IER3-AS1

Summary

IER3-AS1 (IER3 antisense RNA 1, HGNC:53629) is a long non-coding RNA gene on chromosome 6p21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53629
Approved symbol	IER3-AS1
Name	IER3 antisense RNA 1
Location	6p21.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000272273
Ensembl biotype	lncRNA
Entrez	105379695
RNAcentral	URS0000BC43FA — lncRNA, 574 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000607333, ENST00000693016, ENST00000702432, ENST00000720527, ENST00000720528

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000607333 — 2 exons

Exon	Start	End
ENSE00004039341	30743234	30743716
ENSE00004039348	30742769	30743096

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 93.97.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.8698 / max 160.5070, expressed in 1070 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
66781	1.3933	528
66782	0.5661	334
66784	0.5142	80
66785	0.2099	100
66780	0.0967	37
66783	0.0895	34

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	93.97	gold quality
stromal cell of endometrium	CL:0002255	88.69	gold quality
sural nerve	UBERON:0015488	87.44	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.45	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.52	gold quality
left testis	UBERON:0004533	80.90	gold quality
right testis	UBERON:0004534	80.73	gold quality
testis	UBERON:0000473	80.24	gold quality
apex of heart	UBERON:0002098	79.29	gold quality
bone marrow cell	CL:0002092	78.61	gold quality
temporal lobe	UBERON:0001871	78.23	gold quality
amygdala	UBERON:0001876	78.12	gold quality
anterior cingulate cortex	UBERON:0009835	77.99	gold quality
heart left ventricle	UBERON:0002084	77.54	gold quality
cortical plate	UBERON:0005343	76.82	gold quality
Ammon’s horn	UBERON:0001954	76.79	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	76.02	gold quality
mucosa of transverse colon	UBERON:0004991	75.95	gold quality
cerebral cortex	UBERON:0000956	75.88	gold quality
substantia nigra	UBERON:0002038	75.65	gold quality
right frontal lobe	UBERON:0002810	75.58	gold quality
superior frontal gyrus	UBERON:0002661	74.95	gold quality
primary visual cortex	UBERON:0002436	74.77	gold quality
right atrium auricular region	UBERON:0006631	74.74	gold quality
heart	UBERON:0000948	74.69	gold quality
frontal cortex	UBERON:0001870	74.39	gold quality
hypothalamus	UBERON:0001898	73.43	gold quality
hindlimb stylopod muscle	UBERON:0004252	73.27	gold quality
Brodmann (1909) area 9	UBERON:0013540	73.09	gold quality
pancreas	UBERON:0001264	72.65	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	27.54
E-ANND-3	yes	23.36

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.