HTRA1-AS1

Summary

HTRA1-AS1 (HTRA1 and ARMS2 antisense RNA 1, HGNC:58122) is a long non-coding RNA gene on chromosome 10q26.13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58122
Approved symbol	HTRA1-AS1
Name	HTRA1 and ARMS2 antisense RNA 1
Location	10q26.13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000285955
Ensembl biotype	lncRNA
Entrez	105378525
RNAcentral	URS0000DB90B0 — lncRNA, 2561 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000647969, ENST00000650300, ENST00000811415, ENST00000811416

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000647969 — 2 exons

Exon	Start	End
ENSE00003836290	122450526	122450909
ENSE00003839162	122458495	122458676

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 77.12.

Top tissues by expression

112 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.12	silver quality
cortical plate	UBERON:0005343	74.75	gold quality
left ovary	UBERON:0002119	70.53	gold quality
ovary	UBERON:0000992	69.63	gold quality
sural nerve	UBERON:0015488	68.21	gold quality
right ovary	UBERON:0002118	67.91	gold quality
pituitary gland	UBERON:0000007	66.39	gold quality
ventricular zone	UBERON:0003053	63.69	gold quality
adenohypophysis	UBERON:0002196	63.31	gold quality
ectocervix	UBERON:0012249	61.95	gold quality
body of uterus	UBERON:0009853	60.52	gold quality
prefrontal cortex	UBERON:0000451	59.15	gold quality
hypothalamus	UBERON:0001898	58.84	gold quality
myometrium	UBERON:0001296	58.82	gold quality
frontal cortex	UBERON:0001870	58.69	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.38	silver quality
right frontal lobe	UBERON:0002810	58.37	gold quality
anterior cingulate cortex	UBERON:0009835	58.33	gold quality
mucosa of stomach	UBERON:0001199	58.29	gold quality
ganglionic eminence	UBERON:0004023	58.02	gold quality
cerebral cortex	UBERON:0000956	57.39	gold quality
endocervix	UBERON:0000458	57.29	gold quality
superior frontal gyrus	UBERON:0002661	57.28	gold quality
gall bladder	UBERON:0002110	56.64	gold quality
Ammon’s horn	UBERON:0001954	56.46	gold quality
brain	UBERON:0000955	56.31	gold quality
primary visual cortex	UBERON:0002436	56.04	gold quality
stromal cell of endometrium	CL:0002255	55.76	gold quality
liver	UBERON:0002107	55.71	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	55.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.