ICMT-DT

Summary

ICMT-DT (ICMT divergent transcript, HGNC:28620) is a long non-coding RNA gene on chromosome 1p36.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28620
Approved symbol	ICMT-DT
Name	ICMT divergent transcript
Location	1p36.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC40168
Ensembl gene	ENSG00000225077
Ensembl biotype	lncRNA
Entrez	148645
RNAcentral	URS000075C4D1 — lncRNA, 1642 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000429480, ENST00000441724, ENST00000650463, ENST00000796165, ENST00000796166, ENST00000796167, ENST00000796168, ENST00000796169, ENST00000796170, ENST00000796171, ENST00000796172, ENST00000796173, ENST00000796174

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429480 — 4 exons

Exon	Start	End
ENSE00001800493	6237245	6237345
ENSE00003838351	6237470	6237848
ENSE00004181542	6238221	6239444
ENSE00004181544	6235410	6235433

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 77.12.

Top tissues by expression

222 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.12	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.31	gold quality
buccal mucosa cell	CL:0002336	68.76	gold quality
secondary oocyte	CL:0000655	63.87	silver quality
hindlimb stylopod muscle	UBERON:0004252	61.69	gold quality
vena cava	UBERON:0004087	61.47	gold quality
stromal cell of endometrium	CL:0002255	60.26	gold quality
right lobe of liver	UBERON:0001114	58.47	gold quality
lower lobe of lung	UBERON:0008949	57.61	silver quality
ganglionic eminence	UBERON:0004023	56.36	silver quality
oocyte	CL:0000023	55.70	gold quality
mucosa of transverse colon	UBERON:0004991	55.52	gold quality
cortical plate	UBERON:0005343	55.15	silver quality
calcaneal tendon	UBERON:0003701	54.97	gold quality
liver	UBERON:0002107	54.90	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	53.91	gold quality
parotid gland	UBERON:0001831	53.62	gold quality
sperm	CL:0000019	53.23	gold quality
tendon of biceps brachii	UBERON:0008188	53.15	gold quality
muscle of leg	UBERON:0001383	52.65	gold quality
cerebellar vermis	UBERON:0004720	52.23	gold quality
gastrocnemius	UBERON:0001388	52.06	gold quality
nasal cavity epithelium	UBERON:0005384	51.99	gold quality
cardia of stomach	UBERON:0001162	51.86	gold quality
testis	UBERON:0000473	51.50	gold quality
trabecular bone tissue	UBERON:0002483	51.41	gold quality
endothelial cell	CL:0000115	51.25	gold quality
blood	UBERON:0000178	51.16	gold quality
prefrontal cortex	UBERON:0000451	50.90	silver quality
lymph node	UBERON:0000029	50.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.94

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Long non-coding RNA LINC00337 induces autophagy and chemoresistance to cisplatin in esophageal squamous cell carcinoma cells via upregulation of TPX2 by recruiting E2F4. (PMID:32239565)
• Silencing of linc00337 inhibits proliferation, cell cycle progression, migration, and invasion of colorectal cancer cells through the MEK/ERK pathway. (PMID:32495869)
• Long intergenic non-coding RNA 00337 confers progression of esophageal cancer by mediating microrna-145-dependent fscn1. (PMID:32654289)
• Long noncoding RNA Linc00337 functions as an E2F1 co-activator and promotes cell proliferation in pancreatic ductal adenocarcinoma. (PMID:33054826)
• LINC00337 induces tumor development and chemoresistance to paclitaxel of breast cancer by recruiting M2 tumor-associated macrophages. (PMID:34314939)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.