HHIP-AS1

Summary

HHIP-AS1 (HHIP antisense RNA 1, HGNC:44182) is a long non-coding RNA gene on chromosome 4q31.21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44182
Approved symbol	HHIP-AS1
Name	HHIP antisense RNA 1
Location	4q31.21
Locus type	RNA, long non-coding
Status	Approved
Aliases	HHAS1
Ensembl gene	ENSG00000248890
Ensembl biotype	lncRNA
Entrez	646576
RNAcentral	URS000075C3F9 — lncRNA, 1132 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000503066, ENST00000508269, ENST00000512359, ENST00000665214, ENST00000702118

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503066 — 3 exons

Exon	Start	End
ENSE00002029044	144645288	144645467
ENSE00002036818	144643224	144643734
ENSE00002088131	144645707	144645912

Expression profiles

Bgee: expression breadth ubiquitous, 187 present calls, max score 88.29.

FANTOM5 (CAGE): breadth broad, TPM avg 5.4963 / max 97.3357, expressed in 901 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
54217	2.6294	777
54216	2.5811	606
54214	0.1988	113
54215	0.0870	51

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.29	gold quality
sural nerve	UBERON:0015488	80.96	gold quality
tibia	UBERON:0000979	80.26	gold quality
body of pancreas	UBERON:0001150	79.36	gold quality
nucleus accumbens	UBERON:0001882	76.55	gold quality
upper lobe of left lung	UBERON:0008952	76.48	gold quality
hypothalamus	UBERON:0001898	76.46	gold quality
upper lobe of lung	UBERON:0008948	76.41	gold quality
corpus callosum	UBERON:0002336	76.16	gold quality
right lung	UBERON:0002167	75.60	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	75.54	gold quality
lung	UBERON:0002048	75.49	gold quality
tibial nerve	UBERON:0001323	75.38	gold quality
Ammon’s horn	UBERON:0001954	75.34	gold quality
lower lobe of lung	UBERON:0008949	74.96	silver quality
bone marrow cell	CL:0002092	74.89	silver quality
spinal cord	UBERON:0002240	74.44	gold quality
cardiac muscle of right atrium	UBERON:0003379	74.31	gold quality
stromal cell of endometrium	CL:0002255	74.27	gold quality
putamen	UBERON:0001874	73.83	gold quality
left ventricle myocardium	UBERON:0006566	73.77	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.70	gold quality
substantia nigra	UBERON:0002038	73.64	gold quality
thymus	UBERON:0002370	73.35	gold quality
cartilage tissue	UBERON:0002418	73.23	gold quality
midbrain	UBERON:0001891	72.58	gold quality
mucosa of stomach	UBERON:0001199	72.42	gold quality
rectum	UBERON:0001052	72.27	gold quality
amygdala	UBERON:0001876	72.03	gold quality
pancreas	UBERON:0001264	71.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	19.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• HHIP-AS1 is down-regulated in the hepatocellular carcinoma tissues and predicts poor prognosis.HHIP-AS1 represses hepatocellular carcinoma progression by promoting HHIP expression. (PMID:31604528)
• The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors. (PMID:35831316)
• Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability via Interaction with CELF2. (PMID:36374812)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.