HSD17B3-AS1

Summary

HSD17B3-AS1 (HSD17B3 antisense RNA 1, HGNC:53136) is a long non-coding RNA gene on chromosome 9q22.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53136
Approved symbol	HSD17B3-AS1
Name	HSD17B3 antisense RNA 1
Location	9q22.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	ENST00000448857
Ensembl gene	ENSG00000232283
Ensembl biotype	lncRNA
Entrez	105376162
RNAcentral	URS0000BC456B — lncRNA, 939 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000448857, ENST00000749286

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000448857 — 3 exons

Exon	Start	End
ENSE00001659139	96249583	96250393
ENSE00001684223	96247223	96247335
ENSE00001697009	96246462	96246609

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 84.83.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0186 / max 5.0239, expressed in 10 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
97521	0.0186	10

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.83	silver quality
liver	UBERON:0002107	60.57	gold quality
right lobe of liver	UBERON:0001114	60.32	gold quality
right testis	UBERON:0004534	59.21	gold quality
testis	UBERON:0000473	57.80	gold quality
left testis	UBERON:0004533	57.80	gold quality
hindlimb stylopod muscle	UBERON:0004252	55.35	gold quality
primary visual cortex	UBERON:0002436	54.35	gold quality
prefrontal cortex	UBERON:0000451	54.22	gold quality
duodenum	UBERON:0002114	53.68	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	53.50	gold quality
heart left ventricle	UBERON:0002084	52.72	gold quality
substantia nigra	UBERON:0002038	51.23	gold quality
heart	UBERON:0000948	51.22	gold quality
right lung	UBERON:0002167	50.31	gold quality
right atrium auricular region	UBERON:0006631	50.20	gold quality
tibial nerve	UBERON:0001323	49.98	gold quality
monocyte	CL:0000576	49.73	gold quality
pancreas	UBERON:0001264	49.71	gold quality
body of pancreas	UBERON:0001150	49.59	gold quality
islet of Langerhans	UBERON:0000006	49.19	silver quality
blood	UBERON:0000178	49.14	silver quality
muscle of leg	UBERON:0001383	48.87	gold quality
frontal cortex	UBERON:0001870	48.28	gold quality
gastrocnemius	UBERON:0001388	48.03	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	47.74	gold quality
gall bladder	UBERON:0002110	47.20	gold quality
multicellular organism	UBERON:0000468	47.03	gold quality
endocervix	UBERON:0000458	47.01	gold quality
Ammon’s horn	UBERON:0001954	46.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Role of Long Non-coding RNA HSD17B3-AS1 in Trauma for COVID-19. (PMID:37767677)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.