HMMR-AS1

Summary

HMMR-AS1 (HMMR antisense RNA 1, HGNC:49149) is a long non-coding RNA gene on chromosome 5q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49149
Approved symbol	HMMR-AS1
Name	HMMR antisense RNA 1
Location	5q34
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000251018
Ensembl biotype	lncRNA
Entrez	101927813
RNAcentral	URS000075C0A7 — lncRNA, 1269 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000514724, ENST00000521666

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000514724 — 4 exons

Exon	Start	End
ENSE00002036779	163493443	163493549
ENSE00002050480	163489251	163489383
ENSE00002077424	163493699	163494058
ENSE00002104630	163483176	163483272

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 90.29.

Top tissues by expression

178 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	90.29	silver quality
sperm	CL:0000019	85.01	gold quality
ventricular zone	UBERON:0003053	62.99	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	62.90	gold quality
left testis	UBERON:0004533	62.47	gold quality
testis	UBERON:0000473	61.33	gold quality
right testis	UBERON:0004534	60.62	gold quality
stromal cell of endometrium	CL:0002255	52.32	silver quality
mucosa of transverse colon	UBERON:0004991	51.57	gold quality
monocyte	CL:0000576	50.86	silver quality
Brodmann (1909) area 9	UBERON:0013540	50.85	gold quality
ectocervix	UBERON:0012249	50.34	gold quality
lower esophagus mucosa	UBERON:0035834	49.92	gold quality
vermiform appendix	UBERON:0001154	49.65	gold quality
right lobe of liver	UBERON:0001114	47.69	silver quality
muscle of leg	UBERON:0001383	47.24	gold quality
gastrocnemius	UBERON:0001388	46.75	gold quality
adrenal tissue	UBERON:0018303	46.61	silver quality
left adrenal gland cortex	UBERON:0035825	46.60	gold quality
lymph node	UBERON:0000029	45.19	gold quality
caecum	UBERON:0001153	45.05	gold quality
metanephros cortex	UBERON:0010533	45.04	gold quality
skin of hip	UBERON:0001554	44.84	silver quality
uterine cervix	UBERON:0000002	43.49	silver quality
uterus	UBERON:0000995	43.42	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
adrenal cortex	UBERON:0001235	43.34	silver quality
adult mammalian kidney	UBERON:0000082	43.17	silver quality
anatomical system	UBERON:0000467	43.17	gold quality
material anatomical entity	UBERON:0000465	43.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• High expression of HMMR-AS1 is an independent factor for poor survival in newly diagnosed patients with epithelial ovarian cancer. (PMID:30556852)
• significantly over-expressed in lung adenocarcinoma; HMMR-AS1-miR-138-sirt6 axis plays a critical role in tumorigenesis (PMID:31128573)
• Sevoflurane inhibits progression of glioma via regulating the HMMR antisense RNA 1/microRNA-7/cyclin dependent kinase 4 axis. (PMID:34719318)
• Exosomal lncRNA HMMR-AS1 mediates macrophage polarization through miR-147a/ARID3A axis under hypoxia and affects the progression of hepatocellular carcinoma. (PMID:35179300)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.