IFNA7

Summary

IFNA7 (interferon alpha 7, HGNC:5428) is a protein-coding gene on chromosome 9p21.3, encoding Interferon alpha-7 (P01567). Produced by macrophages, IFN-alpha have antiviral activities.

Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including lymphocyte activation involved in immune response; response to exogenous dsRNA; and type I interferon-mediated signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space.

Source: NCBI Gene 3444 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 43 total
• Druggable target: yes
• MANE Select transcript: NM_021057

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5428
Approved symbol	IFNA7
Name	interferon alpha 7
Location	9p21.3
Locus type	gene with protein product
Status	Approved
Aliases	IFNA-J, IFN-alphaJ
Ensembl gene	ENSG00000214042
Ensembl biotype	protein_coding
OMIM	147567
Entrez	3444

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000239347

RefSeq mRNA: 1 — MANE Select: NM_021057 NM_021057

CCDS: CCDS34995

Canonical transcript exons

ENST00000239347 — 1 exons

Exon	Start	End
ENSE00000813445	21201469	21202205

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 68.51.

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cervix squamous epithelium	UBERON:0006922	68.51	gold quality
pancreatic ductal cell	CL:0002079	62.37	silver quality
tibialis anterior	UBERON:0001385	61.64	silver quality
ileal mucosa	UBERON:0000331	59.76	gold quality
hair follicle	UBERON:0002073	58.77	gold quality
upper leg skin	UBERON:0004262	57.27	gold quality
decidua	UBERON:0002450	56.55	gold quality
buccal mucosa cell	CL:0002336	54.43	gold quality
cervix epithelium	UBERON:0004801	54.40	gold quality
epithelial cell of pancreas	CL:0000083	51.61	silver quality
quadriceps femoris	UBERON:0001377	51.55	gold quality
oviduct epithelium	UBERON:0004804	51.42	gold quality
vastus lateralis	UBERON:0001379	50.22	gold quality
Brodmann (1909) area 46	UBERON:0006483	49.55	gold quality
blood vessel layer	UBERON:0004797	49.29	gold quality
olfactory bulb	UBERON:0002264	48.92	gold quality
choroid plexus epithelium	UBERON:0003911	48.89	gold quality
myocardium	UBERON:0002349	48.87	gold quality
type B pancreatic cell	CL:0000169	48.83	gold quality
cardiac muscle of right atrium	UBERON:0003379	48.55	gold quality
CA1 field of hippocampus	UBERON:0003881	48.50	gold quality
left ventricle myocardium	UBERON:0006566	48.24	gold quality
orbitofrontal cortex	UBERON:0004167	48.20	gold quality
upper arm skin	UBERON:0004263	48.06	gold quality
tongue squamous epithelium	UBERON:0006919	47.92	gold quality
mucosa of urinary bladder	UBERON:0001259	47.80	gold quality
nasal cavity epithelium	UBERON:0005384	47.70	gold quality
thymus	UBERON:0002370	47.42	gold quality
inferior olivary complex	UBERON:0002127	47.17	gold quality
periodontal ligament	UBERON:0008266	47.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): IRF3, IRF7

miRNA regulators (miRDB)

8 targeting IFNA7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-203A-3P	99.49	70.56	2806
HSA-MIR-876-3P	98.76	68.23	945
HSA-MIR-4272	98.76	68.74	1810
HSA-MIR-323A-5P	98.59	65.13	651
HSA-MIR-595	98.25	67.44	699
HSA-MIR-1322	97.98	68.96	625
HSA-MIR-15B-3P	97.85	66.68	974
HSA-MIR-924	97.78	66.21	681

Literature-anchored findings (GeneRIF, showing 2)

• Secretome screening reveals immunomodulating functions of IFNalpha-7, PAP and GDF-7 on regulatory T-cells. (PMID:34408239)
• Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest. (PMID:8668211)

Cross-species orthologs

34 orthologs

Organism	Symbol	Gene ID
danio_rerio	ifnphi2	ENSDARG00000069012
danio_rerio	ifnphi3	ENSDARG00000070676
mus_musculus	Ifna13	ENSMUSG00000063376
mus_musculus	Ifna4	ENSMUSG00000070904
mus_musculus	Ifna12	ENSMUSG00000073811
mus_musculus	Ifna2	ENSMUSG00000078354
mus_musculus	Ifna16	ENSMUSG00000078355
mus_musculus	Ifna9	ENSMUSG00000095270
mus_musculus	Ifna1	ENSMUSG00000095498
mus_musculus	Ifna14	ENSMUSG00000095896
mus_musculus	Ifna15	ENSMUSG00000096011
mus_musculus	Ifna5	ENSMUSG00000096682
mus_musculus	Ifnab	ENSMUSG00000100079
mus_musculus	Ifna11	ENSMUSG00000100549
mus_musculus	Ifna7	ENSMUSG00000100713
mus_musculus	Ifna6	ENSMUSG00000101252
rattus_norvegicus		ENSRNOG00000071845
rattus_norvegicus	Ifna12l	ENSRNOG00000072681
rattus_norvegicus	Ifna16l1	ENSRNOG00000074841
rattus_norvegicus		ENSRNOG00000075722
rattus_norvegicus		ENSRNOG00000076372
rattus_norvegicus	Ifna4	ENSRNOG00000077072
rattus_norvegicus	Ifna2	ENSRNOG00000078310
rattus_norvegicus	Ifna5	ENSRNOG00000079725
rattus_norvegicus	Ifna1l1	ENSRNOG00000079800
rattus_norvegicus		ENSRNOG00000079804
rattus_norvegicus		ENSRNOG00000081823
rattus_norvegicus		ENSRNOG00000082441
rattus_norvegicus		ENSRNOG00000082845
rattus_norvegicus		ENSRNOG00000083047
rattus_norvegicus	Ifna1	ENSRNOG00000084770
rattus_norvegicus		ENSRNOG00000085373
rattus_norvegicus		ENSRNOG00000085882
rattus_norvegicus		ENSRNOG00000086565

Paralogs (16): IFNA6 (ENSG00000120235), IFNA8 (ENSG00000120242), IFNA21 (ENSG00000137080), IFNA5 (ENSG00000147873), IFNA16 (ENSG00000147885), IFNK (ENSG00000147896), IFNB1 (ENSG00000171855), IFNW1 (ENSG00000177047), IFNE (ENSG00000184995), IFNA10 (ENSG00000186803), IFNA2 (ENSG00000188379), IFNA1 (ENSG00000197919), IFNA14 (ENSG00000228083), IFNA13 (ENSG00000233816), IFNA17 (ENSG00000234829), IFNA4 (ENSG00000236637)

Protein

Protein identifiers

Interferon alpha-7 — P01567 (reviewed: P01567)

Alternative names: Interferon alpha-J, Interferon alpha-J1

All UniProt accessions (2): A0A7R8C383, P01567

UniProt curated annotations — full annotation on UniProt →

Function. Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Subcellular location. Secreted.

Similarity. Belongs to the type-I (or alpha/beta) interferon family.

RefSeq proteins (1): NP_066401* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000471	Interferon_alpha/beta/delta	Family
IPR009079	4_helix_cytokine-like_core	Homologous_superfamily

Pfam: PF00143

UniProt features (6 total): disulfide bond 2, sequence conflict 2, signal peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P01567-F1	84.10	0.52

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (2): 24–122, 52–162

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-909733	Interferon alpha/beta signaling
R-HSA-912694	Regulation of IFNA/IFNB signaling
R-HSA-933541	TRAF6 mediated IRF7 activation
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses
R-HSA-983231	Factors involved in megakaryocyte development and platelet production
R-HSA-9833109	Evasion by RSV of host interferon responses

MSigDB gene sets: 117 (showing top): REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA, GOBP_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_CELLULAR_RESPONSE_TO_VIRUS, REACTOME_INNATE_IMMUNE_SYSTEM, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, GOBP_RESPONSE_TO_PEPTIDE, GOBP_B_CELL_ACTIVATION, GOBP_T_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE, GOBP_RESPONSE_TO_TYPE_I_INTERFERON, KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY, GOBP_CELL_CELL_SIGNALING, GOBP_CELL_ACTIVATION_INVOLVED_IN_IMMUNE_RESPONSE, LIU_VAV3_PROSTATE_CARCINOGENESIS_DN, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, BLALOCK_ALZHEIMERS_DISEASE_UP

GO Biological Process (13): adaptive immune response (GO:0002250), T cell activation involved in immune response (GO:0002286), B cell activation involved in immune response (GO:0002312), natural killer cell activation involved in immune response (GO:0002323), humoral immune response (GO:0006959), cell-cell signaling (GO:0007267), response to virus (GO:0009615), response to exogenous dsRNA (GO:0043330), defense response to virus (GO:0051607), type I interferon-mediated signaling pathway (GO:0060337), cellular response to virus (GO:0098586), defense response (GO:0006952), signal transduction (GO:0007165)

GO Molecular Function (3): cytokine activity (GO:0005125), type I interferon receptor binding (GO:0005132), cytokine receptor binding (GO:0005126)

GO Cellular Component (2): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Interferon Signaling	1
Interferon alpha/beta signaling	1
DDX58/IFIH1-mediated induction of interferon-alpha/beta	1
SARS-CoV-2-host interactions	1
Hemostasis	1
RSV-host interactions	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
immune response	4
lymphocyte activation involved in immune response	3
cell communication	2
signaling	2
response to virus	2
T cell activation	1
B cell activation	1
natural killer cell activation	1
innate immune response	1
response to other organism	1
response to dsRNA	1
defense response	1
cellular response to type I interferon	1
interferon-mediated signaling pathway	1
response to stress	1
cellular process	1
regulation of cellular process	1
cellular response to stimulus	1
receptor ligand activity	1
cytokine receptor binding	1
protein-containing complex binding	1
signaling receptor binding	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1308 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
IFNA7	IL2	P01585	855
IFNA7	IFNG	P01579	762
IFNA7	IFNAR1	P17181	721
IFNA7	CR2	P20023	671
IFNA7	IFNL3	Q8IZI9	667
IFNA7	IL6	P05231	661
IFNA7	ISG15	P05161	654
IFNA7	TLR3	O15455	637
IFNA7	ABL1	P00519	624
IFNA7	GPT	P24298	624
IFNA7	CD4	P01730	620
IFNA7	MX1	P20591	619
IFNA7	TNF	P01375	609
IFNA7	CD8A	P01732	583
IFNA7	IL1B	P01584	581

IntAct

7 interactions, top by confidence:

A	B	Type	Score
IFNA4	IFNA13	psi-mi:“MI:0914”(association)	0.530
IFNA7	SCGB1D2	psi-mi:“MI:0915”(physical association)	0.400
IFNA7	PEX7	psi-mi:“MI:0914”(association)	0.350
IFNA16	IFNA13	psi-mi:“MI:0914”(association)	0.350
IFNA14	AHCYL1	psi-mi:“MI:0914”(association)	0.350

BioGRID (9): IFNA7 (Affinity Capture-MS), IFIT1 (Affinity Capture-MS), IFIT3 (Affinity Capture-MS), IFNA7 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), IFNA7 (Affinity Capture-MS), ISG15 (Affinity Capture-MS), PEX7 (Affinity Capture-MS), SCGB1D2 (Affinity Capture-MS)

ESM2 similar proteins: O46633, P01562, P01563, P01566, P01567, P01568, P01569, P01570, P01571, P01572, P05000, P05002, P05003, P05004, P05005, P05006, P05007, P05008, P05009, P05010, P05013, P05014, P05015, P07348, P07349, P07352, P09235, P15696, P28169, P28171, P28172, P32881, P49876, P49877, P49878, P49879, P56828, P56829, P56830, P56831

Diamond homologs: A7UHZ5, O46633, O77812, O97945, P01562, P01563, P01566, P01567, P01568, P01569, P01570, P01571, P01572, P01573, P01574, P01575, P01576, P01577, P01578, P05000, P05001, P05002, P05003, P05004, P05005, P05006, P05007, P05008, P05009, P05010, P05011, P05012, P05013, P05014, P05015, P06799, P07348, P07349, P07350, P07351

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	38
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

195 predictions. Top by Δscore:

Variant	Effect	Δscore
9:21201753:T:TA	donor_gain	0.7100
9:21201882:T:TA	donor_gain	0.7100
9:21201789:T:TA	donor_gain	0.6700
9:21201795:A:AC	donor_gain	0.6500
9:21201807:T:TA	donor_gain	0.6500
9:21201604:T:TA	donor_gain	0.6400
9:21202031:T:TA	donor_gain	0.6400
9:21201733:T:TA	donor_gain	0.6100
9:21201730:ATTT:A	donor_gain	0.6000
9:21201739:CAG:C	donor_gain	0.6000
9:21201738:A:AC	donor_gain	0.5900
9:21201739:C:CC	donor_gain	0.5900
9:21201777:TCC:T	donor_gain	0.5900
9:21202032:C:A	donor_gain	0.5900
9:21201538:A:AC	donor_gain	0.5700
9:21201631:T:TC	acceptor_gain	0.5700
9:21201628:T:TC	acceptor_gain	0.5600
9:21201738:ACAG:A	donor_gain	0.5600
9:21201739:CAGC:C	donor_gain	0.5600
9:21201578:T:A	donor_gain	0.5500
9:21201673:C:A	donor_gain	0.5500
9:21201802:A:C	donor_gain	0.5500
9:21201808:C:A	donor_gain	0.5500
9:21201672:T:TA	donor_gain	0.5300
9:21201804:G:A	donor_gain	0.5300
9:21201921:TC:T	acceptor_gain	0.5300
9:21201494:A:C	donor_gain	0.5200
9:21201607:T:TA	donor_gain	0.5200
9:21201777:T:TA	donor_gain	0.5200
9:21201923:A:C	acceptor_gain	0.5200

AlphaMissense

1253 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:21201725:G:C	F147L	0.941
9:21201725:G:T	F147L	0.941
9:21201727:A:G	F147L	0.941
9:21201989:G:C	F59L	0.927
9:21201989:G:T	F59L	0.927
9:21201991:A:G	F59L	0.927
9:21201674:C:A	W164C	0.902
9:21201674:C:G	W164C	0.902
9:21201893:G:C	F91L	0.873
9:21201893:G:T	F91L	0.873
9:21201895:A:G	F91L	0.873
9:21201866:C:A	W100C	0.845
9:21201866:C:G	W100C	0.845
9:21201990:A:C	F59C	0.785
9:21201662:T:A	R168S	0.784
9:21201662:T:G	R168S	0.784
9:21201666:A:T	V167D	0.776
9:21201676:A:G	W164R	0.768
9:21201676:A:T	W164R	0.768
9:21201897:A:G	L90P	0.766
9:21201819:A:G	L116P	0.763
9:21201681:C:G	C162S	0.755
9:21201682:A:T	C162S	0.755
9:21202012:A:G	C52R	0.751
9:21201678:G:T	A163D	0.749
9:21201705:A:G	L154P	0.746
9:21202010:G:C	C52W	0.736
9:21201680:A:C	C162W	0.728
9:21202011:C:G	C52S	0.728
9:21202012:A:T	C52S	0.728

dbSNP variants (sampled 300 via entrez): RS1002264155 (9:21202419 G>A,C), RS1002880550 (9:21203591 C>G,T), RS1002931388 (9:21203861 G>C), RS1003211379 (9:21202958 T>C), RS1003266730 (9:21203093 C>T), RS1004452667 (9:21202339 T>A,C), RS1004839908 (9:21201731 T>C), RS1005509690 (9:21203105 T>G), RS1007763207 (9:21202621 G>A,C), RS1007967532 (9:21204134 A>G,T), RS1009358831 (9:21202948 T>C), RS1009588669 (9:21201007 T>A), RS1011038876 (9:21201010 C>A,G,T), RS1011084678 (9:21201128 A>C), RS1011649160 (9:21203418 T>A,C)

Disease associations

OMIM: gene MIM:147567 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL3856161 (PROTEIN FAMILY)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases mutagenesis	1
Sarin	increases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.