HNRNPH3

Summary

HNRNPH3 (heterogeneous nuclear ribonucleoprotein H3, HGNC:5043) is a protein-coding gene on chromosome 10q21.3, encoding Heterogeneous nuclear ribonucleoprotein H3 (P31942). Involved in the splicing process and participates in early heat shock-induced splicing arrest.

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized.

Source: NCBI Gene 3189 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 30 total
• Druggable target: yes
• MANE Select transcript: NM_012207

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5043
Approved symbol	HNRNPH3
Name	heterogeneous nuclear ribonucleoprotein H3
Location	10q21.3
Locus type	gene with protein product
Status	Approved
Aliases	2H9
Ensembl gene	ENSG00000096746
Ensembl biotype	protein_coding
OMIM	602324
Entrez	3189

Gene structure

Transcript identifiers

Ensembl transcripts: 66 — 57 protein_coding, 9 protein_coding_CDS_not_defined

ENST00000265866, ENST00000354695, ENST00000461310, ENST00000467249, ENST00000469172, ENST00000478698, ENST00000480987, ENST00000481819, ENST00000486854, ENST00000490442, ENST00000491200, ENST00000880278, ENST00000880279, ENST00000880280, ENST00000880281, ENST00000880282, ENST00000880283, ENST00000880284, ENST00000880285, ENST00000880286, ENST00000880287, ENST00000880288, ENST00000880289, ENST00000880290, ENST00000880291, ENST00000880292, ENST00000880293, ENST00000880294, ENST00000880295, ENST00000880296, ENST00000880297, ENST00000880298, ENST00000880299, ENST00000880300, ENST00000880301, ENST00000880302, ENST00000880303, ENST00000880304, ENST00000880305, ENST00000880306, ENST00000880307, ENST00000880308, ENST00000940766, ENST00000940767, ENST00000940768, ENST00000940769, ENST00000940770, ENST00000940771, ENST00000940772, ENST00000940773, ENST00000940774, ENST00000940775, ENST00000940776, ENST00000940777, ENST00000940778, ENST00000940779, ENST00000940780, ENST00000940781, ENST00000940782, ENST00000940783, ENST00000940784, ENST00000940785, ENST00000967049, ENST00000967050, ENST00000967051, ENST00000967052

RefSeq mRNA: 21 — MANE Select: NM_012207 NM_001322434, NM_001322436, NM_001322437, NM_001322438, NM_001322439, NM_001322440, NM_001322441, NM_001322442, NM_001322443, NM_001322444, NM_001322445, NM_001322446, NM_001322447, NM_001322448, NM_001322449, NM_001322450, NM_001322451, NM_001322452, NM_001322453, NM_012207, NM_021644

CCDS: CCDS7278, CCDS7279

Canonical transcript exons

ENST00000265866 — 10 exons

Exon	Start	End
ENSE00001881721	68341978	68343193
ENSE00001899301	68332064	68332216
ENSE00003461270	68339140	68339226
ENSE00003478649	68337858	68337996
ENSE00003571840	68337199	68337333
ENSE00003584989	68341174	68341309
ENSE00003603265	68339440	68339555
ENSE00003611482	68341759	68341851
ENSE00003650127	68341585	68341680
ENSE00003689235	68338503	68338687

Expression profiles

Bgee: expression breadth ubiquitous, 301 present calls, max score 99.57.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 228.8531 / max 10329.0454, expressed in 1827 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
105230	198.7669	1827
105231	21.8518	1797
105237	2.2728	990
105232	1.6075	730
105238	1.6061	743
105236	1.0070	540
105234	1.0018	518
105235	0.5253	267
105240	0.1786	64
105229	0.0353	14

Top tissues by expression

301 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	99.57	gold quality
ventricular zone	UBERON:0003053	99.50	gold quality
ganglionic eminence	UBERON:0004023	99.49	gold quality
cortical plate	UBERON:0005343	99.37	gold quality
embryo	UBERON:0000922	99.13	gold quality
left ovary	UBERON:0002119	99.00	gold quality
right ovary	UBERON:0002118	98.91	gold quality
body of uterus	UBERON:0009853	98.89	gold quality
ovary	UBERON:0000992	98.87	gold quality
endocervix	UBERON:0000458	98.81	gold quality
cerebellar hemisphere	UBERON:0002245	98.74	gold quality
cerebellar cortex	UBERON:0002129	98.73	gold quality
left lobe of thyroid gland	UBERON:0001120	98.70	gold quality
right hemisphere of cerebellum	UBERON:0014890	98.69	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.67	gold quality
right testis	UBERON:0004534	98.64	gold quality
right lung	UBERON:0002167	98.62	gold quality
thyroid gland	UBERON:0002046	98.58	gold quality
medial globus pallidus	UBERON:0002477	98.58	gold quality
cerebellum	UBERON:0002037	98.57	gold quality
left testis	UBERON:0004533	98.57	gold quality
left uterine tube	UBERON:0001303	98.56	gold quality
small intestine Peyer’s patch	UBERON:0003454	98.55	gold quality
right lobe of thyroid gland	UBERON:0001119	98.54	gold quality
nerve	UBERON:0001021	98.51	gold quality
tibial nerve	UBERON:0001323	98.51	gold quality
descending thoracic aorta	UBERON:0002345	98.49	gold quality
muscle layer of sigmoid colon	UBERON:0035805	98.49	gold quality
adenohypophysis	UBERON:0002196	98.48	gold quality
right uterine tube	UBERON:0001302	98.47	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-HCAD-13	yes	20.85
E-CURD-112	no	2.04
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

87 targeting HNRNPH3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-5696	99.98	72.36	4487
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-221-3P	99.86	71.56	1329
HSA-MIR-222-3P	99.86	71.35	1337
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540

Literature-anchored findings (GeneRIF, showing 3)

• Using ORF phage display, heterogeneous nuclear ribonucleoprotein H3 (Hnrph3) was, among other candidates, identified as an autoantigen for acute anterior uveitis. (PMID:20943442)
• A novel heterogeneous nuclear ribonucleoprotein H3-ALK receptor tyrosine kinase rearrangement was found in one de novo salivary duct carcinoma (PMID:30946933)
• Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by Interacting With HNRNPH3 and Enhancing the Transcription of HSP70 in Unexplained Recurrent Spontaneous Abortion. (PMID:34484222)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	hnrnph3	ENSDARG00000039466
mus_musculus	Hnrnph3	ENSMUSG00000020069
rattus_norvegicus	Hnrnph3	ENSRNOG00000048193
drosophila_melanogaster	fus	FBGN0023441
drosophila_melanogaster	glo	FBGN0259139
caenorhabditis_elegans		WBGENE00006367
caenorhabditis_elegans	rbm-12	WBGENE00013703
caenorhabditis_elegans		WBGENE00022253

Paralogs (8): ESRP2 (ENSG00000103067), ESRP1 (ENSG00000104413), HNRNPH2 (ENSG00000126945), GRSF1 (ENSG00000132463), HNRNPH1 (ENSG00000169045), HNRNPF (ENSG00000169813), RBM12B (ENSG00000183808), RBM12 (ENSG00000244462)

Protein

Protein identifiers

Heterogeneous nuclear ribonucleoprotein H3 — P31942 (reviewed: P31942)

Alternative names: Heterogeneous nuclear ribonucleoprotein 2H9

All UniProt accessions (2): P31942, B4DHY1

UniProt curated annotations — full annotation on UniProt →

Function. Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.

Subcellular location. Nucleus.

Isoforms (6)

UniProt ID	Names	Canonical?
P31942-1	1	yes
P31942-2	2, 2H9A
P31942-3	3, 2H9B
P31942-4	4, 2H9C
P31942-5	5, 2H9D
P31942-6	6, 2H9E

RefSeq proteins (21): NP_001309363, NP_001309365, NP_001309366, NP_001309367, NP_001309368, NP_001309369, NP_001309370, NP_001309371, NP_001309372, NP_001309373, NP_001309374, NP_001309375, NP_001309376, NP_001309377, NP_001309378, NP_001309379, NP_001309380, NP_001309381, NP_001309382, NP_036339, NP_067676 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000504	RRM_dom	Domain
IPR012677	Nucleotide-bd_a/b_plait_sf	Homologous_superfamily
IPR034969	hnRNPH3_RRM3	Domain
IPR034970	hnRNPH3_RRM2	Domain
IPR035979	RBD_domain_sf	Homologous_superfamily
IPR050666	ESRP	Family

Pfam: PF00076

UniProt features (27 total): modified residue 13, splice variant 7, domain 2, cross-link 2, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P31942-F1	62.23	0.02

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (15): 314, 323, 343, 6, 67, 116, 121, 129, 1, 121, 174, 216, 287, 296, 298

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 205 (showing top): GOBP_EPITHELIUM_DEVELOPMENT, MULLIGHAN_NPM1_SIGNATURE_3_UP, CMYB_01, GCM_ZNF198, chr10q21, YY1_Q6, DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN, AAACCAC_MIR140, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, MYCMAX_01, BLALOCK_ALZHEIMERS_DISEASE_UP, GOBP_RNA_SPLICING, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, TIEN_INTESTINE_PROBIOTICS_24HR_UP, PPARA_01

GO Biological Process (6): mRNA splicing, via spliceosome (GO:0000398), RNA processing (GO:0006396), RNA splicing (GO:0008380), epithelial cell differentiation (GO:0030855), regulation of RNA splicing (GO:0043484), mRNA processing (GO:0006397)

GO Molecular Function (3): RNA binding (GO:0003723), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), spliceosomal complex (GO:0005681), ribonucleoprotein complex (GO:1990904)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA processing	2
binding	2
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1
mRNA processing	1
gene expression	1
RNA biosynthetic process	1
primary metabolic process	1
cell differentiation	1
epithelium development	1
RNA splicing	1
regulation of gene expression	1
regulation of primary metabolic process	1
mRNA metabolic process	1
nucleic acid binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
nuclear protein-containing complex	1
ribonucleoprotein complex	1
protein-containing complex	1

Protein interactions and networks

STRING

1786 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HNRNPH3	HNRNPC	P07910	691
HNRNPH3	HNRNPM	P52272	687
HNRNPH3	HNRNPA1	P09651	671
HNRNPH3	HNRNPAB	Q99729	655
HNRNPH3	HNRNPA2B1	P22626	642
HNRNPH3	SRSF7	Q16629	573
HNRNPH3	HNRNPDL	O14979	570
HNRNPH3	SYNCRIP	O60506	569
HNRNPH3	PTBP2	Q9UKA9	530
HNRNPH3	HNRNPD	P07029	524
HNRNPH3	PTBP1	P26599	503
HNRNPH3	HNRNPA0	Q13151	497
HNRNPH3	HNRNPUL2	Q1KMD3	489
HNRNPH3	SRSF3	P23152	451
HNRNPH3	RALY	Q9UKM9	448

IntAct

195 interactions, top by confidence:

A	B	Type	Score
N	HNRNPR	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
HNRNPA1	HNRNPH3	psi-mi:“MI:0915”(physical association)	0.660
USE1	NBAS	psi-mi:“MI:0914”(association)	0.640
NCBP2	KPNA3	psi-mi:“MI:0914”(association)	0.640
NCBP1	KPNA3	psi-mi:“MI:0914”(association)	0.640
tat	PPM1G	psi-mi:“MI:0914”(association)	0.560
HNRNPH1	HNRNPH3	psi-mi:“MI:0915”(physical association)	0.550
HNRNPH2	PLOD2	psi-mi:“MI:0914”(association)	0.530
KSR2	POLR3A	psi-mi:“MI:0914”(association)	0.530
P/V/C	KPNA3	psi-mi:“MI:0914”(association)	0.530
CFTR	CNOT1	psi-mi:“MI:0914”(association)	0.480
RBM45	HNRNPDL	psi-mi:“MI:0914”(association)	0.460
HNRNPH3	APOL2	psi-mi:“MI:0915”(physical association)	0.400
HNRNPH3	ZMYM2	psi-mi:“MI:0915”(physical association)	0.400
	HNRNPH3	psi-mi:“MI:0915”(physical association)	0.370
HNRNPH3	ADORA2A	psi-mi:“MI:0915”(physical association)	0.370
HNRNPH3	PCNA	psi-mi:“MI:0915”(physical association)	0.370
MAPK6	HNRNPH3	psi-mi:“MI:0915”(physical association)	0.370
HNRNPH3	CHERP	psi-mi:“MI:0915”(physical association)	0.370
HNRNPH3	HNRNPA0	psi-mi:“MI:0915”(physical association)	0.370
NCBP3	HNRNPH3	psi-mi:“MI:0915”(physical association)	0.370
DDX17	HNRNPH3	psi-mi:“MI:0915”(physical association)	0.370
DDX5	HNRNPH3	psi-mi:“MI:0915”(physical association)	0.370
HNRNPU	HNRNPH3	psi-mi:“MI:0915”(physical association)	0.370
HNRNPUL1	HNRNPH3	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (403): HNRNPH3 (Affinity Capture-RNA), HNRNPH3 (Affinity Capture-RNA), HNRNPH3 (Affinity Capture-RNA), HNRNPH3 (Affinity Capture-MS), HNRNPH3 (Affinity Capture-MS), HNRNPH3 (Affinity Capture-MS), HNRNPH3 (Affinity Capture-MS), HNRNPH3 (Affinity Capture-MS), HNRNPH3 (Affinity Capture-MS), HNRNPH3 (Affinity Capture-MS), HNRNPH3 (Affinity Capture-MS), HNRNPH3 (Affinity Capture-MS), HNRNPDL (Co-fractionation), HNRNPH3 (Co-fractionation), HNRNPH3 (Co-fractionation)

ESM2 similar proteins: A0A2R8Y4L2, A5A6H4, A7VJC2, O01671, O17310, O19049, O61374, O88569, O97018, P04256, P09651, P09867, P17130, P19339, P21522, P22626, P31942, P49312, P51968, P51989, P51990, P51991, P51992, P52272, P61978, P61979, P61980, Q08473, Q13148, Q24668, Q28521, Q28F51, Q2HJ60, Q32P51, Q3T0D0, Q4R4M6, Q5R5H8, Q5R5W2, Q5RBU8, Q5ZIQ3

Diamond homologs: A1L1G1, A8WPC5, B2RYD2, B2RYJ8, O35737, P31942, P31943, P52597, P55795, P70333, Q22708, Q3SZF3, Q3US41, Q5E9J1, Q5RD26, Q5ZLR4, Q60HC3, Q6AY09, Q6DEZ7, Q6NXG1, Q794E4, Q7ZVR8, Q7ZY29, Q8C5Q4, Q8K0G8, Q8VHV7, Q9BJZ5, Q9H6T0, Q9Z2X1, Q12849, Q15020, Q5REG1, Q8R3C6, Q9JLI8, Q9Y4C8, Q5RBM8, Q8R4X3, Q8SQ27, Q9NTZ6, Q66JV4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 204 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Apoptotic execution phase	5	16.4×	1e-03
FGFR2 alternative splicing	5	14.6×	2e-03
mRNA Polyadenylation	20	12.1×	1e-13
Dengue Virus Genome Translation and Replication	5	10.9×	7e-03
Processing of Capped Intron-Containing Pre-mRNA	18	10.2×	3e-11
mRNA Splicing - Major Pathway	23	8.7×	6e-13
mRNA Splicing	9	6.8×	9e-04
Dengue Virus-Host Interactions	21	6.6×	1e-09

GO biological processes:

GO term	Partners	Fold	FDR
alternative mRNA splicing, via spliceosome	8	30.6×	7e-08
positive regulation of cytoplasmic translation	5	28.2×	1e-04
intrinsic apoptotic signaling pathway	7	14.3×	1e-04
regulation of alternative mRNA splicing, via spliceosome	10	13.9×	1e-06
mRNA stabilization	6	12.5×	7e-04
RNA processing	9	11.2×	2e-05
autophagosome maturation	5	10.0×	7e-03
mRNA splicing, via spliceosome	19	9.9×	8e-11

Disease & clinical

Clinical variants and AI predictions

ClinVar

30 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1819 predictions. Top by Δscore:

Variant	Effect	Δscore
10:68332215:GG:G	donor_gain	1.0000
10:68332216:GG:G	donor_gain	1.0000
10:68332223:G:GT	donor_gain	1.0000
10:68332226:G:GG	donor_gain	1.0000
10:68332232:GGGG:G	donor_gain	1.0000
10:68332233:GGGG:G	donor_gain	1.0000
10:68337312:G:GT	donor_gain	1.0000
10:68337313:A:T	donor_gain	1.0000
10:68337980:G:GT	donor_gain	1.0000
10:68337981:A:T	donor_gain	1.0000
10:68338610:G:GT	donor_gain	1.0000
10:68338640:G:GT	donor_gain	1.0000
10:68338643:G:GG	donor_gain	1.0000
10:68338667:G:GT	donor_gain	1.0000
10:68339135:CACA:C	acceptor_loss	1.0000
10:68339136:A:AG	acceptor_gain	1.0000
10:68339136:ACAG:A	acceptor_gain	1.0000
10:68339136:ACAGG:A	acceptor_loss	1.0000
10:68339137:CA:C	acceptor_loss	1.0000
10:68339138:A:AG	acceptor_gain	1.0000
10:68339138:A:G	acceptor_loss	1.0000
10:68339139:G:GA	acceptor_loss	1.0000
10:68339139:G:GG	acceptor_gain	1.0000
10:68339139:GGTT:G	acceptor_gain	1.0000
10:68339224:GAG:G	donor_gain	1.0000
10:68339225:AG:A	donor_loss	1.0000
10:68339226:GGTAA:G	donor_loss	1.0000
10:68339227:G:C	donor_loss	1.0000
10:68339434:TTCCA:T	acceptor_loss	1.0000
10:68339437:CAGGT:C	acceptor_loss	1.0000

AlphaMissense

2266 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:68337274:T:A	V18E	1.000
10:68337277:G:C	R19P	1.000
10:68337280:T:A	L20H	1.000
10:68337280:T:C	L20P	1.000
10:68337280:T:G	L20R	1.000
10:68337282:C:A	R21S	1.000
10:68337282:C:G	R21G	1.000
10:68337282:C:T	R21C	1.000
10:68337283:G:A	R21H	1.000
10:68337283:G:C	R21P	1.000
10:68337283:G:T	R21L	1.000
10:68337285:G:A	G22R	1.000
10:68337285:G:C	G22R	1.000
10:68337286:G:A	G22E	1.000
10:68337286:G:C	G22A	1.000
10:68337286:G:T	G22V	1.000
10:68337289:T:A	L23Q	1.000
10:68337289:T:C	L23P	1.000
10:68337289:T:G	L23R	1.000
10:68337291:C:A	P24T	1.000
10:68337291:C:G	P24A	1.000
10:68337291:C:T	P24S	1.000
10:68337292:C:A	P24Q	1.000
10:68337292:C:G	P24R	1.000
10:68337292:C:T	P24L	1.000
10:68337294:T:A	F25I	1.000
10:68337294:T:C	F25L	1.000
10:68337294:T:G	F25V	1.000
10:68337295:T:C	F25S	1.000
10:68337295:T:G	F25C	1.000

dbSNP variants (sampled 300 via entrez): RS1000183533 (10:68340139 A>T), RS1000242351 (10:68340406 C>T), RS1000292075 (10:68332632 A>T), RS1000725840 (10:68332461 A>G), RS1000742449 (10:68333089 G>A), RS1000987610 (10:68333256 T>A,G), RS1001517412 (10:68333157 G>A,C), RS1001649849 (10:68338438 C>A,G,T), RS1001705913 (10:68340481 G>A), RS1001761779 (10:68332040 C>A,T), RS1002167249 (10:68333132 T>G), RS1002233823 (10:68332147 C>A,T), RS1002498526 (10:68332854 G>A), RS1002613750 (10:68336247 A>G), RS1002646181 (10:68336519 G>A)

Disease associations

OMIM: gene MIM:602324 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066917 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 4 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
8.37	Kd	4.308	nM	CHEMBL3752910
8.29	ED50	5.127	nM	CHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 4 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148532: Binding affinity to human HNRNPH3 incubated for 45 mins by Kinobead based pull down assay	kd	0.0043	uM

CTD chemical–gene interactions

62 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	6
bisphenol A	increases expression, decreases expression, affects cotreatment, affects expression, increases abundance	4
Benzo(a)pyrene	decreases expression, increases methylation, affects cotreatment, increases expression	3
Cyclosporine	decreases expression	3
bisphenol F	increases expression, affects cotreatment	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression, decreases expression	2
Cisplatin	affects cotreatment, decreases expression	2
Hydrogen Peroxide	affects cotreatment, decreases expression, affects expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
Tetrachlorodibenzodioxin	decreases expression	2
Tobacco Smoke Pollution	affects expression, increases expression	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
ginger extract	affects cotreatment, affects expression, increases abundance	1
triphenyl phosphate	affects expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, affects localization, increases expression	1
trichostatin A	affects expression	1
methylparaben	increases expression	1
sodium arsenite	decreases expression	1
resorcinol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
ICG 001	increases expression	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	increases methylation	1
jinfukang	affects cotreatment, decreases expression	1
LDN 193189	affects cotreatment, increases expression	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651574	Binding	Binding affinity to human HNRNPH3 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.