HSBP1

Summary

HSBP1 (heat shock factor binding protein 1, HGNC:5203) is a protein-coding gene on chromosome 16q23.3, encoding Heat shock factor-binding protein 1 (O75506). Negative regulator of the heat shock response.

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.

Source: NCBI Gene 3281 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 22 total
• MANE Select transcript: NM_001537

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5203
Approved symbol	HSBP1
Name	heat shock factor binding protein 1
Location	16q23.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000230989
Ensembl biotype	protein_coding
OMIM	604553
Entrez	3281

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 7 protein_coding, 4 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000433866, ENST00000567382, ENST00000569301, ENST00000570259, ENST00000685468, ENST00000685807, ENST00000689426, ENST00000690173, ENST00000693379, ENST00000693758, ENST00000959458, ENST00000959459, ENST00000959460

RefSeq mRNA: 1 — MANE Select: NM_001537 NM_001537

CCDS: CCDS45534

Canonical transcript exons

ENST00000433866 — 4 exons

Exon	Start	End
ENSE00001103920	83808680	83808746
ENSE00002576831	83807978	83808121
ENSE00002581925	83811421	83819737
ENSE00003599662	83809305	83809425

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.19.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 148.1477 / max 1945.4391, expressed in 1826 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155263	145.7440	1825
155262	2.4037	1334

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oral cavity	UBERON:0000167	99.19	gold quality
bronchial epithelial cell	CL:0002328	99.14	gold quality
epithelium of bronchus	UBERON:0002031	99.06	gold quality
ganglionic eminence	UBERON:0004023	99.04	gold quality
bronchus	UBERON:0002185	98.95	gold quality
embryo	UBERON:0000922	98.94	gold quality
ventricular zone	UBERON:0003053	98.80	gold quality
adult organism	UBERON:0007023	98.73	gold quality
endometrium epithelium	UBERON:0004811	98.69	gold quality
pharyngeal mucosa	UBERON:0000355	98.68	gold quality
stromal cell of endometrium	CL:0002255	98.45	gold quality
adrenal tissue	UBERON:0018303	98.39	gold quality
tongue squamous epithelium	UBERON:0006919	98.28	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.26	gold quality
cortical plate	UBERON:0005343	98.09	gold quality
endothelial cell	CL:0000115	98.00	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.91	gold quality
cranial nerve II	UBERON:0000941	97.86	gold quality
left testis	UBERON:0004533	97.83	gold quality
spinal cord	UBERON:0002240	97.77	gold quality
right testis	UBERON:0004534	97.77	gold quality
type B pancreatic cell	CL:0000169	97.71	gold quality
heart right ventricle	UBERON:0002080	97.71	gold quality
body of tongue	UBERON:0011876	97.71	gold quality
medial globus pallidus	UBERON:0002477	97.67	gold quality
monocyte	CL:0000576	97.63	gold quality
nasal cavity mucosa	UBERON:0001826	97.63	gold quality
mucosa of paranasal sinus	UBERON:0005030	97.63	gold quality
lower esophagus mucosa	UBERON:0035834	97.59	gold quality
nasal cavity epithelium	UBERON:0005384	97.58	gold quality

Single-cell (SCXA)

Detected in 9 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-HCAD-4	yes	62.84
E-HCAD-1	yes	28.23
E-MTAB-10287	yes	25.46
E-MTAB-10042	yes	11.70
E-CURD-112	yes	4.25
E-MTAB-9388	no	2931.54
E-HCAD-30	no	202.23
E-HCAD-5	no	10.18
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

103 targeting HSBP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-3151-5P	99.86	63.83	1069
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349

Literature-anchored findings (GeneRIF, showing 10)

• HSBP likely mediates its function through its trimerization domain. (PMID:11679589)
• This study reports the crystal structure of a degradation-resistant fragment of HSBP1. A continuous, long-helix conformation of HSBP1 assembles into a coiled-coil three-helix bundle and subsequently into an elongated, symmetrical hexamer. (PMID:18767159)
• HspBP1 inhibited the cytotoxic activity of the Tag7-Hsp70 complex secreted by lymphocytes. HspBP1 (PMID:21247889)
• HSBP1 is crucial for regulating resistance to radiotherapy of oral squamous epithelial carcinoma cells by inducing stem-like status. (PMID:24816843)
• Results presented here show that acquisition of a positive charge in HSBP1, either by protonation of His124 or its substitution by lysine, reduces the stability of the dimer interface of the alpha-crystallin domain, increases oligomeric size, and modestly increases chaperone activity. (PMID:28332148)
• HSPB1 protects cells against proapoptotic agents when expressed at high level, while inhibition of its expression has been found to predispose cells to apoptosis. (PMID:28828227)
• the armadillo-type NEFs budding yeast Fes1 and its human homolog HspBP1 employ flexible N-terminal release domains (RDs) with substrate-mimicking properties to ensure the efficient release of persistent substrates from Hsp70 (PMID:29323280)
• Here, we identify the small coiled-coil protein HSBP1 as a factor that specifically promotes the assembly of a ternary complex composed of CCDC53, WASH, and FAM21 by dissociating the CCDC53 homotrimeric precursor. HSBP1 operates at the centrosome, which concentrates the building blocks. (PMID:29844016)
• The functional HSPB1 rs2868371 promoter variant may affect lung cancer survival by regulation of HSPB1 expression levels through glucocorticoid receptor interaction. (PMID:31015126)
• Lin28A Regulates Stem-like Properties of Ovarian Cancer Cells by Enriching RAN and HSBP1 mRNA and Up-regulating its Protein Expression. (PMID:32398961)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	hsbp1b	ENSDARG00000041921
danio_rerio	hsbp1a	ENSDARG00000069425
mus_musculus	Hsbp1	ENSMUSG00000031839
rattus_norvegicus	Hsbp1	ENSRNOG00000014415
drosophila_melanogaster	CG5446	FBGN0032429
caenorhabditis_elegans		WBGENE00002002

Paralogs (1): HSBP1L1 (ENSG00000226742)

Protein

Protein identifiers

Heat shock factor-binding protein 1 — O75506 (reviewed: O75506)

Alternative names: Nasopharyngeal carcinoma-associated antigen 13

All UniProt accessions (3): A0A8I5KTJ3, A0A8I5KYC9, O75506

UniProt curated annotations — full annotation on UniProt →

Function. Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.

Subunit / interactions. Homohexamer. Associates with heptad repeats of HSF1 trimers and probably also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.

Subcellular location. Nucleus.

Similarity. Belongs to the HSBP1 family.

RefSeq proteins (1): NP_001528* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009643	HS1-bd	Family

Pfam: PF06825

UniProt features (8 total): mutagenesis site 4, sequence conflict 2, chain 1, helix 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
3CI9	X-RAY DIFFRACTION	1.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75506-F1	87.35	0.68

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (4):

Position	Phenotype
16	loss of interaction with hsf1; in association with k-19.
19	loss of interaction with hsf1; in association with k-16.
45	loss of interaction with hsf1; in association with k-48.
48	loss of interaction with hsf1; in association with k-45.

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-3371511	HSF1 activation
R-HSA-3371568	Attenuation phase
R-HSA-3371571	HSF1-dependent transactivation

MSigDB gene sets: 224 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_DN, SHEPARD_BMYB_MORPHOLINO_UP, MORF_MBD4, GOBP_AXO_DENDRITIC_TRANSPORT, MORF_RAB5A, GOBP_FORMATION_OF_PRIMARY_GERM_LAYER, MODULE_151, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_DN, GOBP_ORGANELLE_TRANSPORT_ALONG_MICROTUBULE, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, MORF_PSMC2, MORF_SKP1A, GOBP_MUSCLE_CONTRACTION

GO Biological Process (6): negative regulation of transcription by RNA polymerase II (GO:0000122), muscle contraction (GO:0006936), axonal transport of mitochondrion (GO:0019896), endodermal cell differentiation (GO:0035987), cellular heat acclimation (GO:0070370), negative regulation of DNA-templated transcription (GO:0045892)

GO Molecular Function (3): transcription corepressor activity (GO:0003714), identical protein binding (GO:0042802), protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829), axon cytoplasm (GO:1904115)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Cellular response to heat stress	2
HSF1-dependent transactivation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
negative regulation of DNA-templated transcription	2
cellular anatomical structure	2
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
muscle system process	1
mitochondrion transport along microtubule	1
axonal transport	1
axon cytoplasm	1
endoderm formation	1
cell differentiation	1
heat acclimation	1
cellular response to heat	1
DNA-templated transcription	1
regulation of DNA-templated transcription	1
negative regulation of RNA biosynthetic process	1
transcription coregulator activity	1
protein binding	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasm	1
axon	1
neuron projection cytoplasm	1

Protein interactions and networks

STRING

570 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HSBP1	HSPA4	P34932	693
HSBP1	WASHC3	Q9Y3C0	496
HSBP1	IREB2	P48200	463
HSBP1	STOML2	Q9UJZ1	447
HSBP1	LPCAT3	Q6P1A2	442
HSBP1	SMS	P52788	437
HSBP1	ARPP19	P56211	433
HSBP1	HSPH1	Q92598	423
HSBP1	CARS1	P49589	413
HSBP1	LAMTOR1	Q6IAA8	410
HSBP1	UCHL3	P15374	410
HSBP1	CARS2	Q9HA77	409
HSBP1	GAPT	Q8N292	398
HSBP1	OTUD6A	Q7L8S5	393
HSBP1	PSMD4	P55036	392

IntAct

169 interactions, top by confidence:

A	B	Type	Score
ATG101	ATG13	psi-mi:“MI:0914”(association)	0.950
WASHC3	HSBP1	psi-mi:“MI:0915”(physical association)	0.940
HSBP1	WASHC3	psi-mi:“MI:0915”(physical association)	0.940
ATG13	ULK1	psi-mi:“MI:2364”(proximity)	0.940
RB1CC1	ATG13	psi-mi:“MI:0914”(association)	0.820
HSBP1	LNX1	psi-mi:“MI:0915”(physical association)	0.780
HSBP1	BRK1	psi-mi:“MI:0915”(physical association)	0.740
BRK1	HSBP1	psi-mi:“MI:0914”(association)	0.740
HSBP1	SDCBP	psi-mi:“MI:0915”(physical association)	0.720
SDCBP	HSBP1	psi-mi:“MI:0915”(physical association)	0.720
HSBP1	CCHCR1	psi-mi:“MI:0915”(physical association)	0.720

BioGRID (91): HSBP1 (Two-hybrid), KIFC3 (Two-hybrid), SDCBP (Two-hybrid), CCDC53 (Two-hybrid), CCHCR1 (Two-hybrid), KIAA1217 (Two-hybrid), LNX1 (Two-hybrid), KRTAP10-7 (Two-hybrid), KRTAP10-3 (Two-hybrid), NOTCH2NL (Two-hybrid), HSBP1 (Affinity Capture-MS), HSBP1 (Affinity Capture-MS), CCDC53 (Two-hybrid), HSBP1 (Affinity Capture-MS), HSBP1 (Proximity Label-MS)

ESM2 similar proteins: B2RXB2, B5X3I1, C9JCN9, D4A7N1, D4A9E1, O75506, P58686, Q0P4J3, Q0VCF3, Q13503, Q2NKS9, Q3TY65, Q3ZC22, Q4R6N3, Q4V7L5, Q5E9D3, Q5EAU9, Q5FWT9, Q5R561, Q5R8J5, Q5RDI2, Q5RE46, Q5RGJ6, Q5ZKJ4, Q66H15, Q68EW7, Q6DF11, Q6ID77, Q6IP02, Q6P255, Q6TA25, Q7SYL1, Q7T338, Q8AVR2, Q8GW48, Q8K3X8, Q8R0H9, Q99LE1, Q9BRQ6, Q9BRV8

Diamond homologs: O75506, Q3ZC22, Q5RDI2, Q8K3X8, Q9CQZ1, Q8GW48

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
HSBP1	“up-regulates quantity”	“WASH complex”	relocalization
HSBP1	“down-regulates activity”	HSF1	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 96 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
mitotic spindle organization	5	16.4×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

22 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	12
Likely benign	1
Benign	6

Top pathogenic / likely-pathogenic (0)

SpliceAI

1834 predictions. Top by Δscore:

Variant	Effect	Δscore
16:83748107:GGT:G	acceptor_gain	1.0000
16:83748246:CAGTG:C	donor_gain	1.0000
16:83748248:GTG:G	donor_gain	1.0000
16:83748249:TG:T	donor_gain	1.0000
16:83748250:GG:G	donor_gain	1.0000
16:83748251:G:C	donor_loss	1.0000
16:83748251:G:GG	donor_gain	1.0000
16:83748252:TGA:T	donor_loss	1.0000
16:83748253:GAG:G	donor_loss	1.0000
16:83748254:AGT:A	donor_loss	1.0000
16:83779962:CCACA:C	acceptor_loss	1.0000
16:83779963:CACA:C	acceptor_loss	1.0000
16:83779964:ACAGG:A	acceptor_loss	1.0000
16:83779965:CA:C	acceptor_loss	1.0000
16:83779966:A:AG	acceptor_gain	1.0000
16:83779966:AGGCA:A	acceptor_loss	1.0000
16:83779967:G:GA	acceptor_gain	1.0000
16:83779967:GGC:G	acceptor_gain	1.0000
16:83779967:GGCA:G	acceptor_gain	1.0000
16:83780197:CAACA:C	donor_gain	1.0000
16:83780198:AACA:A	donor_gain	1.0000
16:83780199:ACA:A	donor_gain	1.0000
16:83780200:CA:C	donor_gain	1.0000
16:83780201:AGT:A	donor_loss	1.0000
16:83780202:G:GG	donor_gain	1.0000
16:83780202:GTAA:G	donor_loss	1.0000
16:83780203:T:G	donor_loss	1.0000
16:83783469:GCTT:G	donor_gain	1.0000
16:83811490:C:G	donor_gain	1.0000
16:83748103:TTCA:T	acceptor_loss	0.9900

AlphaMissense

516 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:83809335:T:C	L48P	1.000
16:83808693:T:C	L20P	0.999
16:83808725:T:C	S31P	0.999
16:83808732:A:C	Q33P	0.999
16:83809335:T:A	L48Q	0.999
16:83808690:T:C	L19P	0.998
16:83808713:T:C	F27L	0.998
16:83808714:T:C	F27S	0.998
16:83808715:T:A	F27L	0.998
16:83808715:T:G	F27L	0.998
16:83808735:T:G	I34S	0.998
16:83809323:G:C	R44P	0.998
16:83809338:A:T	E49V	0.998
16:83809356:T:C	L55P	0.998
16:83808717:A:C	Q28P	0.997
16:83808735:T:C	I34T	0.997
16:83809315:G:A	M41I	0.997
16:83809315:G:C	M41I	0.997
16:83809315:G:T	M41I	0.997
16:83809349:G:C	A53P	0.997
16:83809356:T:A	L55H	0.997
16:83809367:G:C	A59P	0.997
16:83808693:T:A	L20Q	0.996
16:83808726:C:T	S31F	0.996
16:83808735:T:A	I34N	0.996
16:83808745:A:C	R37S	0.996
16:83808745:A:T	R37S	0.996
16:83809314:T:G	M41R	0.996
16:83808111:T:C	L12P	0.995
16:83808702:T:G	M23R	0.995

dbSNP variants (sampled 300 via entrez): RS1000119018 (16:83814234 C>A,G,T), RS1000173691 (16:83817196 T>A,C,G), RS1000238678 (16:83814466 A>G), RS1000719161 (16:83813281 C>G), RS1000739928 (16:83808322 C>A,G), RS1001016509 (16:83819799 A>G,T), RS1001161436 (16:83818283 C>G,T), RS1001277471 (16:83818093 G>A), RS1001277850 (16:83815602 C>T), RS1001338304 (16:83815219 T>G), RS1001901270 (16:83810961 CAG>C), RS1001932175 (16:83811153 A>G), RS1002013523 (16:83815165 G>A), RS1002054700 (16:83817143 C>T), RS1002087343 (16:83812711 A>C,G)

Disease associations

OMIM: gene MIM:604553 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST002935_4	Lead levels	3.000000e-07
GCST003830_25	Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1)	4.000000e-07
GCST003830_5	Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1)	9.000000e-08
GCST004097_3	Response to platinum-based neoadjuvant chemotherapy in cervical cancer	3.000000e-06
GCST009391_1747	Metabolite levels	7.000000e-08
GCST009391_2015	Metabolite levels	2.000000e-06
GCST009391_276	Metabolite levels	2.000000e-06

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0005921	FEV change measurement
EFO:0007943	response to platinum-based neoadjuvant chemotherapy
EFO:0010349	cholesteryl ester 20:5 measurement
EFO:0010348	cholesteryl ester 20:4 measurement
EFO:0010495	guanosine monophosphate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects expression, decreases expression	3
Valproic Acid	affects cotreatment, increases expression, affects expression, decreases expression	3
trichostatin A	affects cotreatment, decreases expression	2
Benzo(a)pyrene	decreases expression, decreases methylation, increases methylation	2
aristolochic acid I	increases expression	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
terbufos	increases methylation	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
sodium arsenite	increases expression	1
cobaltous chloride	decreases expression	1
indirubin	decreases expression	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
Resveratrol	affects cotreatment, increases expression	1
Fonofos	increases methylation	1
Gold	decreases expression	1
Hydralazine	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Methylcholanthrene	affects binding, increases reaction	1
Parathion	increases methylation	1
Piroxicam	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Tetrachlorodibenzodioxin	decreases expression	1
Tretinoin	increases expression	1
Cyclosporine	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.