HPN-AS1

Summary

HPN-AS1 (HPN antisense RNA 1, HGNC:47041) is a long non-coding RNA gene on chromosome 19q13.11-q13.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:47041
Approved symbol	HPN-AS1
Name	HPN antisense RNA 1
Location	19q13.11-q13.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227392
Ensembl biotype	lncRNA
Entrez	100128675
RNAcentral	URS000075C3F8 — lncRNA, 3681 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 32 — 32 lncRNA

ENST00000392227, ENST00000653822, ENST00000666194, ENST00000668923, ENST00000702186, ENST00000796454, ENST00000796455, ENST00000796456, ENST00000796457, ENST00000796458, ENST00000796459, ENST00000796460, ENST00000796461, ENST00000796462, ENST00000796463, ENST00000796464, ENST00000796465, ENST00000796466, ENST00000796467, ENST00000796468, ENST00000796469, ENST00000796470, ENST00000796471, ENST00000796472, ENST00000796473, ENST00000796474, ENST00000796475, ENST00000796476, ENST00000796477, ENST00000796478, ENST00000796479, ENST00000796480

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000392227 — 4 exons

Exon	Start	End
ENSE00001640812	35059059	35059778
ENSE00001717627	35086956	35087100
ENSE00001734432	35106229	35106304
ENSE00001800252	35099205	35099387

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 85.26.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.8437 / max 104.7166, expressed in 68 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180479	0.5162	65
180480	0.2654	60
180481	0.0622	38

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	85.26	gold quality
liver	UBERON:0002107	85.20	gold quality
body of pancreas	UBERON:0001150	79.39	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.03	silver quality
cortex of kidney	UBERON:0001225	75.07	gold quality
metanephros cortex	UBERON:0010533	75.02	gold quality
substantia nigra	UBERON:0002038	73.87	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	73.26	gold quality
Ammon’s horn	UBERON:0001954	72.31	gold quality
kidney	UBERON:0002113	71.70	gold quality
pancreas	UBERON:0001264	71.59	gold quality
adult mammalian kidney	UBERON:0000082	70.81	gold quality
corpus callosum	UBERON:0002336	70.16	gold quality
primary visual cortex	UBERON:0002436	69.83	gold quality
putamen	UBERON:0001874	68.24	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.76	gold quality
temporal lobe	UBERON:0001871	67.74	gold quality
amygdala	UBERON:0001876	67.67	gold quality
gastrocnemius	UBERON:0001388	66.34	gold quality
prefrontal cortex	UBERON:0000451	65.77	gold quality
muscle of leg	UBERON:0001383	65.56	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.21	gold quality
body of stomach	UBERON:0001161	64.89	gold quality
skeletal muscle tissue	UBERON:0001134	64.64	gold quality
cerebral cortex	UBERON:0000956	64.61	gold quality
frontal cortex	UBERON:0001870	64.41	gold quality
hypothalamus	UBERON:0001898	63.97	gold quality
muscle tissue	UBERON:0002385	63.76	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.48	gold quality
stomach	UBERON:0000945	63.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.13

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.