HORMAD2-AS1

Summary

HORMAD2-AS1 (HORMAD2 and MTMR3 antisense RNA 1, HGNC:50729) is a long non-coding RNA gene on chromosome 22q12.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50729
Approved symbol	HORMAD2-AS1
Name	HORMAD2 and MTMR3 antisense RNA 1
Location	22q12.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	MTMR3-AS1, NONHSAG033653
Ensembl gene	ENSG00000227117
Ensembl biotype	lncRNA
Entrez	101929664
RNAcentral	URS0000EEACE2 — lncRNA, 925 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000429350, ENST00000432568, ENST00000453743, ENST00000717625, ENST00000759922, ENST00000759923, ENST00000759924

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429350 — 5 exons

Exon	Start	End
ENSE00001674437	30050461	30050589
ENSE00001695196	30040177	30040278
ENSE00001708587	30018617	30018729
ENSE00004113110	30080128	30080311
ENSE00004113112	30008740	30009196

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 85.63.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3493 / max 18.6683, expressed in 148 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193562	0.3193	144
193561	0.0300	12

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	85.63	gold quality
liver	UBERON:0002107	85.62	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.06	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.70	gold quality
bone marrow cell	CL:0002092	70.65	silver quality
putamen	UBERON:0001874	68.46	gold quality
caudate nucleus	UBERON:0001873	68.04	gold quality
skeletal muscle tissue	UBERON:0001134	68.00	gold quality
ventricular zone	UBERON:0003053	65.89	gold quality
right testis	UBERON:0004534	65.58	gold quality
testis	UBERON:0000473	65.32	gold quality
left testis	UBERON:0004533	65.13	gold quality
ganglionic eminence	UBERON:0004023	63.87	gold quality
cortical plate	UBERON:0005343	63.87	gold quality
substantia nigra	UBERON:0002038	63.74	gold quality
hypothalamus	UBERON:0001898	62.54	gold quality
tonsil	UBERON:0002372	62.01	gold quality
prefrontal cortex	UBERON:0000451	61.82	gold quality
bone marrow	UBERON:0002371	61.01	gold quality
nucleus accumbens	UBERON:0001882	60.80	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.73	gold quality
frontal cortex	UBERON:0001870	59.03	gold quality
blood	UBERON:0000178	58.95	gold quality
brain	UBERON:0000955	58.71	gold quality
leukocyte	CL:0000738	58.64	gold quality
monocyte	CL:0000576	58.51	gold quality
subcutaneous adipose tissue	UBERON:0002190	58.46	gold quality
granulocyte	CL:0000094	58.39	gold quality
amygdala	UBERON:0001876	57.84	gold quality
primary visual cortex	UBERON:0002436	57.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.54

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.