HOXC11

Summary

HOXC11 (homeobox C11, HGNC:5123) is a protein-coding gene on chromosome 12q13.13, encoding Homeobox protein Hox-C11 (O43248). Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined.

Source: NCBI Gene 3227 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 10 total
• MANE Select transcript: NM_014212

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5123
Approved symbol	HOXC11
Name	homeobox C11
Location	12q13.13
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000123388
Ensembl biotype	protein_coding
OMIM	605559
Entrez	3227

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000243082, ENST00000546378

RefSeq mRNA: 1 — MANE Select: NM_014212 NM_014212

CCDS: CCDS8867

Canonical transcript exons

ENST00000546378 — 2 exons

Exon	Start	End
ENSE00002343306	53973126	53973923
ENSE00002362919	53975181	53977643

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 97.04.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0850 / max 211.0531, expressed in 203 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
125822	0.3865	126
125821	0.2632	109
125820	0.2497	65
125823	0.1149	65
125818	0.0646	23
125819	0.0062	2

Top tissues by expression

273 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	97.04	gold quality
type B pancreatic cell	CL:0000169	78.14	gold quality
olfactory bulb	UBERON:0002264	76.65	gold quality
diaphragm	UBERON:0001103	74.69	gold quality
skin of leg	UBERON:0001511	73.34	gold quality
popliteal artery	UBERON:0002250	73.18	gold quality
tibial artery	UBERON:0007610	73.14	gold quality
mucosa of paranasal sinus	UBERON:0005030	72.48	gold quality
endometrium epithelium	UBERON:0004811	72.43	gold quality
vastus lateralis	UBERON:0001379	70.20	gold quality
epithelial cell of pancreas	CL:0000083	70.00	gold quality
zone of skin	UBERON:0000014	69.97	gold quality
quadriceps femoris	UBERON:0001377	69.82	gold quality
hair follicle	UBERON:0002073	69.44	gold quality
superficial temporal artery	UBERON:0001614	69.17	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	68.34	gold quality
skin of abdomen	UBERON:0001416	68.21	gold quality
tibialis anterior	UBERON:0001385	66.70	silver quality
pancreatic ductal cell	CL:0002079	66.55	silver quality
cerebellar vermis	UBERON:0004720	65.71	gold quality
decidua	UBERON:0002450	65.55	gold quality
epithelium of nasopharynx	UBERON:0001951	65.28	gold quality
thymus	UBERON:0002370	65.13	gold quality
saphenous vein	UBERON:0007318	65.13	silver quality
cardia of stomach	UBERON:0001162	64.88	gold quality
layer of synovial tissue	UBERON:0007616	64.81	gold quality
dorsal plus ventral thalamus	UBERON:0001897	64.30	gold quality
subthalamic nucleus	UBERON:0001906	64.20	gold quality
inferior vagus X ganglion	UBERON:0005363	63.99	gold quality
ventral tegmental area	UBERON:0002691	63.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

4 targets.

Target	Regulation
CD24
LCT	Unknown
PAWR	Repression
S100B	Unknown

JASPAR motifs

Motif	Name	Family
MA0651.1	HOXC11	HOX
MA0651.2	HOXC11	HOX
MA0651.3	HOXC11	HOX

JASPAR matrix evidence (PMIDs): PMID:18585359

Upstream regulators (CollecTRI, top): KDM6A, PITX1

miRNA regulators (miRDB)

37 targeting HOXC11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4776-3P	100.00	68.73	1340
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-12121	99.99	66.64	255
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-3120-3P	99.54	70.28	2669
HSA-MIR-642A-5P	99.51	65.10	1152
HSA-MIR-217-5P	99.49	69.93	1419
HSA-MIR-147B-5P	99.45	70.62	2432
HSA-MIR-513A-3P	99.39	70.63	3620
HSA-MIR-513C-3P	99.39	70.63	3620
HSA-MIR-3978	99.24	68.39	2201
HSA-MIR-122B-3P	99.21	68.90	1333
HSA-MIR-21-3P	99.21	68.95	1312

Literature-anchored findings (GeneRIF, showing 7)

• HOXC11 increases transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwann cells. (PMID:17488478)
• HOXC11 and SRC-1 cooperate to regulate expression of the calcium-binding protein S100beta in resistant breast cancer cells. (PMID:20145129)
• Our data suggest that HOXC11 may contribute to RCC carcinogenesis by increasing tumor cell proliferation and imply that HOXC11 may be an important determinant of RCC patient prognosis (PMID:25476856)
• MiR-1197 was upregulated in non-small cell lung cancer (NSCLC) and its downregulation has tumor-suppressing effects in NSCLC, very likely through inverse regulation on downstream target gene of HOXC11. (PMID:31181445)
• HOXC11 was up-regulated and closely correlated with overall patient survival in colon adenocarcinoma and kidney renal clear cell carcinoma. (PMID:31923422)
• HOXC11 Expression Is Associated with the Progression of Colon Adenocarcinoma and Is a Prognostic Biomarker. (PMID:34415792)
• HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1. (PMID:36823149)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	hoxc11a	ENSDARG00000070351
mus_musculus	Hoxc11	ENSMUSG00000001656
rattus_norvegicus	Hoxc11	ENSRNOG00000016141

Paralogs (42): HOXA11 (ENSG00000005073), HOXC8 (ENSG00000037965), HOXA1 (ENSG00000105991), HOXA2 (ENSG00000105996), HOXA3 (ENSG00000105997), HOXA5 (ENSG00000106004), HOXA6 (ENSG00000106006), HOXA13 (ENSG00000106031), TLX1 (ENSG00000107807), HOXB6 (ENSG00000108511), TLX2 (ENSG00000115297), HOXB8 (ENSG00000120068), HOXB5 (ENSG00000120075), HOXB3 (ENSG00000120093), HOXB1 (ENSG00000120094), HOXA7 (ENSG00000122592), HOXC13 (ENSG00000123364), HOXC12 (ENSG00000123407), HOXD1 (ENSG00000128645), HOXD3 (ENSG00000128652), HOXD9 (ENSG00000128709), HOXD10 (ENSG00000128710), HOXD11 (ENSG00000128713), HOXD13 (ENSG00000128714), PDX1 (ENSG00000139515), HOXB13 (ENSG00000159184), TLX3 (ENSG00000164438), HOXD4 (ENSG00000170166), HOXD12 (ENSG00000170178), HOXB9 (ENSG00000170689), HOXC5 (ENSG00000172789), HOXB2 (ENSG00000173917), HOXD8 (ENSG00000175879), GSX2 (ENSG00000180613), HOXC9 (ENSG00000180806), HOXC10 (ENSG00000180818), HOXB4 (ENSG00000182742), HOXA4 (ENSG00000197576), HOXC6 (ENSG00000197757), HOXC4 (ENSG00000198353)

Protein

Protein identifiers

Homeobox protein Hox-C11 — O43248 (reviewed: O43248)

Alternative names: Homeobox protein Hox-3H

All UniProt accessions (2): O43248, J3KMZ0

UniProt curated annotations — full annotation on UniProt →

Function. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.

Subcellular location. Nucleus.

Similarity. Belongs to the Abd-B homeobox family.

RefSeq proteins (1): NP_055027* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001356	HD	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017970	Homeobox_CS	Conserved_site
IPR020479	HD_metazoa	Domain
IPR021918	DUF3528	Domain

Pfam: PF00046, PF12045

UniProt features (9 total): cross-link 3, sequence variant 2, chain 1, DNA-binding region 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O43248-F1	61.31	0.21

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 82, 116, 178

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9830674	Formation of the ureteric bud

MSigDB gene sets: 180 (showing top): RNGTGGGC_UNKNOWN, MYAATNNNNNNNGGC_UNKNOWN, GOBP_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING, BENPORATH_ES_WITH_H3K27ME3, GOBP_METANEPHROS_DEVELOPMENT, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GOBP_EMBRYONIC_DIGIT_MORPHOGENESIS, GOBP_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT, GOBP_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS, GOBP_DEVELOPMENTAL_INDUCTION, GGGTGGRR_PAX4_03, USF_C, MORF_RAD51L3, TCF4_Q5

GO Biological Process (11): metanephros development (GO:0001656), organ induction (GO:0001759), regulation of transcription by RNA polymerase II (GO:0006357), endoderm development (GO:0007492), anterior/posterior pattern specification (GO:0009952), proximal/distal pattern formation (GO:0009954), embryonic digit morphogenesis (GO:0042733), positive regulation of transcription by RNA polymerase II (GO:0045944), embryonic skeletal joint morphogenesis (GO:0060272), skeletal system development (GO:0001501), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (6): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (4): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Kidney development	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
cellular anatomical structure	3
transcription by RNA polymerase II	2
regionalization	2
regulation of transcription by RNA polymerase II	2
kidney development	1
regulation of animal organ formation	1
specification of animal organ identity	1
developmental induction	1
positive regulation of animal organ morphogenesis	1
regulation of DNA-templated transcription	1
tissue development	1
embryonic limb morphogenesis	1
embryonic morphogenesis	1
positive regulation of DNA-templated transcription	1
embryonic skeletal system morphogenesis	1
embryonic skeletal joint development	1
system development	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
chromosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasm	1

Protein interactions and networks

STRING

686 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HOXC11	TBX4	P57082	842
HOXC11	TBX5	Q99593	724
HOXC11	TBX3	O15119	580
HOXC11	TBX6	O95947	580
HOXC11	TBX2	Q13207	571
HOXC11	SALL4	Q9UJQ4	567
HOXC11	DUX4L2	P0CJ85	554
HOXC11	EYA1	Q99502	545
HOXC11	PAX2	Q02962	509
HOXC11	HOXC5	Q00444	480
HOXC11	TBR1	Q16650	470
HOXC11	GAPDH	P00354	458
HOXC11	SRC	P12931	453
HOXC11	TBX1	O43435	450
HOXC11	ATP2A2	P16614	411

IntAct

41 interactions, top by confidence:

A	B	Type	Score
HOXC11	HTT	psi-mi:“MI:0915”(physical association)	0.670
HOXC11	TRIP10	psi-mi:“MI:0915”(physical association)	0.560
HOXC11	PSMA1	psi-mi:“MI:0915”(physical association)	0.560
HOXC11		psi-mi:“MI:0915”(physical association)	0.560
HOXC11	FGFR3	psi-mi:“MI:0915”(physical association)	0.560
HOXC11	HRAS	psi-mi:“MI:0915”(physical association)	0.560
HOXC11	PMP22	psi-mi:“MI:0915”(physical association)	0.560
HOXC11	HDAC5	psi-mi:“MI:0915”(physical association)	0.370
HOXC11	GTF2A1L	psi-mi:“MI:0915”(physical association)	0.370
HOXC11	TBX21	psi-mi:“MI:0915”(physical association)	0.370
HOXC11	SOX8	psi-mi:“MI:0915”(physical association)	0.370
GTF2H1	HOXC11	psi-mi:“MI:0915”(physical association)	0.370
HOXC11	IRF4	psi-mi:“MI:0915”(physical association)	0.370
HOXC11	SMAD3	psi-mi:“MI:0915”(physical association)	0.370
HOXC11	MEIS1	psi-mi:“MI:0915”(physical association)	0.370
HOXC11	SP1	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (23): HOXC11 (Reconstituted Complex), HOXC11 (Affinity Capture-MS), RCHY1 (PCA), TRIP10 (Two-hybrid), PSMA1 (Two-hybrid), HOXC11 (Affinity Capture-RNA), HOXC11 (Affinity Capture-MS), HOXC11 (Affinity Capture-MS), HOXC11 (Proximity Label-MS), HOXC11 (Proximity Label-MS), HOXC11 (Two-hybrid), IRF4 (Two-hybrid), SMAD3 (Two-hybrid), MEIS1 (Two-hybrid), SP1 (Two-hybrid)

ESM2 similar proteins: A1YEY5, A1YFA5, A1YFI3, A1YG57, A2T733, A2T764, A2T7P4, A6NJ46, O42115, O43248, O43711, O55144, O95096, P02830, P09023, P09024, P09629, P09633, P17509, P17919, P18864, P23410, P28362, P29454, P31259, P31311, P31313, P31315, P42586, P43120, P43345, P43697, P48031, P52951, P53544, P53545, P53546, P56915, P97334, Q02591

Diamond homologs: A1YFT7, A2D5V0, A2D635, A2T6F8, A2T7D1, A2T7H7, B5DFK3, O42502, O42503, O42506, O43248, P09013, P09014, P09023, P09025, P09067, P09079, P09087, P09631, P09632, P09633, P10179, P14838, P15861, P17481, P17482, P17509, P18863, P18866, P20615, P23459, P23813, P24340, P24341, P24342, P28356, P28357, P28358, P28359, P31257

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
KDM6A	“up-regulates quantity by expression”	HOXC11	“transcriptional regulation”
HOXC11	“up-regulates quantity by expression”	S100B	“transcriptional regulation”
HOXC11	up-regulates	HNF1A

Disease & clinical

Clinical variants and AI predictions

ClinVar

10 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	9
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

283 predictions. Top by Δscore:

Variant	Effect	Δscore
12:53973924:G:GG	donor_gain	1.0000
12:53973912:G:GT	donor_gain	0.9900
12:53973921:CCAG:C	donor_loss	0.9900
12:53973923:AG:A	donor_loss	0.9900
12:53973924:G:GA	donor_loss	0.9900
12:53975157:ACTT:A	acceptor_gain	0.9900
12:53975179:A:AG	acceptor_gain	0.9900
12:53975180:G:GA	acceptor_gain	0.9900
12:53975180:GAC:G	acceptor_gain	0.9900
12:53973921:CCA:C	donor_gain	0.9800
12:53973922:CA:C	donor_gain	0.9800
12:53975157:A:AG	acceptor_gain	0.9800
12:53975158:C:G	acceptor_gain	0.9800
12:53975176:TCCAG:T	acceptor_loss	0.9800
12:53975177:CCAG:C	acceptor_loss	0.9800
12:53975178:CAGA:C	acceptor_loss	0.9800
12:53975179:A:C	acceptor_loss	0.9800
12:53975179:AGAC:A	acceptor_gain	0.9800
12:53975180:GA:G	acceptor_gain	0.9800
12:53975180:GACG:G	acceptor_gain	0.9800
12:53975180:GACGC:G	acceptor_gain	0.9800
12:53973920:CCCA:C	donor_gain	0.9700
12:53975505:C:A	acceptor_gain	0.9700
12:53973919:CCCCA:C	donor_gain	0.9600
12:53974277:G:GT	donor_gain	0.9400
12:53973760:C:T	donor_gain	0.9300
12:53975160:T:TA	acceptor_gain	0.9200
12:53975154:C:A	acceptor_gain	0.8800
12:53973911:G:GT	donor_gain	0.8500
12:53973848:G:GT	donor_gain	0.8300

AlphaMissense

1965 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:53975204:C:A	R236S	1.000
12:53975204:C:T	R236C	1.000
12:53975213:T:C	Y239H	1.000
12:53975213:T:G	Y239D	1.000
12:53975214:A:G	Y239C	1.000
12:53975227:G:C	Q243H	1.000
12:53975227:G:T	Q243H	1.000
12:53975229:T:G	I244S	1.000
12:53975232:G:C	R245P	1.000
12:53975238:T:A	L247Q	1.000
12:53975238:T:C	L247P	1.000
12:53975238:T:G	L247R	1.000
12:53975240:G:A	E248K	1.000
12:53975241:A:T	E248V	1.000
12:53975242:G:C	E248D	1.000
12:53975242:G:T	E248D	1.000
12:53975244:G:C	R249P	1.000
12:53975246:G:A	E250K	1.000
12:53975249:T:A	F251I	1.000
12:53975249:T:C	F251L	1.000
12:53975249:T:G	F251V	1.000
12:53975250:T:C	F251S	1.000
12:53975250:T:G	F251C	1.000
12:53975251:T:A	F251L	1.000
12:53975251:T:G	F251L	1.000
12:53975264:T:C	Y256H	1.000
12:53975264:T:G	Y256D	1.000
12:53975265:A:G	Y256C	1.000
12:53975268:T:A	I257N	1.000
12:53975268:T:C	I257T	1.000

dbSNP variants (sampled 300 via entrez): RS1000921625 (12:53973330 C>T), RS1001373646 (12:53973910 A>G), RS1001538915 (12:53975582 T>A), RS1001888327 (12:53974126 G>T), RS1002759828 (12:53972982 C>A,G,T), RS1002783761 (12:53972562 G>T), RS1002859654 (12:53976821 T>A,C), RS1003216059 (12:53977145 C>A,T), RS1003374468 (12:53971348 G>GA), RS1003896859 (12:53971601 G>A,T), RS1004791199 (12:53977334 A>G), RS1006063441 (12:53972422 G>A), RS1006120679 (12:53972746 A>T), RS1006738783 (12:53974933 C>A,G,T), RS1007789162 (12:53973991 G>A,C)

Disease associations

OMIM: gene MIM:605559 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST005956_70	Waist-to-hip ratio adjusted for BMI	4.000000e-13
GCST005957_6	Waist-to-hip ratio adjusted for BMI (age <50)	6.000000e-06
GCST005958_9	Waist-to-hip ratio adjusted for BMI (age >50)	1.000000e-08
GCST005962_20	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	7.000000e-13
GCST90014033_57	Haemorrhoidal disease	7.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

15 total (human), top 15 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Aflatoxin B1	decreases methylation	2
arsenite	increases methylation	1
sodium arsenite	affects methylation	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
(+)-JQ1 compound	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Catechin	increases expression, affects cotreatment	1
Estradiol	decreases expression	1
Fluorouracil	affects expression, affects response to substance	1
Methylcholanthrene	affects binding, increases reaction	1
Nickel	decreases expression	1
Asbestos, Serpentine	decreases methylation	1
Asbestos, Crocidolite	decreases methylation	1
Asbestos, Amosite	decreases methylation	1
Lactic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.