HOXD-AS2

Summary

HOXD-AS2 (HOXD cluster antisense RNA 2, HGNC:43756) is a long non-coding RNA gene on chromosome 2q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43756
Approved symbol	HOXD-AS2
Name	HOXD cluster antisense RNA 2
Location	2q31.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237380
Ensembl biotype	lncRNA
Entrez	100506783
RNAcentral	URS000075C24F — lncRNA, 692 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000426965, ENST00000440016, ENST00000651440, ENST00000821484, ENST00000821485

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000426965 — 3 exons

Exon	Start	End
ENSE00001758190	176135319	176135422
ENSE00004228330	176136621	176137098
ENSE00004228331	176134432	176134950

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 86.83.

FANTOM5 (CAGE): breadth broad, TPM avg 2.7419 / max 58.2824, expressed in 650 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
31952	1.9428	598
31953	0.5051	356
31951	0.2940	174

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.83	gold quality
hindlimb stylopod muscle	UBERON:0004252	86.43	gold quality
body of uterus	UBERON:0009853	86.41	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.84	gold quality
metanephros cortex	UBERON:0010533	82.64	gold quality
deltoid	UBERON:0001476	81.50	silver quality
biceps brachii	UBERON:0001507	81.03	silver quality
endocervix	UBERON:0000458	80.23	gold quality
muscle layer of sigmoid colon	UBERON:0035805	79.87	gold quality
right uterine tube	UBERON:0001302	79.80	gold quality
ectocervix	UBERON:0012249	78.81	gold quality
sperm	CL:0000019	78.17	gold quality
left ovary	UBERON:0002119	77.98	gold quality
cortex of kidney	UBERON:0001225	77.29	gold quality
right ovary	UBERON:0002118	77.15	gold quality
adult mammalian kidney	UBERON:0000082	76.26	gold quality
left adrenal gland cortex	UBERON:0035825	76.22	gold quality
left adrenal gland	UBERON:0001234	76.04	gold quality
metanephros	UBERON:0000081	75.98	gold quality
stromal cell of endometrium	CL:0002255	75.63	gold quality
calcaneal tendon	UBERON:0003701	75.57	gold quality
left uterine tube	UBERON:0001303	75.28	gold quality
right adrenal gland	UBERON:0001233	75.18	gold quality
tibialis anterior	UBERON:0001385	75.05	silver quality
vagina	UBERON:0000996	74.85	gold quality
muscle of leg	UBERON:0001383	74.63	gold quality
gastrocnemius	UBERON:0001388	74.59	gold quality
adrenal gland	UBERON:0002369	74.09	gold quality
right adrenal gland cortex	UBERON:0035827	74.07	gold quality
adrenal cortex	UBERON:0001235	73.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long non-coding RNA (lncRNA) HOXD-AS2 promotes glioblastoma cell proliferation, migration and invasion by regulating the miR-3681-5p/MALT1 signaling pathway. (PMID:34802389)
• Production and Stabilization of Specific Upregulated Long Noncoding RNA HOXD-AS2 in Glioblastomas Are Mediated by TFE3 and miR-661, Respectively. (PMID:35269968)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.