HLA-F-AS1

Summary

HLA-F-AS1 (HLA-F antisense RNA 1, HGNC:26645) is a long non-coding RNA gene on chromosome 6p22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26645
Approved symbol	HLA-F-AS1
Name	HLA-F antisense RNA 1
Location	6p22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000214922
Ensembl biotype	lncRNA
Entrez	285830
RNAcentral	URS000075D2CA — lncRNA, 1914 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 71 — 71 lncRNA

ENST00000399247, ENST00000434086, ENST00000458236, ENST00000849873, ENST00000849874, ENST00000849875, ENST00000849876, ENST00000849877, ENST00000849878, ENST00000849879, ENST00000849880, ENST00000849881, ENST00000849882, ENST00000849883, ENST00000849884, ENST00000849885, ENST00000849886, ENST00000849887, ENST00000849888, ENST00000849889, ENST00000849890, ENST00000849891, ENST00000849892, ENST00000849893, ENST00000849894, ENST00000849895, ENST00000849896, ENST00000849897, ENST00000849898, ENST00000849899, ENST00000849900, ENST00000849901, ENST00000849902, ENST00000849903, ENST00000849904, ENST00000849905, ENST00000849906, ENST00000849907, ENST00000849908, ENST00000849909, ENST00000849910, ENST00000849911, ENST00000849912, ENST00000849913, ENST00000849914, ENST00000849915, ENST00000849916, ENST00000849917, ENST00000849918, ENST00000849919, ENST00000849920, ENST00000849921, ENST00000849922, ENST00000849923, ENST00000849924, ENST00000849925, ENST00000849926, ENST00000849927, ENST00000849928, ENST00000849929, ENST00000849930, ENST00000849931, ENST00000849932, ENST00000849933, ENST00000849934, ENST00000849935, ENST00000849936, ENST00000849937, ENST00000849938, ENST00000849939, ENST00000849940

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000399247 — 6 exons

Exon	Start	End
ENSE00001592665	29748900	29749049
ENSE00001679523	29747148	29747425
ENSE00001697425	29728365	29728495
ENSE00001736088	29726601	29727139
ENSE00001752975	29738551	29738886
ENSE00001793254	29737966	29738436

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 81.17.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.7127 / max 66.6959, expressed in 1242 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
72477	2.6100	1220
72476	0.1027	24

Top tissues by expression

135 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	81.17	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.99	silver quality
lymph node	UBERON:0000029	79.74	gold quality
endocervix	UBERON:0000458	79.41	gold quality
spleen	UBERON:0002106	79.37	gold quality
body of uterus	UBERON:0009853	79.11	gold quality
ectocervix	UBERON:0012249	78.65	gold quality
granulocyte	CL:0000094	78.60	gold quality
descending thoracic aorta	UBERON:0002345	78.47	gold quality
right lung	UBERON:0002167	78.35	gold quality
right adrenal gland cortex	UBERON:0035827	78.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	77.94	gold quality
lower esophagus	UBERON:0013473	77.90	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	77.90	gold quality
ascending aorta	UBERON:0001496	77.88	gold quality
thoracic aorta	UBERON:0001515	77.88	gold quality
heart left ventricle	UBERON:0002084	77.59	gold quality
right ovary	UBERON:0002118	77.58	gold quality
myometrium	UBERON:0001296	77.52	gold quality
mucosa of stomach	UBERON:0001199	77.42	gold quality
uterine cervix	UBERON:0000002	77.39	gold quality
right adrenal gland	UBERON:0001233	77.39	gold quality
calcaneal tendon	UBERON:0003701	77.33	gold quality
left ovary	UBERON:0002119	77.13	gold quality
popliteal artery	UBERON:0002250	77.05	gold quality
tibial artery	UBERON:0007610	77.05	gold quality
ovary	UBERON:0000992	76.73	gold quality
heart	UBERON:0000948	76.66	gold quality
vagina	UBERON:0000996	76.60	gold quality
small intestine Peyer’s patch	UBERON:0003454	76.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Potentials as biomarker and therapeutic target of upregulated long non-coding RNA HLA-F antisense RNA 1 in hepatitis B virus-associated hepatocellular carcinoma. (PMID:38568442)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.