HOXA-AS3

Summary

HOXA-AS3 (HOXA cluster antisense RNA 3, HGNC:43748) is a long non-coding RNA gene on chromosome 7p15.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43748
Approved symbol	HOXA-AS3
Name	HOXA cluster antisense RNA 3
Location	7p15.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	HOXA6as
Ensembl gene	ENSG00000254369
Ensembl biotype	lncRNA
OMIM	618706
Entrez	100133311
RNAcentral	URS000075BCB2 — lncRNA, 3992 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000518848, ENST00000518947, ENST00000521197, ENST00000521231, ENST00000524304, ENST00000730237

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000518848 — 3 exons

Exon	Start	End
ENSE00002116795	27152294	27152576
ENSE00002134710	27129977	27130148
ENSE00002416665	27151575	27151681

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 74.02.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2362 / max 23.5868, expressed in 85 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
77802	0.1148	46
77803	0.0466	24
77799	0.0382	13
77801	0.0366	11

Top tissues by expression

218 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	74.02	gold quality
left uterine tube	UBERON:0001303	73.02	gold quality
metanephros cortex	UBERON:0010533	72.88	gold quality
stromal cell of endometrium	CL:0002255	72.25	gold quality
mucosa of transverse colon	UBERON:0004991	72.13	gold quality
bone marrow cell	CL:0002092	71.30	silver quality
transverse colon	UBERON:0001157	71.23	gold quality
sural nerve	UBERON:0015488	70.54	gold quality
rectum	UBERON:0001052	68.13	gold quality
left adrenal gland cortex	UBERON:0035825	67.61	gold quality
metanephros	UBERON:0000081	67.45	gold quality
left adrenal gland	UBERON:0001234	66.95	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.92	gold quality
right adrenal gland cortex	UBERON:0035827	66.88	gold quality
right adrenal gland	UBERON:0001233	66.83	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.39	gold quality
adrenal cortex	UBERON:0001235	65.78	gold quality
body of uterus	UBERON:0009853	65.55	gold quality
adrenal gland	UBERON:0002369	65.50	gold quality
colon	UBERON:0001155	65.25	gold quality
skin of abdomen	UBERON:0001416	65.06	gold quality
skin of leg	UBERON:0001511	65.05	gold quality
large intestine	UBERON:0000059	64.44	gold quality
intestine	UBERON:0000160	64.20	gold quality
small intestine	UBERON:0002108	64.01	gold quality
right uterine tube	UBERON:0001302	63.92	gold quality
muscle of leg	UBERON:0001383	63.87	gold quality
adult mammalian kidney	UBERON:0000082	63.57	gold quality
adrenal tissue	UBERON:0018303	63.47	gold quality
gastrocnemius	UBERON:0001388	63.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 15)

• These results demonstrate that HOXA-AS3 was activated in lung adenocarcinoma and supported cancer cell progression. (PMID:29899328)
• HOXA-AS3 sponged miR-29c to facilitate cell proliferation, metastasis and EMT process, and activated the MEK/ERK signaling pathway in hepatocellular carcinoma(HCC). Our findings suggested that HOXA-AS3 functioned as a vital oncogene and might provide a new potential therapeutic strategy for HCC. (PMID:30963785)
• HOXA-AS3 interacts with NF-kB and promotes the activation of NF-kB signaling through mediation of its target genes expression. Also, the expression of HOXA-AS3 is dramatically elevated in patients with atherosclerosis compared with the control group, suggesting a significant positive correlation of HOXA-AS3 with inflammatory atherosclerosis. HOXA-AS3 may serve as a crucial biomarker for the diagnosis of atherosclerosis. (PMID:31285272)
• LncRNA Hoxaas3 promotes lung fibroblast activation and fibrosis by targeting miR-450b-5p to regulate Runx1. (PMID:32848140)
• LncRNA HOXA-AS3 promotes the malignancy of glioblastoma through regulating miR-455-5p/USP3 axis. (PMID:32918360)
• LncRNA HOXA-AS3 Promotes the Progression of Pulmonary Arterial Hypertension through Mediation of miR-675-3p/PDE5A Axis. (PMID:33687636)
• Highly conserved and cis-acting lncRNAs produced from paralogous regions in the center of HOXA and HOXB clusters in the endoderm lineage. (PMID:34280202)
• Long non-coding RNA HOXA-AS3 facilitates the malignancy in colorectal cancer by miR-4319/SPNS2 axis. (PMID:34671931)
• Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p. (PMID:34698001)
• HOXA-AS3 Promotes Proliferation and Migration of Hepatocellular Carcinoma Cells via the miR-455-5p/PD-L1 Axis. (PMID:34988230)
• Prognostic value of lncRNA HOXA-AS3 in cervical cancer by targeting miR-29a-3p and its regulatory effect on tumor progression. (PMID:35817473)
• The integrated comprehension of lncRNA HOXA-AS3 implication on human diseases. (PMID:35986859)
• HOXAAS3 induces tumor progression through the epithelialmesenchymal transition pathway in epithelial ovarian cancer. (PMID:36799173)
• Long non-coding HOXA-AS3 contributes to osteosarcoma progression through the miR-1286/TEAD1 axis. (PMID:37752588)
• LncRNA HOXA-AS3 promotes cell proliferation and invasion via targeting miR-218-5p/FOXP1 axis in osteosarcoma. (PMID:39019995)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.