HEY2-AS1

Summary

HEY2-AS1 (HEY2 antisense RNA 1, HGNC:55652) is a long non-coding RNA gene on chromosome 6q22.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55652
Approved symbol	HEY2-AS1
Name	HEY2 antisense RNA 1
Location	6q22.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237742
Ensembl biotype	lncRNA
Entrez	105377986
RNAcentral	URS00026A23BA — lncRNA, 1947 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000427852, ENST00000432121, ENST00000451660, ENST00000606001, ENST00000606334, ENST00000656901, ENST00000834214, ENST00000834215, ENST00000834216, ENST00000834217, ENST00000834218, ENST00000834219, ENST00000834220, ENST00000834221, ENST00000834222, ENST00000834223, ENST00000834224, ENST00000834225, ENST00000834226, ENST00000834227, ENST00000834228, ENST00000834229

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000427852 — 6 exons

Exon	Start	End
ENSE00001656640	125657429	125657466
ENSE00001660526	125645634	125645700
ENSE00001802303	125720424	125720507
ENSE00003699503	125744902	125745065
ENSE00004251551	125745585	125745609
ENSE00004251562	125578558	125578725

Expression profiles

Bgee: expression breadth ubiquitous, 121 present calls, max score 86.63.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.63	gold quality
endometrium	UBERON:0001295	83.22	gold quality
right uterine tube	UBERON:0001302	81.81	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.36	gold quality
skeletal muscle tissue	UBERON:0001134	77.88	gold quality
muscle of leg	UBERON:0001383	76.95	gold quality
gastrocnemius	UBERON:0001388	76.80	gold quality
popliteal artery	UBERON:0002250	76.73	gold quality
tibial artery	UBERON:0007610	76.73	gold quality
substantia nigra	UBERON:0002038	74.76	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	74.03	gold quality
spinal cord	UBERON:0002240	74.00	gold quality
hindlimb stylopod muscle	UBERON:0004252	74.00	gold quality
putamen	UBERON:0001874	73.93	gold quality
sural nerve	UBERON:0015488	73.61	gold quality
heart left ventricle	UBERON:0002084	73.35	gold quality
right coronary artery	UBERON:0001625	72.80	gold quality
left coronary artery	UBERON:0001626	72.55	gold quality
amygdala	UBERON:0001876	71.70	gold quality
temporal lobe	UBERON:0001871	71.65	gold quality
descending thoracic aorta	UBERON:0002345	70.92	gold quality
apex of heart	UBERON:0002098	70.76	gold quality
hypothalamus	UBERON:0001898	70.69	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.54	gold quality
Ammon’s horn	UBERON:0001954	70.33	gold quality
caudate nucleus	UBERON:0001873	69.68	gold quality
fallopian tube	UBERON:0003889	69.39	gold quality
corpus callosum	UBERON:0002336	69.31	gold quality
nucleus accumbens	UBERON:0001882	68.54	gold quality
thoracic aorta	UBERON:0001515	68.08	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-10287	yes	49.19
E-ANND-3	no	2.92

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.