HMBOX1-IT1

Summary

HMBOX1-IT1 (HMBOX1 intronic transcript 1, HGNC:43632) is a long non-coding RNA gene on chromosome 8p12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43632
Approved symbol	HMBOX1-IT1
Name	HMBOX1 intronic transcript 1
Location	8p12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259196
Ensembl biotype	lncRNA
Entrez	106481795
RNAcentral	URS0000619EAD — lncRNA, 347 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000558292

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558292 — 2 exons

Exon	Start	End
ENSE00002556323	28955851	28955955
ENSE00002559441	28949676	28949917

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 84.06.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
thymus	UBERON:0002370	84.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.56	gold quality
colonic epithelium	UBERON:0000397	79.43	gold quality
sural nerve	UBERON:0015488	75.65	gold quality
ganglionic eminence	UBERON:0004023	72.89	gold quality
muscle tissue	UBERON:0002385	69.69	gold quality
quadriceps femoris	UBERON:0001377	69.42	gold quality
cerebellar vermis	UBERON:0004720	67.75	gold quality
tonsil	UBERON:0002372	66.78	gold quality
bone marrow cell	CL:0002092	66.12	silver quality
skeletal muscle tissue	UBERON:0001134	65.93	gold quality
calcaneal tendon	UBERON:0003701	65.41	gold quality
liver	UBERON:0002107	64.00	gold quality
bone marrow	UBERON:0002371	62.96	gold quality
adrenal tissue	UBERON:0018303	62.85	gold quality
monocyte	CL:0000576	62.79	gold quality
corpus callosum	UBERON:0002336	62.68	gold quality
islet of Langerhans	UBERON:0000006	62.14	gold quality
adult mammalian kidney	UBERON:0000082	61.50	gold quality
kidney	UBERON:0002113	61.07	gold quality
duodenum	UBERON:0002114	60.10	gold quality
primary visual cortex	UBERON:0002436	60.08	gold quality
blood	UBERON:0000178	58.72	gold quality
muscle of leg	UBERON:0001383	58.38	gold quality
uterine cervix	UBERON:0000002	56.62	gold quality
placenta	UBERON:0001987	56.07	silver quality
urinary bladder	UBERON:0001255	55.97	silver quality
prefrontal cortex	UBERON:0000451	55.96	gold quality
lymph node	UBERON:0000029	55.77	gold quality
frontal cortex	UBERON:0001870	55.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.06

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.