HOXB6

Summary

HOXB6 (homeobox B6, HGNC:5117) is a protein-coding gene on chromosome 17q21.32, encoding Homeobox protein Hox-B6 (P17509). Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.

Source: NCBI Gene 3216 — RefSeq curated summary.

At a glance

• Gene–disease (curated): hypospadias (Limited, GenCC)
• GWAS associations: 2
• Clinical variants (ClinVar): 3 total
• MANE Select transcript: NM_018952

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5117
Approved symbol	HOXB6
Name	homeobox B6
Location	17q21.32
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000108511
Ensembl biotype	protein_coding
OMIM	142961
Entrez	3216

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 8 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000225648, ENST00000470193, ENST00000484302, ENST00000490419, ENST00000880387, ENST00000880388, ENST00000880389, ENST00000880390, ENST00000952645, ENST00000952646

RefSeq mRNA: 2 — MANE Select: NM_018952 NM_001369397, NM_018952

CCDS: CCDS11531

Canonical transcript exons

ENST00000225648 — 4 exons

Exon	Start	End
ENSE00000735996	48597736	48598228
ENSE00001043800	48604862	48604986
ENSE00001241471	48604480	48604615
ENSE00002352501	48595751	48596672

Expression profiles

Bgee: expression breadth ubiquitous, 170 present calls, max score 97.21.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.7789 / max 296.0139, expressed in 1007 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
166707	3.7131	709
166699	1.7411	612
166702	1.4984	393
166700	0.8065	219
166703	0.3311	171
166701	0.2692	109
166698	0.2047	97
166704	0.1305	55
166708	0.0843	31

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus epididymis	UBERON:0004359	97.21	gold quality
seminal vesicle	UBERON:0000998	95.75	gold quality
metanephros cortex	UBERON:0010533	95.32	gold quality
caput epididymis	UBERON:0004358	95.13	gold quality
right uterine tube	UBERON:0001302	90.59	gold quality
transverse colon	UBERON:0001157	89.46	gold quality
mucosa of transverse colon	UBERON:0004991	88.94	gold quality
cauda epididymis	UBERON:0004360	87.84	gold quality
adult mammalian kidney	UBERON:0000082	87.78	gold quality
renal medulla	UBERON:0000362	87.31	gold quality
endometrium	UBERON:0001295	87.19	gold quality
small intestine Peyer’s patch	UBERON:0003454	87.19	gold quality
rectum	UBERON:0001052	86.42	gold quality
kidney	UBERON:0002113	84.96	gold quality
colon	UBERON:0001155	84.09	gold quality
large intestine	UBERON:0000059	83.73	gold quality
muscle layer of sigmoid colon	UBERON:0035805	83.59	gold quality
intestine	UBERON:0000160	83.14	gold quality
small intestine	UBERON:0002108	82.57	gold quality
sigmoid colon	UBERON:0001159	82.32	gold quality
metanephros	UBERON:0000081	81.80	gold quality
omental fat pad	UBERON:0010414	80.84	gold quality
ileal mucosa	UBERON:0000331	80.81	gold quality
peritoneum	UBERON:0002358	80.79	gold quality
cortex of kidney	UBERON:0001225	80.63	gold quality
adipose tissue of abdominal region	UBERON:0007808	80.61	gold quality
mucosa of stomach	UBERON:0001199	80.40	gold quality
right adrenal gland	UBERON:0001233	79.95	gold quality
left adrenal gland cortex	UBERON:0035825	79.32	gold quality
endocervix	UBERON:0000458	79.25	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-10	yes	45.01
E-MTAB-6701	yes	16.38
E-ANND-3	yes	16.31

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

5 targets.

Target	Regulation
HBA1	Repression
HBG1	Repression
HOXB6
KDR
USF2

JASPAR motifs

Motif	Name	Family
MA1500.1	HOXB6	HOX
MA1500.2	HOXB6	HOX

JASPAR matrix evidence (PMIDs): PMID:18585359

Upstream regulators (CollecTRI, top): ARID4B, HOXB6

Literature-anchored findings (GeneRIF, showing 6)

• the homeodomain contains most or all of the important structures required for HOXB6 activity in blood cells. (PMID:15269212)
• Data show that inducible Hox genes are selectively sensitive to the inhibition of actin polymerization and that actin polymerization is required for the assembly of a transcription complex on the regulatory region of the Hox genes. (PMID:19477923)
• HOXB5, HOXB6, and HOXB7 are activated in Barrett esophagus, and the midcluster HOXB gene signature in BE most resembled the colon rather than other GI epithelia. (PMID:22603795)
• HOXA5, HOXB6, and GLTP were direct target genes of MIR196B in CRC cells. (PMID:29532406)
• ST8SIA6-AS1 promotes hepatocellular carcinoma by absorbing miR-5195-3p to regulate HOXB6. (PMID:32420798)
• An epigenome-wide association study of Alzheimer’s disease blood highlights robust DNA hypermethylation in the HOXB6 gene. (PMID:32745807)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	hoxb6a	ENSDARG00000010630
mus_musculus	Hoxb6	ENSMUSG00000000690

Paralogs (42): HOXA11 (ENSG00000005073), HOXC8 (ENSG00000037965), HOXA1 (ENSG00000105991), HOXA2 (ENSG00000105996), HOXA3 (ENSG00000105997), HOXA5 (ENSG00000106004), HOXA6 (ENSG00000106006), HOXA13 (ENSG00000106031), TLX1 (ENSG00000107807), TLX2 (ENSG00000115297), HOXB8 (ENSG00000120068), HOXB5 (ENSG00000120075), HOXB3 (ENSG00000120093), HOXB1 (ENSG00000120094), HOXA7 (ENSG00000122592), HOXC13 (ENSG00000123364), HOXC11 (ENSG00000123388), HOXC12 (ENSG00000123407), HOXD1 (ENSG00000128645), HOXD3 (ENSG00000128652), HOXD9 (ENSG00000128709), HOXD10 (ENSG00000128710), HOXD11 (ENSG00000128713), HOXD13 (ENSG00000128714), PDX1 (ENSG00000139515), HOXB13 (ENSG00000159184), TLX3 (ENSG00000164438), HOXD4 (ENSG00000170166), HOXD12 (ENSG00000170178), HOXB9 (ENSG00000170689), HOXC5 (ENSG00000172789), HOXB2 (ENSG00000173917), HOXD8 (ENSG00000175879), GSX2 (ENSG00000180613), HOXC9 (ENSG00000180806), HOXC10 (ENSG00000180818), HOXB4 (ENSG00000182742), HOXA4 (ENSG00000197576), HOXC6 (ENSG00000197757), HOXC4 (ENSG00000198353)

Protein

Protein identifiers

Homeobox protein Hox-B6 — P17509 (reviewed: P17509)

Alternative names: Homeobox protein Hox-2.2, Homeobox protein Hox-2B, Homeobox protein Hu-2

All UniProt accessions (1): P17509

UniProt curated annotations — full annotation on UniProt →

Function. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location. Nucleus.

Similarity. Belongs to the Antp homeobox family.

Isoforms (2)

UniProt ID	Names	Canonical?
P17509-1	1	yes
P17509-2	2, Homeobox-less

RefSeq proteins (2): NP_001356326, NP_061825* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001356	HD	Domain
IPR001827	Homeobox_Antennapedia_CS	Conserved_site
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017970	Homeobox_CS	Conserved_site
IPR017995	Homeobox_antennapedia	Family
IPR020479	HD_metazoa	Domain
IPR050296	Antp_homeobox	Family

Pfam: PF00046

UniProt features (11 total): sequence conflict 5, splice variant 2, chain 1, DNA-binding region 1, short sequence motif 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P17509-F1	66.67	0.30

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 214

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 232 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_DN, VALK_AML_WITH_FLT3_ITD, RRAGTTGT_UNKNOWN, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, MULLIGHAN_NPM1_SIGNATURE_3_UP, ACTACCT_MIR196A_MIR196B, BENPORATH_ES_WITH_H3K27ME3, GOBP_MYELOID_CELL_HOMEOSTASIS, PAX4_01, KANG_FLUOROURACIL_RESISTANCE_UP, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, NKX25_02, GOBP_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT, TTTGTAG_MIR520D, SP3_Q3

GO Biological Process (6): regulation of transcription by RNA polymerase II (GO:0006357), anterior/posterior pattern specification (GO:0009952), erythrocyte homeostasis (GO:0034101), embryonic skeletal system morphogenesis (GO:0048704), regulation of DNA-templated transcription (GO:0006355), embryonic skeletal system development (GO:0048706)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), RNA binding (GO:0003723), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), protein binding (GO:0005515)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of DNA-templated transcription	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
nucleic acid binding	2
transcription by RNA polymerase II	1
regionalization	1
myeloid cell homeostasis	1
embryonic organ morphogenesis	1
skeletal system morphogenesis	1
embryonic skeletal system development	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
skeletal system development	1
chordate embryonic development	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

45 interactions, top by confidence:

A	B	Type	Score
HOXB6	CLK3	psi-mi:“MI:0915”(physical association)	0.720
CLK3	HOXB6	psi-mi:“MI:0915”(physical association)	0.720
ANKRD17	HOXB6	psi-mi:“MI:0914”(association)	0.640
HOXB6	SRPK2	psi-mi:“MI:0915”(physical association)	0.560
HOXB6	TEKT5	psi-mi:“MI:0915”(physical association)	0.560
HOXB6	NTAQ1	psi-mi:“MI:0915”(physical association)	0.560
HOXB6	NEK6	psi-mi:“MI:0915”(physical association)	0.560
GYS1	HOXB6	psi-mi:“MI:0915”(physical association)	0.560
NAGK	ZBTB43	psi-mi:“MI:0914”(association)	0.530
HOXB6	ALX4	psi-mi:“MI:0915”(physical association)	0.370
HOXB6	TCF21	psi-mi:“MI:0915”(physical association)	0.370
HOXB6	TCEAL1	psi-mi:“MI:0915”(physical association)	0.370
HOXB6	SAT1	psi-mi:“MI:0915”(physical association)	0.370
PLSCR1	HOXB6	psi-mi:“MI:0915”(physical association)	0.370
HOXB6	KRT15	psi-mi:“MI:0915”(physical association)	0.370
SLC15A3		psi-mi:“MI:0914”(association)	0.350
AHCYL2	AHCYL1	psi-mi:“MI:0914”(association)	0.350
MAPK14	PRKY	psi-mi:“MI:0914”(association)	0.350
SDE2	HOXB6	psi-mi:“MI:0914”(association)	0.350
CANX	HLA-A	psi-mi:“MI:0914”(association)	0.350
DDOST	ATL3	psi-mi:“MI:0914”(association)	0.350
OST4	ATL3	psi-mi:“MI:0914”(association)	0.350
PSME3	C11orf98	psi-mi:“MI:0914”(association)	0.350
S100P	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
HOXB6	TRAPPC3	psi-mi:“MI:0914”(association)	0.350
TMED7	ATP9A	psi-mi:“MI:0914”(association)	0.350

BioGRID (66): HOXB6 (Two-hybrid), HOXB6 (Affinity Capture-MS), SAT1 (Two-hybrid), PLSCR1 (Two-hybrid), KRT15 (Two-hybrid), HOXB6 (Affinity Capture-MS), HOXB6 (Affinity Capture-MS), HOXB6 (Affinity Capture-MS), HOXB6 (Affinity Capture-RNA), HOXB6 (Affinity Capture-MS), HOXB6 (Affinity Capture-MS), HOXB6 (Two-hybrid), NEK6 (Two-hybrid), SRPK2 (Two-hybrid), TEKT5 (Two-hybrid)

ESM2 similar proteins: A1YER7, A1YF08, A1YFD8, A1YFY3, A1YG01, A1YG85, A2D4P8, A2D4R4, A2D5I1, A2D649, A2T6H5, A2T6X6, A2T6Z0, A2T748, A2T756, A2T7H5, A2T7J2, P06798, P09016, P09017, P09023, P09024, P10284, P10628, P13378, P14653, P17277, P17483, P17509, P18111, P18864, P23463, P23813, P31259, P31275, P31276, P31277, P31310, P47902, P50207

Diamond homologs: A1YER7, A1YFA5, A1YFD8, A1YFY3, A2D4P8, A2D5I1, A2D5K9, A2D5Y4, A2T6X6, A2T7F3, O13074, O42504, O57374, P02830, P02832, P02833, P04476, P06798, P07548, P09013, P09014, P09016, P09017, P09019, P09020, P09021, P09023, P09024, P09067, P09070, P09071, P09074, P09077, P09079, P09092, P09629, P09630, P10284, P10628, P10629

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
HOXB6	“down-regulates quantity by repression”	HBA1	“transcriptional regulation”
HOXB6	“down-regulates quantity by repression”	HBG1	“transcriptional regulation”
CSNK2B	unknown	HOXB6	phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

650 predictions. Top by Δscore:

Variant	Effect	Δscore
17:48597734:A:AC	donor_gain	1.0000
17:48597735:C:CC	donor_gain	1.0000
17:48596671:ACCTG:A	acceptor_loss	0.9900
17:48596673:CT:C	acceptor_loss	0.9900
17:48596674:T:G	acceptor_loss	0.9900
17:48597729:CACT:C	donor_loss	0.9900
17:48597730:A:AC	donor_gain	0.9900
17:48597731:C:CC	donor_gain	0.9900
17:48597731:CTCA:C	donor_gain	0.9900
17:48597732:TCACT:T	donor_loss	0.9900
17:48597735:CT:C	donor_gain	0.9900
17:48597735:CTG:C	donor_gain	0.9900
17:48596673:C:CC	acceptor_gain	0.9800
17:48597728:TCAC:T	donor_loss	0.9800
17:48597730:AC:A	donor_loss	0.9800
17:48597731:CT:C	donor_gain	0.9800
17:48597735:CTGT:C	donor_gain	0.9800
17:48596676:T:TC	acceptor_gain	0.9700
17:48596676:T:C	acceptor_gain	0.9600
17:48604475:CTTA:C	donor_loss	0.9600
17:48604476:TTA:T	donor_loss	0.9600
17:48604478:A:AG	donor_loss	0.9600
17:48604479:C:T	donor_loss	0.9600
17:48604907:TGAAG:T	donor_gain	0.9600
17:48596679:C:CT	acceptor_gain	0.9500
17:48597668:A:AC	donor_gain	0.9400
17:48597669:C:CC	donor_gain	0.9400
17:48597735:CTGTT:C	donor_gain	0.9400
17:48596652:C:CT	acceptor_gain	0.9300
17:48596661:C:CT	acceptor_gain	0.9300

AlphaMissense

1445 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:48596482:T:A	K202N	1.000
17:48596482:T:G	K202N	1.000
17:48596483:T:A	K202I	1.000
17:48596488:C:A	K200N	1.000
17:48596488:C:G	K200N	1.000
17:48596490:T:C	K200E	1.000
17:48596491:C:A	M199I	1.000
17:48596491:C:G	M199I	1.000
17:48596491:C:T	M199I	1.000
17:48596492:A:G	M199T	1.000
17:48596492:A:T	M199K	1.000
17:48596495:C:G	R198P	1.000
17:48596495:C:T	R198H	1.000
17:48596496:G:A	R198C	1.000
17:48596496:G:C	R198G	1.000
17:48596496:G:T	R198S	1.000
17:48596498:C:A	R197L	1.000
17:48596498:C:G	R197P	1.000
17:48596499:G:C	R197G	1.000
17:48596500:G:C	N196K	1.000
17:48596500:G:T	N196K	1.000
17:48596501:T:A	N196I	1.000
17:48596501:T:C	N196S	1.000
17:48596501:T:G	N196T	1.000
17:48596502:T:C	N196D	1.000
17:48596502:T:G	N196H	1.000
17:48596503:C:A	Q195H	1.000
17:48596503:C:G	Q195H	1.000
17:48596504:T:G	Q195P	1.000
17:48596505:G:T	Q195K	1.000

dbSNP variants (sampled 300 via entrez): RS1000181428 (17:48596132 G>A,T), RS1000324884 (17:48605943 T>C), RS1000424920 (17:48605746 C>T), RS1000584508 (17:48600883 C>T), RS1000888125 (17:48604151 G>A), RS1001599896 (17:48605062 C>A), RS1001697430 (17:48598516 G>A), RS1001790857 (17:48598738 G>A,C), RS1001858320 (17:48606582 C>T), RS1002004249 (17:48600794 T>C), RS1002035371 (17:48600486 G>A), RS1002208267 (17:48603350 T>A), RS1002522056 (17:48603927 C>G), RS1002595827 (17:48603667 G>A), RS1002756365 (17:48597546 T>G)

Disease associations

OMIM: gene MIM:142961 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
hypospadias	Limited	Autosomal dominant

Mondo (1): hypospadias (MONDO:0005345)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003177_5	Childhood body mass index	2.000000e-06
GCST90002384_417	Hemoglobin	2.000000e-14

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0004509	hemoglobin measurement

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D007021	Hypospadias	C12.050.351.875.466; C12.100.500.494.400; C12.200.294.494.400; C12.200.706.516; C12.800.516; C16.131.939.516

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Estradiol	affects cotreatment, increases expression, decreases expression	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
testosterone enanthate	affects expression	1
apocarotenal	increases expression	1
2,5,2’,5’-tetrachlorobiphenyl	decreases expression	1
beta-lapachone	decreases expression	1
arsenite	increases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	decreases expression	1
butyraldehyde	decreases expression	1
ferrous chloride	decreases expression	1
CGP 52608	affects binding, increases reaction	1
azaspiracid	increases expression	1
abrine	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Air Pollutants	affects methylation, increases abundance	1
Amiodarone	increases expression	1
Vehicle Emissions	increases abundance, affects methylation	1
Cytarabine	decreases expression	1
Hydrogen Peroxide	affects expression	1
Mercury	increases expression	1
Nitrogen Dioxide	affects methylation, increases abundance	1
Plant Extracts	affects cotreatment, decreases expression	1
Quercetin	decreases expression	1
Silicon Dioxide	decreases expression	1
Smoke	decreases expression	1
Tretinoin	increases expression	1
Triclosan	increases expression	1
Valproic Acid	affects expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A2Z0	SEES3-1V human HOXB6, clone1	Embryonic stem cell	Male
CVCL_A2Z1	SEES3-1V human HOXB6, clone2	Embryonic stem cell	Male
CVCL_A2Z2	SEES3-1V human HOXB6, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

88 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02848157	PHASE4	COMPLETED	Effects of Dexmedetomidine as Adjunct to Pudendal Block for Pediatric Penile Surgery
NCT02861950	PHASE4	COMPLETED	Does Caudal Block Increase the Incidence of Urethrocutaneous Fistula Formation Following Hypospadias Repair in Infants?
NCT03902249	PHASE4	COMPLETED	Effect of Intravenous Dexamethasone With Pudendal Nerve Block on Postoperative Pain in Pediatric Hypospadias Repair
NCT05708989	PHASE4	WITHDRAWN	Caudal vs. Pudendal Block in Peds GU
NCT05837000	PHASE4	UNKNOWN	Dexmedetomidine, Ketamine and Magnesium Sulphate in Caudal Block for Hypospadias Repair
NCT05922605	PHASE4	UNKNOWN	Analgesic Effects of Caudal S-ketamine for Supplementation of Ropivacaine Caudal Analgesia in Children With Hypospadias
NCT07121764	PHASE4	COMPLETED	Postoperative Pain Relief in Children: Comparing Caudal Bupivacaine Alone Versus Bupivacaine With Dexmedetomidine for Infra-Umbilical Surgeries Under General Anesthesia
NCT07240649	PHASE4	NOT_YET_RECRUITING	Outcomes From Hyperbaric Oxygen (HBO2) Treatment for Emerging Indications
NCT01370798	PHASE3	COMPLETED	Local Oestrogen Versus Placebo as Preoperative Treatment in Patients With Severe Hypospadias: Effects on Post-operative Complications
NCT04423107	PHASE3	UNKNOWN	Assessment of Postop Hypospadias Pain
NCT04826484	PHASE3	TERMINATED	Opioid Reduction Initiative During Outpatient Pediatric Urologic Procedures Using Exparel
NCT07197203	PHASE3	NOT_YET_RECRUITING	Comparison of Caudal Block and Sacral Erector Spinae Plane Block With Dexmedetomidine in Pediatric Penile Hypospadias Repair
NCT05253456	PHASE2	COMPLETED	Modified Second Layer Repair for Distal Penile Hypospadias
NCT04479371	PHASE1	WITHDRAWN	Liposomal Bupivacaine vs Standard Penile Block for Hypospadias Repair
NCT02752308	PHASE2/PHASE3	COMPLETED	Effectiveness of Caudal Epidural Block on Intraoperative Blood Loss During Hypospadias Repair
NCT04876976	PHASE2/PHASE3	COMPLETED	Isoamyl 2-Cyanoacrylate in the Urethro-cutaneous Fistula Repair
NCT05093166	PHASE1/PHASE2	TERMINATED	Clinical Trial to Assess the Safety and Efficacy of Investigational Product in Patients Due to Hypospadias Treatment Failure
NCT04196400	EARLY_PHASE1	UNKNOWN	The Role of Local Long Acting Corticosteroid Injection in Hypospadias Surgery.
NCT01762007	Not specified	WITHDRAWN	The Change of the Detrusor Thickness After Hypospadias Repair - Comparison With the Normal Control Group
NCT01875640	Not specified	COMPLETED	Decision Support for Parents Receiving Information About Child’s Rare Disease
NCT02040389	Not specified	COMPLETED	Visual Guidelines and Tutoring in Pediatric Urological Surgery
NCT02096159	Not specified	ACTIVE_NOT_RECRUITING	Prophylactic Antibiotics or Placebo After Hypospadias Repair
NCT02103712	Not specified	COMPLETED	Long Term Outcome of Hypospadias Repair
NCT02162810	Not specified	TERMINATED	Effect of Steroids on Post-Operative Complications Following Proximal Hypospadias Repair
NCT02164682	Not specified	COMPLETED	The Effect of Caudal Block on the Postoperative Complications in Pediatric Patients After Hypospadias Repair
NCT02495090	Not specified	COMPLETED	Hypospadias and Exome: Identification of New Genes for Familial Hypospadias
NCT02497963	Not specified	UNKNOWN	Foreskin Graft Tubularized Incised Plate Urethroplasty vs Tubularized Incised Plate for Primary Hypospadias (FGTIP-TIP)
NCT02512887	Not specified	UNKNOWN	Caudal vs Local Anesthesia in Hypospadias
NCT02593903	Not specified	COMPLETED	Antibiotic Use Following Distal and Mid-shaft Hypospadias Repair
NCT02805491	Not specified	COMPLETED	Influence of Pesticide Exposure on the Occurrence of Hypospadias in Newborns in Picardie
NCT02851290	Not specified	COMPLETED	Effect of Caudal and Penile Block on Hypospadias Repair Complications
NCT03102554	Not specified	ENROLLING_BY_INVITATION	Genetics of Differences of Sex Development and Hypospadias
NCT03275519	Not specified	COMPLETED	Antibiotic Use in Distal Hypospadias Repair
NCT03575377	Not specified	COMPLETED	Opioid Use, Storage, and Disposal Among Pediatric Patients After Surgery
NCT03593720	Not specified	COMPLETED	Glans Size in Hypospadias Compared to Normal
NCT03677453	Not specified	COMPLETED	Interactive Perioperative Teaching Platform (IPTP)
NCT03685955	Not specified	WITHDRAWN	Efficacy of Amniotic Membranes in Complex Genitourinary Reconstruction
NCT03698721	Not specified	NOT_YET_RECRUITING	Urothelium Tissue Engineering Using Biopsies From Transurethral Resection of Prostate
NCT03838458	Not specified	COMPLETED	Molecular and Structural Comparison of Hypospadic and Normal Children Prepuces
NCT03911635	Not specified	UNKNOWN	Selective Criteria and a Modified Technique of Applying URAGPI Technique for More Proximal Degree of Hypospadias