ICE2

Summary

ICE2 (interactor of little elongation complex ELL subunit 2, HGNC:29885) is a protein-coding gene on chromosome 15q22.2, encoding Little elongation complex subunit 2 (Q659A1). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. It is a selective cancer dependency (DepMap: 53.6% of cell lines).

This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4.

Source: NCBI Gene 79664 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 195 total — 1 pathogenic, 1 likely-pathogenic
• Cancer dependency (DepMap): dependent in 53.6% of screened cell lines
• MANE Select transcript: NM_024611

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29885
Approved symbol	ICE2
Name	interactor of little elongation complex ELL subunit 2
Location	15q22.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ11896, BRCC1
Ensembl gene	ENSG00000128915
Ensembl biotype	protein_coding
OMIM	610835
Entrez	79664

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 16 protein_coding, 4 retained_intron, 4 nonsense_mediated_decay, 3 protein_coding_CDS_not_defined

ENST00000261520, ENST00000558121, ENST00000558181, ENST00000558451, ENST00000558512, ENST00000558654, ENST00000560072, ENST00000560406, ENST00000560520, ENST00000560668, ENST00000560895, ENST00000561087, ENST00000561114, ENST00000561124, ENST00000561144, ENST00000561328, ENST00000561446, ENST00000874574, ENST00000874575, ENST00000874576, ENST00000915338, ENST00000915339, ENST00000915340, ENST00000915341, ENST00000915342, ENST00000915343, ENST00000915344

RefSeq mRNA: 3 — MANE Select: NM_024611 NM_001018089, NM_001276385, NM_024611

CCDS: CCDS10176, CCDS61657

Canonical transcript exons

ENST00000261520 — 16 exons

Exon	Start	End
ENSE00001228283	60479003	60479142
ENSE00001228314	60468061	60468322
ENSE00001423756	60419609	60423762
ENSE00003472675	60436143	60436227
ENSE00003484569	60453603	60453784
ENSE00003513096	60455326	60455442
ENSE00003529637	60466594	60466713
ENSE00003538237	60431934	60431984
ENSE00003543779	60448848	60449841
ENSE00003622632	60442416	60442545
ENSE00003627494	60476063	60476167
ENSE00003630970	60455003	60455162
ENSE00003649070	60477937	60478069
ENSE00003657078	60447970	60448145
ENSE00003658471	60428429	60428687
ENSE00003663067	60456657	60456794

Expression profiles

Bgee: expression breadth ubiquitous, 275 present calls, max score 94.18.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.4520 / max 309.0581, expressed in 1775 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
150323	14.1197	1775
150322	0.3323	146

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	94.18	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.64	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.30	gold quality
ventricular zone	UBERON:0003053	93.26	gold quality
adrenal tissue	UBERON:0018303	92.04	gold quality
ganglionic eminence	UBERON:0004023	91.96	gold quality
calcaneal tendon	UBERON:0003701	91.51	gold quality
tendon	UBERON:0000043	91.11	gold quality
embryo	UBERON:0000922	90.99	gold quality
left ovary	UBERON:0002119	90.08	gold quality
hindlimb stylopod muscle	UBERON:0004252	89.97	gold quality
secondary oocyte	CL:0000655	89.94	gold quality
oocyte	CL:0000023	89.65	gold quality
islet of Langerhans	UBERON:0000006	89.60	gold quality
right ovary	UBERON:0002118	89.59	gold quality
right uterine tube	UBERON:0001302	89.22	gold quality
ovary	UBERON:0000992	88.91	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	88.71	gold quality
right lobe of thyroid gland	UBERON:0001119	88.55	gold quality
nerve	UBERON:0001021	88.52	gold quality
tibial nerve	UBERON:0001323	88.52	gold quality
pituitary gland	UBERON:0000007	88.51	gold quality
monocyte	CL:0000576	88.39	gold quality
adenohypophysis	UBERON:0002196	88.38	gold quality
body of uterus	UBERON:0009853	88.35	gold quality
leukocyte	CL:0000738	88.30	gold quality
mononuclear cell	CL:0000842	88.29	gold quality
endocervix	UBERON:0000458	88.23	gold quality
bone marrow cell	CL:0002092	88.15	gold quality
body of pancreas	UBERON:0001150	87.98	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9801	yes	6.80
E-MTAB-7303	no	126.75
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

134 targeting ICE2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-4267	99.96	66.53	2368

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 53.6% of screened cell lines.

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	ice2	ENSDARG00000086670
mus_musculus	Ice2	ENSMUSG00000032235
rattus_norvegicus	Ice2	ENSRNOG00000010160

Protein

Protein identifiers

Little elongation complex subunit 2 — Q659A1 (reviewed: Q659A1)

Alternative names: Interactor of little elongator complex ELL subunit 2, NMDA receptor-regulated protein 2

All UniProt accessions (8): Q659A1, H0YK14, H0YK96, H0YK97, H0YL35, H0YMX6, H0YN09, H0YNU9

UniProt curated annotations — full annotation on UniProt →

Function. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.

Subunit / interactions. Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain). Interacts with ELL.

Subcellular location. Nucleus.

Tissue specificity. Expressed at low levels in lung and testis.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity. Belongs to the ICE2 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q659A1-1	1	yes
Q659A1-2	2

RefSeq proteins (3): NP_001018099, NP_001263314, NP_078887* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019535	ICE2_C	Domain

Pfam: PF10505

UniProt features (26 total): compositionally biased region 7, sequence conflict 7, region of interest 5, modified residue 4, splice variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q659A1-F1	66.24	0.30

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 17, 326, 571, 573

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6807505	RNA polymerase II transcribes snRNA genes

MSigDB gene sets: 135 (showing top): GOBP_TRANSCRIPTION_BY_RNA_POLYMERASE_III, GTGCCTT_MIR506, DODD_NASOPHARYNGEAL_CARCINOMA_UP, CREB_Q3, YRTCANNRCGC_UNKNOWN, IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR, NUYTTEN_EZH2_TARGETS_DN, GOCC_CAJAL_BODY, GOCC_NUCLEAR_BODY, GOCC_RIBONUCLEOPROTEIN_GRANULE, MARSON_BOUND_BY_E2F4_UNSTIMULATED, GOCC_EUCHROMATIN, GOCC_TRANSCRIPTION_ELONGATION_FACTOR_COMPLEX, BENPORATH_ES_1, HAMAI_APOPTOSIS_VIA_TRAIL_UP

GO Biological Process (3): snRNA transcription by RNA polymerase II (GO:0042795), snRNA transcription by RNA polymerase III (GO:0042796), positive regulation of transcription by RNA polymerase III (GO:0045945)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (8): euchromatin (GO:0000791), nucleoplasm (GO:0005654), cytosol (GO:0005829), transcription elongation factor complex (GO:0008023), Cajal body (GO:0015030), nuclear body (GO:0016604), histone locus body (GO:0035363), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RNA Polymerase II Transcription	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
snRNA transcription	2
transcription by RNA polymerase III	2
cellular anatomical structure	2
nucleoplasm	2
nuclear ribonucleoprotein granule	2
transcription by RNA polymerase II	1
regulation of transcription by RNA polymerase III	1
positive regulation of DNA-templated transcription	1
binding	1
chromatin	1
nuclear lumen	1
cytoplasm	1
nuclear protein-containing complex	1
intracellular membraneless organelle	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1184 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ICE2	ICE1	Q9Y2F5	985
ICE2	ZNF346	Q9UL40	947
ICE2	NAA15	Q9BXJ9	940
ICE2	ZC3H8	Q8N5P1	834
ICE2	NAA10	P41227	763
ICE2	ELL	P55199	750
ICE2	GRIN1	P35437	648
ICE2	USPL1	Q5W0Q7	591
ICE2	MNAT1	P51948	581
ICE2	MED26	O95402	514
ICE2	EAF1	Q96JC9	504
ICE2	NAT1	P18440	474
ICE2	EAF2	Q96CJ1	457
ICE2	ELL2	O00472	434
ICE2	ELL3	Q9HB65	425

IntAct

60 interactions, top by confidence:

A	B	Type	Score
EAF1	ELL2	psi-mi:“MI:0914”(association)	0.840
ELL3	ICE2	psi-mi:“MI:0914”(association)	0.730
ELL3	CCNT1	psi-mi:“MI:0914”(association)	0.640
SNRPA1	HTATSF1	psi-mi:“MI:0914”(association)	0.640
SNRPA1	U2SURP	psi-mi:“MI:0914”(association)	0.640
SNRPB	SART1	psi-mi:“MI:0914”(association)	0.640
ICE1	ELL	psi-mi:“MI:0915”(physical association)	0.620
ICE2	ELL	psi-mi:“MI:0915”(physical association)	0.620
ELL	ICE2	psi-mi:“MI:0914”(association)	0.620
ICE2	ELL	psi-mi:“MI:0914”(association)	0.620
ICE1	ELL	psi-mi:“MI:0914”(association)	0.620
ICE2	HP	psi-mi:“MI:0914”(association)	0.530
DYRK1B	BMAL1	psi-mi:“MI:0914”(association)	0.530
Ncbp2	ZC3H18	psi-mi:“MI:0914”(association)	0.350
OFD1	CCDC14	psi-mi:“MI:0914”(association)	0.350
Ankrd26	TBC1D31	psi-mi:“MI:0914”(association)	0.350
Scai	BCR	psi-mi:“MI:0914”(association)	0.350
Osgep	RPSA	psi-mi:“MI:0914”(association)	0.350
FGFR1OP2	STK24	psi-mi:“MI:0914”(association)	0.350
SIKE1	STK24	psi-mi:“MI:0914”(association)	0.350

BioGRID (112): ICE2 (Affinity Capture-MS), ICE2 (Affinity Capture-MS), ICE2 (Affinity Capture-MS), ACTA2 (Affinity Capture-MS), IGKC (Affinity Capture-MS), IGLC7 (Affinity Capture-MS), IGHG2 (Affinity Capture-MS), IGHG1 (Affinity Capture-MS), CCT6B (Affinity Capture-MS), PIGR (Affinity Capture-MS), HP (Affinity Capture-MS), LTF (Affinity Capture-MS), MUC5B (Affinity Capture-MS), SERPINA1 (Affinity Capture-MS), BPIFA1 (Affinity Capture-MS)

ESM2 similar proteins: A0A0M3U1B0, A0A1L8EYB2, A0JMF7, A4D1B5, A4FUB0, D3IUT5, D3Z6S9, F1QB81, O60281, O70167, P53995, Q0VCQ7, Q13129, Q14699, Q2T9I9, Q3TCV3, Q3UJC8, Q402B2, Q4R9E9, Q5RA75, Q5RB52, Q5XI46, Q5XI56, Q5ZKI7, Q659A1, Q6AYM1, Q6DRL4, Q6INI0, Q6PUR7, Q7Z2Z1, Q8BQ33, Q8CCC3, Q8CDN1, Q8IXR9, Q8K1K4, Q8NB91, Q8ND61, Q90WN7, Q920I9, Q92674

Diamond homologs: Q0VCQ7, Q3UZ18, Q659A1

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
ICE2	“form complex”	ELL/ICE2	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 69 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
RNA polymerase II transcribes snRNA genes	6	21.5×	7e-05
mRNA Splicing	6	15.3×	2e-04
CHD1 and CHD2 subfamily	5	12.7×	2e-03
mRNA Polyadenylation	6	12.3×	4e-04
Processing of Capped Intron-Containing Pre-mRNA	6	11.5×	5e-04
mRNA Splicing - Major Pathway	8	10.2×	1e-04
Metabolism of RNA	7	6.8×	2e-03
Dengue Virus-Host Interactions	6	6.4×	7e-03

GO biological processes:

GO term	Partners	Fold	FDR
U2-type prespliceosome assembly	5	55.7×	4e-06
positive regulation of transcription elongation by RNA polymerase II	6	32.2×	4e-06
mRNA splicing, via spliceosome	7	11.4×	2e-04
RNA splicing	6	9.4×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

195 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	1
Uncertain significance	147
Likely benign	17
Benign	5

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
4820238	Single allele	Pathogenic
2685518	GRCh37/hg19 15q22.2(chr15:60688155-60888244)x1	Likely pathogenic

SpliceAI

3427 predictions. Top by Δscore:

Variant	Effect	Δscore
15:60436141:A:AC	donor_gain	1.0000
15:60436142:C:CC	donor_gain	1.0000
15:60436224:TGCC:T	acceptor_gain	1.0000
15:60436226:CC:C	acceptor_gain	1.0000
15:60436227:CC:C	acceptor_gain	1.0000
15:60436227:CCTA:C	acceptor_loss	1.0000
15:60436228:C:CC	acceptor_gain	1.0000
15:60436228:CTA:C	acceptor_loss	1.0000
15:60436229:T:A	acceptor_loss	1.0000
15:60449843:T:C	acceptor_gain	1.0000
15:60449845:A:AC	acceptor_gain	1.0000
15:60449845:A:C	acceptor_gain	1.0000
15:60453601:A:AC	donor_gain	1.0000
15:60453601:ACGT:A	donor_gain	1.0000
15:60453602:C:CC	donor_gain	1.0000
15:60453602:CGT:C	donor_gain	1.0000
15:60453602:CGTC:C	donor_gain	1.0000
15:60453604:T:TA	donor_gain	1.0000
15:60453605:C:A	donor_gain	1.0000
15:60453786:T:C	acceptor_gain	1.0000
15:60455320:ACTT:A	donor_loss	1.0000
15:60455322:TTACA:T	donor_loss	1.0000
15:60455323:TA:T	donor_loss	1.0000
15:60455324:A:AC	donor_gain	1.0000
15:60455324:A:C	donor_loss	1.0000
15:60455325:C:CT	donor_gain	1.0000
15:60455325:CA:C	donor_gain	1.0000
15:60455325:CAT:C	donor_gain	1.0000
15:60455325:CATA:C	donor_gain	1.0000
15:60455325:CATAA:C	donor_gain	1.0000

AlphaMissense

6448 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:60449021:A:G	L649S	0.999
15:60449024:A:C	I648S	0.999
15:60449024:A:G	I648T	0.999
15:60449033:A:T	V645D	0.999
15:60449003:A:G	L655P	0.998
15:60449015:A:G	M651T	0.998
15:60428533:A:G	W906R	0.997
15:60428533:A:T	W906R	0.997
15:60449024:A:T	I648N	0.997
15:60428465:A:C	F928L	0.996
15:60428465:A:T	F928L	0.996
15:60428467:A:G	F928L	0.996
15:60447970:T:A	R765S	0.996
15:60447970:T:G	R765S	0.996
15:60449011:C:A	Q652H	0.996
15:60449011:C:G	Q652H	0.996
15:60449039:T:C	D643G	0.996
15:60442535:A:T	V769D	0.995
15:60455042:A:G	W302R	0.995
15:60455042:A:T	W302R	0.995
15:60466675:G:C	F149L	0.995
15:60466675:G:T	F149L	0.995
15:60466677:A:G	F149L	0.995
15:60442416:C:G	G809R	0.994
15:60442416:C:T	G809R	0.994
15:60447973:T:A	R764S	0.994
15:60447973:T:G	R764S	0.994
15:60448071:A:C	Y732D	0.994
15:60455131:A:G	L272P	0.994
15:60436227:C:T	G809E	0.993

dbSNP variants (sampled 300 via entrez): RS1000023766 (15:60451528 T>C), RS1000054552 (15:60465202 C>A,T), RS1000086576 (15:60479325 G>A,C), RS1000093034 (15:60441197 A>G), RS1000167256 (15:60471813 A>G), RS1000227119 (15:60430135 A>G), RS1000258485 (15:60433979 C>G), RS1000283296 (15:60433656 A>G), RS1000288579 (15:60438702 G>A), RS1000340326 (15:60438287 A>G), RS1000481988 (15:60444549 T>A), RS1000494330 (15:60457056 G>A,C), RS1000512542 (15:60472813 C>A), RS1000543619 (15:60472620 T>C), RS1000586430 (15:60433013 T>A,C)

Disease associations

OMIM: gene MIM:610835 | disease phenotypes: MIM:618060

GenCC curated gene-disease

Mondo (1): intellectual developmental disorder with or without epilepsy or cerebellar ataxia (MONDO:0060745)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST005212_29	Asthma	1.000000e-09
GCST006862_16	Asthma	8.000000e-11
GCST009391_1441	Metabolite levels	3.000000e-06
GCST009391_1845	Metabolite levels	3.000000e-06
GCST009798_17	Asthma	2.000000e-19
GCST90002381_617	Eosinophil count	4.000000e-09
GCST90002382_236	Eosinophil percentage of white cells	7.000000e-12

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0010409	triacylglycerol 50:2 measurement
EFO:0010413	triacylglycerol 52:1 measurement
EFO:0004842	eosinophil count
EFO:0007991	eosinophil percentage of leukocytes

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression	6
Arsenic	affects methylation, increases methylation, affects cotreatment, decreases expression, increases abundance	3
sodium arsenite	decreases expression, affects cotreatment, increases abundance	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
p-Chloromercuribenzoic Acid	affects cotreatment, decreases expression	2
FR900359	increases phosphorylation	1
dicrotophos	decreases expression	1
geldanamycin	increases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, increases activity, increases expression	1
testosterone undecanoate	affects cotreatment, decreases expression	1
beta-lapachone	increases expression	1
butyraldehyde	decreases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
coumarin	decreases phosphorylation	1
lei gong teng	increases expression	1
epigallocatechin gallate	increases expression	1
pentanal	decreases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
belinostat	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	increases expression, increases response to substance	1
jinfukang	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	increases abundance, increases expression	1
Caffeine	increases phosphorylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.