HELLPAR

Summary

HELLPAR (HELLP associated long non-coding RNA, HGNC:43984) is a long non-coding RNA gene on chromosome 12q23.2.

Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting.

Source: NCBI Gene 101101692 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43984
Approved symbol	HELLPAR
Name	HELLP associated long non-coding RNA
Location	12q23.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC-HELLP
Ensembl gene	ENSG00000281344
Ensembl biotype	lncRNA
OMIM	614985
Entrez	101101692
RNAcentral	URS000019E0CD — lncRNA, 205012 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000626826

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000626826 — 1 exons

Exon	Start	End
ENSE00003765584	102197585	102402596

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 61.76.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	61.76	gold quality
liver	UBERON:0002107	55.05	silver quality
gastrocnemius	UBERON:0001388	52.11	gold quality
endometrium	UBERON:0001295	50.56	silver quality
smooth muscle tissue	UBERON:0001135	44.12	silver quality
tibial artery	UBERON:0007610	40.60	silver quality
lower esophagus muscularis layer	UBERON:0035833	37.96	silver quality
esophagus mucosa	UBERON:0002469	37.45	silver quality
omental fat pad	UBERON:0010414	37.30	silver quality
Ammon’s horn	UBERON:0001954	35.52	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	12.56

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Data show that LINC-HELLP transcript levels are significantly upregulated in plasma of women in their first trimester of pregnancy but not in patients later developing pregnancy complications, indicative of its functional significance in vivo. (PMID:26173455)
• Anticancer function of microRNA-30e is mediated by negative regulation of HELLPAR, a noncoding macroRNA, and genes involved in ubiquitination and cell cycle progression in prostate cancer. (PMID:35612714)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.