HNF1A-AS1

Summary

HNF1A-AS1 (HNF1A antisense RNA 1, HGNC:26785) is a long non-coding RNA gene on chromosome 12q24.31.

Biomarker of colon cancer and stomach cancer.

Source: NCBI Gene 283460 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26785
Approved symbol	HNF1A-AS1
Name	HNF1A antisense RNA 1
Location	12q24.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ38690, HAS1, HASTER
Ensembl gene	ENSG00000241388
Ensembl biotype	lncRNA
Entrez	283460
RNAcentral	URS000075C27F — lncRNA, 2455 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 13 lncRNA, 1 retained_intron

ENST00000433033, ENST00000535301, ENST00000537361, ENST00000539163, ENST00000619441, ENST00000646404, ENST00000647473, ENST00000701238, ENST00000701967, ENST00000760046, ENST00000760047, ENST00000760048, ENST00000760049, ENST00000760050

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433033 — 4 exons

Exon	Start	End
ENSE00002273906	120974485	120974598
ENSE00002281161	120976799	120976921
ENSE00004113290	120970024	120970370
ENSE00004113300	120979614	120979766

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 92.00.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.2667 / max 154.5930, expressed in 113 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133684	0.7584	102
133683	0.3001	75
133686	0.1498	46
133685	0.0251	17
133681	0.0234	17
133682	0.0100	5

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
metanephros cortex	UBERON:0010533	92.00	gold quality
mucosa of transverse colon	UBERON:0004991	90.45	gold quality
colonic epithelium	UBERON:0000397	90.12	gold quality
rectum	UBERON:0001052	89.36	gold quality
body of pancreas	UBERON:0001150	89.11	gold quality
right lobe of liver	UBERON:0001114	88.88	gold quality
kidney	UBERON:0002113	88.87	gold quality
cortex of kidney	UBERON:0001225	88.38	gold quality
liver	UBERON:0002107	88.18	gold quality
adult mammalian kidney	UBERON:0000082	88.02	gold quality
gall bladder	UBERON:0002110	86.45	gold quality
duodenum	UBERON:0002114	85.96	gold quality
stomach	UBERON:0000945	85.66	gold quality
pancreas	UBERON:0001264	85.25	gold quality
body of stomach	UBERON:0001161	85.11	gold quality
transverse colon	UBERON:0001157	84.81	gold quality
right uterine tube	UBERON:0001302	82.66	gold quality
skeletal muscle tissue	UBERON:0001134	82.65	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.14	silver quality
fundus of stomach	UBERON:0001160	79.63	gold quality
small intestine	UBERON:0002108	79.26	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.22	gold quality
small intestine Peyer’s patch	UBERON:0003454	79.03	gold quality
islet of Langerhans	UBERON:0000006	77.74	gold quality
endometrium	UBERON:0001295	77.52	gold quality
cerebellar vermis	UBERON:0004720	77.04	gold quality
thymus	UBERON:0002370	76.92	silver quality
quadriceps femoris	UBERON:0001377	76.39	silver quality
intestine	UBERON:0000160	75.71	gold quality
colon	UBERON:0001155	73.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 31)

• We discovered that a lncRNA, HNF1A-AS1, is markedly upregulated in human primary EACs relative to their corresponding normal oesophageal tissues (mean fold change 10.6, p<0.01). (PMID:24000294)
• increased HNF1A-AS1 expression could regulate cell proliferation and metastasis and it is identified as a poor prognostic biomarker in lung adenocarcinoma. (PMID:25863539)
• In summary, we identified HNF1A-AS1-miR-30b axis as a key regulator in hepatocarcinogenesis, which may be promising biomarkers and therapeutic targets in the future. (PMID:27084450)
• These results suggested that HNF1A-AS1 may contribute to HCC progression, which may be an effective therapeutic target for patients. (PMID:28292020)
• knockdown of HNF1AAS1 expression notably inhibited CRC cell proliferation, migration, invasion and colony formation, and suppressed Sphase entry in vitro. Taken together, these results suggested that HNF1AAS1 might serve as a promising prognostic marker for CRC tumorigenesis and progression. (PMID:28791380)
• Higher expression of HNF1A-AS1 conferred a significantly poorer survival of osteosarcoma patients. (PMID:28866868)
• Long non-coding RNA HNF1A-AS1 mediated the metastatic progression of colon cancer in part through miR-34a/SIRT1/p53 signaling axis. (PMID:28943452)
• Decreased expression of lncRNA HNF1A-AS1 suppressed the Wnt/beta-catenin signaling pathway. (PMID:29145164)
• HNF1A-AS1 promoted lung cancer cells proliferation and invasion via regulating miR-17-5p. (PMID:29289833)
• Our data revealed that HNF1A-AS1 is a direct transactivation target of HNF1alpha in HCC cells and involved in the anti-HCC effect of HNF1alpha. HNF1A-AS1 functions as phosphatase activator through the direct interaction with SHP-1. (PMID:29466992)
• HNF1A-AS1 expression was upregulated inurothelial carcinoma of the bladder (UCB), and it may be a useful prognostic biomarker for patients with UCB. (PMID:29762827)
• EGR1-activated HNF1A-AS1 regulates various pro- and antigrowth factors to promote the development of gastric cancer (PMID:30185552)
• High HNF1A-AS1 expression is associated with oral squamous cell carcinoma. (PMID:30404566)
• lncRNA HNF1A-AS1 modulates non-small cell lung cancer progression by targeting miR-149-5p/Cdk6. (PMID:31243821)
• Study identified two lncRNAs, HNF1A-AS1 and HNF4A-AS1, which were able to affect susceptibility of acetaminophen (APAP)-induced liver injury in HepaRG cells, possibly through regulating the expression of APAP-metabolizing cytochrome P450 enzymes. This discovery added new factors, lncRNAs, which can be used to predict cytochrome P450-mediated drug metabolism and drug-induced toxicity. (PMID:32029527)
• Associations Between Genomic Variants in lncRNA-TRPM2-AS and lncRNA-HNF1A-AS1 Genes and Risk of Multiple Sclerosis. (PMID:32100228)
• Deletion of HNF1A-AS1 Suppresses the Malignant Phenotypes of Breast Cancer Cells In Vitro and In Vivo Through Targeting miRNA-20a-5p/TRIM32 Axis. (PMID:32319789)
• Long non-coding RNA HNF1A-AS1 upregulates OTX1 to enhance angiogenesis in colon cancer via the binding of transcription factor PBX3. (PMID:32325080)
• LncRNA-HNF1A-AS1 functions as a competing endogenous RNA to activate PI3K/AKT signalling pathway by sponging miR-30b-3p in gastric cancer. (PMID:32336754)
• Long noncoding RNA HNF1A-AS1 regulates proliferation and apoptosis of glioma through activation of the JNK signaling pathway via miR-363-3p/MAP2K4. (PMID:32779194)
• Aberrant methylationmediated decrease of lncRNA HNF1AAS1 contributes to malignant progression of laryngeal squamous cell carcinoma via EMT. (PMID:33125127)
• MYC-activated lncRNA HNF1A-AS1 overexpression facilitates glioma progression via cooperating with miR-32-5p/SOX4 axis. (PMID:33448691)
• Silencing long non-coding RNA HNF1A-AS1 inhibits growth and resistance to TAM of breast cancer cells via the microRNA-363/SERTAD3 axis. (PMID:33472456)
• The HNF1A-AS1/miR-92a-3p axis affects the radiosensitivity of non-small cell lung cancer by competitively regulating the JNK pathway. (PMID:33755848)
• TCF-3-mediated transcription of lncRNA HNF1A-AS1 targeting oncostatin M expression inhibits epithelial-mesenchymal transition via TGFbeta signaling in gastroenteropancreatic neuroendocrine neoplasms. (PMID:34037532)
• Differential expression of HNF1A and HNF1A-AS1 in colon cancer cells. (PMID:35184384)
• sh-HNF1A-AS1 reduces the epithelial-mesenchymal transition and stemness of esophageal cancer cells. (PMID:35188404)
• HNF1A-AS1: A Tumor-associated Long Non-coding RNA. (PMID:35619319)
• The New Role of HNF1A-NAS1/miR-214/INHBA Signaling Axis in Colorectal Cancer. (PMID:38062804)
• The long noncoding RNA HNF1A-AS1 with dual functions in the regulation of cytochrome P450 3A4. (PMID:38176619)
• CMYC-initiated HNF1A-AS1 overexpression maintains the stemness of gastric cancer cells. (PMID:38654006)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.