HOXC13-AS
gene geneOn this page
Summary
HOXC13-AS (HOXC13 antisense RNA, HGNC:43753) is a long non-coding RNA gene on chromosome 12q13.13.
At a glance
- Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:43753 |
| Approved symbol | HOXC13-AS |
| Name | HOXC13 antisense RNA |
| Location | 12q13.13 |
| Locus type | RNA, long non-coding |
| Status | Approved |
| Ensembl gene | ENSG00000249641 |
| Ensembl biotype | lncRNA |
| Entrez | 100874366 |
| RNAcentral | URS00003A116B — lncRNA, 1408 nt, 1 organism(s) |
Gene structure
Transcript identifiers
Ensembl transcripts: 4 — 4 lncRNA
ENST00000512916, ENST00000810609, ENST00000810610, ENST00000810611
RefSeq mRNA: 0 — MANE Select: None
Canonical transcript exons
ENST00000512916 — 3 exons
| Exon | Start | End |
|---|---|---|
| ENSE00002062875 | 53937165 | 53937357 |
| ENSE00004207688 | 53935250 | 53936369 |
| ENSE00004207689 | 53939471 | 53939692 |
Expression profiles
Bgee: expression breadth broad, 36 present calls, max score 82.23.
FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0882 / max 5.8068, expressed in 53 samples.
FANTOM5 promoters (1 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 131276 | 0.0882 | 53 |
Top tissues by expression
36 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| colon | UBERON:0001155 | 82.23 | silver quality |
| skin of leg | UBERON:0001511 | 74.36 | gold quality |
| zone of skin | UBERON:0000014 | 73.93 | gold quality |
| skin of abdomen | UBERON:0001416 | 73.58 | gold quality |
| multicellular organism | UBERON:0000468 | 62.60 | gold quality |
| primordial germ cell in gonad | CL:0000670 ∩ UBERON:0000991 | 56.52 | gold quality |
| urinary bladder | UBERON:0001255 | 55.66 | gold quality |
| adrenal gland | UBERON:0002369 | 53.77 | gold quality |
| popliteal artery | UBERON:0002250 | 53.58 | gold quality |
| tibial artery | UBERON:0007610 | 53.54 | gold quality |
| placenta | UBERON:0001987 | 53.11 | gold quality |
| prefrontal cortex | UBERON:0000451 | 51.36 | silver quality |
| tibial nerve | UBERON:0001323 | 50.81 | gold quality |
| ovary | UBERON:0000992 | 50.70 | gold quality |
| adult mammalian kidney | UBERON:0000082 | 50.15 | silver quality |
| lymph node | UBERON:0000029 | 49.99 | silver quality |
| right ovary | UBERON:0002118 | 49.31 | gold quality |
| thoracic mammary gland | UBERON:0005200 | 49.23 | gold quality |
| adipose tissue | UBERON:0001013 | 48.14 | gold quality |
| subcutaneous adipose tissue | UBERON:0002190 | 48.11 | gold quality |
| muscle of leg | UBERON:0001383 | 47.24 | gold quality |
| heart left ventricle | UBERON:0002084 | 46.88 | silver quality |
| gastrocnemius | UBERON:0001388 | 46.13 | gold quality |
| prostate gland | UBERON:0002367 | 45.61 | gold quality |
| esophagus | UBERON:0001043 | 44.83 | gold quality |
| esophagus mucosa | UBERON:0002469 | 44.82 | gold quality |
| omental fat pad | UBERON:0010414 | 44.39 | gold quality |
| cerebral cortex | UBERON:0000956 | 43.98 | silver quality |
| blood | UBERON:0000178 | 41.82 | silver quality |
| right lobe of thyroid gland | UBERON:0001119 | 39.79 | silver quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 0.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | no | 0.98 |
Regulation
Is transcription factor: no
Literature-anchored findings (GeneRIF, showing 7)
- HOXC13-AS, which is significantly upregulated in breast cancers, promoted cell proliferation through the suppressed miR-497-5p and further upregulated PTEN. (PMID:31066051)
- Overexpression of long noncoding RNA HOXC13-AS and its prognostic significance in hepatocellular carcinoma. (PMID:31539123)
- HOXC13-AS accelerates cell proliferation and migration in oral squamous cell carcinoma via miR-378g/HOXC13 axis. (PMID:32763778)
- Genetic factors in the pathogenesis of ameloblastoma, dentigerous cyst and odontogenic keratocyst. (PMID:33346102)
- LncRNA HOXC-AS5 Affects the Proliferation, Invasion and Cell Cycle of Ameloblastoma Cells by Acting on the Target Gene HOXC13. (PMID:36029503)
- Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport. (PMID:36869179)
- M2 Macrophage exosomal HOXC13-AS in laryngeal cancer immunity via targeting miR-485-5p/IGF2BP2/PD-L1. (PMID:39126735)
Cross-species orthologs
0 orthologs
Protein
Non-coding RNA — no protein product; not a drug target.
Function
No curated pathway, Gene-Ontology, or interaction data.
Disease & clinical
No curated disease, variant, or cancer-driver associations.
Drugs & pharmacology
No drug or pharmacology data — not an established drug target.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.