HOXA10-AS
gene geneOn this page
Summary
HOXA10-AS (HOXA10 antisense RNA, HGNC:40281) is a long non-coding RNA gene on chromosome 7p15.2.
Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex.
Source: NCBI Gene 100874323 — RefSeq curated summary.
At a glance
- Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:40281 |
| Approved symbol | HOXA10-AS |
| Name | HOXA10 antisense RNA |
| Location | 7p15.2 |
| Locus type | RNA, long non-coding |
| Status | Approved |
| Ensembl gene | ENSG00000253187 |
| Ensembl biotype | lncRNA |
| Entrez | 100874323 |
| RNAcentral | URS000049D760 — lncRNA, 1161 nt, 1 organism(s) |
Gene structure
Transcript identifiers
Ensembl transcripts: 4 — 4 lncRNA
ENST00000519694, ENST00000519935, ENST00000523790, ENST00000716685
RefSeq mRNA: 0 — MANE Select: None
Canonical transcript exons
ENST00000519694 — 2 exons
| Exon | Start | End |
|---|---|---|
| ENSE00002127021 | 27168619 | 27168993 |
| ENSE00004030407 | 27171308 | 27171373 |
Expression profiles
Bgee: expression breadth ubiquitous, 116 present calls, max score 85.27.
FANTOM5 (CAGE): breadth broad, TPM avg 1.1845 / max 48.3036, expressed in 426 samples.
FANTOM5 promoters (5 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 77809 | 0.4153 | 162 |
| 77806 | 0.2878 | 137 |
| 77805 | 0.2851 | 125 |
| 77808 | 0.1332 | 59 |
| 77807 | 0.0631 | 32 |
Top tissues by expression
210 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| left uterine tube | UBERON:0001303 | 85.27 | gold quality |
| colonic epithelium | UBERON:0000397 | 82.04 | gold quality |
| tibial artery | UBERON:0007610 | 80.58 | gold quality |
| popliteal artery | UBERON:0002250 | 80.57 | gold quality |
| transverse colon | UBERON:0001157 | 79.31 | gold quality |
| metanephros cortex | UBERON:0010533 | 78.91 | gold quality |
| sural nerve | UBERON:0015488 | 78.21 | gold quality |
| mucosa of transverse colon | UBERON:0004991 | 78.00 | gold quality |
| body of uterus | UBERON:0009853 | 77.89 | gold quality |
| aorta | UBERON:0000947 | 76.17 | gold quality |
| muscle of leg | UBERON:0001383 | 75.96 | gold quality |
| gastrocnemius | UBERON:0001388 | 75.78 | gold quality |
| stromal cell of endometrium | CL:0002255 | 74.96 | gold quality |
| ectocervix | UBERON:0012249 | 74.58 | gold quality |
| muscle layer of sigmoid colon | UBERON:0035805 | 74.14 | gold quality |
| endocervix | UBERON:0000458 | 73.92 | gold quality |
| skin of abdomen | UBERON:0001416 | 73.70 | gold quality |
| hindlimb stylopod muscle | UBERON:0004252 | 73.38 | gold quality |
| colon | UBERON:0001155 | 72.99 | gold quality |
| skin of leg | UBERON:0001511 | 72.85 | gold quality |
| small intestine Peyer’s patch | UBERON:0003454 | 71.99 | gold quality |
| large intestine | UBERON:0000059 | 71.80 | gold quality |
| intestine | UBERON:0000160 | 71.04 | gold quality |
| calcaneal tendon | UBERON:0003701 | 71.04 | gold quality |
| cortex of kidney | UBERON:0001225 | 70.94 | gold quality |
| adult mammalian kidney | UBERON:0000082 | 70.76 | gold quality |
| uterine cervix | UBERON:0000002 | 70.55 | gold quality |
| zone of skin | UBERON:0000014 | 70.23 | gold quality |
| prostate gland | UBERON:0002367 | 68.83 | gold quality |
| small intestine | UBERON:0002108 | 68.80 | gold quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 0.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | no | 2.77 |
Regulation
Is transcription factor: no
Literature-anchored findings (GeneRIF, showing 6)
- HOXA10-AS is upregulated by the transcription factor ELK1. (PMID:29729275)
- Study addressed HOXA10-AS as a regulator of cell proliferation and apoptosis in glioma, and identified HOXA10 as a target of HOXA10-AS. Additionally, the oncogene HOXA10 had an important role in promoting the tumorigenesis of glioma. (PMID:30132568)
- Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas. (PMID:34686327)
- LncRNA HOXA10-AS functions as an oncogene by binding miR-6509-5p to upregulate Y-box binding protein 1 in gastric cancer. (PMID:35521747)
- Modular scaffolding by lncRNA HOXA10-AS promotes oral cancer progression. (PMID:35858923)
- LncRNA HOXA10-AS promotes the progression of esophageal carcinoma by regulating the expression of HOXA10. (PMID:36588458)
Cross-species orthologs
0 orthologs
Protein
Non-coding RNA — no protein product; not a drug target.
Function
No curated pathway, Gene-Ontology, or interaction data.
Disease & clinical
No curated disease, variant, or cancer-driver associations.
Drugs & pharmacology
No drug or pharmacology data — not an established drug target.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.