HIC2

Summary

HIC2 (HIC ZBTB transcriptional repressor 2, HGNC:18595) is a protein-coding gene on chromosome 22q11.21, encoding Hypermethylated in cancer 2 protein (Q96JB3). Transcriptional repressor.

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleoplasm and plasma membrane.

Source: NCBI Gene 23119 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 113 total — 2 pathogenic
• MANE Select transcript: NM_015094

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18595
Approved symbol	HIC2
Name	HIC ZBTB transcriptional repressor 2
Location	22q11.21
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1020, HRG22, ZBTB30, ZNF907
Ensembl gene	ENSG00000169635
Ensembl biotype	protein_coding
OMIM	607712
Entrez	23119

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000407464, ENST00000407598, ENST00000443632, ENST00000927189, ENST00000927190

RefSeq mRNA: 1 — MANE Select: NM_015094 NM_015094

CCDS: CCDS13789

Canonical transcript exons

ENST00000407464 — 3 exons

Exon	Start	End
ENSE00001372561	21417371	21417560
ENSE00001385660	21442759	21442857
ENSE00001548117	21444922	21451463

Expression profiles

Bgee: expression breadth ubiquitous, 260 present calls, max score 99.20.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.5431 / max 107.5337, expressed in 1351 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191184	4.3510	1320
209399	0.1922	69

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	99.20	gold quality
oocyte	CL:0000023	98.65	gold quality
amniotic fluid	UBERON:0000173	90.45	gold quality
endothelial cell	CL:0000115	88.34	gold quality
placenta	UBERON:0001987	87.69	gold quality
cervix squamous epithelium	UBERON:0006922	87.43	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.26	gold quality
vena cava	UBERON:0004087	82.11	silver quality
Brodmann (1909) area 23	UBERON:0013554	81.61	gold quality
parotid gland	UBERON:0001831	81.18	gold quality
CA1 field of hippocampus	UBERON:0003881	81.16	silver quality
gingival epithelium	UBERON:0001949	79.97	silver quality
pancreatic ductal cell	CL:0002079	79.93	silver quality
squamous epithelium	UBERON:0006914	79.64	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.56	gold quality
thymus	UBERON:0002370	79.56	silver quality
embryo	UBERON:0000922	79.24	gold quality
cerebellar vermis	UBERON:0004720	79.10	gold quality
sperm	CL:0000019	78.85	silver quality
gingiva	UBERON:0001828	78.82	gold quality
triceps brachii	UBERON:0001509	78.49	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	78.44	gold quality
male germ cell	CL:0000015	77.96	silver quality
oviduct epithelium	UBERON:0004804	77.24	silver quality
esophagus squamous epithelium	UBERON:0006920	77.01	gold quality
epithelium of esophagus	UBERON:0001976	76.98	gold quality
middle temporal gyrus	UBERON:0002771	76.97	silver quality
gluteal muscle	UBERON:0002000	76.79	gold quality
primary visual cortex	UBERON:0002436	76.62	gold quality
oral cavity	UBERON:0000167	76.21	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-10018	yes	153.78
E-ANND-3	no	2.10

Regulation

Is transcription factor: yes

JASPAR motifs

Motif	Name	Family
MA0738.1	HIC2	Factors with multiple dispersed zinc fingers
MA0738.2	HIC2	Factors with multiple dispersed zinc fingers

JASPAR matrix evidence (PMIDs): PMID:15231840

miRNA regulators (miRDB)

303 targeting HIC2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787

Literature-anchored findings (GeneRIF, showing 6)

• HIC1 and HRG22 define a subgroup of BTB/POZ domains unable to recruit repressing complexes containing a histone deacetylase activity. (PMID:11554746)
• data suggest that HIC2 haploinsufficiency likely contributes to the cardiac defects seen in distal 22q11 deletion syndrome (PMID:24748541)
• HIC2 is a pivotal transcriptional activator of SIRT1 (PMID:31127867)
• HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. (PMID:35941187)
• Hypermethylation of HIC2 is a potential prognostic biomarker and tumor suppressor of glioma based on bioinformatics analysis and experiments. (PMID:36650953)
• let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching. (PMID:38364109)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	hic2	ENSDARG00000100497
mus_musculus	Hic2	ENSMUSG00000050240
rattus_norvegicus	Hic2	ENSRNOG00000051458

Paralogs (36): ZBTB32 (ENSG00000011590), SNAI2 (ENSG00000019549), PRDM1 (ENSG00000057657), PRDM6 (ENSG00000061455), ZNF76 (ENSG00000065029), PATZ1 (ENSG00000100105), MAZ (ENSG00000103495), ZBTB16 (ENSG00000109906), ZNF451 (ENSG00000112200), ZBTB45 (ENSG00000119574), ZNF410 (ENSG00000119725), SNAI1 (ENSG00000124216), ZNF384 (ENSG00000126746), ZBTB1 (ENSG00000126804), VEZF1 (ENSG00000136451), PRDM14 (ENSG00000147596), ZNF276 (ENSG00000158805), ZNF362 (ENSG00000160094), ZNF653 (ENSG00000161914), ZNF281 (ENSG00000162702), ZNF148 (ENSG00000163848), ZNF143 (ENSG00000166478), PRDM10 (ENSG00000170325), ZNF296 (ENSG00000170684), ZNF692 (ENSG00000171163), ZNF575 (ENSG00000176472), HIC1 (ENSG00000177374), ZBTB18 (ENSG00000179456), ZBTB42 (ENSG00000179627), ZBTB20 (ENSG00000181722), ZBTB7C (ENSG00000184828), SNAI3 (ENSG00000185669), ZFP91 (ENSG00000186660), MTF1 (ENSG00000188786), SCRT2 (ENSG00000215397), SCRT1 (ENSG00000261678)

Protein

Protein identifiers

Hypermethylated in cancer 2 protein — Q96JB3 (reviewed: Q96JB3)

Alternative names: HIC1-related gene on chromosome 22 protein, Hic-3, Zinc finger and BTB domain-containing protein 30

All UniProt accessions (1): Q96JB3

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional repressor.

Subunit / interactions. Self-associates. Interacts with HIC1.

Subcellular location. Nucleus.

Tissue specificity. Highest levels in cerebellum.

Similarity. Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96JB3-1	1	yes
Q96JB3-2	2

RefSeq proteins (1): NP_055909* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000210	BTB/POZ_dom	Domain
IPR011333	SKP1/BTB/POZ_sf	Homologous_superfamily
IPR013087	Znf_C2H2_type	Domain
IPR036236	Znf_C2H2_sf	Homologous_superfamily

Pfam: PF00096, PF00651

UniProt features (35 total): strand 7, modified residue 5, zinc finger region 5, helix 5, region of interest 4, compositionally biased region 3, sequence conflict 2, chain 1, domain 1, splice variant 1, turn 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7TXC	X-RAY DIFFRACTION	3.04

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96JB3-F1	50.39	0.03

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 166, 169, 197, 348, 412

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 260 (showing top): GGGACCA_MIR133A_MIR133B, MORF_MSH3, PEREZ_TP63_TARGETS, ATACCTC_MIR202, MORF_BRCA1, NAGASHIMA_NRG1_SIGNALING_UP, AAAYRNCTG_UNKNOWN, YY1_Q6, AGTCTTA_MIR499, YY1_02, KMCATNNWGGA_UNKNOWN, GOBP_CYTOKINE_PRODUCTION, E4F1_Q6, ACATTCC_MIR1_MIR206, AGGAGTG_MIR483

GO Biological Process (4): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of cytokine production (GO:0001817), regulation of immune system process (GO:0002682), negative regulation of DNA-templated transcription (GO:0045892)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), DNA binding (GO:0003677), zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (3): nucleus (GO:0005634), nucleoplasm (GO:0005654), plasma membrane (GO:0005886)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
cytokine production	1
regulation of gene expression	1
regulation of multicellular organismal process	1
immune system process	1
regulation of biological process	1
DNA-templated transcription	1
regulation of DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
nucleic acid binding	1
transition metal ion binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

606 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HIC2	CTBP2	P56545	649
HIC2	CTBP1	Q13363	625
HIC2	CCDC61	Q9Y6R9	542
HIC2	FNDC4	Q9H6D8	462
HIC2	PNPO	Q9NVS9	434
HIC2	PALS1	Q8N3R9	393
HIC2	VSX2	P58304	383
HIC2	AKAP12	Q02952	375
HIC2	MDFIC	Q9P1T7	363
HIC2	FOXD4L4	Q8WXT5	359
HIC2	DUSP5	Q16690	306
HIC2	CD200	P41217	280
HIC2	ASXL3	Q9C0F0	278
HIC2	EGR1	P18146	272
HIC2	ZNF862	O60290	269
HIC2	C2CD4C	Q8TF44	269

IntAct

68 interactions, top by confidence:

A	B	Type	Score
CTBP1	ZEB2	psi-mi:“MI:0914”(association)	0.800
CTBP1	CBX4	psi-mi:“MI:0914”(association)	0.700
ZBTB8A	HIC2	psi-mi:“MI:0915”(physical association)	0.630
HIC2	ZBTB8A	psi-mi:“MI:0915”(physical association)	0.630
HIC2	EHMT2	psi-mi:“MI:0915”(physical association)	0.560
CEP70	HIC2	psi-mi:“MI:0915”(physical association)	0.560
ZNF169	ZNF316	psi-mi:“MI:0914”(association)	0.530
E4F1	ZBTB24	psi-mi:“MI:0914”(association)	0.530
PRICKLE3	SIAH2	psi-mi:“MI:0914”(association)	0.530
ZNF460	ZNF324	psi-mi:“MI:0914”(association)	0.530
HIC2	MFHAS1	psi-mi:“MI:0407”(direct interaction)	0.440
CALU	HIC2	psi-mi:“MI:0915”(physical association)	0.400
	HIC2	psi-mi:“MI:0915”(physical association)	0.370
HIC2	HIC1	psi-mi:“MI:0915”(physical association)	0.370
HIC2	HIC2	psi-mi:“MI:0915”(physical association)	0.370
C	HIC2	psi-mi:“MI:0915”(physical association)	0.370
FOXA3	DDX39A	psi-mi:“MI:0914”(association)	0.350
FOXB1	DDX39A	psi-mi:“MI:0914”(association)	0.350
FOXJ2	TCERG1	psi-mi:“MI:0914”(association)	0.350
FOXQ1	DDX39A	psi-mi:“MI:0914”(association)	0.350
JUN		psi-mi:“MI:0914”(association)	0.350
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
NUDCD1	TUBAL3	psi-mi:“MI:0914”(association)	0.350
KLF8		psi-mi:“MI:0914”(association)	0.350
CUL4A	DDX39A	psi-mi:“MI:0914”(association)	0.350
CTBP2	ZEB2	psi-mi:“MI:0914”(association)	0.350
MIF	BLTP3B	psi-mi:“MI:0914”(association)	0.350
S100B	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
FBLN5	ZNF320	psi-mi:“MI:0914”(association)	0.350

BioGRID (91): HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS), HIC2 (Affinity Capture-MS)

ESM2 similar proteins: A3KNX5, A6NI15, A7YWL5, B0BN13, D3ZLB7, E9Q9M8, O02761, O35906, O70240, O94983, O97930, P01102, P11939, P13346, P23050, P53539, P70298, P70595, P70660, P97303, Q15742, Q28C89, Q3U1J1, Q5EBA3, Q61122, Q61127, Q62722, Q62912, Q62985, Q6NW59, Q80Y50, Q86UZ6, Q8CD60, Q8HZP6, Q90ZL1, Q91ZM2, Q92886, Q96JB3, Q99NA2, Q9BE45

Diamond homologs: A0A1B8YAB1, A1YPR0, B0WWP2, B1H285, B3M9V8, B3NDN0, B4GRJ2, B4HIK1, B4J045, B4L0G9, B4LIG6, B4MXW3, B4PD06, B4QLQ2, C9JR72, D3Z8N4, E0CZ16, G3X9X1, O15062, O88939, O93567, O95365, P28575, P41182, P41183, Q08CL3, Q08DK3, Q13105, Q16RL8, Q2M0J9, Q3UQV5, Q52KB5, Q5EXX3, Q5R7B8, Q5RDY3, Q5TC79, Q5ZI33, Q5ZKD9, Q5ZM39, Q60821

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 84 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
mRNA Splicing	6	12.4×	7e-04
Processing of Capped Intron-Containing Pre-mRNA	8	12.4×	4e-05
mRNA Polyadenylation	7	11.6×	2e-04
mRNA Splicing - Major Pathway	10	10.3×	1e-05
Dengue Virus-Host Interactions	8	6.9×	1e-03

GO biological processes:

GO term	Partners	Fold	FDR
mRNA splicing, via spliceosome	7	8.2×	4e-03
RNA splicing	7	7.9×	4e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

113 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	99
Likely benign	6
Benign	1

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
1807715	GRCh37/hg19 22q11.21(chr22:20728957-21798907)x1	Pathogenic
548980	GRCh37/hg19 22q11.21(chr22:18886915-21811991)x1	Pathogenic

SpliceAI

1109 predictions. Top by Δscore:

Variant	Effect	Δscore
22:21417558:GAG:G	donor_gain	1.0000
22:21417561:GTGAG:G	donor_loss	1.0000
22:21417562:T:G	donor_loss	1.0000
22:21417561:G:GG	donor_gain	0.9900
22:21444916:CCACA:C	acceptor_loss	0.9900
22:21444917:CACA:C	acceptor_loss	0.9900
22:21444919:CA:C	acceptor_loss	0.9900
22:21444920:AGGT:A	acceptor_gain	0.9900
22:21444921:G:GT	acceptor_loss	0.9900
22:21444921:GGTG:G	acceptor_gain	0.9900
22:21417557:CGAG:C	donor_gain	0.9800
22:21417558:GAGG:G	donor_gain	0.9800
22:21434586:T:TA	donor_gain	0.9800
22:21434587:A:AA	donor_gain	0.9800
22:21444913:T:TA	acceptor_gain	0.9800
22:21444920:A:AG	acceptor_gain	0.9800
22:21444921:G:GG	acceptor_gain	0.9800
22:21417556:ACGAG:A	donor_gain	0.9700
22:21433124:G:GT	donor_gain	0.9700
22:21444920:AG:A	acceptor_gain	0.9700
22:21444920:AGGTG:A	acceptor_gain	0.9700
22:21444921:GG:G	acceptor_gain	0.9700
22:21444921:GGT:G	acceptor_gain	0.9700
22:21444921:GGTGG:G	acceptor_gain	0.9700
22:21417559:AG:A	donor_gain	0.9600
22:21417560:GG:G	donor_gain	0.9600
22:21418197:G:GT	donor_gain	0.9600
22:21433178:A:G	donor_gain	0.9500
22:21442785:G:GT	donor_gain	0.9400
22:21417561:GTGA:G	donor_gain	0.9200

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000212880 (22:21420174 T>C), RS1000282375 (22:21444849 C>T), RS1000414449 (22:21420585 G>A), RS1000443024 (22:21444587 G>A,C), RS1000553688 (22:21425492 C>T), RS1000750928 (22:21426583 C>G,T), RS1001080868 (22:21443248 G>T), RS1001188176 (22:21446807 G>A,C), RS1001491009 (22:21443509 T>G), RS1001514882 (22:21450051 C>T), RS1001711176 (22:21451088 G>T), RS1002049132 (22:21446835 C>G), RS1002068018 (22:21450974 G>A), RS1002100528 (22:21450467 G>A), RS1002206269 (22:21437980 C>G,T)

Disease associations

OMIM: gene MIM:607712 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): megacolon (MONDO:0001273)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST000507_6	Systemic lupus erythematosus	1.000000e-16
GCST000585_2	Mean corpuscular volume	1.000000e-08

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D008531	Megacolon	C06.405.469.158.701

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	2
Acetaminophen	increases expression	2
Acrolein	affects cotreatment, increases expression, increases abundance	2
Benzo(a)pyrene	increases methylation, affects methylation	2
Ozone	affects cotreatment, increases expression, increases abundance	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
dicrotophos	increases expression	1
methylmercuric chloride	increases expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
pirinixic acid	affects binding, increases activity, increases expression	1
sulforaphane	increases expression	1
sodium arsenite	decreases expression	1
N,N,N’,N’-tetrakis(2-pyridylmethyl)ethylenediamine	decreases expression	1
CGP 52608	affects binding, increases reaction	1
licochalcone B	increases expression	1
jinfukang	affects cotreatment, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Sunitinib	increases expression	1
Vorinostat	decreases expression	1
Air Pollutants	affects cotreatment, increases abundance, increases expression	1
Arsenic	affects methylation	1
Atrazine	decreases expression	1
Cadmium	increases abundance, increases expression	1
Caffeine	increases phosphorylation	1
Cisplatin	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Fluorouracil	affects response to substance	1
Formaldehyde	decreases expression	1
Tobacco Smoke Pollution	increases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A2Q5	SEES3-1V human HIC2, clone1	Embryonic stem cell	Male
CVCL_A2Q6	SEES3-1V human HIC2, clone2	Embryonic stem cell	Male
CVCL_A2Q7	SEES3-1V human HIC2, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

2 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT04340856	Not specified	COMPLETED	Retrospective, Uncontrolled Cohort Study on the Therapy of Chronic Megalon
NCT07470892	Not specified	NOT_YET_RECRUITING	Preoperative Fish Oil PN and Prognosis After Constipation Surgery