IFITM10

Summary

IFITM10 (interferon induced transmembrane protein 10, HGNC:40022) is a protein-coding gene on chromosome 11p15.5, encoding Interferon-induced transmembrane protein 10 (A6NMD0).

Predicted to be located in membrane. Predicted to be active in plasma membrane.

Source: NCBI Gene 402778 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 47 total
• MANE Select transcript: NM_001170820

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40022
Approved symbol	IFITM10
Name	interferon induced transmembrane protein 10
Location	11p15.5
Locus type	gene with protein product
Status	Approved
Aliases	DSPA3
Ensembl gene	ENSG00000244242
Ensembl biotype	protein_coding
OMIM	618293
Entrez	402778

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 2 protein_coding, 1 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000340134, ENST00000382123, ENST00000482459, ENST00000486852, ENST00000902500

RefSeq mRNA: 1 — MANE Select: NM_001170820 NM_001170820

CCDS: CCDS53593

Canonical transcript exons

ENST00000340134 — 3 exons

Exon	Start	End
ENSE00001923828	1750359	1750595
ENSE00003498447	1732406	1735429
ENSE00003546487	1747667	1748119

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 92.09.

FANTOM5 (CAGE): breadth broad, TPM avg 4.9067 / max 239.0823, expressed in 698 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
117994	1.7779	389
117989	1.7650	531
117992	0.6118	298
117991	0.4736	239
117990	0.1539	81
117995	0.0900	36
117993	0.0344	14

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left adrenal gland cortex	UBERON:0035825	92.09	gold quality
left adrenal gland	UBERON:0001234	91.22	gold quality
right adrenal gland cortex	UBERON:0035827	90.43	gold quality
right adrenal gland	UBERON:0001233	90.24	gold quality
adrenal gland	UBERON:0002369	85.66	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.59	gold quality
cerebellum	UBERON:0002037	83.17	gold quality
ascending aorta	UBERON:0001496	83.15	gold quality
cerebellar cortex	UBERON:0002129	83.10	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.06	gold quality
cerebellar hemisphere	UBERON:0002245	82.95	gold quality
thoracic aorta	UBERON:0001515	82.82	gold quality
right lobe of liver	UBERON:0001114	82.56	gold quality
descending thoracic aorta	UBERON:0002345	81.69	gold quality
sural nerve	UBERON:0015488	80.83	gold quality
primary visual cortex	UBERON:0002436	78.41	gold quality
liver	UBERON:0002107	78.16	gold quality
metanephros cortex	UBERON:0010533	77.99	gold quality
right coronary artery	UBERON:0001625	77.40	gold quality
superior frontal gyrus	UBERON:0002661	76.23	gold quality
anterior cingulate cortex	UBERON:0009835	76.12	gold quality
hypothalamus	UBERON:0001898	75.14	gold quality
left coronary artery	UBERON:0001626	74.96	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	74.90	gold quality
right frontal lobe	UBERON:0002810	74.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.13	gold quality
cerebral cortex	UBERON:0000956	74.08	gold quality
frontal cortex	UBERON:0001870	73.96	gold quality
substantia nigra	UBERON:0002038	73.72	gold quality
Ammon’s horn	UBERON:0001954	73.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.39

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

79 targeting IFITM10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4713-3P	100.00	65.92	505
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-29B-2-5P	99.67	68.98	1726
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-6512-3P	99.65	66.07	1468
HSA-MIR-6720-5P	99.65	66.22	1459
HSA-MIR-6134	99.63	65.68	1537
HSA-MIR-1915-3P	99.58	66.79	1988

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	ifitm1	ENSDARG00000093303
mus_musculus	Ifitm10	ENSMUSG00000045777
rattus_norvegicus	Ifitm10	ENSRNOG00000020164

Paralogs (5): IFITM3 (ENSG00000142089), IFITM2 (ENSG00000185201), IFITM1 (ENSG00000185885), IFITM5 (ENSG00000206013), (ENSG00000300510)

Protein

Protein identifiers

Interferon-induced transmembrane protein 10 — A6NMD0 (reviewed: A6NMD0)

Alternative names: Dispanin subfamily A member 3

All UniProt accessions (2): A6NMD0, H0Y3H0

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Cell membrane.

Similarity. Belongs to the CD225/Dispanin family.

RefSeq proteins (1): NP_001164291* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007593	CD225/Dispanin_fam	Family
IPR051517	IFITM_antiviral_protein	Family

Pfam: PF04505

UniProt features (9 total): topological domain 3, transmembrane region 2, lipid moiety-binding region 2, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NMD0-F1	55.13	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 167, 168

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 104 (showing top): STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN, GOZGIT_ESR1_TARGETS_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, MATSUDA_NATURAL_KILLER_DIFFERENTIATION, DODD_NASOPHARYNGEAL_CARCINOMA_DN, MEISSNER_NPC_HCP_WITH_H3_UNMETHYLATED, KRIEG_HYPOXIA_NOT_VIA_KDM3A, PEDRIOLI_MIR31_TARGETS_DN, ZWANG_EGF_PERSISTENTLY_DN, SRC_UP.V1_DN, NRL_DN.V1_DN, RB_P130_DN.V1_DN, GREB1_TARGET_GENES, KAECH_NAIVE_VS_DAY8_EFF_CD8_TCELL_DN

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

620 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
IFITM10	PGGHG	Q32M88	529
IFITM10	IFITM5	A6NNB3	466
IFITM10	KRTAP5-1	Q6L8H4	444
IFITM10	PRRT1B	A0A1B0GWB2	419
IFITM10	SCNN1A	P37088	406
IFITM10	TMEM233	B4DJY2	376
IFITM10	MISP3	Q96FF7	374
IFITM10	TMEM91	Q6ZNR0	370
IFITM10	IFI27L2	Q9H2X8	365
IFITM10	SYNDIG1L	A6NDD5	358
IFITM10	NEDD4	P46934	349
IFITM10	TRARG1	Q8IXB3	320
IFITM10	VAPA	Q9P0L0	308
IFITM10	IFI27L1	Q96BM0	304
IFITM10	ZNF488	Q96MN9	303

IntAct

0 interactions, top by confidence:

BioGRID (2): IFITM10 (Two-hybrid), IFITM10 (Proximity Label-MS)

ESM2 similar proteins: A0A087WVF3, A0A087WXS9, A0A087X179, A0A087X1G2, A6NDS4, A6NER0, A6NMD0, A6QPT6, B9A6J9, M3WHG5, O15482, O15553, O19110, O76081, P0C7X1, P0C7X3, P0C7X4, P35125, P48778, P48967, P48968, P79209, Q13670, Q15697, Q2TBC4, Q3T191, Q3UZD7, Q4R2Z8, Q5DRQ5, Q5SSQ6, Q69ZB3, Q6DHY5, Q6IPX1, Q6ZMN8, Q8BLR5, Q8IYF1, Q8IZP1, Q8JZW5, Q8N7G0, Q8N831

Diamond homologs: A6NMD0, A6NNB3, C9JQL5, O88728, P13164, P26376, Q01628, Q01629, Q8BR26, Q91499, Q99J93, Q9CQW9, Q9D103, D3ZFB6, E9PUL5, Q2MHH0, Q5RAC1, Q6DFT4, Q7Z6L0, Q8C838

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	45
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

887 predictions. Top by Δscore:

Variant	Effect	Δscore
11:1735437:C:CT	acceptor_gain	1.0000
11:1735437:C:T	acceptor_gain	1.0000
11:1735438:G:T	acceptor_gain	1.0000
11:1747665:A:AC	donor_gain	1.0000
11:1747666:C:CC	donor_gain	1.0000
11:1735425:CGCAC:C	acceptor_gain	0.9900
11:1735427:CAC:C	acceptor_gain	0.9900
11:1735430:C:CC	acceptor_gain	0.9900
11:1747666:CT:C	donor_gain	0.9900
11:1735428:AC:A	acceptor_gain	0.9800
11:1735429:CC:C	acceptor_gain	0.9800
11:1747661:GCTCA:G	donor_loss	0.9800
11:1747662:CT:C	donor_loss	0.9800
11:1747663:TCA:T	donor_loss	0.9800
11:1747664:CA:C	donor_loss	0.9800
11:1747666:C:CA	donor_loss	0.9800
11:1748116:GGGCC:G	acceptor_gain	0.9800
11:1748117:GGCCT:G	acceptor_gain	0.9800
11:1748118:GCCTG:G	acceptor_gain	0.9800
11:1748118:GCCT:G	acceptor_gain	0.9700
11:1748120:C:A	acceptor_gain	0.9700
11:1749018:CAAG:C	donor_gain	0.9700
11:1750496:A:C	donor_gain	0.9700
11:1735426:GCAC:G	acceptor_gain	0.9600
11:1735427:CACC:C	acceptor_gain	0.9600
11:1747660:GGCT:G	donor_loss	0.9600
11:1747666:CTTTG:C	donor_gain	0.9600
11:1747907:C:CT	acceptor_gain	0.9600
11:1749009:CCTCA:C	donor_loss	0.9600
11:1749010:CTCA:C	donor_loss	0.9600

AlphaMissense

1467 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:1735358:G:C	N203K	1.000
11:1735358:G:T	N203K	1.000
11:1735422:T:G	D182A	1.000
11:1747696:C:G	G170R	1.000
11:1747709:G:C	N165K	1.000
11:1747709:G:T	N165K	1.000
11:1747724:G:C	N160K	1.000
11:1747724:G:T	N160K	1.000
11:1747738:A:G	W156R	1.000
11:1747738:A:T	W156R	1.000
11:1735344:G:T	A208D	0.999
11:1735349:A:C	S206R	0.999
11:1735349:A:T	S206R	0.999
11:1735351:T:G	S206R	0.999
11:1735360:T:C	N203D	0.999
11:1735371:G:T	A199D	0.999
11:1735404:T:C	D188G	0.999
11:1735422:T:A	D182V	0.999
11:1735423:C:G	D182H	0.999
11:1747667:T:A	K179N	0.999
11:1747667:T:G	K179N	0.999
11:1747686:G:T	A173D	0.999
11:1747695:C:A	G170V	0.999
11:1747695:C:T	G170D	0.999
11:1747696:C:A	G170C	0.999
11:1747734:G:A	S157F	0.999
11:1747749:T:A	D152V	0.999
11:1747749:T:G	D152A	0.999
11:1747750:C:G	D152H	0.999
11:1735330:A:G	C213R	0.998

dbSNP variants (sampled 300 via entrez): RS1000306608 (11:1733666 ATCT>A), RS1000588534 (11:1738799 G>A,T), RS1000676064 (11:1744933 T>G), RS1000734176 (11:1749904 C>G), RS1000884542 (11:1751610 G>A,C), RS1001349762 (11:1741575 A>G), RS1001537895 (11:1735620 T>C), RS1001609348 (11:1750604 CCT>C), RS1001626545 (11:1746148 C>T), RS1001666363 (11:1745815 C>A), RS1001698615 (11:1740480 G>T), RS1001768951 (11:1735473 G>A), RS1001779473 (11:1745949 T>C,G), RS1001911729 (11:1732229 A>G), RS1002125548 (11:1750796 G>A)

Disease associations

OMIM: gene MIM:618293 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST006479_34	Diverticular disease	3.000000e-06
GCST007000_5	Logical memory (delayed recall) in mild cognitive impairment	2.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0009959	diverticular disease
EFO:0004874	memory performance

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases methylation, increases expression	3
Estradiol	increases expression, increases reaction	3
aristolochic acid I	increases expression	1
Esketamine	increases expression	1
bisphenol A	decreases methylation	1
2,5,2’,5’-tetrachlorobiphenyl	increases expression	1
potassium chromate(VI)	decreases expression	1
abrine	decreases expression	1
NSC 689534	affects binding, increases expression	1
2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	decreases expression	1
Sunitinib	increases expression	1
Calcitriol	increases expression	1
Copper	affects binding, increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Doxorubicin	decreases expression	1
Endosulfan	increases expression	1
Hydrogen Peroxide	increases expression	1
T-2 Toxin	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Urethane	increases expression	1
Cadmium Chloride	decreases expression	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.