HOXB-AS1

Summary

HOXB-AS1 (HOXB cluster antisense RNA 1, HGNC:43744) is a long non-coding RNA gene on chromosome 17q21.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43744
Approved symbol	HOXB-AS1
Name	HOXB cluster antisense RNA 1
Location	17q21.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230148
Ensembl biotype	lncRNA
OMIM	618066
Entrez	100874362
RNAcentral	URS000075DCF5 — lncRNA, 797 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 29 lncRNA

ENST00000435312, ENST00000502764, ENST00000504972, ENST00000508688, ENST00000717337, ENST00000717338, ENST00000717407, ENST00000717408, ENST00000717409, ENST00000717410, ENST00000717411, ENST00000717412, ENST00000717413, ENST00000717414, ENST00000717415, ENST00000717416, ENST00000717418, ENST00000717419, ENST00000717420, ENST00000717421, ENST00000717422, ENST00000717423, ENST00000717424, ENST00000717430, ENST00000717431, ENST00000717432, ENST00000717433, ENST00000717434, ENST00000717435

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000435312 — 7 exons

Exon	Start	End
ENSE00001649261	48551024	48551250
ENSE00001654224	48544319	48544412
ENSE00001680659	48550340	48550402
ENSE00001721990	48548375	48548463
ENSE00001793998	48545495	48545564
ENSE00003593773	48549889	48549946
ENSE00004032501	48545121	48545357

Expression profiles

Bgee: expression breadth ubiquitous, 193 present calls, max score 89.49.

FANTOM5 (CAGE): breadth broad, TPM avg 4.4215 / max 202.3155, expressed in 831 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
161434	3.8237	733
161433	0.2841	133
161431	0.1769	90
161432	0.1368	68

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
omental fat pad	UBERON:0010414	89.49	gold quality
peritoneum	UBERON:0002358	89.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	89.20	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.56	gold quality
adipose tissue of abdominal region	UBERON:0007808	88.51	gold quality
lower esophagus muscularis layer	UBERON:0035833	87.39	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	87.35	gold quality
lower esophagus	UBERON:0013473	87.32	gold quality
spinal cord	UBERON:0002240	86.82	gold quality
left coronary artery	UBERON:0001626	85.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	84.84	gold quality
right coronary artery	UBERON:0001625	84.83	gold quality
mucosa of stomach	UBERON:0001199	84.55	gold quality
adipose tissue	UBERON:0001013	84.53	gold quality
pancreatic ductal cell	CL:0002079	84.37	silver quality
coronary artery	UBERON:0001621	83.99	gold quality
right testis	UBERON:0004534	83.72	gold quality
left testis	UBERON:0004533	83.50	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.28	gold quality
mucosa of paranasal sinus	UBERON:0005030	83.21	gold quality
descending thoracic aorta	UBERON:0002345	83.05	gold quality
endocervix	UBERON:0000458	82.85	gold quality
tibial nerve	UBERON:0001323	82.83	gold quality
gall bladder	UBERON:0002110	82.41	gold quality
oviduct epithelium	UBERON:0004804	82.41	gold quality
left uterine tube	UBERON:0001303	82.26	gold quality
muscle layer of sigmoid colon	UBERON:0035805	82.19	gold quality
metanephros cortex	UBERON:0010533	82.12	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.98	gold quality
left adrenal gland cortex	UBERON:0035825	81.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.74

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA HOXB-AS1 promotes cell growth in multiple myeloma via FUT4 mRNA stability by ELAVL1. (PMID:31886581)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.