HLA-DQB1-AS1

Summary

HLA-DQB1-AS1 (HLA-DQB1 antisense RNA 1, HGNC:39762) is a long non-coding RNA gene on chromosome 6p21.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39762
Approved symbol	HLA-DQB1-AS1
Name	HLA-DQB1 antisense RNA 1
Location	6p21.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223534
Ensembl biotype	lncRNA
Entrez	106480429
RNAcentral	URS0000412E4B — lncRNA, 552 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000419852

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419852 — 2 exons

Exon	Start	End
ENSE00001676506	32659880	32660056
ENSE00001765481	32660355	32660729

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 92.69.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	92.69	gold quality
leukocyte	CL:0000738	90.96	gold quality
lymph node	UBERON:0000029	87.52	gold quality
spleen	UBERON:0002106	86.43	gold quality
upper lobe of left lung	UBERON:0008952	83.24	gold quality
tonsil	UBERON:0002372	82.98	gold quality
rectum	UBERON:0001052	82.33	gold quality
right lung	UBERON:0002167	82.31	gold quality
lung	UBERON:0002048	81.72	gold quality
colonic epithelium	UBERON:0000397	81.27	gold quality
bone marrow cell	CL:0002092	79.89	gold quality
tibial nerve	UBERON:0001323	79.55	gold quality
bone marrow	UBERON:0002371	79.46	gold quality
subcutaneous adipose tissue	UBERON:0002190	79.42	gold quality
gall bladder	UBERON:0002110	78.48	gold quality
vermiform appendix	UBERON:0001154	77.91	gold quality
skin of leg	UBERON:0001511	77.77	gold quality
zone of skin	UBERON:0000014	77.28	gold quality
right coronary artery	UBERON:0001625	76.67	gold quality
skin of abdomen	UBERON:0001416	76.64	gold quality
adipose tissue	UBERON:0001013	76.42	gold quality
blood	UBERON:0000178	76.17	gold quality
thoracic mammary gland	UBERON:0005200	76.16	gold quality
lower esophagus mucosa	UBERON:0035834	75.72	gold quality
smooth muscle tissue	UBERON:0001135	75.02	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.87	gold quality
uterine cervix	UBERON:0000002	74.09	gold quality
small intestine Peyer’s patch	UBERON:0003454	73.98	gold quality
ectocervix	UBERON:0012249	73.91	gold quality
urinary bladder	UBERON:0001255	73.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• NUDT3 and KLF5 were found to associate with lean mass and HLA-DQB1-AS1 for hand grip strength as candidate genes to target for these phenotypes in sarcopenia. The associated regulatory SNPs are rs464553, rs1028883 and rs3129753 respectively. (PMID:32093658)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.