HTR2A-AS1

Summary

HTR2A-AS1 (HTR2A antisense RNA 1, HGNC:40289) is a long non-coding RNA gene on chromosome 13q14.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40289
Approved symbol	HTR2A-AS1
Name	HTR2A antisense RNA 1
Location	13q14.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224517
Ensembl biotype	lncRNA
Entrez	100874082
RNAcentral	URS000075C02A — lncRNA, 441 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000430913, ENST00000452352, ENST00000455126, ENST00000779168

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430913 — 4 exons

Exon	Start	End
ENSE00001724411	46856090	46856299
ENSE00001724475	46853939	46854082
ENSE00004149350	46845281	46845366
ENSE00004149352	46852145	46852226

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 91.40.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.40	gold quality
skeletal muscle tissue	UBERON:0001134	67.24	silver quality
liver	UBERON:0002107	65.34	gold quality
superior frontal gyrus	UBERON:0002661	63.21	gold quality
calcaneal tendon	UBERON:0003701	62.51	gold quality
right testis	UBERON:0004534	61.29	gold quality
monocyte	CL:0000576	58.92	gold quality
right lobe of liver	UBERON:0001114	58.29	gold quality
testis	UBERON:0000473	58.20	gold quality
left testis	UBERON:0004533	58.00	gold quality
islet of Langerhans	UBERON:0000006	56.58	gold quality
blood	UBERON:0000178	56.37	gold quality
adrenal tissue	UBERON:0018303	55.33	gold quality
corpus callosum	UBERON:0002336	55.07	gold quality
descending thoracic aorta	UBERON:0002345	54.32	gold quality
popliteal artery	UBERON:0002250	53.75	gold quality
tibial artery	UBERON:0007610	53.61	gold quality
right lung	UBERON:0002167	53.15	gold quality
amygdala	UBERON:0001876	52.61	gold quality
kidney	UBERON:0002113	52.25	gold quality
gastrocnemius	UBERON:0001388	51.83	gold quality
prefrontal cortex	UBERON:0000451	51.44	gold quality
multicellular organism	UBERON:0000468	51.40	gold quality
thoracic aorta	UBERON:0001515	51.15	gold quality
left coronary artery	UBERON:0001626	51.02	gold quality
ascending aorta	UBERON:0001496	51.01	gold quality
adult mammalian kidney	UBERON:0000082	50.55	gold quality
body of stomach	UBERON:0001161	48.83	gold quality
left adrenal gland	UBERON:0001234	48.49	gold quality
hypothalamus	UBERON:0001898	47.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.63

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Antisense gene is expressed in the frontal cortex (as determined by PCR). Some associated SNPS are present within exonic regions of the antisense gene. (PMID:21173788)
• Human HTR2A-AS1 gene spans ~474 kilobases and consists of 18, rather than 3 exons. Three HTR2A exons directly overlap with HTR2A-AS1 exons. A mouse Htr2a-as1 was also identified and the mouse expresses antisense isoforms that overlap sense-encoded exons of Htr2a at similar positions as the human transcripts. (PMID:26738766)
• human HTR2A gene spans ~66 kilobases and consists of 7, rather than 4 exons; Furthermore, the revised human HTR2A-AS1 gene spans ~474 kilobases and consists of 18, rather than 3 exons (PMID:26738766)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.