ICAM5

Summary

ICAM5 (intercellular adhesion molecule 5, HGNC:5348) is a protein-coding gene on chromosome 19p13.2, encoding Intercellular adhesion molecule 5 (Q9UMF0). Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion.

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.

Source: NCBI Gene 7087 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 98 total
• MANE Select transcript: NM_003259

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5348
Approved symbol	ICAM5
Name	intercellular adhesion molecule 5
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	TLN
Ensembl gene	ENSG00000105376
Ensembl biotype	protein_coding
OMIM	601852
Entrez	7087

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 3 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000221980, ENST00000586004, ENST00000586480, ENST00000587398, ENST00000588912, ENST00000948402

RefSeq mRNA: 1 — MANE Select: NM_003259 NM_003259

CCDS: CCDS12233

Canonical transcript exons

ENST00000221980 — 11 exons

Exon	Start	End
ENSE00000676112	10291072	10291341
ENSE00000676113	10291489	10291809
ENSE00001188317	10289952	10290125
ENSE00002876143	10296339	10296778
ENSE00003467976	10294040	10294318
ENSE00003516317	10292998	10293246
ENSE00003545972	10292035	10292322
ENSE00003562998	10292612	10292866
ENSE00003653547	10295346	10295612
ENSE00003680275	10293698	10293943
ENSE00003685164	10294401	10294640

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 89.79.

FANTOM5 (CAGE): breadth broad, TPM avg 8.4258 / max 403.2302, expressed in 872 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
173780	6.2598	667
173782	1.8357	344
173779	0.2782	137
173781	0.0521	22

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right frontal lobe	UBERON:0002810	89.79	gold quality
prefrontal cortex	UBERON:0000451	88.94	gold quality
cingulate cortex	UBERON:0003027	88.92	gold quality
anterior cingulate cortex	UBERON:0009835	88.91	gold quality
nucleus accumbens	UBERON:0001882	88.46	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	88.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	87.12	gold quality
caudate nucleus	UBERON:0001873	86.32	gold quality
frontal cortex	UBERON:0001870	85.88	gold quality
frontal pole	UBERON:0002795	85.88	gold quality
Ammon’s horn	UBERON:0001954	84.81	gold quality
neocortex	UBERON:0001950	84.75	gold quality
middle frontal gyrus	UBERON:0002702	84.34	gold quality
cerebral cortex	UBERON:0000956	84.05	gold quality
amygdala	UBERON:0001876	84.00	gold quality
right lung	UBERON:0002167	83.47	gold quality
Brodmann (1909) area 10	UBERON:0013541	83.37	gold quality
telencephalon	UBERON:0001893	83.29	gold quality
putamen	UBERON:0001874	82.87	gold quality
stromal cell of endometrium	CL:0002255	82.05	gold quality
upper lobe of left lung	UBERON:0008952	80.58	gold quality
temporal lobe	UBERON:0001871	80.29	gold quality
superior frontal gyrus	UBERON:0002661	79.79	gold quality
paraflocculus	UBERON:0005351	78.91	gold quality
entorhinal cortex	UBERON:0002728	78.45	silver quality
postcentral gyrus	UBERON:0002581	78.43	silver quality
forebrain	UBERON:0001890	78.41	gold quality
upper lobe of lung	UBERON:0008948	77.26	gold quality
pancreatic ductal cell	CL:0002079	74.31	silver quality
parietal lobe	UBERON:0001872	74.02	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.89

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYCN

miRNA regulators (miRDB)

36 targeting ICAM5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-4422	99.72	72.07	2908
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-4650-3P	99.01	68.39	1062
HSA-MIR-219A-1-3P	98.91	67.87	639
HSA-MIR-4703-5P	98.53	70.13	1645
HSA-MIR-3942-5P	98.52	69.51	1517
HSA-MIR-5585-3P	98.25	67.41	941
HSA-MIR-3132	97.96	67.91	711
HSA-MIR-197-5P	97.23	68.10	596
HSA-MIR-1226-5P	96.50	65.28	643

Literature-anchored findings (GeneRIF, showing 5)

• study does not confirm association between ICAM 5 V3001 polymorphism and breast cancer risk (PMID:16434609)
• ICAM-5 is involved in immune privilege of the brain and acts as an anti-inflammatory agent. (PMID:18223167)
• A specific microenvironment facilitating ARF6-mediated mobilization of TLN that contributes to promotion of dendritic spine development. (PMID:22781129)
• ICAM5 V301I and rs281439 variants may contribute to the susceptibility of breast cancer. [Meta-analysis] (PMID:23079714)
• Here the authors identify neuron-specific intercellular adhesion molecule 5 (ICAM-5/telencephalin) as a cellular receptor for sialic acid-dependent and -independent entry of enterovirus D68. (PMID:27923705)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Icam5	ENSMUSG00000032174
rattus_norvegicus	Icam5	ENSRNOG00000020694

Paralogs (4): ICAM3 (ENSG00000076662), ICAM1 (ENSG00000090339), ICAM4 (ENSG00000105371), ICAM2 (ENSG00000108622)

Protein

Protein identifiers

Intercellular adhesion molecule 5 — Q9UMF0 (reviewed: Q9UMF0)

Alternative names: Telencephalin

All UniProt accessions (2): Q9UMF0, A0A9L9PXE8

UniProt curated annotations — full annotation on UniProt →

Function. Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion. Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons.

Subunit / interactions. Homotetramer.

Subcellular location. Cell membrane. Cell projection. Uropodium. Dendritic spine membrane.

Tissue specificity. Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon. Brain specific expression. Within the brain, only expressed in regions derived from the telencephalon. Highly expressed in the hippocampus and cerebral cortex, followed by the amygdala, caudate nucleus, occipital pole, frontal lobe, temporal lobe, and putamen. Lower expressed in the corpus callosum, subthalamic nucleus, and thalamus.

Domain organisation. Ig-like C2-type 1 domain mediates neuronal homophilic adhesion with Ig-like C2-type 4-5 domains.

Similarity. Belongs to the immunoglobulin superfamily. ICAM family.

RefSeq proteins (1): NP_003250* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003598	Ig_sub2	Domain
IPR003599	Ig_sub	Domain
IPR003987	ICAM_VCAM_N	Domain
IPR003988	ICAM	Domain
IPR007110	Ig-like_dom	Domain
IPR013768	ICAM_N	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR047012	ICAM_VCAM	Family
IPR048679	ICAM1_3_5_D2	Domain

Pfam: PF03921, PF13927, PF21146

UniProt features (88 total): strand 33, glycosylation site 14, disulfide bond 10, domain 9, sequence variant 5, helix 5, sequence conflict 3, modified residue 2, topological domain 2, signal peptide 1, chain 1, region of interest 1, compositionally biased region 1, transmembrane region 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
3BN3	X-RAY DIFFRACTION	2.1
4OI9	X-RAY DIFFRACTION	2.5
4OIB	X-RAY DIFFRACTION	3.5
4OIA	X-RAY DIFFRACTION	3.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UMF0-F1	81.15	0.45

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 182, 184

Disulfide bonds (10): 55–99, 59–103, 142–198, 249–302, 344–383, 415–470, 498–552, 580–645, 673–725, 769–814

Glycosylation sites (14): 54, 74, 137, 195, 214, 303, 316, 371, 397, 583, 646, 764, 795, 796

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083	Integrin cell surface interactions

MSigDB gene sets: 163 (showing top): BENPORATH_ES_WITH_H3K27ME3, YAGI_AML_WITH_INV_16_TRANSLOCATION, GOBP_PROTEIN_HOMOTETRAMERIZATION, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, GOBP_SYNAPSE_ASSEMBLY, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, GOBP_REGULATION_OF_CELL_JUNCTION_ASSEMBLY, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_CELL_CELL_ADHESION, GOBP_CELL_JUNCTION_ORGANIZATION, FREAC3_01, SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4, GOBP_REGULATION_OF_SYNAPSE_ASSEMBLY

GO Biological Process (8): phagocytosis (GO:0006909), cell adhesion (GO:0007155), homophilic cell-cell adhesion (GO:0007156), neuron cell-cell adhesion (GO:0007158), cell-cell adhesion mediated by integrin (GO:0033631), protein homotetramerization (GO:0051289), regulation of synapse assembly (GO:0051963), cell-cell adhesion (GO:0098609)

GO Molecular Function (3): integrin binding (GO:0005178), receptor ligand activity (GO:0048018), protein binding (GO:0005515)

GO Cellular Component (7): plasma membrane (GO:0005886), uropod membrane (GO:0031259), dendritic spine membrane (GO:0032591), cell projection (GO:0042995), glutamatergic synapse (GO:0098978), membrane (GO:0016020), postsynapse (GO:0098794)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Adaptive Immune System	1
Extracellular matrix organization	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell-cell adhesion	3
cellular anatomical structure	3
signaling receptor binding	2
synapse	2
endocytosis	1
cellular process	1
cell adhesion mediated by integrin	1
protein homooligomerization	1
protein tetramerization	1
synapse assembly	1
regulation of synapse organization	1
regulation of cell junction assembly	1
cell adhesion	1
protein-containing complex binding	1
cell adhesion molecule binding	1
signal transduction	1
signaling receptor activator activity	1
binding	1
membrane	1
cell periphery	1
uropod	1
cell projection membrane	1
cell trailing edge membrane	1
neuron projection membrane	1
dendrite membrane	1
dendritic spine	1
synaptic membrane	1

Protein interactions and networks

STRING

1196 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ICAM5	ITGAL	P20701	875
ICAM5	ITGB2	P05107	771
ICAM5	TMED10	P49755	586
ICAM5	EZR	P15311	574
ICAM5	RDX	P35241	558
ICAM5	ITGB1	P05556	551
ICAM5	PSEN1	P49768	550
ICAM5	APH1A	Q96BI3	548
ICAM5	NCSTN	Q92542	540
ICAM5	MSN	P26038	524
ICAM5	EIF2B2	P49770	494
ICAM5	VTN	P01141	488
ICAM5	CD47	Q08722	480
ICAM5	UBQLN1	Q9UMX0	449
ICAM5	PVR	P15151	444

IntAct

142 interactions, top by confidence:

A	B	Type	Score
FBXO6	MAN2B1	psi-mi:“MI:0914”(association)	0.640
ACTN1	ICAM5	psi-mi:“MI:0915”(physical association)	0.600
ACTN1	ICAM5	psi-mi:“MI:0407”(direct interaction)	0.600
ALAS1	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
AMBN	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
ICAM5	KLF5	psi-mi:“MI:0915”(physical association)	0.560
GPM6A	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
MT2A	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
VDAC2	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
AKAP9	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
TADA3	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
MYLIP	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
FAM135B	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
CRLF3	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
REX1BD	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
RNF31	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
OTUB1	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
CD248	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
GINS3	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
LRRC61	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
DSN1	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
LZTS2	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
KLHL32	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
RAB3IP	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
KRT222	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
ASB9	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
FAM117B	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
CNST	ICAM5	psi-mi:“MI:0915”(physical association)	0.560
H3-5	ICAM5	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (69): ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS), ICAM5 (Affinity Capture-MS)

ESM2 similar proteins: A6NMB1, D3ZQE1, E9QA28, G1T7E7, G1TR84, O75054, O75144, P05362, P07722, P09564, P11364, P15151, P16573, P20916, P20917, P32506, P32942, P33729, Q08ET2, Q1WIM1, Q1WIM3, Q28110, Q28125, Q28730, Q28806, Q2WEN9, Q5DRQ8, Q5NKU6, Q5NKV4, Q5NKV6, Q5NKV9, Q5R996, Q60625, Q64JA4, Q6BAA4, Q7TSU7, Q8N126, Q8NFZ8, Q8R464, Q8VBT3

Diamond homologs: P05362, P13597, P13598, P32942, P33729, P35330, Q00238, Q14773, Q28125, Q28730, Q28806, Q5NKT8, Q5NKU6, Q5NKV1, Q5NKV2, Q5NKV4, Q5NKV6, Q5NKV9, Q60625, Q95132, Q9UMF0, A0A0B4J1L0, A0A140LHF2, D3ZQE1, E9QA28, O75871, P06731, P11464, P11465, P13688, P16573, P31809, P31997, P35329, P40198, P40199, P79701, Q00887, Q00888, Q00889

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

98 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	87
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1660 predictions. Top by Δscore:

Variant	Effect	Δscore
19:10290122:TCAGG:T	donor_loss	1.0000
19:10290123:CAGGT:C	donor_loss	1.0000
19:10290125:GGTAA:G	donor_loss	1.0000
19:10290126:G:GA	donor_loss	1.0000
19:10290127:T:G	donor_loss	1.0000
19:10291810:G:GG	donor_gain	1.0000
19:10292323:G:GG	donor_gain	1.0000
19:10292328:G:GT	donor_gain	1.0000
19:10292332:G:GT	donor_gain	1.0000
19:10292845:A:T	donor_gain	1.0000
19:10292867:G:GG	donor_gain	1.0000
19:10293225:G:GT	donor_gain	1.0000
19:10293245:GT:G	donor_gain	1.0000
19:10293938:TGGA:T	donor_gain	1.0000
19:10293939:GGAAT:G	donor_gain	1.0000
19:10293940:GAAT:G	donor_gain	1.0000
19:10293940:GAATG:G	donor_gain	1.0000
19:10293942:ATGT:A	donor_loss	1.0000
19:10293943:TGTG:T	donor_loss	1.0000
19:10293944:G:GA	donor_loss	1.0000
19:10293944:G:GG	donor_gain	1.0000
19:10293945:T:TG	donor_loss	1.0000
19:10293946:GAG:G	donor_loss	1.0000
19:10294641:G:GG	donor_gain	1.0000
19:10295344:A:AG	acceptor_gain	1.0000
19:10295344:AGACC:A	acceptor_gain	1.0000
19:10295345:G:GG	acceptor_gain	1.0000
19:10295345:GACC:G	acceptor_gain	1.0000
19:10295345:GACCG:G	acceptor_gain	1.0000
19:10295608:GGCCG:G	donor_gain	1.0000

AlphaMissense

5828 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:10291235:G:C	W82C	1.000
19:10291235:G:T	W82C	1.000
19:10295458:G:C	W781C	1.000
19:10295458:G:T	W781C	1.000
19:10291291:T:G	F101C	0.999
19:10295420:T:A	C769S	0.999
19:10295421:G:C	C769S	0.999
19:10295456:T:A	W781R	0.999
19:10295456:T:C	W781R	0.999
19:10295550:A:G	Y812C	0.999
19:10295555:T:A	C814S	0.999
19:10295556:G:C	C814S	0.999
19:10291152:T:A	C55S	0.998
19:10291152:T:C	C55R	0.998
19:10291153:G:A	C55Y	0.998
19:10291153:G:C	C55S	0.998
19:10291154:C:G	C55W	0.998
19:10291164:T:A	C59S	0.998
19:10291164:T:C	C59R	0.998
19:10291165:G:A	C59Y	0.998
19:10291165:G:C	C59S	0.998
19:10291284:T:C	C99R	0.998
19:10291285:G:A	C99Y	0.998
19:10291286:C:G	C99W	0.998
19:10293189:T:A	C470S	0.998
19:10293190:G:C	C470S	0.998
19:10295420:T:C	C769R	0.998
19:10295421:G:A	C769Y	0.998
19:10295549:T:G	Y812D	0.998
19:10295555:T:C	C814R	0.998

dbSNP variants (sampled 300 via entrez): RS1000071669 (19:10295469 C>T), RS1000131028 (19:10289747 G>C), RS1000439713 (19:10296944 A>G,T), RS1000495516 (19:10290851 T>C), RS1001581628 (19:10296621 G>C,T), RS1001631422 (19:10289787 A>G), RS1001971499 (19:10290906 C>A,T), RS1002136774 (19:10293017 T>A,G), RS1002527145 (19:10294724 C>T), RS1002548764 (19:10294566 A>G), RS1002689661 (19:10289004 G>T), RS1002989774 (19:10295073 A>G), RS1004185068 (19:10288469 A>C,T), RS1004301233 (19:10288265 T>A), RS1006539002 (19:10292114 G>A)

Disease associations

OMIM: gene MIM:601852 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST002740_79	Inflammatory skin disease	3.000000e-07
GCST004610_90	White blood cell count	2.000000e-11
GCST004632_17	Lymphocyte percentage of white cells	5.000000e-14
GCST006585_1488	Blood protein levels	7.000000e-103
GCST006585_39	Blood protein levels	2.000000e-111
GCST90002389_262	Lymphocyte percentage of white cells	3.000000e-29
GCST90002399_219	Neutrophil percentage of white cells	9.000000e-14

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0007993	lymphocyte percentage of leukocytes
EFO:0007990	neutrophil percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs901886	ICAM5		0.00	0

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression	2
Arsenic	affects expression, increases abundance	2
Benzo(a)pyrene	affects methylation, decreases methylation, increases expression	2
Tobacco Smoke Pollution	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
propionaldehyde	increases expression	1
bisphenol A	decreases expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
arsenite	increases methylation	1
butyraldehyde	increases expression	1
3,4,5,3’,4’-pentachlorobiphenyl	increases expression	1
K 7174	decreases expression	1
abrine	increases expression	1
Sunitinib	decreases expression	1
Air Pollutants	increases expression, increases abundance	1
Arsenicals	affects expression, increases abundance	1
Cacodylic Acid	affects expression, increases abundance	1
Carmustine	decreases expression	1
Diazinon	decreases methylation	1
Lead	affects expression	1
Niclosamide	increases expression	1
Silicon Dioxide	increases expression	1
Smoke	decreases expression	1
Dronabinol	decreases expression	1
Triclosan	decreases expression	1
1-Methyl-4-phenylpyridinium	increases expression	1
Aflatoxin B1	increases methylation	1
Gold Compounds	decreases methylation	1
Asbestos, Serpentine	decreases methylation	1
Acrylamide	decreases expression	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SR94	HAP1 ICAM5 (-) 1	Cancer cell line	Male
CVCL_XP66	HAP1 ICAM5 (-) 2	Cancer cell line	Male
CVCL_XP67	HAP1 ICAM5 (-) 3	Cancer cell line	Male
CVCL_XP68	HAP1 ICAM5 (-) 4	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.