IATPR

Summary

IATPR (ITGB1 adjacent tumor promoting lncRNA, HGNC:53719) is a long non-coding RNA gene on chromosome 10p11.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53719
Approved symbol	IATPR
Name	ITGB1 adjacent tumor promoting lncRNA
Location	10p11.22
Locus type	RNA, long non-coding
Status	Approved
Aliases	TCONS_00018476, linc-ITGB1
Ensembl gene	ENSG00000233387
Ensembl biotype	lncRNA
Entrez	101929447
RNAcentral	URS0000E60B05 — lncRNA, 680 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000414308, ENST00000688819, ENST00000821581, ENST00000821582, ENST00000821583

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414308 — 2 exons

Exon	Start	End
ENSE00004228534	33096009	33096606
ENSE00004228536	33116471	33116809

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 74.88.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5077 / max 131.1144, expressed in 56 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
109050	0.3754	49
109049	0.0672	29
109048	0.0652	27

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	74.88	gold quality
granulocyte	CL:0000094	74.02	gold quality
tonsil	UBERON:0002372	71.14	gold quality
lymph node	UBERON:0000029	67.57	gold quality
blood	UBERON:0000178	65.15	gold quality
urinary bladder	UBERON:0001255	64.82	gold quality
leukocyte	CL:0000738	63.96	gold quality
bone marrow	UBERON:0002371	62.98	gold quality
gall bladder	UBERON:0002110	57.86	gold quality
monocyte	CL:0000576	56.49	gold quality
liver	UBERON:0002107	55.86	gold quality
calcaneal tendon	UBERON:0003701	55.70	gold quality
vermiform appendix	UBERON:0001154	53.78	gold quality
rectum	UBERON:0001052	53.03	gold quality
smooth muscle tissue	UBERON:0001135	51.83	gold quality
multicellular organism	UBERON:0000468	51.34	gold quality
islet of Langerhans	UBERON:0000006	50.94	gold quality
muscle of leg	UBERON:0001383	50.67	gold quality
gastrocnemius	UBERON:0001388	49.17	gold quality
right lobe of thyroid gland	UBERON:0001119	48.66	gold quality
right lobe of liver	UBERON:0001114	47.66	gold quality
right adrenal gland cortex	UBERON:0035827	46.85	gold quality
heart left ventricle	UBERON:0002084	46.70	gold quality
body of pancreas	UBERON:0001150	46.31	gold quality
spleen	UBERON:0002106	46.24	gold quality
heart	UBERON:0000948	45.55	gold quality
adrenal gland	UBERON:0002369	45.37	silver quality
tibial artery	UBERON:0007610	45.03	silver quality
right coronary artery	UBERON:0001625	44.65	gold quality
endometrium	UBERON:0001295	44.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA ITGB1 promotes the development of bladder cancer through regulating microRNA-10a expression. (PMID:31486485)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.