HLCS-AS1

Summary

HLCS-AS1 (HLCS antisense RNA 1, HGNC:55850) is a long non-coding RNA gene on chromosome 21q22.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55850
Approved symbol	HLCS-AS1
Name	HLCS antisense RNA 1
Location	21q22.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224790
Ensembl biotype	lncRNA
Entrez	122455337
RNAcentral	URS00026A223D — lncRNA, 2219 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000430068, ENST00000637940, ENST00000653177, ENST00000754808

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430068 — 4 exons

Exon	Start	End
ENSE00001675633	36971765	36971828
ENSE00001741068	36969601	36969620
ENSE00001755883	36966512	36966611
ENSE00001792727	36968554	36968807

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 78.99.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.99	gold quality
bone marrow cell	CL:0002092	70.86	silver quality
cortical plate	UBERON:0005343	70.03	gold quality
colonic epithelium	UBERON:0000397	69.03	silver quality
islet of Langerhans	UBERON:0000006	68.39	gold quality
ganglionic eminence	UBERON:0004023	67.01	gold quality
adenohypophysis	UBERON:0002196	65.80	gold quality
cerebellum	UBERON:0002037	65.21	gold quality
cerebellar cortex	UBERON:0002129	65.18	gold quality
ventricular zone	UBERON:0003053	65.15	gold quality
cerebellar hemisphere	UBERON:0002245	65.07	gold quality
pancreas	UBERON:0001264	64.44	gold quality
pituitary gland	UBERON:0000007	64.39	gold quality
sural nerve	UBERON:0015488	64.24	silver quality
right hemisphere of cerebellum	UBERON:0014890	64.15	gold quality
stromal cell of endometrium	CL:0002255	63.65	gold quality
body of pancreas	UBERON:0001150	62.29	gold quality
prefrontal cortex	UBERON:0000451	62.15	gold quality
right lobe of thyroid gland	UBERON:0001119	60.46	gold quality
left lobe of thyroid gland	UBERON:0001120	60.43	gold quality
skeletal muscle tissue	UBERON:0001134	60.41	gold quality
thyroid gland	UBERON:0002046	60.32	gold quality
hypothalamus	UBERON:0001898	60.18	gold quality
frontal cortex	UBERON:0001870	59.58	gold quality
metanephros cortex	UBERON:0010533	59.54	gold quality
cortex of kidney	UBERON:0001225	59.51	gold quality
kidney	UBERON:0002113	59.43	gold quality
brain	UBERON:0000955	59.26	gold quality
adult mammalian kidney	UBERON:0000082	59.08	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	58.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.43

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.