IDI1

Summary

IDI1 (isopentenyl-diphosphate delta isomerase 1, HGNC:5387) is a protein-coding gene on chromosome 10p15.3, encoding Isopentenyl-diphosphate Delta-isomerase 1 (Q13907). Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.

Source: NCBI Gene 3422 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 48 total
• MANE Select transcript: NM_004508

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5387
Approved symbol	IDI1
Name	isopentenyl-diphosphate delta isomerase 1
Location	10p15.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000067064
Ensembl biotype	protein_coding
OMIM	604055
Entrez	3422

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000381344, ENST00000427898, ENST00000429642, ENST00000482091, ENST00000491735, ENST00000695775

RefSeq mRNA: 4 — MANE Select: NM_004508 NM_001317955, NM_001317956, NM_001317957, NM_004508

CCDS: CCDS7056, CCDS91201

Canonical transcript exons

ENST00000381344 — 5 exons

Exon	Start	End
ENSE00001488346	1039419	1041504
ENSE00003500071	1043301	1043393
ENSE00003638182	1043999	1044171
ENSE00003785876	1042632	1042762
ENSE00003964996	1048864	1049119

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 99.62.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 43.5164 / max 816.2354, expressed in 1812 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
107877	36.3954	1807
107878	4.2163	1234
107879	2.6105	1369
107876	0.1704	56
107875	0.1239	47

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.62	gold quality
amniotic fluid	UBERON:0000173	99.21	gold quality
pons	UBERON:0000988	98.46	gold quality
ventricular zone	UBERON:0003053	98.46	gold quality
superior vestibular nucleus	UBERON:0007227	98.34	gold quality
ganglionic eminence	UBERON:0004023	98.30	gold quality
endometrium epithelium	UBERON:0004811	98.30	gold quality
embryo	UBERON:0000922	97.97	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	97.88	gold quality
pigmented layer of retina	UBERON:0001782	97.72	gold quality
frontal pole	UBERON:0002795	97.71	gold quality
medulla oblongata	UBERON:0001896	97.52	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.50	gold quality
spinal cord	UBERON:0002240	97.48	gold quality
biceps brachii	UBERON:0001507	97.45	gold quality
lateral nuclear group of thalamus	UBERON:0002736	97.41	gold quality
cortical plate	UBERON:0005343	97.36	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	97.26	gold quality
inferior vagus X ganglion	UBERON:0005363	97.26	gold quality
substantia nigra pars compacta	UBERON:0001965	97.23	gold quality
dorsal root ganglion	UBERON:0000044	97.22	gold quality
medial globus pallidus	UBERON:0002477	97.16	gold quality
cranial nerve II	UBERON:0000941	97.12	gold quality
deltoid	UBERON:0001476	97.12	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	97.09	gold quality
ventral tegmental area	UBERON:0002691	97.03	gold quality
dorsal plus ventral thalamus	UBERON:0001897	97.00	gold quality
gastrocnemius	UBERON:0001388	96.98	gold quality
Brodmann (1909) area 10	UBERON:0013541	96.96	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-HCAD-25	yes	3955.17
E-MTAB-10485	yes	1292.07
E-GEOD-84465	yes	22.75
E-GEOD-135922	yes	13.48
E-MTAB-6819	no	1066.19
E-MTAB-7606	no	546.71
E-MTAB-3929	no	409.65
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

76 targeting IDI1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-221-5P	99.86	65.45	1052
HSA-MIR-8073	99.86	65.21	1118
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-369-3P	99.85	70.52	2264
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-4639-5P	99.81	67.37	1028
HSA-MIR-4517	99.76	69.19	1867
HSA-MIR-646	99.68	67.84	1645
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-7157-5P	99.66	69.33	1829

Literature-anchored findings (GeneRIF, showing 4)

• only one of the two isoforms (IDI1) is highly conserved, ubiquitously expressed and most likely responsible for housekeeping isomerase activity (PMID:14629038)
• Within the 40-kb region on 10p15.3 subtelomere, which harbours two genes encoding isopentenyl diphosphate isomerase 1 (IDI1) and IDI2, there was found a segmental copy-number gain in a large proportion of sporadic amyotrophic lateral sclerosis patients. (PMID:20955688)
• The present findings suggest that IDI1 and IDI2 may be associated with the production of cholesterol metabolites in neurons, leading to alpha-synuclein aggregation during the process of Lewy body formation. (PMID:25950736)
• Canonical pathway analysis, using Ingenuity Pathway Analysis software, revealed that the only genes in the “superpathway of cholesterol biosynthesis” were Idi1 (upregulated) and Hmgcs2 (downregulated). The Idi1 and Hmgcs2 genes have regulatory roles in atrial lipotoxic myopathy associated with atrial enlargement (PMID:30567295)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	idi1	ENSDARG00000019976
mus_musculus	Idi1	ENSMUSG00000058258
rattus_norvegicus	Idi1	ENSRNOG00000016690
drosophila_melanogaster	Idi	FBGN0038876
caenorhabditis_elegans		WBGENE00019460

Paralogs (1): IDI2 (ENSG00000148377)

Protein

Protein identifiers

Isopentenyl-diphosphate Delta-isomerase 1 — Q13907 (reviewed: Q13907)

Alternative names: Isopentenyl pyrophosphate isomerase 1

All UniProt accessions (3): Q13907, A0A8Q3WKR8, C9JD53

UniProt curated annotations — full annotation on UniProt →

Function. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

Subunit / interactions. Monomer.

Subcellular location. Peroxisome.

Cofactor. Binds 1 Mg(2+) ion per subunit.

Pathway. Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.

Similarity. Belongs to the IPP isomerase type 1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q13907-1	1	yes
Q13907-2	2

RefSeq proteins (4): NP_001304884, NP_001304885, NP_001304886, NP_004499* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000086	NUDIX_hydrolase_dom	Domain
IPR011876	IsopentenylPP_isomerase_typ1	Family
IPR015797	NUDIX_hydrolase-like_dom_sf	Homologous_superfamily

Pfam: PF00293

Enzyme classification (BRENDA):

• EC 5.3.3.2 — isopentenyl-diphosphate DELTA-isomerase (BRENDA: 50 organisms, 36 substrates, 92 inhibitors, 76 Km, 23 kcat entries)

Substrate kinetics (BRENDA)

3 substrates with measured Km, best-characterized 3. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
ISOPENTENYL DIPHOSPHATE	0.0008–15.3	72
NADH	0.0874–0.0904	2
DIMETHYLALLYL DIPHOSPHATE	0.017	1

Catalyzed reactions (Rhea), 1 shown:

• isopentenyl diphosphate = dimethylallyl diphosphate (RHEA:23284)

UniProt features (47 total): helix 13, strand 11, binding site 8, sequence conflict 5, turn 3, active site 2, chain 1, domain 1, modified residue 1, splice variant 1, short sequence motif 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
2DHO	X-RAY DIFFRACTION	1.6
2ICJ	X-RAY DIFFRACTION	1.7
2ICK	X-RAY DIFFRACTION	1.93
2I6K	X-RAY DIFFRACTION	2

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13907-F1	97.14	0.96

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (2): 86; 148

Ligand- & substrate-binding residues (8): 87; 146; 148; 36; 40; 51; 70; 74

Post-translational modifications (1): 176

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)
R-HSA-9969896	Lanosterol biosynthesis
R-HSA-191273	Cholesterol biosynthesis

MSigDB gene sets: 303 (showing top): GOBP_PHOSPHOLIPID_METABOLIC_PROCESS, JI_RESPONSE_TO_FSH_UP, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS, PATIL_LIVER_CANCER, PUJANA_CHEK2_PCC_NETWORK, GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS, SENESE_HDAC1_AND_HDAC2_TARGETS_DN, WEI_MYCN_TARGETS_WITH_E_BOX, SMITH_TERT_TARGETS_DN, GOBP_SMALL_MOLECULE_BIOSYNTHETIC_PROCESS, KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP, YU_MYC_TARGETS_UP, UEDA_PERIFERAL_CLOCK, DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_DN

GO Biological Process (10): cholesterol biosynthetic process (GO:0006695), isoprenoid biosynthetic process (GO:0008299), isopentenyl diphosphate biosynthetic process (GO:0009240), response to stilbenoid (GO:0035634), dimethylallyl diphosphate biosynthetic process (GO:0050992), lipid metabolic process (GO:0006629), steroid biosynthetic process (GO:0006694), steroid metabolic process (GO:0008202), cholesterol metabolic process (GO:0008203), sterol biosynthetic process (GO:0016126)

GO Molecular Function (7): magnesium ion binding (GO:0000287), isopentenyl-diphosphate delta-isomerase activity (GO:0004452), manganese ion binding (GO:0030145), metal ion binding (GO:0046872), protein binding (GO:0005515), isomerase activity (GO:0016853), intramolecular oxidoreductase activity (GO:0016860)

GO Cellular Component (3): cytoplasm (GO:0005737), peroxisome (GO:0005777), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Regulation of cholesterol biosynthesis by SREBP (SREBF)	1
Cholesterol biosynthesis	1
Metabolism of steroids	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
lipid biosynthetic process	2
phospholipid biosynthetic process	2
sterol metabolic process	2
cellular anatomical structure	2
cholesterol metabolic process	1
sterol biosynthetic process	1
secondary alcohol biosynthetic process	1
isoprenoid metabolic process	1
isoprenoid biosynthetic process	1
isopentenyl diphosphate metabolic process	1
response to chemical	1
dimethylallyl diphosphate metabolic process	1
primary metabolic process	1
steroid metabolic process	1
lipid metabolic process	1
secondary alcohol metabolic process	1
steroid biosynthetic process	1
metal ion binding	1
intramolecular oxidoreductase activity, transposing C=C bonds	1
transition metal ion binding	1
cation binding	1
binding	1
catalytic activity	1
isomerase activity	1
intracellular anatomical structure	1
microbody	1
cytoplasm	1

Protein interactions and networks

STRING

1204 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
IDI1	MVD	P53602	843
IDI1	SQLE	Q14534	842
IDI1	FDFT1	P37268	842
IDI1	HMGCS1	Q01581	828
IDI1	FDPS	P14324	825
IDI1	MVK	Q03426	810
IDI1	HMGCR	P04035	809
IDI1	GGPS1	O95749	805
IDI1	PMVK	Q15126	799
IDI1	DHCR7	Q9UBM7	769
IDI1	MSMO1	Q15800	767
IDI1	CYP51A1	Q16850	764
IDI1	INSIG1	O15503	739
IDI1	HSD17B7	P56937	731
IDI1	DHCR24	Q15392	717

IntAct

13 interactions, top by confidence:

A	B	Type	Score
IDI1	VWA8	psi-mi:“MI:0915”(physical association)	0.400
IDI1		psi-mi:“MI:0915”(physical association)	0.370
IDI1	WT1	psi-mi:“MI:0915”(physical association)	0.370
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
KSR1	FBLL1	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
rep	MYCBP2	psi-mi:“MI:0914”(association)	0.350
IDI1	BLMH	psi-mi:“MI:0914”(association)	0.350
FECH	POTEF	psi-mi:“MI:0914”(association)	0.350
FN1	ESYT2	psi-mi:“MI:0914”(association)	0.350
IMMP1L	NUDT19	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (46): VWA8 (Affinity Capture-MS), VWA8 (Affinity Capture-MS), IDI1 (Two-hybrid), IDI1 (Proximity Label-MS), IDI1 (Affinity Capture-MS), IDI1 (Affinity Capture-MS), IDI1 (Affinity Capture-MS), IDI1 (Affinity Capture-MS), ZNF655 (Two-hybrid), IDI1 (Affinity Capture-MS), IDI1 (Proximity Label-MS), IDI1 (Affinity Capture-MS), IDI1 (Proximity Label-MS), IDI1 (Proximity Label-MS), IDI1 (Proximity Label-MS)

ESM2 similar proteins: A0A7C9FSB8, A2TLM1, A6H7H7, B8BKI7, B9N1F9, B9SQI7, D2XV59, E0CSI1, F1N9S8, O00178, O08582, O35586, O35760, O48964, O48965, O76031, O81770, P11029, P11497, P58044, P69341, Q0J035, Q13085, Q13907, Q14165, Q1LZ95, Q1LZ96, Q28559, Q2R483, Q38929, Q39471, Q39472, Q39664, Q3UMR5, Q42553, Q4R4W5, Q5NVE1, Q5R8R6, Q5SWU9, Q5U2U0

Diamond homologs: A0A1D8PLI2, A0A7C9FSB8, A1T5G2, A4FK76, A8GDW2, A9AST0, A9MRI5, B1VTW2, B5F9P6, I1RZ92, O35586, O35760, O42641, O48964, O48965, P15496, P58044, Q0RBQ7, Q10132, Q13907, Q1LZ95, Q38929, Q39471, Q39472, Q39664, Q42553, Q4R4W5, Q4WM52, Q5E7U8, Q5NWG5, Q5R8R6, Q5YYB6, Q6A5Z1, Q6D3F5, Q7N0A6, Q82MJ7, Q8BFZ6, Q9BXS1, Q9NH02, Q9X7Q6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	37
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

719 predictions. Top by Δscore:

Variant	Effect	Δscore
10:1041504:CCTAA:C	acceptor_loss	1.0000
10:1041505:C:CA	acceptor_loss	1.0000
10:1041505:C:CC	acceptor_gain	1.0000
10:1041506:T:G	acceptor_loss	1.0000
10:1042627:GTTAC:G	donor_loss	1.0000
10:1042628:TTAC:T	donor_loss	1.0000
10:1042629:TA:T	donor_loss	1.0000
10:1042631:C:CA	donor_loss	1.0000
10:1042631:CCT:C	donor_gain	1.0000
10:1042759:CAAC:C	acceptor_gain	1.0000
10:1042764:T:G	acceptor_loss	1.0000
10:1043298:AAC:A	donor_loss	1.0000
10:1043299:A:AC	donor_gain	1.0000
10:1043299:A:AT	donor_loss	1.0000
10:1043300:C:CC	donor_gain	1.0000
10:1043300:C:CG	donor_loss	1.0000
10:1043389:TAATC:T	acceptor_gain	1.0000
10:1043390:AATC:A	acceptor_gain	1.0000
10:1043391:ATC:A	acceptor_gain	1.0000
10:1043391:ATCC:A	acceptor_loss	1.0000
10:1043392:TC:T	acceptor_gain	1.0000
10:1043393:CC:C	acceptor_gain	1.0000
10:1043393:CCT:C	acceptor_loss	1.0000
10:1043394:C:CC	acceptor_gain	1.0000
10:1043394:CTG:C	acceptor_loss	1.0000
10:1043395:T:C	acceptor_loss	1.0000
10:1043401:C:CT	acceptor_gain	1.0000
10:1043402:A:T	acceptor_gain	1.0000
10:1042647:T:TA	donor_gain	0.9900
10:1042652:G:C	donor_gain	0.9900

AlphaMissense

1878 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:1042734:A:C	H88Q	0.996
10:1042734:A:T	H88Q	0.996
10:1042736:G:C	H88D	0.996
10:1043371:A:C	S55R	0.996
10:1043371:A:T	S55R	0.996
10:1043373:T:G	S55R	0.996
10:1043305:A:C	F77L	0.995
10:1043305:A:T	F77L	0.995
10:1043307:A:G	F77L	0.995
10:1043327:C:G	R70T	0.995
10:1043374:A:C	F54L	0.995
10:1043374:A:T	F54L	0.995
10:1043376:A:G	F54L	0.995
10:1044033:C:A	K36N	0.995
10:1044033:C:G	K36N	0.995
10:1042749:A:C	N83K	0.994
10:1042749:A:T	N83K	0.994
10:1043314:C:A	K74N	0.994
10:1043314:C:G	K74N	0.994
10:1043326:T:A	R70S	0.994
10:1043326:T:G	R70S	0.994
10:1043385:G:C	H51D	0.993
10:1044023:G:C	H40D	0.993
10:1044024:A:C	C39W	0.993
10:1042663:A:G	L112P	0.992
10:1041285:A:G	W196R	0.991
10:1041285:A:T	W196R	0.991
10:1041427:T:A	E148D	0.991
10:1041427:T:G	E148D	0.991
10:1042737:A:C	S87R	0.991

dbSNP variants (sampled 300 via entrez): RS1000115722 (10:1049307 C>A,T), RS1000127747 (10:1046000 A>C), RS1000216791 (10:1039848 G>A), RS1000336083 (10:1048078 G>A), RS1000340233 (10:1051424 G>A), RS1000783377 (10:1039409 T>C,G), RS1001465854 (10:1040150 G>A), RS1001552146 (10:1047931 C>T), RS1001669736 (10:1052479 A>G), RS1001673336 (10:1047601 T>C), RS1001743449 (10:1052748 G>A,C), RS1001810412 (10:1052353 T>C), RS1001919698 (10:1047721 G>C), RS1002168730 (10:1050785 A>G), RS1002507679 (10:1056184 A>C)

Disease associations

OMIM: gene MIM:604055 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — Lanosterol biosynthesis pathway

Most potent curated ligand interactions (1 total), top 1:

Ligand	Action	Affinity	Parameter
NE21650	Inhibition	4.2	pIC50

CTD chemical–gene interactions

124 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
perfluorooctane sulfonic acid	decreases expression	5
Valproic Acid	affects expression, decreases expression	4
Cyclosporine	affects cotreatment, affects expression, decreases expression	4
bisphenol A	decreases methylation, increases expression, affects expression, affects methylation, affects cotreatment	3
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	3
Cisplatin	affects cotreatment, increases expression, affects expression	3
Acetaminophen	decreases expression, increases expression	2
Benzo(a)pyrene	decreases expression	2
Quercetin	decreases expression	2
Tunicamycin	decreases expression	2
Aflatoxin B1	affects expression, decreases expression, decreases methylation	2
beta-Naphthoflavone	decreases expression	2
aristolochic acid I	decreases expression, increases expression	1
afuresertib	increases expression	1
6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	increases expression	1
bisphenol F	increases expression	1
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
22-hydroxycholesterol	decreases expression	1
methyleugenol	decreases expression	1
alpha phellandrene	decreases expression	1
triphenyl phosphate	affects expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
trichostatin A	affects expression	1
dodecyldimethylamine oxide	increases expression	1
o,p’-DDT	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	increases expression	1
perfluorooctanoic acid	increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.