◎ Sugi Atlas

Atlas / Gene / HOXA3

HOXA3

gene
On this page

Summary

HOXA3 (homeobox A3, HGNC:5104) is a protein-coding gene on chromosome 7p15.2, encoding Homeobox protein Hox-A3 (O43365). Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.

Source: NCBI Gene 3200 — RefSeq curated summary.

At a glance

  • GWAS associations: 23
  • Clinical variants (ClinVar): 185 total — 1 likely-pathogenic
  • MANE Select transcript: NM_153631

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:5104
Approved symbolHOXA3
Namehomeobox A3
Location7p15.2
Locus typegene with protein product
StatusApproved
Ensembl geneENSG00000105997
Ensembl biotypeprotein_coding
OMIM142954
Entrez3200

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 14 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000317201, ENST00000396352, ENST00000521401, ENST00000522456, ENST00000522788, ENST00000612286, ENST00000851228, ENST00000851229, ENST00000851230, ENST00000851231, ENST00000851232, ENST00000851233, ENST00000851234, ENST00000851235, ENST00000956341

RefSeq mRNA: 14 — MANE Select: NM_153631 NM_001384335, NM_001384336, NM_001384337, NM_001384338, NM_001384339, NM_001384340, NM_001384341, NM_001384342, NM_001384343, NM_001384344, NM_001384345, NM_001384346, NM_030661, NM_153631

CCDS: CCDS5404

Canonical transcript exons

ENST00000612286 — 6 exons

ExonStartEnd
ENSE000012176112712255927122642
ENSE000013797002711011527110760
ENSE000021233842712688627127070
ENSE000021391092715228827152583
ENSE000037080192714008327140186
ENSE000037298042710701027108720

Expression profiles

Bgee: expression breadth ubiquitous, 192 present calls, max score 93.50.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.6638 / max 157.5535, expressed in 1044 samples.

FANTOM5 promoters (18 alternative TSS)

Promoter IDTPM avgSamples expressed
832983.0399590
832640.9758357
832960.6912357
832860.3491153
832670.3175170
832620.2102112
832690.132373
832730.130169
832660.125557
832870.104849

Top tissues by expression

268 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
caput epididymisUBERON:000435893.50gold quality
corpus epididymisUBERON:000435991.51gold quality
right uterine tubeUBERON:000130289.52gold quality
left uterine tubeUBERON:000130388.29gold quality
parietal pleuraUBERON:000240087.63gold quality
metanephros cortexUBERON:001053387.38gold quality
renal medullaUBERON:000036286.60gold quality
tibiaUBERON:000097986.55gold quality
descending thoracic aortaUBERON:000234585.85gold quality
visceral pleuraUBERON:000240185.31gold quality
pleuraUBERON:000097785.28gold quality
esophagogastric junction muscularis propriaUBERON:003584185.07gold quality
mucosa of stomachUBERON:000119985.05gold quality
transverse colonUBERON:000115784.86gold quality
mucosa of transverse colonUBERON:000499184.85gold quality
lower esophagus muscularis layerUBERON:003583384.75gold quality
lower esophagusUBERON:001347384.73gold quality
thoracic aortaUBERON:000151583.85gold quality
ascending aortaUBERON:000149683.58gold quality
buccal mucosa cellCL:000233683.09gold quality
body of uterusUBERON:000985382.73gold quality
mucosa of sigmoid colonUBERON:000499382.24gold quality
esophagus squamous epitheliumUBERON:000692082.09gold quality
aortaUBERON:000094782.02gold quality
muscle layer of sigmoid colonUBERON:003580581.98gold quality
skeletal muscle tissue of rectus abdominisUBERON:000451181.97gold quality
colonic mucosaUBERON:000031781.86gold quality
cauda epididymisUBERON:000436081.84gold quality
colonUBERON:000115581.57gold quality
esophagusUBERON:000104381.47gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes7.11

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

TargetRegulation
GATA2Unknown
MMP14

JASPAR motifs

MotifNameFamily
MA2119.1HOXA3HOX

JASPAR matrix evidence (PMIDs): PMID:20079828

Upstream regulators (CollecTRI, top): MAFB

Literature-anchored findings (GeneRIF, showing 9)

  • HOXA7, HOXB3, HOXA3, and HOXB13 expression levels changed during angiogenesis, sugessting these proteins might be involved in the angiogenesis of hMSCs. (PMID:17972163)
  • aim of this work was to search for mutations in thyroid developmental candidate genes HOXA3, HOXB3, HOXD3 and PITX2 (PMID:24127533)
  • we demonstrate that HOXA3 and HOXA5 genes are markedly upregulated when NAP1L3 is suppressed in umbilical cord blood (UCB) haematopoietic stem cells (HSCs). Taken together, our findings establish an important role for NAP1L3 in haematopoietic stem cells homeostasis and haematopoietic differentiation. (PMID:30046127)
  • Study indicated that low HOXA3 expression may play a certain role in lung adenocarcinoma; however, its association with lung squamous cell carcinoma still requires further investigation. (PMID:30066858)
  • Bioinformatics analysis of putative target mRNAs of miR3383p identified a direct binding site in the 3’untranslated of homeobox A3 (HOXA3). (PMID:31322185)
  • ARID1B/SUB1-activated lncRNA HOXA-AS2 drives the malignant behaviour of hepatoblastoma through regulation of HOXA3. (PMID:33683826)
  • Homeobox A3 and KDM6A cooperate in transcriptional control of aerobic glycolysis and glioblastoma progression. (PMID:36215227)
  • HOXA3 functions as the on-off switch to regulate the development of hESC-derived third pharyngeal pouch endoderm through EPHB2-mediated Wnt pathway. (PMID:38259452)
  • Upregulation of HOXA3 by isoform-specific Wilms tumour 1 drives chemotherapy resistance in acute myeloid leukaemia. (PMID:38867543)

Cross-species orthologs

4 orthologs

OrganismSymbolGene ID
danio_reriohoxc3aENSDARG00000070339
danio_reriohoxa3aENSDARG00000103862
mus_musculusHoxa3ENSMUSG00000079560
rattus_norvegicusHoxa3ENSRNOG00000006281

Paralogs (42): HOXA11 (ENSG00000005073), HOXC8 (ENSG00000037965), HOXA1 (ENSG00000105991), HOXA2 (ENSG00000105996), HOXA5 (ENSG00000106004), HOXA6 (ENSG00000106006), HOXA13 (ENSG00000106031), TLX1 (ENSG00000107807), HOXB6 (ENSG00000108511), TLX2 (ENSG00000115297), HOXB8 (ENSG00000120068), HOXB5 (ENSG00000120075), HOXB3 (ENSG00000120093), HOXB1 (ENSG00000120094), HOXA7 (ENSG00000122592), HOXC13 (ENSG00000123364), HOXC11 (ENSG00000123388), HOXC12 (ENSG00000123407), HOXD1 (ENSG00000128645), HOXD3 (ENSG00000128652), HOXD9 (ENSG00000128709), HOXD10 (ENSG00000128710), HOXD11 (ENSG00000128713), HOXD13 (ENSG00000128714), PDX1 (ENSG00000139515), HOXB13 (ENSG00000159184), TLX3 (ENSG00000164438), HOXD4 (ENSG00000170166), HOXD12 (ENSG00000170178), HOXB9 (ENSG00000170689), HOXC5 (ENSG00000172789), HOXB2 (ENSG00000173917), HOXD8 (ENSG00000175879), GSX2 (ENSG00000180613), HOXC9 (ENSG00000180806), HOXC10 (ENSG00000180818), HOXB4 (ENSG00000182742), HOXA4 (ENSG00000197576), HOXC6 (ENSG00000197757), HOXC4 (ENSG00000198353)

Protein

Protein identifiers

Homeobox protein Hox-A3 — O43365 (reviewed: O43365)

Alternative names: Homeobox protein Hox-1E

All UniProt accessions (3): O43365, E5RIJ8, F2Z3A4

UniProt curated annotations — full annotation on UniProt →

Function. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location. Nucleus.

Similarity. Belongs to the Antp homeobox family.

RefSeq proteins (14): NP_001371264, NP_001371265, NP_001371266, NP_001371267, NP_001371268, NP_001371269, NP_001371270, NP_001371271, NP_001371272, NP_001371273, NP_001371274, NP_001371275, NP_109377, NP_705895* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR001356HDDomain
IPR001827Homeobox_Antennapedia_CSConserved_site
IPR009057Homeodomain-like_sfHomologous_superfamily
IPR017970Homeobox_CSConserved_site
IPR020479HD_metazoaDomain
IPR025281DUF4074Domain

Pfam: PF00046, PF13293

UniProt features (14 total): compositionally biased region 5, region of interest 4, sequence variant 2, chain 1, DNA-binding region 1, short sequence motif 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-O43365-F159.410.15

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis

MSigDB gene sets: 299 (showing top): GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, MULLIGHAN_NPM1_SIGNATURE_3_UP, BENPORATH_ES_WITH_H3K27ME3, GOBP_CARTILAGE_DEVELOPMENT, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, RORA1_01, NKX25_02, TGCACTT_MIR519C_MIR519B_MIR519A, GCANCTGNY_MYOD_Q6, GOBP_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT, GOBP_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS, GOBP_THYMUS_DEVELOPMENT, CREBP1_Q2, GOBP_CRANIAL_NERVE_MORPHOGENESIS

GO Biological Process (24): angiogenesis (GO:0001525), blood vessel remodeling (GO:0001974), regulation of transcription by RNA polymerase II (GO:0006357), calcium ion transport (GO:0006816), anterior/posterior pattern specification (GO:0009952), specification of animal organ position (GO:0010159), gene expression (GO:0010467), magnesium ion homeostasis (GO:0010960), glossopharyngeal nerve morphogenesis (GO:0021615), bone mineralization (GO:0030282), thyroid gland development (GO:0030878), thymus development (GO:0048538), animal organ formation (GO:0048645), embryonic skeletal system morphogenesis (GO:0048704), cartilage development (GO:0051216), phosphate ion homeostasis (GO:0055062), calcium ion homeostasis (GO:0055074), parathyroid gland development (GO:0060017), stem cell proliferation (GO:0072089), positive regulation of stem cell proliferation (GO:2000648), regulation of DNA-templated transcription (GO:0006355), cell population proliferation (GO:0008283), animal organ morphogenesis (GO:0009887), embryonic skeletal system development (GO:0048706)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), HMG box domain binding (GO:0071837), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), protein binding (GO:0005515)

GO Cellular Component (3): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
Activation of HOX genes during differentiation1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
inorganic ion homeostasis3
gland development3
anatomical structure formation involved in morphogenesis2
regulation of DNA-templated transcription2
regionalization2
animal organ morphogenesis2
monoatomic cation homeostasis2
endocrine system development2
RNA polymerase II transcription regulatory region sequence-specific DNA binding2
cellular anatomical structure2
blood vessel morphogenesis1
tissue remodeling1
transcription by RNA polymerase II1
metal ion transport1
macromolecule biosynthetic process1
glossopharyngeal nerve development1
cranial nerve morphogenesis1
ossification1
biomineral tissue development1
hematopoietic or lymphoid organ development1
embryonic organ morphogenesis1
skeletal system morphogenesis1
embryonic skeletal system development1
skeletal system development1
animal organ development1
connective tissue development1
cell population proliferation1
stem cell division1
positive regulation of cell population proliferation1
stem cell proliferation1
regulation of stem cell proliferation1
cis-regulatory region sequence-specific DNA binding1
chromatin1
DNA-binding transcription factor activity1
regulation of transcription by RNA polymerase II1
protein domain specific binding1
nucleic acid binding1
transcription cis-regulatory region binding1
transcription regulator activity1
binding1

Protein interactions and networks

STRING

1158 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
HOXA3FOXN1O15353648
HOXA3HIRAP54198638
HOXA3MEIS1O00470615
HOXA3PAX1P15863610
HOXA3PAX9P55771521
HOXA3HOXD8P13378510
HOXA3HOXD10P28358507
HOXA3HOXA9P31269503
HOXA3EYA1Q99502503
HOXA3HHEXQ03014497
HOXA3HOXD9P28356490
HOXA3RARBP10826478
HOXA3HOXA13P31271476
HOXA3HOXA6P31267469
HOXA3HOXA10P31260446

IntAct

24 interactions, top by confidence:

ABTypeScore
ARPC3HOXA3psi-mi:“MI:0915”(physical association)0.720
HOXA3ARPC3psi-mi:“MI:0915”(physical association)0.720
HOXA3SEC23Bpsi-mi:“MI:0915”(physical association)0.670
SEC23BHOXA3psi-mi:“MI:0915”(physical association)0.670
HOXA3BDNFpsi-mi:“MI:0915”(physical association)0.560
TERF1HOXA3psi-mi:“MI:0915”(physical association)0.370
HOXA3TINF2psi-mi:“MI:0915”(physical association)0.370
POT1HOXA3psi-mi:“MI:0915”(physical association)0.370
HOXA3PWP1psi-mi:“MI:0915”(physical association)0.370
HOXA3ALX4psi-mi:“MI:0915”(physical association)0.370
ZDHHC17HOXA3psi-mi:“MI:0915”(physical association)0.370
GUSBHOXA3psi-mi:“MI:0914”(association)0.350
BMI1MEIS3P1psi-mi:“MI:0914”(association)0.350
S100PPLEKHG3psi-mi:“MI:0914”(association)0.350
ARPC3HOXA3psi-mi:“MI:0915”(physical association)0.000

BioGRID (21): ARPC3 (Two-hybrid), SEC23B (Two-hybrid), HOXA3 (Two-hybrid), HOXA3 (Two-hybrid), HOXA3 (Affinity Capture-MS), RCHY1 (PCA), ARPC3 (Two-hybrid), HOXA3 (Affinity Capture-MS), HOXA3 (Affinity Capture-RNA), HOXA3 (Affinity Capture-MS), HOXA3 (Affinity Capture-MS), HK2 (Co-localization), PKM (Co-localization), KDM6A (Affinity Capture-Western), HOXA3 (Affinity Capture-RNA)

ESM2 similar proteins: A1YFU7, A2AJK6, A2BH40, B2RWS6, D3YWE6, E9Q4N7, M9NEY8, O00512, O14497, O35126, O42368, O43365, O57401, P02831, P02833, P22810, P23441, P23512, P25822, P32182, P34545, P35582, P35583, P43698, P43699, P50220, P50901, P54258, P54259, P54269, P55317, Q06A37, Q08DG7, Q08E31, Q09472, Q0VCT9, Q10571, Q1KKX7, Q24248, Q24645

Diamond homologs: A1L2P5, A1YER7, A1YF08, A1YFD8, A1YFY3, A1YG85, A2D4P8, A2D5I1, A2D5K9, A2D5Y4, A2T6X6, A2T756, A8DT10, A9L937, B0VXK3, O13074, O42365, O42367, O42368, O42370, O43364, O43365, O57374, O93353, P02830, P02831, P06798, P09013, P09014, P09016, P09019, P09020, P09021, P09026, P09027, P09067, P09070, P09074, P09079, P09080

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

185 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic1
Uncertain significance150
Likely benign12
Benign13

Top pathogenic / likely-pathogenic (1)

Variant IDHGVSClassification
4684972NM_153631.3(HOXA3):c.562C>T (p.Gln188Ter)Likely pathogenic

SpliceAI

1341 predictions. Top by Δscore:

VariantEffectΔscore
7:27108716:TTCGC:Tacceptor_gain1.0000
7:27108717:TCGC:Tacceptor_gain1.0000
7:27108718:CGC:Cacceptor_gain1.0000
7:27108718:CGCC:Cacceptor_gain1.0000
7:27108719:GC:Gacceptor_gain1.0000
7:27108719:GCC:Gacceptor_loss1.0000
7:27108720:CC:Cacceptor_gain1.0000
7:27108720:CCT:Cacceptor_loss1.0000
7:27108721:C:Aacceptor_loss1.0000
7:27108721:C:CCacceptor_gain1.0000
7:27108722:T:Aacceptor_loss1.0000
7:27108724:C:CTacceptor_gain1.0000
7:27108730:C:CTacceptor_gain1.0000
7:27108731:A:Tacceptor_gain1.0000
7:27130113:CGTA:Cdonor_loss1.0000
7:27130114:GTACC:Gdonor_loss1.0000
7:27130116:A:ACdonor_gain1.0000
7:27130117:C:CAdonor_gain1.0000
7:27130117:CCG:Cdonor_gain1.0000
7:27130117:CCGG:Cdonor_gain1.0000
7:27142082:TTGT:Tacceptor_gain1.0000
7:27142083:TGT:Tacceptor_gain1.0000
7:27142083:TGTCT:Tacceptor_loss1.0000
7:27142084:GTC:Gacceptor_loss1.0000
7:27142086:C:Aacceptor_loss1.0000
7:27142086:C:CCacceptor_gain1.0000
7:27145925:C:CTacceptor_gain1.0000
7:27147303:CTTA:Cdonor_loss1.0000
7:27147305:TACC:Tdonor_loss1.0000
7:27147306:A:ACdonor_gain1.0000

AlphaMissense

2853 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
7:27108503:C:AK248N1.000
7:27108503:C:GK248N1.000
7:27108505:T:CK248E1.000
7:27108506:T:AK247N1.000
7:27108506:T:GK247N1.000
7:27108507:T:AK247I1.000
7:27108508:T:CK247E1.000
7:27108512:C:AK245N1.000
7:27108512:C:GK245N1.000
7:27108513:T:AK245M1.000
7:27108514:T:CK245E1.000
7:27108514:T:GK245Q1.000
7:27108515:C:AM244I1.000
7:27108515:C:GM244I1.000
7:27108515:C:TM244I1.000
7:27108516:A:CM244R1.000
7:27108516:A:GM244T1.000
7:27108516:A:TM244K1.000
7:27108519:C:GR243P1.000
7:27108519:C:TR243H1.000
7:27108520:G:AR243C1.000
7:27108520:G:CR243G1.000
7:27108520:G:TR243S1.000
7:27108522:C:AR242L1.000
7:27108522:C:GR242P1.000
7:27108523:G:AR242C1.000
7:27108523:G:CR242G1.000
7:27108523:G:TR242S1.000
7:27108524:A:CN241K1.000
7:27108524:A:TN241K1.000

dbSNP variants (sampled 300 via entrez): RS1000045615 (7:27113619 G>C), RS1000079925 (7:27150131 G>C), RS1000231152 (7:27116735 C>G,T), RS1000241812 (7:27147143 C>G), RS1000312377 (7:27145740 C>A,T), RS1000349087 (7:27114969 A>T), RS1000370752 (7:27109679 T>C), RS1000381898 (7:27114478 C>G), RS1000446074 (7:27152626 A>G), RS1000474917 (7:27152416 C>A,G), RS1000494721 (7:27139340 C>CA), RS1000539675 (7:27134108 T>A), RS1000568883 (7:27108840 A>G), RS1000644918 (7:27115274 T>A), RS1000812872 (7:27151040 G>A)

Disease associations

OMIM: gene MIM:142954 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

23 associations (top):

StudyTraitp-value
GCST004279_39Systolic blood pressure9.000000e-24
GCST004343_3Chronic venous disease3.000000e-07
GCST004625_95Monocyte count1.000000e-12
GCST006227_6Diastolic blood pressure1.000000e-08
GCST006228_6Systolic blood pressure3.000000e-08
GCST006229_1Hypertension2.000000e-09
GCST006231_31Mean arterial pressure5.000000e-08
GCST007703_97Systolic blood pressure2.000000e-06
GCST007705_13Pulse pressure6.000000e-06
GCST007707_55Hypertension5.000000e-06
GCST90002388_22Lymphocyte count4.000000e-17
GCST90002393_540Monocyte count6.000000e-15
GCST90002407_545White blood cell count5.000000e-09
GCST90020024_89A body shape index1.000000e-12
GCST90020024_91A body shape index4.000000e-10
GCST90020025_736Waist-to-hip ratio adjusted for BMI4.000000e-08
GCST90020025_737Waist-to-hip ratio adjusted for BMI5.000000e-14
GCST90020025_739Waist-to-hip ratio adjusted for BMI2.000000e-10
GCST90020027_1338Waist-hip index2.000000e-08
GCST90020027_1339Waist-hip index7.000000e-15
GCST90020027_1341Waist-hip index5.000000e-11
GCST90020029_860Waist circumference adjusted for body mass index4.000000e-12
GCST90020029_861Waist circumference adjusted for body mass index9.000000e-09

EFO canonical traits (8, from GWAS)

EFO IDTrait name
EFO:0006335systolic blood pressure
EFO:0005091monocyte count
EFO:0006336diastolic blood pressure
EFO:0006340mean arterial pressure
EFO:0005763pulse pressure measurement
EFO:0004587lymphocyte count
EFO:0007789BMI-adjusted waist circumference
EFO:0007788BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
bisphenol Aincreases expression, increases methylation, affects cotreatment, affects methylation3
Benzo(a)pyreneaffects methylation, decreases expression, increases methylation3
Tretinoinaffects cotreatment, increases expression3
S-(1,2-dichlorovinyl)cysteinedecreases expression, affects response to substance, increases expression2
Nickeldecreases expression2
Valproic Acidaffects expression, increases expression2
Cyclosporinedecreases expression2
lasiocarpinedecreases expression1
lead acetateincreases expression1
tris(1,3-dichloro-2-propyl)phosphatedecreases expression1
butyraldehydedecreases expression1
ferrous chloridedecreases expression1
nickel sulfateincreases expression1
NCS 382decreases expression1
azoxystrobindecreases expression1
CGP 52608increases reaction, affects binding1
cyproconazoledecreases expression1
Resveratroldecreases expression, affects cotreatment1
Arsenic Trioxidedecreases expression1
Fulvestrantaffects cotreatment, affects methylation1
Leflunomidedecreases expression1
Acetaminophendecreases expression1
Diethylhexyl Phthalatedecreases expression1
Golddecreases expression1
Lipopolysaccharidesdecreases expression, affects response to substance, increases expression1
Plant Extractsaffects cotreatment, decreases expression1
Quercetindecreases expression1
Smokedecreases expression1
Thiramdecreases expression1
Tobacco Smoke Pollutiondecreases expression1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_A2X0SEES3-1V human HOXA3, clone1Embryonic stem cellMale
CVCL_A2X1SEES3-1V human HOXA3, clone2Embryonic stem cellMale
CVCL_A2X2SEES3-1V human HOXA3, clone3Embryonic stem cellMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

  • Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): chronic venous insufficiency

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot