HSD11B1-AS1

Summary

HSD11B1-AS1 (HSD11B1 antisense RNA 1, HGNC:54053) is a long non-coding RNA gene on chromosome 1q32.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54053
Approved symbol	HSD11B1-AS1
Name	HSD11B1 antisense RNA 1
Location	1q32.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227591
Ensembl biotype	lncRNA
Entrez	101930114
RNAcentral	URS0000A76C2E — lncRNA, 456 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000441672, ENST00000445272, ENST00000774900, ENST00000774901, ENST00000774902, ENST00000774903, ENST00000774904, ENST00000774905, ENST00000774906, ENST00000774907, ENST00000774908, ENST00000774909, ENST00000774910, ENST00000774911

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000441672 — 4 exons

Exon	Start	End
ENSE00001604203	209662911	209663061
ENSE00004141172	209757476	209757643
ENSE00004141179	209661364	209661567
ENSE00004141190	209724030	209724144

Expression profiles

Bgee: expression breadth ubiquitous, 171 present calls, max score 91.48.

FANTOM5 (CAGE): breadth broad, TPM avg 2.4846 / max 1316.9099, expressed in 227 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
17293	0.9774	64
17295	0.5670	134
17294	0.4418	64
17290	0.2098	33
17289	0.1320	32
17291	0.0864	13
17298	0.0417	18
17292	0.0285	5

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adipose tissue	UBERON:0001013	91.48	gold quality
subcutaneous adipose tissue	UBERON:0002190	91.36	gold quality
adipose tissue of abdominal region	UBERON:0007808	87.38	gold quality
omental fat pad	UBERON:0010414	86.75	gold quality
peritoneum	UBERON:0002358	86.63	gold quality
gastrocnemius	UBERON:0001388	84.62	gold quality
muscle of leg	UBERON:0001383	84.29	gold quality
colonic epithelium	UBERON:0000397	82.74	gold quality
oocyte	CL:0000023	82.26	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.75	gold quality
cardiac muscle of right atrium	UBERON:0003379	81.65	gold quality
vastus lateralis	UBERON:0001379	81.64	silver quality
quadriceps femoris	UBERON:0001377	81.48	silver quality
left adrenal gland cortex	UBERON:0035825	81.42	gold quality
kidney epithelium	UBERON:0004819	81.40	gold quality
left ventricle myocardium	UBERON:0006566	80.89	gold quality
left adrenal gland	UBERON:0001234	80.57	gold quality
right adrenal gland	UBERON:0001233	79.91	gold quality
right lobe of liver	UBERON:0001114	79.65	gold quality
secondary oocyte	CL:0000655	78.74	gold quality
right adrenal gland cortex	UBERON:0035827	78.74	gold quality
adrenal cortex	UBERON:0001235	78.34	gold quality
biceps brachii	UBERON:0001507	77.58	silver quality
skeletal muscle tissue	UBERON:0001134	76.98	gold quality
adrenal gland	UBERON:0002369	76.39	gold quality
thoracic mammary gland	UBERON:0005200	76.38	gold quality
metanephros cortex	UBERON:0010533	76.18	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	76.17	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	76.15	silver quality
muscle tissue	UBERON:0002385	76.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• G0S2 regulates innate immunity in Kawasaki disease via lncRNA HSD11B1-AS1. (PMID:35292727)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.