HOXD8

Summary

HOXD8 (homeobox D8, HGNC:5139) is a protein-coding gene on chromosome 2q31.1, encoding Homeobox protein Hox-D8 (P13378). Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5’ end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.

Source: NCBI Gene 3234 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 70 total
• MANE Select transcript: NM_019558

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5139
Approved symbol	HOXD8
Name	homeobox D8
Location	2q31.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000175879
Ensembl biotype	protein_coding
OMIM	142985
Entrez	3234

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000313173, ENST00000429017, ENST00000450510, ENST00000544999

RefSeq mRNA: 3 — MANE Select: NM_019558 NM_001199746, NM_001199747, NM_019558

CCDS: CCDS2268, CCDS56148, CCDS56149

Canonical transcript exons

ENST00000313173 — 2 exons

Exon	Start	End
ENSE00001270639	176131317	176132695
ENSE00001270651	176129705	176130943

Expression profiles

Bgee: expression breadth ubiquitous, 175 present calls, max score 96.52.

FANTOM5 (CAGE): breadth broad, TPM avg 2.8038 / max 63.8744, expressed in 680 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
23848	2.0610	622
23849	0.3550	178
23852	0.1732	93
23850	0.0688	17
202482	0.0600	17
23851	0.0590	15
23846	0.0132	3
23847	0.0077	2
23845	0.0060	2

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
germinal epithelium of ovary	UBERON:0001304	96.52	gold quality
calcaneal tendon	UBERON:0003701	94.48	gold quality
adult mammalian kidney	UBERON:0000082	94.16	gold quality
kidney	UBERON:0002113	92.91	gold quality
metanephros cortex	UBERON:0010533	92.78	gold quality
corpus epididymis	UBERON:0004359	91.59	gold quality
renal medulla	UBERON:0000362	91.44	gold quality
kidney epithelium	UBERON:0004819	91.02	gold quality
cortex of kidney	UBERON:0001225	90.38	gold quality
deltoid	UBERON:0001476	89.61	gold quality
metanephros	UBERON:0000081	89.15	gold quality
secondary oocyte	CL:0000655	88.79	gold quality
tendon	UBERON:0000043	88.70	gold quality
body of uterus	UBERON:0009853	87.99	gold quality
hindlimb stylopod muscle	UBERON:0004252	87.87	gold quality
oviduct epithelium	UBERON:0004804	87.72	gold quality
left ovary	UBERON:0002119	87.40	gold quality
ovary	UBERON:0000992	87.27	gold quality
right ovary	UBERON:0002118	87.19	gold quality
adrenal tissue	UBERON:0018303	86.25	gold quality
caput epididymis	UBERON:0004358	84.74	gold quality
left adrenal gland cortex	UBERON:0035825	84.70	gold quality
left adrenal gland	UBERON:0001234	84.68	gold quality
smooth muscle tissue	UBERON:0001135	84.63	gold quality
right adrenal gland cortex	UBERON:0035827	84.33	gold quality
right testis	UBERON:0004534	84.27	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.22	gold quality
right adrenal gland	UBERON:0001233	84.22	gold quality
fallopian tube	UBERON:0003889	84.21	gold quality
adrenal gland	UBERON:0002369	83.84	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-HCAD-10	yes	20.41
E-ANND-3	yes	7.85

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

5 targets.

Target	Regulation
ANGPT2	Activation
CDKN2A
KDM1A
PROX1	Activation
TTF1

JASPAR motifs

Motif	Name	Family
MA0910.2	HOXD8	HOX
MA0910.3	HOXD8	HOX

JASPAR matrix evidence (PMIDs): PMID:18585359

Upstream regulators (CollecTRI, top): PROX1

miRNA regulators (miRDB)

73 targeting HOXD8, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-373-3P	99.84	70.68	1668
HSA-MIR-520E-3P	99.84	70.55	1698

Literature-anchored findings (GeneRIF, showing 10)

• Prox1 and HoxD8 play important roles in the maturation and maintenance of lymphatic vessels. (PMID:19825936)
• microRNA-520a-3p inhibits proliferation and cancer stem cell phenotype by targeting HOXD8 in non small cell lung cancer cells and restoration of microRNA-520a-3p might be a therapeutic strategy to reverse gefitinib resistance. (PMID:27748920)
• HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer (PMID:28457970)
• Taken together, these results suggest that HOXD8 is potentially associated with both cisplatin resistance and metastasis in advanced ovarian cancer. (PMID:30194340)
• Two transcription factors, HOXD8 and Lhx3, predicted to regulate the expression of lncRNAs, were also selected. Using RNA interference technology, HOXD8 and Lhx3 were found to positively regulate DIAPH2-AS1 and RP11-445K13.2 in HTR-8/SVneo cells (PMID:30626726)
• verified that HOXD8 was a target of miR-5692a via online prediction database and dual luciferase reporter assay (PMID:30941968)
• LINC01106 post-transcriptionally regulates ELK3 and HOXD8 to promote bladder cancer progression. (PMID:33311496)
• HOXD8 inhibits the proliferation and migration of triple-negative breast cancer cells and induces apoptosis in them through regulation of AKT/mTOR pathway. (PMID:34454307)
• HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples. (PMID:35177798)
• CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the Proliferation and Metastasis of Colorectal Cancer by Regulating HOXD8. (PMID:35426617)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Hoxd8	ENSMUSG00000027102
rattus_norvegicus	Hoxd8	ENSRNOG00000071108

Paralogs (42): HOXA11 (ENSG00000005073), HOXC8 (ENSG00000037965), HOXA1 (ENSG00000105991), HOXA2 (ENSG00000105996), HOXA3 (ENSG00000105997), HOXA5 (ENSG00000106004), HOXA6 (ENSG00000106006), HOXA13 (ENSG00000106031), TLX1 (ENSG00000107807), HOXB6 (ENSG00000108511), TLX2 (ENSG00000115297), HOXB8 (ENSG00000120068), HOXB5 (ENSG00000120075), HOXB3 (ENSG00000120093), HOXB1 (ENSG00000120094), HOXA7 (ENSG00000122592), HOXC13 (ENSG00000123364), HOXC11 (ENSG00000123388), HOXC12 (ENSG00000123407), HOXD1 (ENSG00000128645), HOXD3 (ENSG00000128652), HOXD9 (ENSG00000128709), HOXD10 (ENSG00000128710), HOXD11 (ENSG00000128713), HOXD13 (ENSG00000128714), PDX1 (ENSG00000139515), HOXB13 (ENSG00000159184), TLX3 (ENSG00000164438), HOXD4 (ENSG00000170166), HOXD12 (ENSG00000170178), HOXB9 (ENSG00000170689), HOXC5 (ENSG00000172789), HOXB2 (ENSG00000173917), GSX2 (ENSG00000180613), HOXC9 (ENSG00000180806), HOXC10 (ENSG00000180818), HOXB4 (ENSG00000182742), HOXA4 (ENSG00000197576), HOXC6 (ENSG00000197757), HOXC4 (ENSG00000198353)

Protein

Protein identifiers

Homeobox protein Hox-D8 — P13378 (reviewed: P13378)

Alternative names: Homeobox protein Hox-4E, Homeobox protein Hox-5.4

All UniProt accessions (3): A0A0A0MSX5, A0A0A0MTF4, P13378

UniProt curated annotations — full annotation on UniProt →

Function. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location. Nucleus.

Similarity. Belongs to the Antp homeobox family.

Isoforms (3)

UniProt ID	Names	Canonical?
P13378-1	1	yes
P13378-2	2
P13378-3	3

RefSeq proteins (3): NP_001186675, NP_001186676, NP_062458* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001356	HD	Domain
IPR001827	Homeobox_Antennapedia_CS	Conserved_site
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017970	Homeobox_CS	Conserved_site
IPR020479	HD_metazoa	Domain
IPR050948	Antp_homeobox_TF	Family

Pfam: PF00046

UniProt features (13 total): splice variant 3, region of interest 3, compositionally biased region 3, sequence conflict 2, chain 1, DNA-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P13378-F1	63.28	0.22

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 144 (showing top): ATF_B, WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN, BENPORATH_ES_WITH_H3K27ME3, GOBP_AXIS_SPECIFICATION, WWTAAGGC_UNKNOWN, TSENG_IRS1_TARGETS_UP, GOBP_SKELETAL_SYSTEM_DEVELOPMENT, GOBP_EMBRYONIC_AXIS_SPECIFICATION, NKX25_02, TGCACTT_MIR519C_MIR519B_MIR519A, AREB6_01, CREBP1_Q2, NKX61_01, PAX8_B, GOBP_ANIMAL_ORGAN_MORPHOGENESIS

GO Biological Process (7): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), anterior/posterior axis specification, embryo (GO:0008595), positive regulation of transcription by RNA polymerase II (GO:0045944), skeletal system morphogenesis (GO:0048705), regulation of DNA-templated transcription (GO:0006355), anterior/posterior pattern specification (GO:0009952)

GO Molecular Function (7): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), protein binding (GO:0005515)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of transcription by RNA polymerase II	3
transcription by RNA polymerase II	3
regulation of DNA-templated transcription	2
transcription cis-regulatory region binding	2
RNA polymerase II transcription regulatory region sequence-specific DNA binding	2
negative regulation of DNA-templated transcription	1
embryonic axis specification	1
tripartite regional subdivision	1
anterior/posterior axis specification	1
positive regulation of DNA-templated transcription	1
skeletal system development	1
animal organ morphogenesis	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
regionalization	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
transcription regulator activity	1
binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

816 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HOXD8	HOXB5	P09067	545
HOXD8	CRIP3	Q6Q6R5	538
HOXD8	HOXA9	P31269	523
HOXD8	HOXA3	O43365	510
HOXD8	HOXB4	P17483	489
HOXD8	SUZ12	Q15022	468
HOXD8	HOXA6	P31267	452
HOXD8	HOXC9	P31274	409
HOXD8	ISL1	P20663	403
HOXD8	TBX15	Q96SF7	399
HOXD8	COL2A1	P02458	385
HOXD8	HOXC4	P09017	383
HOXD8	EVX2	Q03828	367
HOXD8	HOXD1	Q9GZZ0	363
HOXD8	HOXD13	P35453	357

IntAct

21 interactions, top by confidence:

A	B	Type	Score
HOXD8	BAIAP2	psi-mi:“MI:0915”(physical association)	0.560
HOXD8	LDLRAP1	psi-mi:“MI:0915”(physical association)	0.560
NCK2	HOXD8	psi-mi:“MI:0915”(physical association)	0.560
IFNA10	HOXD8	psi-mi:“MI:0915”(physical association)	0.370
ANXA7	HOXD8	psi-mi:“MI:0915”(physical association)	0.370
HOXD8	CDKN1A	psi-mi:“MI:0915”(physical association)	0.370
PFDN1	HOXD8	psi-mi:“MI:0915”(physical association)	0.370
HOXD8	RCC1	psi-mi:“MI:0915”(physical association)	0.370
	LPXN	psi-mi:“MI:0915”(physical association)	0.370
	HOXD8	psi-mi:“MI:0915”(physical association)	0.370
HOXD8		psi-mi:“MI:0915”(physical association)	0.370
LDLRAP1	HOXD8	psi-mi:“MI:0915”(physical association)	0.000
BAIAP2	HOXD8	psi-mi:“MI:0915”(physical association)	0.000
NCK2	HOXD8	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (14): HOXD8 (Two-hybrid), HOXD8 (Two-hybrid), HOXD8 (Two-hybrid), HOXD8 (Reconstituted Complex), HOXD8 (Proximity Label-MS), HOXD8 (Proximity Label-MS), HOXD8 (Proximity Label-MS), HOXD8 (Proximity Label-MS), HOXD8 (Proximity Label-MS), HOXD8 (Two-hybrid), HOXD8 (Two-hybrid), HOXD8 (Two-hybrid), HOXD8 (Two-hybrid), HOXD8 (Two-hybrid)

ESM2 similar proteins: A1YER7, A1YF08, A1YFD8, A1YFY3, A1YG01, A1YG85, A2D4P8, A2D4R4, A2D5I1, A2D649, A2T6H5, A2T6X6, A2T6Z0, A2T748, A2T756, A2T7H5, A2T7J2, P06798, P09016, P09017, P09023, P09024, P10284, P10628, P13378, P14653, P17277, P17483, P17509, P18111, P18864, P23463, P23813, P31259, P31275, P31276, P31277, P31310, P47902, P50207

Diamond homologs: A1YER7, A1YFA5, A1YFD8, A1YFY3, A1YGK7, A2D4P8, A2D5I1, A2D5K9, A2D5Y4, A2T6X6, A2T748, A2T7F3, O42504, O57374, P02830, P02832, P02833, P04476, P09013, P09014, P09016, P09019, P09021, P09023, P09024, P09025, P09067, P09071, P09074, P09077, P09079, P09080, P09092, P09629, P09630, P09632, P09634, P09636, P10284, P10628

SIGNOR signaling

0 interactions.

Disease & clinical

Cancer significance

Clinical variants and AI predictions

ClinVar

70 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	64
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

208 predictions. Top by Δscore:

Variant	Effect	Δscore
2:176131311:A:AG	acceptor_gain	0.9800
2:176131316:GCA:G	acceptor_gain	0.9700
2:176131315:A:AG	acceptor_gain	0.9500
2:176131316:G:GG	acceptor_gain	0.9500
2:176131305:T:A	acceptor_gain	0.9400
2:176130869:A:AG	donor_gain	0.9300
2:176131316:GC:G	acceptor_gain	0.9300
2:176131312:A:G	acceptor_gain	0.9100
2:176131312:ATCAG:A	acceptor_loss	0.9000
2:176131313:TCAGC:T	acceptor_loss	0.9000
2:176131316:GCAG:G	acceptor_loss	0.9000
2:176131318:A:AG	acceptor_gain	0.8700
2:176131319:G:GG	acceptor_gain	0.8700
2:176131316:GCAGC:G	acceptor_gain	0.8300
2:176131317:CAGCT:C	acceptor_loss	0.8300
2:176131318:AGCTC:A	acceptor_loss	0.8300
2:176131319:G:GT	acceptor_loss	0.8300
2:176129788:C:A	donor_gain	0.8200
2:176131319:GCTC:G	acceptor_gain	0.8200
2:176130863:GTG:G	donor_gain	0.8100
2:176130939:ACAAG:A	donor_loss	0.8100
2:176130940:CAAG:C	donor_loss	0.8100
2:176130941:AAGGT:A	donor_loss	0.8100
2:176130942:AGGT:A	donor_loss	0.8100
2:176130943:GGTT:G	donor_loss	0.8100
2:176129787:T:TA	donor_gain	0.7900
2:176130862:AGT:A	donor_gain	0.7900
2:176131313:T:G	acceptor_gain	0.7700
2:176130837:AC:A	donor_gain	0.7500
2:176129809:C:T	donor_gain	0.7400

AlphaMissense

1891 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:176130928:T:A	W188R	1.000
2:176130928:T:C	W188R	1.000
2:176130932:T:C	M189T	1.000
2:176131349:T:C	Y204H	1.000
2:176131349:T:G	Y204D	1.000
2:176131350:A:G	Y204C	1.000
2:176131363:A:C	Q208H	1.000
2:176131363:A:T	Q208H	1.000
2:176131368:T:C	L210P	1.000
2:176131374:T:C	L212S	1.000
2:176131374:T:G	L212W	1.000
2:176131377:A:T	E213V	1.000
2:176131378:A:C	E213D	1.000
2:176131378:A:T	E213D	1.000
2:176131385:T:C	F216L	1.000
2:176131386:T:C	F216S	1.000
2:176131386:T:G	F216C	1.000
2:176131387:T:A	F216L	1.000
2:176131387:T:G	F216L	1.000
2:176131404:T:C	L222P	1.000
2:176131410:G:T	R224M	1.000
2:176131420:A:C	R227S	1.000
2:176131420:A:T	R227S	1.000
2:176131430:T:C	S231P	1.000
2:176131446:T:A	L236H	1.000
2:176131446:T:C	L236P	1.000
2:176131452:A:T	E238V	1.000
2:176131459:G:C	Q240H	1.000
2:176131459:G:T	Q240H	1.000
2:176131463:A:G	K242E	1.000

dbSNP variants (sampled 300 via entrez): RS1001383013 (2:176130269 G>C,T), RS1001595837 (2:176132415 C>A), RS1002199988 (2:176130834 G>A), RS1002420999 (2:176129922 T>A,C), RS1003391653 (2:176132997 C>G,T), RS1003439768 (2:176129530 A>C,G), RS1003494706 (2:176129151 A>C), RS1003607288 (2:176129183 A>G), RS1003829582 (2:176128942 C>T), RS1004662749 (2:176128819 T>A,G), RS1004695280 (2:176129050 G>C,T), RS1004757602 (2:176128579 G>C), RS1004780332 (2:176130497 ACGC>A,ACGCCGC,ACGCCGCCGC), RS1004831110 (2:176130684 G>GGCC), RS1005917749 (2:176128660 C>T)

Disease associations

OMIM: gene MIM:142985 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST004292_43	Glomerular filtration rate (creatinine)	5.000000e-10
GCST006661_148	Male-pattern baldness	3.000000e-18
GCST007344_32	Estimated glomerular filtration rate	1.000000e-09
GCST007876_9	Estimated glomerular filtration rate	1.000000e-14
GCST008058_51	Estimated glomerular filtration rate	8.000000e-30
GCST008059_136	Estimated glomerular filtration rate	6.000000e-30
GCST008062_101	Blood urea nitrogen levels	3.000000e-06
GCST008064_27	Chronic kidney disease	3.000000e-10
GCST008971_140	Urate levels	3.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
urushiol	decreases expression	1
methylselenic acid	increases expression	1
ascorbate-2-phosphate	increases expression, affects binding, affects cotreatment	1
terbufos	increases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	affects methylation	1
aflatoxin B2	increases methylation	1
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid	increases expression, affects cotreatment	1
brequinar	decreases expression	1
perfluorooctane sulfonic acid	increases expression	1
perfluoro-n-nonanoic acid	increases expression	1
Chir 99021	affects binding, affects cotreatment, increases expression	1
XAV939	affects binding, affects cotreatment, increases expression	1
3-(4-pyridyl)-1H-indole	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Arsenic Trioxide	increases expression	1
Ascorbic Acid	affects binding, affects cotreatment, increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Fonofos	increases methylation	1
Hydrocortisone	affects cotreatment, increases expression	1
Parathion	increases methylation	1
Silicon Dioxide	decreases expression	1
Triclosan	increases expression	1
Valproic Acid	increases methylation	1
Aflatoxin B1	decreases methylation	1
Asbestos, Crocidolite	decreases methylation	1
Asbestos, Amosite	decreases methylation	1
Antirheumatic Agents	increases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.