IADEN

Summary

IADEN (IGF2BP1 associated definitive endoderm lncRNA, HGNC:56877) is a long non-coding RNA gene on chromosome 8q24.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56877
Approved symbol	IADEN
Name	IGF2BP1 associated definitive endoderm lncRNA
Location	8q24.22
Locus type	RNA, long non-coding
Status	Approved
Aliases	HIDEN
Ensembl gene	ENSG00000253507
Ensembl biotype	lncRNA
Entrez	124902069
RNAcentral	URS0002A35FEB — lncRNA, 1160 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000519005, ENST00000519695, ENST00000524275, ENST00000745879, ENST00000745880

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000519005 — 4 exons

Exon	Start	End
ENSE00002061896	131312556	131312748
ENSE00002102788	131315760	131315883
ENSE00004086182	131317334	131317889
ENSE00004086185	131310461	131310712

Expression profiles

Bgee: expression breadth ubiquitous, 108 present calls, max score 85.34.

Top tissues by expression

108 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.34	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.94	silver quality
bone marrow cell	CL:0002092	72.61	gold quality
bone marrow	UBERON:0002371	68.78	gold quality
sural nerve	UBERON:0015488	67.49	silver quality
colonic epithelium	UBERON:0000397	65.28	silver quality
urinary bladder	UBERON:0001255	63.81	silver quality
skeletal muscle tissue	UBERON:0001134	63.25	gold quality
muscle tissue	UBERON:0002385	62.90	gold quality
hindlimb stylopod muscle	UBERON:0004252	62.11	gold quality
liver	UBERON:0002107	61.76	gold quality
uterine cervix	UBERON:0000002	59.44	silver quality
right lung	UBERON:0002167	56.19	gold quality
blood	UBERON:0000178	54.58	gold quality
adrenal tissue	UBERON:0018303	54.16	gold quality
stromal cell of endometrium	CL:0002255	54.06	silver quality
endometrium	UBERON:0001295	53.81	silver quality
prefrontal cortex	UBERON:0000451	53.80	gold quality
primary visual cortex	UBERON:0002436	53.50	gold quality
duodenum	UBERON:0002114	53.33	gold quality
lymph node	UBERON:0000029	53.07	gold quality
small intestine	UBERON:0002108	52.50	gold quality
amygdala	UBERON:0001876	52.48	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	51.98	gold quality
hypothalamus	UBERON:0001898	51.80	gold quality
superior frontal gyrus	UBERON:0002661	51.70	gold quality
substantia nigra	UBERON:0002038	51.60	gold quality
lung	UBERON:0002048	51.38	gold quality
right lobe of liver	UBERON:0001114	51.13	gold quality
tonsil	UBERON:0002372	50.90	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA. (PMID:37095549)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.