HEPFAL

Summary

HEPFAL (hepatocellular carcinoma ferroptosis associative lncRNA, HGNC:56244) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56244
Approved symbol	HEPFAL
Name	hepatocellular carcinoma ferroptosis associative lncRNA
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	KB-68A7.1
Ensembl gene	ENSG00000274225
Ensembl biotype	lncRNA
Entrez	124905036
RNAcentral	URS0002A3C887 — lncRNA, 1392 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000617205

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000617205 — 2 exons

Exon	Start	End
ENSE00004197152	44475723	44475849
ENSE00004197153	44477229	44478493

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 86.41.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	86.41	gold quality
cortical plate	UBERON:0005343	84.82	gold quality
liver	UBERON:0002107	81.93	gold quality
muscle layer of sigmoid colon	UBERON:0035805	81.37	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.56	gold quality
mucosa of stomach	UBERON:0001199	75.14	gold quality
colon	UBERON:0001155	73.39	gold quality
ganglionic eminence	UBERON:0004023	72.38	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.30	gold quality
lower esophagus mucosa	UBERON:0035834	72.04	gold quality
fundus of stomach	UBERON:0001160	71.88	gold quality
tibial nerve	UBERON:0001323	71.51	gold quality
left ovary	UBERON:0002119	71.01	gold quality
body of stomach	UBERON:0001161	70.66	gold quality
descending thoracic aorta	UBERON:0002345	70.57	gold quality
ovary	UBERON:0000992	70.49	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.34	gold quality
lower esophagus	UBERON:0013473	70.30	gold quality
sural nerve	UBERON:0015488	70.26	gold quality
right ovary	UBERON:0002118	70.21	gold quality
intestine	UBERON:0000160	69.67	gold quality
ascending aorta	UBERON:0001496	69.41	gold quality
thoracic aorta	UBERON:0001515	69.29	gold quality
transverse colon	UBERON:0001157	68.96	gold quality
stomach	UBERON:0000945	68.82	gold quality
left uterine tube	UBERON:0001303	68.76	gold quality
apex of heart	UBERON:0002098	68.21	gold quality
ventricular zone	UBERON:0003053	67.61	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.16	gold quality
skin of abdomen	UBERON:0001416	67.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.79

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.