HOXC-AS2

Summary

HOXC-AS2 (HOXC cluster antisense RNA 2, HGNC:43750) is a long non-coding RNA gene on chromosome 12q13.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43750
Approved symbol	HOXC-AS2
Name	HOXC cluster antisense RNA 2
Location	12q13.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000250133
Ensembl biotype	lncRNA
Entrez	100874364
RNAcentral	URS00000F783F — lncRNA, 504 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 lncRNA, 1 retained_intron

ENST00000513533, ENST00000604081

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000513533 — 3 exons

Exon	Start	End
ENSE00002050334	53995208	53995518
ENSE00002057019	53995833	53995909
ENSE00002079290	53996670	53996785

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 82.47.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2878 / max 12.6934, expressed in 163 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
131288	0.2560	149
131289	0.0318	9

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.47	gold quality
metanephros cortex	UBERON:0010533	77.04	gold quality
left uterine tube	UBERON:0001303	74.06	gold quality
adult mammalian kidney	UBERON:0000082	73.71	gold quality
kidney	UBERON:0002113	72.47	gold quality
cortex of kidney	UBERON:0001225	72.45	gold quality
muscle of leg	UBERON:0001383	71.92	gold quality
gastrocnemius	UBERON:0001388	71.76	gold quality
skeletal muscle tissue	UBERON:0001134	71.50	gold quality
popliteal artery	UBERON:0002250	71.20	gold quality
tibial artery	UBERON:0007610	71.15	gold quality
sural nerve	UBERON:0015488	69.71	gold quality
hindlimb stylopod muscle	UBERON:0004252	69.03	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.73	gold quality
tibial nerve	UBERON:0001323	66.64	gold quality
fallopian tube	UBERON:0003889	66.05	gold quality
skin of leg	UBERON:0001511	64.68	gold quality
zone of skin	UBERON:0000014	64.10	gold quality
skin of abdomen	UBERON:0001416	63.54	gold quality
calcaneal tendon	UBERON:0003701	60.87	gold quality
adipose tissue	UBERON:0001013	60.13	gold quality
multicellular organism	UBERON:0000468	60.05	gold quality
smooth muscle tissue	UBERON:0001135	59.43	gold quality
small intestine	UBERON:0002108	57.52	gold quality
small intestine Peyer’s patch	UBERON:0003454	57.51	gold quality
right ovary	UBERON:0002118	57.46	gold quality
ventricular zone	UBERON:0003053	57.16	silver quality
placenta	UBERON:0001987	56.93	gold quality
left ovary	UBERON:0002119	55.60	gold quality
ovary	UBERON:0000992	55.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The HOXC-AS2/miR-876-5p/HKDC1 axis regulates endometrial cancer progression in a high glucose-related tumor microenvironment. (PMID:35485648)
• LncRNA-HOXC-AS2 regulates tumor-associated macrophage polarization through the STAT1/SOCS1 and STAT1/CIITA pathways to promote the progression of non-small cell lung cancer. (PMID:38168631)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.