ID2-AS1

Summary

ID2-AS1 (ID2 antisense RNA 1, HGNC:51103) is a long non-coding RNA gene on chromosome 2p25.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51103
Approved symbol	ID2-AS1
Name	ID2 antisense RNA 1
Location	2p25.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000235092
Ensembl biotype	lncRNA
Entrez	100506299
RNAcentral	URS000075DDF2 — lncRNA, 826 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 26 lncRNA

ENST00000412712, ENST00000418957, ENST00000421298, ENST00000433592, ENST00000453900, ENST00000455965, ENST00000656008, ENST00000661063, ENST00000665989, ENST00000669696, ENST00000687473, ENST00000691069, ENST00000691754, ENST00000844141, ENST00000844142, ENST00000844143, ENST00000844144, ENST00000844145, ENST00000844146, ENST00000844147, ENST00000844148, ENST00000844149, ENST00000844150, ENST00000844151, ENST00000844152, ENST00000844153

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412712 — 4 exons

Exon	Start	End
ENSE00001656451	8675744	8676029
ENSE00001674534	8673150	8673307
ENSE00001745575	8666636	8666787
ENSE00001786296	8677978	8678334

Expression profiles

Bgee: expression breadth ubiquitous, 197 present calls, max score 93.00.

FANTOM5 (CAGE): breadth broad, TPM avg 0.3546 / max 9.6350, expressed in 185 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
26794	0.3546	185

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	93.00	gold quality
upper arm skin	UBERON:0004263	84.60	gold quality
kidney epithelium	UBERON:0004819	83.69	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.87	gold quality
spinal cord	UBERON:0002240	82.64	gold quality
medial globus pallidus	UBERON:0002477	81.80	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.26	gold quality
globus pallidus	UBERON:0001875	80.74	gold quality
vena cava	UBERON:0004087	80.33	silver quality
pancreatic ductal cell	CL:0002079	79.51	silver quality
sperm	CL:0000019	78.70	silver quality
saphenous vein	UBERON:0007318	78.54	gold quality
amygdala	UBERON:0001876	77.73	gold quality
inferior vagus X ganglion	UBERON:0005363	77.65	gold quality
subthalamic nucleus	UBERON:0001906	77.20	silver quality
body of tongue	UBERON:0011876	76.99	gold quality
substantia nigra	UBERON:0002038	76.97	gold quality
popliteal artery	UBERON:0002250	76.80	gold quality
tibial artery	UBERON:0007610	76.79	gold quality
midbrain	UBERON:0001891	76.77	gold quality
nasal cavity epithelium	UBERON:0005384	76.62	gold quality
layer of synovial tissue	UBERON:0007616	76.57	silver quality
tendon	UBERON:0000043	76.45	gold quality
medulla oblongata	UBERON:0001896	76.37	gold quality
dorsal plus ventral thalamus	UBERON:0001897	75.85	silver quality
putamen	UBERON:0001874	75.53	gold quality
cardia of stomach	UBERON:0001162	75.41	gold quality
ventral tegmental area	UBERON:0002691	75.34	silver quality
nipple	UBERON:0002030	75.32	gold quality
trigeminal ganglion	UBERON:0001675	75.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.52

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• ID2-AS1 significantly suppressed the migration, invasion and metastasis of hepatocellular carcinoma (HCC) cells in vitro and in vivo. Mechanistically, ID2-AS1 regulated the transcription of its adjacent gene inhibitor of DNA binding 2 (ID2) by blocking the binding of histone deacetylase 8 (HDAC8) on the ID2 enhancer (PMID:31730902)
• Down-Regulation of ID2-AS1 Alleviates the Neuronal Injury Induced by 1-Methy1-4-Phenylpyridinium in Human Neuroblastoma Cell Line SH-SY5Y Cells Through Regulating miR-199a-5p/IFNAR1/JAK2/STAT1 Axis. (PMID:34050453)
• Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer. (PMID:35776987)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.