HSDL2

Summary

HSDL2 (hydroxysteroid dehydrogenase like 2, HGNC:18572) is a protein-coding gene on chromosome 9q32, encoding Hydroxysteroid dehydrogenase-like protein 2 (Q6YN16). Has apparently no steroid dehydrogenase activity.

Predicted to enable oxidoreductase activity. Involved in cholesterol homeostasis. Located in mitochondrion and peroxisome.

Source: NCBI Gene 84263 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 50 total
• Druggable target: yes
• MANE Select transcript: NM_032303

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18572
Approved symbol	HSDL2
Name	hydroxysteroid dehydrogenase like 2
Location	9q32
Locus type	gene with protein product
Status	Approved
Aliases	SDR13C1
Ensembl gene	ENSG00000119471
Ensembl biotype	protein_coding
Entrez	84263

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 21 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000398803, ENST00000398805, ENST00000467434, ENST00000480881, ENST00000488101, ENST00000860565, ENST00000860566, ENST00000860567, ENST00000860568, ENST00000860569, ENST00000860570, ENST00000860571, ENST00000860572, ENST00000860573, ENST00000860574, ENST00000860575, ENST00000929491, ENST00000942134, ENST00000942135, ENST00000942136, ENST00000942137, ENST00000942138, ENST00000942139, ENST00000942140

RefSeq mRNA: 2 — MANE Select: NM_032303 NM_001195822, NM_032303

CCDS: CCDS43864, CCDS56582

Canonical transcript exons

ENST00000398805 — 11 exons

Exon	Start	End
ENSE00000926858	112459449	112459577
ENSE00001534954	112470432	112472405
ENSE00001812440	112380108	112380180
ENSE00003461240	112454013	112454162
ENSE00003503188	112408907	112409021
ENSE00003548369	112441699	112441770
ENSE00003615191	112403995	112404158
ENSE00003617051	112416841	112416944
ENSE00003623188	112418860	112418958
ENSE00003625463	112438431	112438625
ENSE00003626224	112405624	112405722

Expression profiles

Bgee: expression breadth ubiquitous, 286 present calls, max score 98.18.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 32.0621 / max 589.4630, expressed in 1812 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
98048	28.1476	1811
98049	3.9145	1383

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart right ventricle	UBERON:0002080	98.18	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	97.77	gold quality
biceps brachii	UBERON:0001507	97.61	gold quality
diaphragm	UBERON:0001103	97.60	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	97.51	gold quality
triceps brachii	UBERON:0001509	97.28	gold quality
adrenal tissue	UBERON:0018303	97.22	gold quality
deltoid	UBERON:0001476	97.18	gold quality
skeletal muscle tissue	UBERON:0001134	96.99	gold quality
gastrocnemius	UBERON:0001388	96.74	gold quality
hindlimb stylopod muscle	UBERON:0004252	96.65	gold quality
muscle of leg	UBERON:0001383	96.63	gold quality
jejunal mucosa	UBERON:0000399	96.62	gold quality
gluteal muscle	UBERON:0002000	96.62	gold quality
cardiac ventricle	UBERON:0002082	96.41	gold quality
heart left ventricle	UBERON:0002084	96.36	gold quality
muscle organ	UBERON:0001630	96.30	gold quality
muscle tissue	UBERON:0002385	96.12	gold quality
body of tongue	UBERON:0011876	96.01	gold quality
nephron tubule	UBERON:0001231	95.98	gold quality
choroid plexus epithelium	UBERON:0003911	95.98	gold quality
left ventricle myocardium	UBERON:0006566	95.81	gold quality
pigmented layer of retina	UBERON:0001782	95.64	gold quality
liver	UBERON:0002107	95.57	gold quality
myocardium	UBERON:0002349	95.56	gold quality
right lobe of liver	UBERON:0001114	95.51	gold quality
jejunum	UBERON:0002115	95.29	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	95.15	gold quality
heart	UBERON:0000948	95.12	gold quality
tibialis anterior	UBERON:0001385	95.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	14.07

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

74 targeting HSDL2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-6753-3P	99.93	66.57	637
HSA-MIR-7107-3P	99.93	66.73	627
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-6715A-3P	99.83	68.05	1473
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-3156-3P	99.76	66.72	939
HSA-MIR-12129	99.72	67.45	1311
HSA-MIR-7154-5P	99.69	70.52	1900

Literature-anchored findings (GeneRIF, showing 10)

• High expression of HSDL2 is associated with glioma. (PMID:27658777)
• Study shows that HSDL2 upregulation is associated with ovarian cancer progression. HSDL2 knockdown inhibited cell proliferation, colony formation, motility, and tumorigenesis. (PMID:29894468)
• Hydroxysteroid dehydrogenase like 2 (HSDL2) expression was increased in papillary thyroid carcinoma (PTC) tissues and cells, which could promote tumor progression in vitro and in vivo. (PMID:31101684)
• Study reported that HSDL2 was upregulated in two human bladder cancer cell lines 5637 and T24 compared to normal human urothelial cells. Lentiviral-mediated HSDL2 knockdown inhibited the proliferation and colony formation while promoted the apoptosis of human bladder cancer T24 cells in vitro and in nude mice T24 derived xenografts in vivo. Results suggest that HSDL2 plays an oncogenic role in bladder cancer. (PMID:31217732)
• Knockdown of HSDL2 inhibits lung adenocarcinoma progression via down-regulating AKT2 expression. (PMID:32211805)
• Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis. (PMID:33738911)
• [HSDL2 overexpression promotes rectal cancer progression by regulating cancer cell cycle and promoting cell proliferation]. (PMID:37202189)
• HSDL2 knockdown promotes the progression of cholangiocarcinoma by inhibiting ferroptosis through the P53/SLC7A11 axis. (PMID:37718459)
• HSDL2 links nutritional cues to bile acid and cholesterol homeostasis. (PMID:38820148)
• Circular RNA HSDL2 promotes breast cancer progression via miR-7978 ZNF704 axis and regulating hippo signaling pathway. (PMID:38937788)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	hsdl2	ENSDARG00000002523
mus_musculus	Hsdl2	ENSMUSG00000028383
rattus_norvegicus	Hsdl2	ENSRNOG00000016692
drosophila_melanogaster	Hsdl2	FBGN0039537
caenorhabditis_elegans		WBGENE00000970
caenorhabditis_elegans		WBGENE00000975
caenorhabditis_elegans		WBGENE00000981
caenorhabditis_elegans		WBGENE00008985
caenorhabditis_elegans		WBGENE00008986
caenorhabditis_elegans		WBGENE00011424
caenorhabditis_elegans		WBGENE00022809

Paralogs (13): RDH8 (ENSG00000080511), DHRS7 (ENSG00000100612), DHRS2 (ENSG00000100867), DHRS7B (ENSG00000109016), HSD11B1 (ENSG00000117594), DHRS4 (ENSG00000157326), DHRS1 (ENSG00000157379), CBR1 (ENSG00000159228), CBR3 (ENSG00000159231), HSD11B1L (ENSG00000167733), DHRS7C (ENSG00000184544), DHRS4L2 (ENSG00000187630), DHRS11 (ENSG00000278535)

Protein

Protein identifiers

Hydroxysteroid dehydrogenase-like protein 2 — Q6YN16 (reviewed: Q6YN16)

Alternative names: Short chain dehydrogenase/reductase family 13C member 1

All UniProt accessions (1): Q6YN16

UniProt curated annotations — full annotation on UniProt →

Function. Has apparently no steroid dehydrogenase activity. Controls bile acid (BA) and lipid metabolism in response to nutritional cues.

Subcellular location. Peroxisome. Mitochondrion.

Tissue specificity. Ubiquitous.

Similarity. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q6YN16-1	1	yes
Q6YN16-2	2

RefSeq proteins (2): NP_001182751, NP_115679* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002347	SDR_fam	Family
IPR003033	SCP2_sterol-bd_dom	Domain
IPR020904	Sc_DH/Rdtase_CS	Conserved_site
IPR036291	NAD(P)-bd_dom_sf	Homologous_superfamily
IPR036527	SCP2_sterol-bd_dom_sf	Homologous_superfamily
IPR051935	HSDL2	Family

Pfam: PF00106, PF02036

UniProt features (40 total): helix 12, strand 10, turn 5, binding site 4, modified residue 3, sequence conflict 2, chain 1, domain 1, splice variant 1, active site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
3KVO	X-RAY DIFFRACTION	2.25

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6YN16-F1	89.91	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 168 (proton acceptor)

Ligand- & substrate-binding residues (4): 17–23; 42; 74; 172

Post-translational modifications (3): 42, 116, 318

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 177 (showing top): GOBP_STEROL_HOMEOSTASIS, GOBP_LIPID_HOMEOSTASIS, GAZDA_DIAMOND_BLACKFAN_ANEMIA_PROGENITOR_DN, CHIANG_LIVER_CANCER_SUBCLASS_INTERFERON_DN, TIEN_INTESTINE_PROBIOTICS_24HR_UP, MAYBURD_RESPONSE_TO_L663536_DN, CUI_TCF21_TARGETS_2_DN, RASHI_RESPONSE_TO_IONIZING_RADIATION_5, WENG_POR_TARGETS_GLOBAL_DN, CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP, GOBP_HOMEOSTATIC_PROCESS, GOCC_MICROBODY, LIU_SOX4_TARGETS_UP, GOBP_CHEMICAL_HOMEOSTASIS, STAT5A_02

GO Biological Process (1): cholesterol homeostasis (GO:0042632)

GO Molecular Function (1): oxidoreductase activity (GO:0016491)

GO Cellular Component (3): mitochondrion (GO:0005739), peroxisome (GO:0005777), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
sterol homeostasis	1
catalytic activity	1
cytoplasm	1
intracellular membrane-bounded organelle	1
microbody	1
cellular anatomical structure	1

Protein interactions and networks

STRING

5204 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
HSDL2	SCP2	P22307	481
HSDL2	MCCC2	Q9HCC0	477
HSDL2	NUDT19	A8MXV4	453
HSDL2	PCCB	P05166	453
HSDL2	ACAD11	Q709F0	449
HSDL2	ANKRD42	Q8N9B4	447
HSDL2	ETFDH	Q16134	441
HSDL2	FASN	P49327	434
HSDL2	BSDC1	Q9NW68	433
HSDL2	MCEE	Q96PE7	422
HSDL2	ECI2	O75521	420
HSDL2	SYCP2L	Q5T4T6	419
HSDL2	WDR97	A6NE52	408
HSDL2	ACOX1	Q15067	393
HSDL2	DNAI1	Q9UI46	393

IntAct

80 interactions, top by confidence:

A	B	Type	Score
HRAS	MTHFD2	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
NDUFS6	NDUFS8	psi-mi:“MI:0914”(association)	0.640
PRPS1	NMT2	psi-mi:“MI:0914”(association)	0.640
LHFPL4	ATP5F1B	psi-mi:“MI:0914”(association)	0.530
	VAPB	psi-mi:“MI:0914”(association)	0.500
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
HSCB	NDUFS8	psi-mi:“MI:0914”(association)	0.460
HSDL2	ENO1	psi-mi:“MI:0915”(physical association)	0.400
Bub1	PEX10	psi-mi:“MI:0914”(association)	0.350
HDAC1	TRAK1	psi-mi:“MI:0914”(association)	0.350
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
	E2F3	psi-mi:“MI:0914”(association)	0.350
KIF3A	KIF3B	psi-mi:“MI:0914”(association)	0.350
MAPK6		psi-mi:“MI:0914”(association)	0.350
PLEKHA7	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
DLD	NFKBIE	psi-mi:“MI:0914”(association)	0.350
DLST		psi-mi:“MI:0914”(association)	0.350
PDHA1		psi-mi:“MI:0914”(association)	0.350
DLD	IRS4	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
COQ9	ACOT7	psi-mi:“MI:0914”(association)	0.350
PRKCB	CHEK1	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
PPM1A	BCKDK	psi-mi:“MI:0914”(association)	0.350
GABARAP		psi-mi:“MI:0914”(association)	0.350

BioGRID (160): HSDL2 (Co-fractionation), HSDL2 (Co-fractionation), SF1 (Co-fractionation), TAGLN2 (Co-fractionation), TRAP1 (Co-fractionation), HSDL2 (Synthetic Lethality), HSDL2 (Proximity Label-MS), HSDL2 (Proximity Label-MS), HSDL2 (Proximity Label-MS), HSDL2 (Proximity Label-MS), HSDL2 (Affinity Capture-MS), HSDL2 (Affinity Capture-MS), HSDL2 (Affinity Capture-MS), HSDL2 (Affinity Capture-MS), MIPEP (Affinity Capture-MS)

ESM2 similar proteins: A2VCW9, A4FUZ6, A8E657, A8XKG6, O02485, O08699, O17732, O48905, P11708, P13228, P14152, P15428, P46794, P51659, P51660, P57106, P70684, P93819, P97852, Q01373, Q08062, Q16698, Q29LW1, Q2TPA8, Q32PF2, Q3T0C2, Q3T145, Q4V8F9, Q54VM2, Q55FT1, Q59987, Q5RA68, Q66KC4, Q6DIY9, Q6P5L8, Q6PAB3, Q6PAY8, Q6YN16, Q7XDC8, Q7YRU4

Diamond homologs: A0A097ZPE8, A0A0S2CGD3, A0A140FAN3, A0A144Y7G4, A0A162J3X8, A0A1U8QWA2, A0A1V0QSC6, A0A1W5SR39, A0QYC2, A4FUZ6, A4IGM4, A6SSW9, A7IQF2, A7IQH5, A7LB60, B6HV34, C0KTJ6, F1QWW8, G9FRD7, G9N4A9, O34782, O86034, P0A2D1, P0A2D2, P0DKC5, P0DKC6, P14802, P16544, P37059, P37440, P39831, P50171, P54554, P66778, P66780, P73574, P9WGS0, P9WGS1, P9WGS2, P9WGS3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 98 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
VEGFR2 mediated cell proliferation	5	36.1×	4e-05
Peroxisomal protein import	5	10.9×	2e-03
Signaling by BRAF and RAF1 fusions	5	10.8×	2e-03
Translocation of SLC2A4 (GLUT4) to the plasma membrane	5	9.8×	3e-03
Mitochondrial protein degradation	6	8.7×	2e-03
Anchoring of the basal body to the plasma membrane	5	7.2×	6e-03
Organelle biogenesis and maintenance	6	5.0×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

50 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	29
Likely benign	5
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

1866 predictions. Top by Δscore:

Variant	Effect	Δscore
9:112380158:A:T	donor_gain	1.0000
9:112403991:GTAG:G	acceptor_loss	1.0000
9:112403992:TAG:T	acceptor_loss	1.0000
9:112403993:AGG:A	acceptor_loss	1.0000
9:112403994:G:A	acceptor_loss	1.0000
9:112403994:GGA:G	acceptor_gain	1.0000
9:112404154:AGAAA:A	donor_gain	1.0000
9:112404155:GAAA:G	donor_gain	1.0000
9:112404155:GAAAG:G	donor_gain	1.0000
9:112404156:A:T	donor_gain	1.0000
9:112404157:AA:A	donor_gain	1.0000
9:112404158:AG:A	donor_loss	1.0000
9:112404159:G:GG	donor_gain	1.0000
9:112405607:T:TA	acceptor_gain	1.0000
9:112405610:A:AG	acceptor_gain	1.0000
9:112405611:T:G	acceptor_gain	1.0000
9:112405617:A:AG	acceptor_gain	1.0000
9:112405619:A:AG	acceptor_gain	1.0000
9:112405620:T:G	acceptor_gain	1.0000
9:112405620:TAAG:T	acceptor_loss	1.0000
9:112405621:A:AG	acceptor_gain	1.0000
9:112405621:AAGTT:A	acceptor_gain	1.0000
9:112405622:A:C	acceptor_loss	1.0000
9:112405622:A:G	acceptor_gain	1.0000
9:112405623:G:GA	acceptor_gain	1.0000
9:112405623:GTT:G	acceptor_gain	1.0000
9:112405720:G:GT	donor_gain	1.0000
9:112405724:T:A	donor_loss	1.0000
9:112408902:AACAG:A	acceptor_loss	1.0000
9:112408903:ACAGG:A	acceptor_loss	1.0000

AlphaMissense

2774 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:112408933:A:C	S103R	0.998
9:112408935:T:A	S103R	0.998
9:112408935:T:G	S103R	0.998
9:112416899:A:C	S152R	0.996
9:112416901:T:A	S152R	0.996
9:112416901:T:G	S152R	0.996
9:112438489:A:C	R219S	0.996
9:112438489:A:T	R219S	0.996
9:112438488:G:C	R219T	0.995
9:112418887:C:T	S176F	0.994
9:112418946:T:A	W196R	0.994
9:112418946:T:C	W196R	0.994
9:112418940:G:C	A194P	0.993
9:112409001:C:A	N125K	0.992
9:112409001:C:G	N125K	0.992
9:112438511:G:C	A227P	0.992
9:112408926:T:A	N100K	0.991
9:112408926:T:G	N100K	0.991
9:112418876:G:C	K172N	0.991
9:112418876:G:T	K172N	0.991
9:112438434:T:A	I201K	0.991
9:112408934:G:T	S103I	0.990
9:112408937:C:A	A104D	0.990
9:112408985:T:C	L120P	0.989
9:112418935:T:A	V192D	0.989
9:112418939:T:A	N193K	0.989
9:112418939:T:G	N193K	0.989
9:112418944:T:C	L195S	0.989
9:112418871:G:C	A171P	0.988
9:112418886:T:C	S176P	0.988

dbSNP variants (sampled 300 via entrez): RS1000013126 (9:112462725 A>G), RS1000019981 (9:112469983 T>C), RS1000023997 (9:112389982 T>C,G), RS1000131795 (9:112383201 G>A), RS1000186045 (9:112443837 C>T), RS1000300419 (9:112419246 C>T), RS1000364572 (9:112463224 G>T), RS1000399337 (9:112440243 TATG>T), RS1000404200 (9:112396512 A>G), RS1000431524 (9:112413867 A>G), RS1000439162 (9:112435978 A>G), RS1000450509 (9:112412878 C>A,T), RS1000498375 (9:112455546 G>C,T), RS1000584365 (9:112402957 AC>A), RS1000585371 (9:112383582 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST003264_83	Post bronchodilator FEV1/FVC ratio	2.000000e-06
GCST004735_26	Epstein-Barr virus copy number in lymphoblastoid cell lines	3.000000e-06
GCST010397_66	Gut microbiota (bacterial taxa, rank normal transformation method)	5.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004713	FEV/FVC ratio
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067292 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

1 potent at pChembl≥5 of 2 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.00	Kd	9945	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148545: Binding affinity to human HSDL2 incubated for 45 mins by Kinobead based pull down assay	kd	9.9450	uM

CTD chemical–gene interactions

47 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression, increases expression	6
bisphenol A	affects expression, decreases expression, increases expression	3
Tetrachlorodibenzodioxin	affects expression, increases expression	3
Cyclosporine	decreases expression	3
trichostatin A	affects expression, increases expression	2
Cisplatin	increases expression, affects cotreatment	2
aristolochic acid I	increases expression	1
bisphenol F	increases expression	1
dicrotophos	decreases expression	1
22-hydroxycholesterol	affects binding, affects cotreatment	1
triphenyl phosphate	affects expression	1
3,4,5,3’,4’-pentachlorobiphenyl	increases expression	1
manganese chloride	increases abundance, increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
decanoyl-coenzyme A	affects binding, affects cotreatment	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
lauroyl-coenzyme A	affects binding, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
GW 501516	affects binding, increases expression	1
ICG 001	decreases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
bisphenol S	increases expression	1
jinfukang	affects cotreatment, increases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Decitabine	decreases expression	1
Acetaminophen	affects expression	1
Azathioprine	decreases expression	1
Cadmium	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651587	Binding	Binding affinity to human HSDL2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.