HOXD12

Summary

HOXD12 (homeobox D12, HGNC:5135) is a protein-coding gene on chromosome 2q31.1, encoding Homeobox protein Hox-D12 (P35452). Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5’ end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.

Source: NCBI Gene 3238 — RefSeq curated summary.

At a glance

• Gene–disease (curated): clubfoot (Moderate, GenCC)
• GWAS associations: 5
• Clinical variants (ClinVar): 66 total
• MANE Select transcript: NM_021193

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5135
Approved symbol	HOXD12
Name	homeobox D12
Location	2q31.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000170178
Ensembl biotype	protein_coding
OMIM	142988
Entrez	3238

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000404162, ENST00000406506

RefSeq mRNA: 1 — MANE Select: NM_021193 NM_021193

CCDS: CCDS46456

Canonical transcript exons

ENST00000406506 — 2 exons

Exon	Start	End
ENSE00001559421	176100522	176102489
ENSE00001562720	176099795	176100375

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 53.87.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0413 / max 31.8679, expressed in 10 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
23819	0.0413	10

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vagina	UBERON:0000996	53.87	gold quality
muscle layer of sigmoid colon	UBERON:0035805	53.14	gold quality
tendon of biceps brachii	UBERON:0008188	51.36	gold quality
rectum	UBERON:0001052	50.09	gold quality
ectocervix	UBERON:0012249	49.87	gold quality
lower lobe of lung	UBERON:0008949	46.50	silver quality
prostate gland	UBERON:0002367	46.34	gold quality
uterine cervix	UBERON:0000002	44.78	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
sural nerve	UBERON:0015488	43.22	gold quality
amniotic fluid	UBERON:0000173	42.95	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
substantia nigra pars compacta	UBERON:0001965	41.98	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	41.97	gold quality
middle temporal gyrus	UBERON:0002771	41.96	gold quality
vastus lateralis	UBERON:0001379	41.81	gold quality
quadriceps femoris	UBERON:0001377	41.75	gold quality
endocervix	UBERON:0000458	41.70	silver quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
biceps brachii	UBERON:0001507	41.14	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
epithelium of nasopharynx	UBERON:0001951	40.45	gold quality
myocardium	UBERON:0002349	40.45	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
mammalian vulva	UBERON:0000997	40.40	gold quality
germinal epithelium of ovary	UBERON:0001304	40.33	gold quality
esophagus squamous epithelium	UBERON:0006920	40.29	gold quality
jejunum	UBERON:0002115	40.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.83

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets.

Target	Regulation
SHH

JASPAR motifs

Motif	Name	Family
MA0873.1	HOXD12	HOX
MA0873.2	HOXD12	HOX
MA1958.1	HOXD12::ELK1	HOX::Ets-related
MA1958.2	HOXD12::ELK1	HOX::Ets-related

JASPAR matrix evidence (PMIDs): PMID:18585359, PMID:24218641

Literature-anchored findings (GeneRIF, showing 4)

• Data show that HOXD12 are important susceptible genes of idiopathic congenital talipes equinovarus. (PMID:16331564)
• data show no significant difference in HOXD11, HOXD12 & HOXD13 genotype frequencies between the autism spectrum disorder & healthy controls, but one SNP in promoter region of HOXD11 was observed in only 4 patients with ASD (PMID:19540081)
• In human embryonic stem cell (hESCs)differentiation, a 1.8kb region between HOXD11 and HOXD12 (D11.12) that is associated with PcG proteins was discovered, it shows alteration in nuclease sensitivity as hESCs differentiate. (PMID:20085705)
• HOXD12 defines an age-related aggressive subtype of oligodendroglioma. (PMID:39259414)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	hoxd12a	ENSDARG00000059263
mus_musculus	Hoxd12	ENSMUSG00000001823
rattus_norvegicus	Hoxd12	ENSRNOG00000001587

Paralogs (42): HOXA11 (ENSG00000005073), HOXC8 (ENSG00000037965), HOXA1 (ENSG00000105991), HOXA2 (ENSG00000105996), HOXA3 (ENSG00000105997), HOXA5 (ENSG00000106004), HOXA6 (ENSG00000106006), HOXA13 (ENSG00000106031), TLX1 (ENSG00000107807), HOXB6 (ENSG00000108511), TLX2 (ENSG00000115297), HOXB8 (ENSG00000120068), HOXB5 (ENSG00000120075), HOXB3 (ENSG00000120093), HOXB1 (ENSG00000120094), HOXA7 (ENSG00000122592), HOXC13 (ENSG00000123364), HOXC11 (ENSG00000123388), HOXC12 (ENSG00000123407), HOXD1 (ENSG00000128645), HOXD3 (ENSG00000128652), HOXD9 (ENSG00000128709), HOXD10 (ENSG00000128710), HOXD11 (ENSG00000128713), HOXD13 (ENSG00000128714), PDX1 (ENSG00000139515), HOXB13 (ENSG00000159184), TLX3 (ENSG00000164438), HOXD4 (ENSG00000170166), HOXB9 (ENSG00000170689), HOXC5 (ENSG00000172789), HOXB2 (ENSG00000173917), HOXD8 (ENSG00000175879), GSX2 (ENSG00000180613), HOXC9 (ENSG00000180806), HOXC10 (ENSG00000180818), HOXB4 (ENSG00000182742), HOXA4 (ENSG00000197576), HOXC6 (ENSG00000197757), HOXC4 (ENSG00000198353)

Protein

Protein identifiers

Homeobox protein Hox-D12 — P35452 (reviewed: P35452)

Alternative names: Homeobox protein Hox-4H

All UniProt accessions (2): P35452, B5MCD3

UniProt curated annotations — full annotation on UniProt →

Function. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location. Nucleus.

Similarity. Belongs to the Abd-B homeobox family.

Isoforms (2)

UniProt ID	Names	Canonical?
P35452-1	1	yes
P35452-2	2

RefSeq proteins (1): NP_067016* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001356	HD	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017970	Homeobox_CS	Conserved_site
IPR020479	HD_metazoa	Domain

Pfam: PF00046

UniProt features (10 total): sequence conflict 5, chain 1, DNA-binding region 1, region of interest 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P35452-F1	65.09	0.27

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 70 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_UP, BENPORATH_ES_WITH_H3K27ME3, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, GOBP_EMBRYONIC_DIGIT_MORPHOGENESIS, PAX8_B, TCF4_Q5, GOBP_APPENDAGE_DEVELOPMENT, MA_MYELOID_DIFFERENTIATION_DN, LEF1_Q6, GOBP_EMBRYO_DEVELOPMENT, PTF1BETA_Q6, LEE_AGING_CEREBELLUM_UP, SCHLESINGER_H3K27ME3_IN_NORMAL_AND_METHYLATED_IN_CANCER, GATGKMRGCG_UNKNOWN, GOCC_TRANSCRIPTION_REGULATOR_COMPLEX

GO Biological Process (5): skeletal system development (GO:0001501), pattern specification process (GO:0007389), embryonic digit morphogenesis (GO:0042733), regulation of DNA-templated transcription (GO:0006355), regulation of transcription by RNA polymerase II (GO:0006357)

GO Molecular Function (4): DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (3): chromatin (GO:0000785), nucleus (GO:0005634), transcription regulator complex (GO:0005667)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
system development	1
multicellular organism development	1
multicellular organismal process	1
embryonic limb morphogenesis	1
embryonic morphogenesis	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
regulation of DNA-templated transcription	1
transcription by RNA polymerase II	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
regulation of transcription by RNA polymerase II	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

750 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HOXD12	SHH	Q15465	759
HOXD12	EVX2	Q03828	583
HOXD12	HAND2	P61296	567
HOXD12	HOXD10	P28358	527
HOXD12	HOXD1	Q9GZZ0	520
HOXD12	SUZ12	Q15022	512
HOXD12	ZP2	Q05996	500
HOXD12	SALL1	Q9NSC2	499
HOXD12	GLI3	P10071	489
HOXD12	YY1	P25490	475
HOXD12	SMOC1	Q9H4F8	438
HOXD12	IRX2	Q9BZI1	429
HOXD12	R4GMX3	R4GMX3	427
HOXD12	BMI1	P35226	426
HOXD12	TOX3	O15405	412

IntAct

6 interactions, top by confidence:

A	B	Type	Score
HOXD12	TRAF1	psi-mi:“MI:0915”(physical association)	0.560
TRAF1	HOXD12	psi-mi:“MI:0915”(physical association)	0.560
KLRB1	HOXD12	psi-mi:“MI:0914”(association)	0.350
KLRB1	ESYT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (19): TRAF1 (Two-hybrid), HOXD12 (Two-hybrid), HOXD12 (Two-hybrid), HOXD12 (Two-hybrid), HOXD12 (Two-hybrid), HOXD12 (Two-hybrid), HOXD12 (Two-hybrid), POLR1C (Two-hybrid), MKRN3 (Two-hybrid), ACTN3 (Two-hybrid), HOXD12 (Affinity Capture-MS), HOXD12 (Affinity Capture-MS), HOXD12 (Reconstituted Complex), MAFB (Reconstituted Complex), MAFK (Reconstituted Complex)

ESM2 similar proteins: A1YER7, A1YF08, A1YFD8, A1YFY3, A1YG85, A2D4P8, A2D5I1, A2T6X6, A2T756, A2T7H5, A6NCS4, O08934, O14813, O42230, O43763, O70218, O93367, P06798, P09016, P10284, P10628, P13378, P17277, P17483, P18111, P23683, P23813, P31277, P31310, P35452, P42580, P47902, P49640, P50207, P50223, P52945, P52946, P52947, P70118, P82976

Diamond homologs: A1YFT7, A2D5V0, A2D635, A2T6F8, A2T7D1, A2T7H7, G5EFY5, O14627, O42502, O42506, O43248, P02835, P09013, P09067, P09079, P09087, P09631, P09633, P10038, P10179, P17482, P17919, P20615, P23812, P24061, P24341, P24342, P24343, P24344, P28358, P28359, P31257, P31260, P31263, P31268, P31269, P31271, P31272, P31274, P31275

SIGNOR signaling

6 interactions.

A	Effect	B	Mechanism
HOXD12	“down-regulates activity”	MAFF	binding
HOXD12	“down-regulates activity”	MAF	binding
HOXD12	“down-regulates activity”	MAFB	binding
HOXD12	“down-regulates activity”	MAFK	binding
HOXD12	“down-regulates activity”	MAFG	binding
HOXD12	“up-regulates activity”	MEIS1	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

66 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	63
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

160 predictions. Top by Δscore:

Variant	Effect	Δscore
2:176100372:GACG:G	donor_gain	0.9900
2:176100372:GACGG:G	donor_loss	0.9900
2:176100376:G:GG	donor_gain	0.9900
2:176100377:T:G	donor_loss	0.9900
2:176100093:GC:G	donor_gain	0.9800
2:176100516:TTGCA:T	acceptor_loss	0.9800
2:176100517:TGCA:T	acceptor_loss	0.9800
2:176100518:GCAG:G	acceptor_loss	0.9800
2:176100519:CA:C	acceptor_loss	0.9800
2:176100520:A:AG	acceptor_gain	0.9800
2:176100520:AGG:A	acceptor_loss	0.9800
2:176100521:G:GG	acceptor_gain	0.9800
2:176100515:GTTGC:G	acceptor_loss	0.9600
2:176100521:GGC:G	acceptor_gain	0.9600
2:176100521:GGCCT:G	acceptor_gain	0.9600
2:176100291:G:GT	donor_gain	0.9300
2:176100094:C:G	donor_gain	0.9200
2:176100520:AG:A	acceptor_gain	0.9200
2:176100521:GG:G	acceptor_gain	0.9200
2:176100521:GGCC:G	acceptor_gain	0.9200
2:176100514:T:TA	acceptor_gain	0.8700
2:176100372:G:GT	donor_gain	0.8600
2:176100736:G:GT	donor_gain	0.8600
2:176100420:G:T	donor_gain	0.8200
2:176100871:T:A	acceptor_gain	0.8100
2:176100512:T:A	acceptor_loss	0.7800
2:176100406:T:A	donor_gain	0.7100
2:176100426:G:A	donor_gain	0.6900
2:176100374:CG:C	donor_gain	0.6700
2:176100375:GG:G	donor_gain	0.6700

AlphaMissense

1718 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:176100572:T:C	Y209H	1.000
2:176100572:T:G	Y209D	1.000
2:176100597:T:C	L217S	1.000
2:176100600:A:T	E218V	1.000
2:176100608:T:C	F221L	1.000
2:176100609:T:C	F221S	1.000
2:176100609:T:G	F221C	1.000
2:176100610:C:A	F221L	1.000
2:176100610:C:G	F221L	1.000
2:176100623:T:C	F226L	1.000
2:176100624:T:C	F226S	1.000
2:176100624:T:G	F226C	1.000
2:176100625:C:A	F226L	1.000
2:176100625:C:G	F226L	1.000
2:176100641:C:A	R232S	1.000
2:176100669:T:A	L241H	1.000
2:176100669:T:C	L241P	1.000
2:176100684:T:A	V246D	1.000
2:176100686:A:G	K247E	1.000
2:176100688:A:C	K247N	1.000
2:176100688:A:T	K247N	1.000
2:176100690:T:C	I248T	1.000
2:176100690:T:G	I248S	1.000
2:176100692:T:A	W249R	1.000
2:176100692:T:C	W249R	1.000
2:176100694:G:C	W249C	1.000
2:176100694:G:T	W249C	1.000
2:176100695:T:A	F250I	1.000
2:176100695:T:C	F250L	1.000
2:176100695:T:G	F250V	1.000

dbSNP variants (sampled 300 via entrez): RS1000189431 (2:176099216 G>A), RS1000488319 (2:176099403 T>A), RS1000614106 (2:176102854 G>A,T), RS1000891192 (2:176100766 C>A,G,T), RS1001276988 (2:176098474 G>A,T), RS1001853922 (2:176102220 A>G), RS1002252417 (2:176100104 T>C,G), RS1002850514 (2:176101023 C>G,T), RS1003070856 (2:176101222 G>A), RS1003664342 (2:176098726 A>T), RS1004629278 (2:176100975 A>C), RS1004665704 (2:176100856 C>G,T), RS1004805739 (2:176100045 C>A), RS1005847287 (2:176099029 T>C), RS1006043488 (2:176099941 G>C)

Disease associations

OMIM: gene MIM:142988 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
clubfoot	Moderate	Autosomal dominant

Mondo (1): clubfoot (MONDO:0007342)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST005748_3	Digit length ratio (right hand)	6.000000e-09
GCST005749_5	Digit length ratio (left hand)	6.000000e-07
GCST005749_6	Digit length ratio (left hand)	1.000000e-07
GCST005750_4	Digit length ratio	1.000000e-10
GCST006661_148	Male-pattern baldness	3.000000e-18

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004841	digit length ratio

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D003025	Clubfoot	C05.330.488.655.063; C05.330.495.681.063; C05.660.585.512.380.813.063; C16.131.621.585.512.500.681.063

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression	2
CGP 52608	increases reaction, affects binding	1
Resveratrol	affects cotreatment, decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	increases expression, increases abundance	1
Cadmium	decreases expression, increases abundance	1
Plant Extracts	affects cotreatment, decreases expression	1
Aflatoxin B1	decreases methylation	1
Asbestos, Serpentine	decreases methylation	1
Asbestos, Crocidolite	decreases methylation	1
Asbestos, Amosite	decreases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1
Okadaic Acid	decreases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

46 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT04564430	PHASE4	UNKNOWN	Clonidine for Tourniquet-related Pain in Children
NCT04766684	PHASE4	COMPLETED	Clubfoot Tenotomy Trial
NCT02815215	EARLY_PHASE1	UNKNOWN	Efficacy Analysis of Minimally Invasive Carroll’s Technique in Treatment of Congenital Idiopathic Clubfoot
NCT00175708	Not specified	COMPLETED	Pedobarographic Assessments of Clubfoot Treated Patients
NCT00474032	Not specified	UNKNOWN	Using Botox to Treat Patients With Idiopathic Clubfoot
NCT00474344	Not specified	COMPLETED	Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)
NCT00475631	Not specified	WITHDRAWN	Economic Evaluation of Clubfoot Treatment: One Centre’s Experience
NCT00607191	Not specified	COMPLETED	Clubfoot DNA Repository
NCT01050088	Not specified	UNKNOWN	Sucrose Analgesia in Infants Undergoing Casting for Club Foot
NCT01067651	Not specified	COMPLETED	Comparison of Casting Materials for the Treatment of Clubfoot Using the Ponseti Method
NCT01088828	Not specified	COMPLETED	Exploring the Causes of Clubfoot Using Magnetic Resonance Imaging, MRI
NCT01481324	Not specified	COMPLETED	Outcomes of Compliance With Brace Wear in Clubfoot
NCT02022267	Not specified	COMPLETED	Gait Analysis in Ponseti Clubfoot
NCT02395185	Not specified	COMPLETED	A Randomized Controlled Trial of Three Non-pharmacologic Analgesic Techniques for Casting of Clubfoot Infants
NCT02815306	Not specified	COMPLETED	Polyaxial Brace Fixing for the Treatment of Congenital Clubfoot
NCT03249805	Not specified	UNKNOWN	MiracleFeet Foot Abduction Brace Sensor Trial
NCT03580746	Not specified	WITHDRAWN	Comparison of Ponseti Method Versus Older Treatments in Talipes Equinovarus Through Gait Analysis and Clinical Results
NCT03671863	Not specified	COMPLETED	Children Born With Club Feet
NCT03749265	Not specified	UNKNOWN	Rate Of Residual Clubfoot Deformity With Correlation To Absence Of Peroneus Tertius Muscle
NCT03853811	Not specified	TERMINATED	Customized Orthosis for Children With Clubfoot
NCT03953430	Not specified	COMPLETED	Gait Analysis in Children With Clubfoot Treated With Tibialis Anterior Tendon Transfer
NCT04212663	Not specified	UNKNOWN	A Study on the Treatment of Recurrent Clubfoot With the Tendon Release of Musculi Tibialis Posterior
NCT04693065	Not specified	UNKNOWN	Pronostic Factors of Long Term Outcome in Patients With Clubfoot Treated by the Ponseti Method
NCT04737083	Not specified	UNKNOWN	CGH Array in Bilateral Clubfoot
NCT04897100	Not specified	COMPLETED	Outcome After Needle vs Blade Achilles Tenotomy in Clubfoot
NCT05293743	Not specified	COMPLETED	Novel Dynamic Foot Abduction Bar for Treatment of Clubfoot
NCT05456737	Not specified	COMPLETED	Functional Assessment in Children With Clubfoot
NCT05767762	Not specified	RECRUITING	Evertor Muscle Activity as a Predictor of Achilles Tenotomy in the Management of Idiopathic Varus Equinus Clubfoot
NCT05794334	Not specified	COMPLETED	Low Dye Taping Technique Versus Robert Debre Method On Foot Posture And Range Of Motion In Children With Club Foot.
NCT05913934	Not specified	UNKNOWN	Clubfeet and Twins and Gait Analysis
NCT05957627	Not specified	UNKNOWN	Management of Congenital Talipes Equinovarus by Saleem’s Protocol
NCT06033638	Not specified	COMPLETED	Video Documented PBS-Score in Children With Clubfoot
NCT06050564	Not specified	COMPLETED	Therapeutic Recommendations Based on Clinical History and Video Documented PBS-Score
NCT06050746	Not specified	ACTIVE_NOT_RECRUITING	Predictive Value of the PBS-score in Children With Clubfoot
NCT06300645	Not specified	UNKNOWN	SPLATT to Peroneus Brevis vs TATT to Lateral Cuneiform
NCT06407739	Not specified	COMPLETED	Three Phase Physical Therapy in Children With Relapsed Club Foot After Ponseti Treatment
NCT06906406	Not specified	RECRUITING	Health-Related Quality of Life in Children and Adolescents With Clubfoot
NCT07055672	Not specified	ACTIVE_NOT_RECRUITING	Clinical Effectiveness of the Modified WalkFlex DB Splint in Children With Congenital Talipes Equinovarus (CTEV)
NCT07125794	Not specified	RECRUITING	Original Denis Brawn Brace Versus Its Modification for Management of Relapsed Idiopathic Clubfoot Following Ponseti Casting
NCT07154550	Not specified	RECRUITING	Comparing Outcomes and Complications Following Mastisol Application for Clubfoot Casting