/STAT3 axis. (PMID:38549433)
• [Fonction de l’ARNnc exosomal HEIH dans le carcinome hepatocellulaire associe au virus de l’hepatite B]. (PMID:38638022)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.