IDH1-AS1

Summary

IDH1-AS1 (IDH1 antisense RNA 1, HGNC:40292) is a long non-coding RNA gene on chromosome 2q34.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40292
Approved symbol	IDH1-AS1
Name	IDH1 antisense RNA 1
Location	2q34
Locus type	RNA, long non-coding
Status	Approved
Aliases	IADMP
Ensembl gene	ENSG00000231908
Ensembl biotype	lncRNA
Entrez	100507475
RNAcentral	URS000075BD60 — lncRNA, 491 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000440574, ENST00000448588, ENST00000832346, ENST00000832347, ENST00000832348, ENST00000832349

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000440574 — 2 exons

Exon	Start	End
ENSE00004247732	208255903	208256233
ENSE00004247733	208255197	208255431

Expression profiles

Bgee: expression breadth ubiquitous, 166 present calls, max score 90.25.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0332 / max 31.6087, expressed in 665 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
24902	1.0332	665

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.25	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.20	gold quality
left ventricle myocardium	UBERON:0006566	75.10	gold quality
apex of heart	UBERON:0002098	74.98	gold quality
cardiac muscle of right atrium	UBERON:0003379	73.40	gold quality
myocardium	UBERON:0002349	72.89	gold quality
right adrenal gland	UBERON:0001233	72.02	gold quality
kidney epithelium	UBERON:0004819	71.73	gold quality
right adrenal gland cortex	UBERON:0035827	71.66	gold quality
ganglionic eminence	UBERON:0004023	70.99	gold quality
ventricular zone	UBERON:0003053	70.44	gold quality
heart left ventricle	UBERON:0002084	70.34	gold quality
cardiac ventricle	UBERON:0002082	70.00	gold quality
left adrenal gland	UBERON:0001234	69.89	gold quality
left adrenal gland cortex	UBERON:0035825	69.26	gold quality
adrenal cortex	UBERON:0001235	68.85	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.46	gold quality
pancreatic ductal cell	CL:0002079	68.37	silver quality
mucosa of transverse colon	UBERON:0004991	68.25	gold quality
adrenal gland	UBERON:0002369	68.07	gold quality
spinal cord	UBERON:0002240	67.46	gold quality
right lobe of liver	UBERON:0001114	67.26	gold quality
heart	UBERON:0000948	67.14	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	66.94	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.30	gold quality
substantia nigra	UBERON:0002038	66.05	gold quality
cardiac atrium	UBERON:0002081	65.73	gold quality
stromal cell of endometrium	CL:0002255	65.59	gold quality
right atrium auricular region	UBERON:0006631	65.48	gold quality
midbrain	UBERON:0001891	64.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.85

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• PAX5-induced upregulation of IDH1-AS1 promotes tumor growth in prostate cancer by regulating ATG5-mediated autophagy. (PMID:31570703)
• LncRNA IDH1-AS1 suppresses cell proliferation and tumor growth in glioma. (PMID:32990028)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.