HISLA

Summary

HISLA (HIF1A stabilizing long noncoding RNA, HGNC:49467) is a long non-coding RNA gene on chromosome 14q31.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49467
Approved symbol	HISLA
Name	HIF1A stabilizing long noncoding RNA
Location	14q31.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000258867
Ensembl biotype	lncRNA
Entrez	283587
RNAcentral	URS000075DEBF — lncRNA, 859 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 190 — 190 lncRNA

ENST00000553496, ENST00000553929, ENST00000555996, ENST00000556033, ENST00000556673, ENST00000556684, ENST00000557339, ENST00000557355, ENST00000653115, ENST00000653202, ENST00000653288, ENST00000653337, ENST00000653532, ENST00000654022, ENST00000654359, ENST00000654427, ENST00000654510, ENST00000654646, ENST00000654831, ENST00000655110, ENST00000655185, ENST00000655699, ENST00000656018, ENST00000656043, ENST00000656156, ENST00000656466, ENST00000656485, ENST00000656986, ENST00000657214, ENST00000658103, ENST00000658529, ENST00000658614, ENST00000658802, ENST00000658804, ENST00000658873, ENST00000659115, ENST00000659330, ENST00000659391, ENST00000659555, ENST00000660271, ENST00000660394, ENST00000660504, ENST00000660520, ENST00000660665, ENST00000660744, ENST00000661299, ENST00000661820, ENST00000662304, ENST00000662577, ENST00000662720, ENST00000662785, ENST00000663488, ENST00000663527, ENST00000664272, ENST00000664331, ENST00000664613, ENST00000664905, ENST00000664916, ENST00000664976, ENST00000665065, ENST00000665901, ENST00000666156, ENST00000666809, ENST00000667100, ENST00000667558, ENST00000667759, ENST00000668342, ENST00000668853, ENST00000669313, ENST00000669517, ENST00000669569, ENST00000669790, ENST00000670285, ENST00000670474, ENST00000670645, ENST00000670670, ENST00000670733, ENST00000670811, ENST00000671063, ENST00000671064, ENST00000671198, ENST00000671337, ENST00000671585, ENST00000671685, ENST00000686044, ENST00000686285, ENST00000688445, ENST00000690017, ENST00000690670, ENST00000690956, ENST00000691127, ENST00000691198, ENST00000692293, ENST00000693558, ENST00000700767, ENST00000700788, ENST00000700797, ENST00000700872, ENST00000700932, ENST00000700936, ENST00000701015, ENST00000701121, ENST00000701126, ENST00000701152, ENST00000701194, ENST00000701332, ENST00000701354, ENST00000701358, ENST00000701408, ENST00000701472, ENST00000701642, ENST00000701744, ENST00000701798, ENST00000701804, ENST00000828315, ENST00000828316, ENST00000828317, ENST00000828318, ENST00000828319, ENST00000828320, ENST00000828321, ENST00000828322, ENST00000828323, ENST00000828324, ENST00000828325, ENST00000828326, ENST00000828327, ENST00000828328, ENST00000828329, ENST00000828330, ENST00000828331, ENST00000828332, ENST00000828333, ENST00000828334, ENST00000828335, ENST00000828336, ENST00000828337, ENST00000828338, ENST00000828339, ENST00000828340, ENST00000828341, ENST00000828342, ENST00000828343, ENST00000828344, ENST00000828345, ENST00000828346, ENST00000828347, ENST00000828348, ENST00000828349, ENST00000828350, ENST00000828351, ENST00000828352, ENST00000828353, ENST00000828354, ENST00000828355, ENST00000828356, ENST00000828357, ENST00000828358, ENST00000828359, ENST00000828360, ENST00000828361, ENST00000828362, ENST00000828363, ENST00000828364, ENST00000828365, ENST00000828366, ENST00000828367, ENST00000828368, ENST00000828369, ENST00000828370, ENST00000828371, ENST00000828372, ENST00000828373, ENST00000828374, ENST00000828375, ENST00000828376, ENST00000828377, ENST00000828379, ENST00000828380, ENST00000828381, ENST00000828382, ENST00000828383, ENST00000828384, ENST00000828385, ENST00000828386, ENST00000828387, ENST00000828388, ENST00000828389, ENST00000828390, ENST00000828391

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000553496 — 3 exons

Exon	Start	End
ENSE00002434702	88093127	88093165
ENSE00002486005	88079104	88079368
ENSE00002520227	88044728	88044848

Expression profiles

Bgee: expression breadth ubiquitous, 148 present calls, max score 95.46.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1001 / max 16.7748, expressed in 32 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
140951	0.0579	16
140952	0.0421	16

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	95.46	gold quality
liver	UBERON:0002107	87.43	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.53	gold quality
islet of Langerhans	UBERON:0000006	81.88	gold quality
monocyte	CL:0000576	73.87	gold quality
leukocyte	CL:0000738	73.47	gold quality
colonic epithelium	UBERON:0000397	73.06	gold quality
prostate gland	UBERON:0002367	72.98	gold quality
bone marrow cell	CL:0002092	71.23	silver quality
granulocyte	CL:0000094	70.29	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.67	gold quality
gall bladder	UBERON:0002110	68.80	gold quality
pancreas	UBERON:0001264	68.78	gold quality
right testis	UBERON:0004534	68.46	gold quality
left testis	UBERON:0004533	68.45	gold quality
testis	UBERON:0000473	66.55	gold quality
sural nerve	UBERON:0015488	66.13	silver quality
vermiform appendix	UBERON:0001154	65.52	gold quality
blood	UBERON:0000178	63.67	gold quality
right lung	UBERON:0002167	63.65	gold quality
body of pancreas	UBERON:0001150	62.79	gold quality
adrenal tissue	UBERON:0018303	61.56	gold quality
spleen	UBERON:0002106	61.05	gold quality
upper lobe of left lung	UBERON:0008952	60.08	gold quality
caecum	UBERON:0001153	60.03	gold quality
upper lobe of lung	UBERON:0008948	59.49	gold quality
ventricular zone	UBERON:0003053	59.26	silver quality
lymph node	UBERON:0000029	58.76	gold quality
calcaneal tendon	UBERON:0003701	58.61	gold quality
hindlimb stylopod muscle	UBERON:0004252	57.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.59

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Liver-specific LINC01146, a promising prognostic indicator, inhibits the malignant phenotype of hepatocellular carcinoma cells both in vitro and in vivo. (PMID:35101062)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.