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HOXB3

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Summary

HOXB3 (homeobox B3, HGNC:5114) is a protein-coding gene on chromosome 17q21.32, encoding Homeobox protein Hox-B3 (P14651). Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).

Source: NCBI Gene 3213 — RefSeq curated summary.

At a glance

  • GWAS associations: 6
  • Clinical variants (ClinVar): 69 total — 1 likely-pathogenic
  • MANE Select transcript: NM_001384749

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:5114
Approved symbolHOXB3
Namehomeobox B3
Location17q21.32
Locus typegene with protein product
StatusApproved
Ensembl geneENSG00000120093
Ensembl biotypeprotein_coding
OMIM142966
Entrez3213

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 15 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000311626, ENST00000460160, ENST00000464266, ENST00000465120, ENST00000470495, ENST00000471459, ENST00000472863, ENST00000476342, ENST00000478644, ENST00000489475, ENST00000490677, ENST00000498678, ENST00000552000, ENST00000866120, ENST00000866121, ENST00000969628, ENST00000969629, ENST00000969630

RefSeq mRNA: 6 — MANE Select: NM_001384749 NM_001330322, NM_001330323, NM_001384747, NM_001384749, NM_001384750, NM_002146

CCDS: CCDS11528, CCDS82153, CCDS82154

Canonical transcript exons

ENST00000498678 — 5 exons

ExonStartEnd
ENSE000013080784855202748552632
ENSE000013138254854887048551181
ENSE000018765374859012548590241
ENSE000034634984855553148555618
ENSE000034723764857383748574014

Expression profiles

Bgee: expression breadth ubiquitous, 227 present calls, max score 98.71.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0916 / max 116.2189, expressed in 500 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter IDTPM avgSamples expressed
1666821.1012241
1666830.4094162
1666800.3893254
1666810.1917103

Top tissues by expression

271 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
right uterine tubeUBERON:000130298.71gold quality
corpus epididymisUBERON:000435998.33gold quality
caput epididymisUBERON:000435897.76gold quality
seminal vesicleUBERON:000099897.27gold quality
mucosa of stomachUBERON:000119997.13gold quality
metanephros cortexUBERON:001053395.76gold quality
muscle layer of sigmoid colonUBERON:003580594.87gold quality
cauda epididymisUBERON:000436094.29gold quality
esophagogastric junction muscularis propriaUBERON:003584194.07gold quality
sigmoid colonUBERON:000115993.37gold quality
lower esophagus muscularis layerUBERON:003583393.30gold quality
lower esophagusUBERON:001347393.27gold quality
diaphragmUBERON:000110392.32silver quality
transverse colonUBERON:000115792.10gold quality
small intestine Peyer’s patchUBERON:000345491.89gold quality
type B pancreatic cellCL:000016991.80silver quality
endometriumUBERON:000129591.60gold quality
colonUBERON:000115591.16gold quality
rectumUBERON:000105290.96gold quality
large intestineUBERON:000005990.76gold quality
fallopian tubeUBERON:000388990.59gold quality
olfactory bulbUBERON:000226490.58silver quality
renal medullaUBERON:000036290.37gold quality
intestineUBERON:000016090.36gold quality
left uterine tubeUBERON:000130389.88gold quality
vena cavaUBERON:000408789.78gold quality
small intestineUBERON:000210889.50gold quality
omental fat padUBERON:001041489.48gold quality
peritoneumUBERON:000235889.47gold quality
oviduct epitheliumUBERON:000480489.38gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

ExperimentMarker?Max mean expression
E-CURD-119yes22.82
E-HCAD-10yes17.71
E-ANND-3yes7.21
E-CURD-135no892.18

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

9 targets.

TargetRegulation
CDCA3Unknown
DNMT3B
FOXA2Unknown
HOXB1
HOXB2
NKX2-1Activation
OTX2Activation
TG
TTF1

JASPAR motifs

MotifNameFamily
MA0903.1HOXB3HOX
MA0903.2HOXB3HOX

JASPAR matrix evidence (PMIDs): PMID:18585359

Upstream regulators (CollecTRI, top): ARID4B, EGR2, ETS1, FOXA2, HOXB2, MAFB

Literature-anchored findings (GeneRIF, showing 19)

  • Data report novel nucleoporin 98 fusions with homeobox (HOX)A10, HOXB3 and HOXB4, and describe the results of coexpression of these proteins with the Hox cofactor Meis1 in leukemic induction. (PMID:14966272)
  • The HOXb3 was only weakly expressed in the inv(7) positive patients. (PMID:15674412)
  • HOXA7, HOXB3, HOXA3, and HOXB13 expression levels changed during angiogenesis, sugessting these proteins might be involved in the angiogenesis of hMSCs. (PMID:17972163)
  • Data show that inducible Hox genes are selectively sensitive to the inhibition of actin polymerization and that actin polymerization is required for the assembly of a transcription complex on the regulatory region of the Hox genes. (PMID:19477923)
  • RASSF1A silencing strongly correlates with overexpression of HOXB3 and DNMT3B. (PMID:19854132)
  • HoxB3 promote prostate cancer progression by upregulating CDCA3 expression. (PMID:23219899)
  • describe familial cases of TH in two generations (proband and his father), in addition to other two sporadic cases. We have found polymorphisms in the HOXB3, HOXD3, and a new synonymous variant, and PITX2 genes (PMID:24127533)
  • decreased methylation at HOXB3 and HOXB4 was associated with increased gene expression of both HOXB genes specific to the mid-risk AML, while increased DNA methylation at DCC distinctive to the high-risk AML was associated with increased gene expression (PMID:25996682)
  • HOXB2 and HOXB3 act as tumor suppressors in acute myeloid leukemia patients carrying the FLT3 protein mutations. (PMID:26482852)
  • miR-10b might control cell apoptosis, proliferation, migration, and invasion in endometrial cancer via regulation of HOXB3 expression. (PMID:27447302)
  • HOXB3 is degraded by miR-375 in breast cancer cells.HOXB3 plays role in tamoxifen resistance. (PMID:28075453)
  • HOXA4/HOXB3 gene expression-based risk score may be useful for prognostic risk stratification and warrants prospective validation in HGSOC patients. (PMID:29402501)
  • Data indicate a miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry which contributes to leukemogenesis and suggest a therapeutic strategy of restoring miR-375 expression in Acute myeloid leukemia (AML). (PMID:29439669)
  • miR-7 Reduces High Glucose Induced-damage Via HoxB3 and PI3K/AKT/mTOR Signaling Pathways in Retinal Pigment Epithelial Cells. (PMID:31702491)
  • Levels of serum Hoxb3 and sFlt-1 in pre-eclamptic patients and their effects on pregnancy outcomes. (PMID:32748508)
  • CSF levels of HoxB3 and YKL-40 may predict conversion from clinically isolated syndrome to relapsing remitting multiple sclerosis. (PMID:33352356)
  • Extracellular Vesicle-Encapsulated MicroRNA-375 from Bone Marrow-Derived Mesenchymal Stem Cells Inhibits Hepatocellular Carcinoma Progression through Regulating HOXB3-Mediated Wnt/beta-Catenin Pathway. (PMID:35127344)
  • HOXB3 drives WNT-activation associated progression in castration-resistant prostate cancer. (PMID:36973255)
  • Sequential gene expression analysis of myelodysplastic syndrome transformation identifies HOXB3 and HOXB7 as the novel targets for mesenchymal cells in disease. (PMID:38254070)

Cross-species orthologs

3 orthologs

OrganismSymbolGene ID
danio_reriohoxb3aENSDARG00000029263
mus_musculusHoxb3ENSMUSG00000048763
rattus_norvegicusHoxb3ENSRNOG00000008313

Paralogs (42): HOXA11 (ENSG00000005073), HOXC8 (ENSG00000037965), HOXA1 (ENSG00000105991), HOXA2 (ENSG00000105996), HOXA3 (ENSG00000105997), HOXA5 (ENSG00000106004), HOXA6 (ENSG00000106006), HOXA13 (ENSG00000106031), TLX1 (ENSG00000107807), HOXB6 (ENSG00000108511), TLX2 (ENSG00000115297), HOXB8 (ENSG00000120068), HOXB5 (ENSG00000120075), HOXB1 (ENSG00000120094), HOXA7 (ENSG00000122592), HOXC13 (ENSG00000123364), HOXC11 (ENSG00000123388), HOXC12 (ENSG00000123407), HOXD1 (ENSG00000128645), HOXD3 (ENSG00000128652), HOXD9 (ENSG00000128709), HOXD10 (ENSG00000128710), HOXD11 (ENSG00000128713), HOXD13 (ENSG00000128714), PDX1 (ENSG00000139515), HOXB13 (ENSG00000159184), TLX3 (ENSG00000164438), HOXD4 (ENSG00000170166), HOXD12 (ENSG00000170178), HOXB9 (ENSG00000170689), HOXC5 (ENSG00000172789), HOXB2 (ENSG00000173917), HOXD8 (ENSG00000175879), GSX2 (ENSG00000180613), HOXC9 (ENSG00000180806), HOXC10 (ENSG00000180818), HOXB4 (ENSG00000182742), HOXA4 (ENSG00000197576), HOXC6 (ENSG00000197757), HOXC4 (ENSG00000198353)

Protein

Protein identifiers

Homeobox protein Hox-B3 — P14651 (reviewed: P14651)

Alternative names: Homeobox protein Hox-2.7, Homeobox protein Hox-2G

All UniProt accessions (4): C9J2I3, P14651, F8VXG0, F8W1L2

UniProt curated annotations — full annotation on UniProt →

Function. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location. Nucleus.

Similarity. Belongs to the Antp homeobox family.

Isoforms (3)

UniProt IDNamesCanonical?
P14651-11yes
P14651-22
P14651-33

RefSeq proteins (6): NP_001317251, NP_001317252, NP_001371676, NP_001371678, NP_001371679, NP_002137 (=MANE)

Domains & families (InterPro)

IDNameType
IPR001356HDDomain
IPR001827Homeobox_Antennapedia_CSConserved_site
IPR009057Homeodomain-like_sfHomologous_superfamily
IPR017970Homeobox_CSConserved_site
IPR020479HD_metazoaDomain
IPR025281DUF4074Domain

Pfam: PF00046, PF13293

UniProt features (17 total): compositionally biased region 5, region of interest 4, splice variant 2, sequence conflict 2, chain 1, DNA-binding region 1, sequence variant 1, short sequence motif 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-P14651-F158.350.15

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis

MSigDB gene sets: 265 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, VALK_AML_WITH_FLT3_ITD, GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_UP, GOBP_HINDBRAIN_DEVELOPMENT, GOBP_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, MULLIGHAN_NPM1_SIGNATURE_3_UP, YAATNRNNNYNATT_UNKNOWN, BENPORATH_ES_WITH_H3K27ME3, HNF3ALPHA_Q6, GOBP_CARTILAGE_DEVELOPMENT, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, RORA1_01, TGCACTT_MIR519C_MIR519B_MIR519A, GOBP_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT

GO Biological Process (15): negative regulation of transcription by RNA polymerase II (GO:0000122), angiogenesis (GO:0001525), hematopoietic progenitor cell differentiation (GO:0002244), regulation of transcription by RNA polymerase II (GO:0006357), anterior/posterior pattern specification (GO:0009952), rhombomere development (GO:0021546), glossopharyngeal nerve morphogenesis (GO:0021615), thyroid gland development (GO:0030878), positive regulation of transcription by RNA polymerase II (GO:0045944), embryonic skeletal system morphogenesis (GO:0048704), regulation of neurogenesis (GO:0050767), cartilage development (GO:0051216), definitive hemopoiesis (GO:0060216), face development (GO:0060324), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (5): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700)

GO Cellular Component (3): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
Activation of HOX genes during differentiation1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
regulation of transcription by RNA polymerase II3
transcription by RNA polymerase II3
RNA polymerase II transcription regulatory region sequence-specific DNA binding3
hemopoiesis2
regulation of DNA-templated transcription2
anatomical structure development2
cellular anatomical structure2
negative regulation of DNA-templated transcription1
blood vessel morphogenesis1
anatomical structure formation involved in morphogenesis1
cell differentiation1
regionalization1
hindbrain development1
glossopharyngeal nerve development1
cranial nerve morphogenesis1
endocrine system development1
gland development1
positive regulation of DNA-templated transcription1
embryonic organ morphogenesis1
skeletal system morphogenesis1
embryonic skeletal system development1
neurogenesis1
regulation of nervous system development1
regulation of cell development1
skeletal system development1
animal organ development1
connective tissue development1
head development1
DNA-templated transcription1
regulation of gene expression1
regulation of RNA biosynthetic process1
cis-regulatory region sequence-specific DNA binding1
chromatin1
DNA-binding transcription factor activity1
DNA-binding transcription factor activity, RNA polymerase II-specific1
DNA-binding transcription activator activity1
positive regulation of transcription by RNA polymerase II1
nucleic acid binding1
transcription cis-regulatory region binding1
transcription regulator activity1

Protein interactions and networks

STRING

938 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
HOXB3MEIS1O00470776
HOXB3PBX1P40424629
HOXB3MEIS2O14770604
HOXB3EZH1Q92800603
HOXB3RASSF1Q9NS23547
HOXB3HOXB9P17482535
HOXB3DNMT3BQ9UBC3505
HOXB3FOXF1Q12946504
HOXB3MOAP1Q96BY2497
HOXB3PAX1P15863485
HOXB3YAP1P46937482
HOXB3FOXA2Q9Y261477
HOXB3RARBP10826460
HOXB3NKX2-2O95096459
HOXB3FOSP01100435

IntAct

3 interactions, top by confidence:

ABTypeScore
HOXB3SDHApsi-mi:“MI:0915”(physical association)0.400
HOXB3PTX3psi-mi:“MI:0914”(association)0.350

BioGRID (10): SDHA (Proximity Label-MS), HOXB3 (Reconstituted Complex), FBLN5 (Affinity Capture-MS), DPP9 (Affinity Capture-MS), MIPEP (Affinity Capture-MS), PTX3 (Affinity Capture-MS), HOXB3 (Cross-Linking-MS (XL-MS)), HOXB3 (Cross-Linking-MS (XL-MS)), SDHA (Cross-Linking-MS (XL-MS)), HOXB3 (Reconstituted Complex)

ESM2 similar proteins: A1L2P5, A8DT10, O08656, O42368, O42370, O93353, P09014, P09022, P09026, P09027, P09089, P13545, P14651, P23682, P31249, P40657, P46692, P49639, P50574, P53773, P53774, P53775, P56178, Q1KKS7, Q1KKU6, Q1KKX7, Q1KL12, Q1KL13, Q1KL17, Q24248, Q24648, Q3V5Z9, Q4LDQ3, Q5NDM2, Q66IK1, Q6B3N0, Q6DCQ1, Q8AWZ2, Q91904, Q98877

Diamond homologs: A1L2P5, A1YER7, A1YF08, A1YFD8, A1YFY3, A1YG85, A2D4P8, A2D5I1, A2D5K9, A2D5Y4, A2T6X6, A2T756, A8DT10, A9L937, B0VXK3, O13074, O42365, O42367, O42368, O42370, O43364, O43365, O57374, O93353, P02830, P02831, P06798, P09013, P09014, P09016, P09019, P09020, P09021, P09026, P09027, P09067, P09070, P09074, P09079, P09080

SIGNOR signaling

2 interactions.

AEffectBMechanism
HOXB3“up-regulates quantity by expression”OTX2“transcriptional regulation”
HMGB1“up-regulates activity”HOXB3binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

69 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic1
Uncertain significance66
Likely benign0
Benign0

Top pathogenic / likely-pathogenic (1)

Variant IDHGVSClassification
444852GRCh37/hg19 17q21.32-22(chr17:46481089-51396368)x1Likely pathogenic

SpliceAI

3037 predictions. Top by Δscore:

VariantEffectΔscore
17:48551710:A:ACdonor_gain1.0000
17:48551711:A:Cdonor_gain1.0000
17:48576783:C:CTdonor_gain1.0000
17:48576832:T:TAdonor_gain1.0000
17:48577017:TTTA:Tacceptor_gain1.0000
17:48577018:TTA:Tacceptor_gain1.0000
17:48577019:TA:Tacceptor_gain1.0000
17:48577020:AC:Aacceptor_loss1.0000
17:48577021:C:CAacceptor_loss1.0000
17:48577021:C:CCacceptor_gain1.0000
17:48577022:T:Aacceptor_loss1.0000
17:48577026:C:CTacceptor_gain1.0000
17:48577028:C:CTacceptor_gain1.0000
17:48577030:C:CTacceptor_gain1.0000
17:48577032:C:CTacceptor_gain1.0000
17:48577033:G:Tacceptor_gain1.0000
17:48590123:A:ACdonor_gain1.0000
17:48590123:ACTG:Adonor_gain1.0000
17:48590124:C:CAdonor_gain1.0000
17:48590124:CT:Cdonor_gain1.0000
17:48590124:CTG:Cdonor_gain1.0000
17:48590124:CTGC:Cdonor_gain1.0000
17:48590124:CTGCG:Cdonor_gain1.0000
17:48592452:CATAT:Cacceptor_gain1.0000
17:48592453:ATAT:Aacceptor_gain1.0000
17:48592454:TAT:Tacceptor_gain1.0000
17:48592455:AT:Aacceptor_gain1.0000
17:48592456:TCTGG:Tacceptor_loss1.0000
17:48592457:C:CAacceptor_loss1.0000
17:48592457:C:CCacceptor_gain1.0000

AlphaMissense

2787 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
17:48550895:C:AK245N1.000
17:48550895:C:GK245N1.000
17:48550897:T:CK245E1.000
17:48550898:C:AK244N1.000
17:48550898:C:GK244N1.000
17:48550899:T:AK244M1.000
17:48550900:T:CK244E1.000
17:48550904:C:AK242N1.000
17:48550904:C:GK242N1.000
17:48550905:T:AK242M1.000
17:48550906:T:CK242E1.000
17:48550906:T:GK242Q1.000
17:48550907:C:AM241I1.000
17:48550907:C:GM241I1.000
17:48550907:C:TM241I1.000
17:48550908:A:CM241R1.000
17:48550908:A:GM241T1.000
17:48550908:A:TM241K1.000
17:48550911:C:GR240P1.000
17:48550911:C:TR240H1.000
17:48550912:G:AR240C1.000
17:48550912:G:CR240G1.000
17:48550912:G:TR240S1.000
17:48550914:C:AR239L1.000
17:48550914:C:GR239P1.000
17:48550915:G:AR239W1.000
17:48550915:G:CR239G1.000
17:48550916:G:CN238K1.000
17:48550916:G:TN238K1.000
17:48550917:T:AN238I1.000

dbSNP variants (sampled 300 via entrez): RS1000181354 (17:48575888 C>G), RS1000232979 (17:48580132 G>A), RS1000305549 (17:48574737 C>T), RS1000356113 (17:48552680 C>A,G), RS1000589283 (17:48558769 T>C,G), RS1000660499 (17:48557105 G>A,C), RS1000687660 (17:48590733 G>A), RS1000714454 (17:48586602 T>C), RS1000767432 (17:48551901 T>C), RS1000829001 (17:48591226 C>A,G), RS1000832381 (17:48581814 C>T), RS1000889261 (17:48588153 T>C), RS1000894890 (17:48553030 T>C), RS1000915444 (17:48557703 G>A), RS1000940087 (17:48559107 T>C)

Disease associations

OMIM: gene MIM:142966 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

StudyTraitp-value
GCST005235_14Hand grip strength4.000000e-12
GCST005951_17Body mass index3.000000e-09
GCST009685_24Hypertension2.000000e-09
GCST010989_271Body size at age 108.000000e-11
GCST90002384_417Hemoglobin2.000000e-14
GCST90013442_30Keratoconus5.000000e-09

EFO canonical traits (4, from GWAS)

EFO IDTrait name
EFO:0006941grip strength measurement
EFO:0004340body mass index
EFO:0009819comparative body size at age 10, self-reported
EFO:0004509hemoglobin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
bisphenol Adecreases expression, increases expression, affects cotreatment3
Tretinoinaffects cotreatment, increases expression, affects expression3
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, increases expression2
Chir 99021affects cotreatment, increases expression, affects binding2
Estradiolaffects cotreatment, increases expression, decreases expression2
Nickeldecreases expression2
aristolochic acid Iincreases expression1
bisphenol Faffects cotreatment, decreases methylation1
triphenyl phosphateaffects expression1
ascorbate-2-phosphateaffects binding, affects cotreatment, increases expression1
sodium arseniteaffects methylation1
butyraldehydedecreases expression1
perfluorooctanoic aciddecreases expression1
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acidaffects cotreatment, increases expression1
pentanaldecreases expression1
di-n-butylphosphoric acidaffects expression1
3-nitrobenzanthroneincreases expression1
K 7174decreases expression1
ICG 001decreases expression1
14-deoxy-11,12-didehydroandrographolideincreases expression1
XAV939affects binding, affects cotreatment, increases expression1
LDN 193189affects cotreatment, increases expression1
3-(4-pyridyl)-1H-indoleaffects cotreatment, increases expression1
EPZ004777decreases expression1
Resveratrolaffects cotreatment, decreases expression1
Temozolomideincreases expression1
Fulvestrantaffects cotreatment, decreases methylation1
Arsenicaffects methylation1
Ascorbic Acidaffects binding, affects cotreatment, increases expression1
Benzo(a)pyreneaffects methylation1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_A2Y4SEES3-1V human HOXB3, clone1Embryonic stem cellMale
CVCL_A2Y5SEES3-1V human HOXB3, clone2Embryonic stem cellMale
CVCL_A2Y6SEES3-1V human HOXB3, clone3Embryonic stem cellMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot