HMGA2-AS1

Summary

HMGA2-AS1 (HMGA2 antisense RNA 1, HGNC:53973) is a long non-coding RNA gene on chromosome 12q14.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53973
Approved symbol	HMGA2-AS1
Name	HMGA2 antisense RNA 1
Location	12q14.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-366L20.2
Ensembl gene	ENSG00000197301
Ensembl biotype	lncRNA
Entrez	100129940
RNAcentral	URS0000D77FE3 — lncRNA, 995 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000356215, ENST00000439236, ENST00000504038, ENST00000536648

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000356215 — 3 exons

Exon	Start	End
ENSE00001403158	65881718	65882041
ENSE00001479470	65855947	65860088
ENSE00003759400	65866804	65866954

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 79.55.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3376 / max 24.2163, expressed in 156 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
131918	0.2155	101
131919	0.1136	66
131920	0.0085	2

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	79.55	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.93	silver quality
left ovary	UBERON:0002119	76.52	gold quality
sural nerve	UBERON:0015488	76.07	gold quality
ovary	UBERON:0000992	75.14	gold quality
body of pancreas	UBERON:0001150	73.63	gold quality
adrenal tissue	UBERON:0018303	73.03	gold quality
stromal cell of endometrium	CL:0002255	72.95	gold quality
bone marrow	UBERON:0002371	72.11	gold quality
right ovary	UBERON:0002118	70.01	gold quality
right uterine tube	UBERON:0001302	69.54	gold quality
right lobe of thyroid gland	UBERON:0001119	68.50	gold quality
pancreas	UBERON:0001264	68.32	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.08	gold quality
colonic epithelium	UBERON:0000397	67.32	silver quality
thyroid gland	UBERON:0002046	66.31	gold quality
tibial nerve	UBERON:0001323	66.11	gold quality
metanephros cortex	UBERON:0010533	66.06	gold quality
kidney	UBERON:0002113	65.76	gold quality
cortex of kidney	UBERON:0001225	65.73	gold quality
monocyte	CL:0000576	65.51	gold quality
left lobe of thyroid gland	UBERON:0001120	65.26	gold quality
leukocyte	CL:0000738	64.82	gold quality
lymph node	UBERON:0000029	64.21	gold quality
ventricular zone	UBERON:0003053	63.85	gold quality
adipose tissue	UBERON:0001013	62.51	gold quality
adult mammalian kidney	UBERON:0000082	62.49	gold quality
thoracic mammary gland	UBERON:0005200	62.26	gold quality
skin of leg	UBERON:0001511	61.73	gold quality
skeletal muscle tissue	UBERON:0001134	60.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.34

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.